Clinical and Prognostic Factors in Patients with Acute Kidney Injury

İsmet Seven; Habib Emre

doi:10.56016/dahudermj.1793529

Clinical and Prognostic Factors in Patients with Acute Kidney Injury

Abstract

Objectives: This study aimed to evaluate demographic characteristics, underlying etiologies, dialysis requirements, and biochemical prognostic factors associated with mortality in patients with acute kidney injury (AKI). Methods: A total of 72 hospitalized patients with AKI and 50 healthy controls were retrospectively analyzed. Demographic, clinical, and laboratory parameters were compared using Student’s t-test, Chi-square, and Pearson correlation analyses. Statistical significance was set at p<0.05. Results: The etiological distribution was 38.9%, 51.4%, and 9.7% for prerenal, renal, and postrenal causes, respectively. Hemodialysis was required in 15.2%, and overall in-hospital mortality was 20.8%. According to correlation analysis, mortality was significantly associated with higher serum phosphorus (r = 0.35, p < 0.01; 95% CI 0.12–0.56), cortisol (r=0.41, p<0.01), and ferritin (r = 0.54, p < 0.01; 95% CI 0.29–0.72) levels, and lower albumin concentration (r=−0.31, p<0.05). Dialysis requirement correlated with renal etiology (r=0.31, p<0.01), elevated creatinine (r=0.56, p<0.01), and phosphorus (r=0.28, p<0.05). Conclusion: Renal causes were the predominant etiology in AKI. Biochemical markers such as phosphorus, cortisol, ferritin, and albumin may serve as valuable indicators for early risk stratification and mortality prediction.

Keywords

Acute kidney injury, Albumin, Cortisol, Ferritin, Hemodialysis, Mortality, Phosphorus, Prognosis, Renal replacement therapy

Ethical Statement

The research protocol was reviewed and approved by the Institutional Faculty of Medicine Hospital Clinical Research Ethics Committee (Decision Number: 05.09.2013, 2).

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Details

Primary Language

English

Subjects

Internal Diseases

Journal Section

Research Article

Authors

İsmet Seven ^*
0009-0001-4706-0495
Türkiye

Habib Emre
0000-0002-2761-4745
Türkiye

Early Pub Date

November 5, 2025

Publication Date

November 13, 2025

Submission Date

September 29, 2025

Acceptance Date

November 5, 2025

Published in Issue

Year 2025 Volume: 5 Number: 4

DOI

https://doi.org/10.56016/dahudermj.1793529

IZ

https://izlik.org/JA49SL34KY

APA

Seven, İ., & Emre, H. (2025). Clinical and Prognostic Factors in Patients with Acute Kidney Injury. DAHUDER Medical Journal, 5(4), 121-128. https://doi.org/10.56016/dahudermj.1793529

AMA

1.Seven İ, Emre H. Clinical and Prognostic Factors in Patients with Acute Kidney Injury. DAHUDER MJ. 2025;5(4):121-128. doi:10.56016/dahudermj.1793529

Chicago

Seven, İsmet, and Habib Emre. 2025. “Clinical and Prognostic Factors in Patients With Acute Kidney Injury”. DAHUDER Medical Journal 5 (4): 121-28. https://doi.org/10.56016/dahudermj.1793529.

EndNote

Seven İ, Emre H (November 1, 2025) Clinical and Prognostic Factors in Patients with Acute Kidney Injury. DAHUDER Medical Journal 5 4 121–128.

IEEE

[1]İ. Seven and H. Emre, “Clinical and Prognostic Factors in Patients with Acute Kidney Injury”, DAHUDER MJ, vol. 5, no. 4, pp. 121–128, Nov. 2025, doi: 10.56016/dahudermj.1793529.

ISNAD

Seven, İsmet - Emre, Habib. “Clinical and Prognostic Factors in Patients With Acute Kidney Injury”. DAHUDER Medical Journal 5/4 (November 1, 2025): 121-128. https://doi.org/10.56016/dahudermj.1793529.

JAMA

1.Seven İ, Emre H. Clinical and Prognostic Factors in Patients with Acute Kidney Injury. DAHUDER MJ. 2025;5:121–128.

MLA

Seven, İsmet, and Habib Emre. “Clinical and Prognostic Factors in Patients With Acute Kidney Injury”. DAHUDER Medical Journal, vol. 5, no. 4, Nov. 2025, pp. 121-8, doi:10.56016/dahudermj.1793529.

Vancouver

1.İsmet Seven, Habib Emre. Clinical and Prognostic Factors in Patients with Acute Kidney Injury. DAHUDER MJ. 2025 Nov. 1;5(4):121-8. doi:10.56016/dahudermj.1793529

Cited By

Comment on Prognostic Biomarkers in Acute Kidney Injury

DAHUDER Medical Journal

https://doi.org/10.56016/dahudermj.1857876

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