Objective: To investigate the frequency of microalbuminuria and associated risk factors across the stages of chronic kidney disease (CKD).
Methods: This cross-sectional study included 200 patients aged 16-85 who applied to the Internal Medicine Outpatient Clinic between November 2009 and February 2010. Demographic data and blood pressure were recorded. Biochemical parameters, along with 24-hour urinary protein and albumin excretion, were measured. CKD staging was performed according to GFR calculated using the MDRD formula.
Results: Of the patients, 64% were female. The most common etiology was undetermined (58%). Among identified causes, diabetes mellitus and hypertension were primary. As the CKD stage progressed, proteinuria and albuminuria levels increased significantly (p<0.001). The frequency of microalbuminuria was 23.1% in Stage 1 and reached 80% in Stage 5. Significant associations were found between CKD stages and blood pressure, urea, creatinine, potassium, calcium, hemoglobin, and CRP levels (p<0.05). Proteinuria and albuminuria showed a negative correlation with GFR and a positive correlation with CRP (p<0.001).
Conclusion: Microalbuminuria appears from the early stages of CKD, and its frequency increases as the disease progresses. Hypertension and inflammation (elevated CRP) are independent risk factors associated with microalbuminuria. Screening CKD patients for microalbuminuria from the early stages is crucial for slowing disease progression.
Ethical approval for this study was obtained from the Ministry of Health, Diyarbakır Clinical Research Ethics Committee (Decision Date: December 28, 2009; Decision Number: 2009-91).
| Primary Language | English |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | Research Article |
| Authors | |
| Submission Date | February 15, 2026 |
| Acceptance Date | April 10, 2026 |
| Early Pub Date | April 17, 2026 |
| DOI | https://doi.org/10.56016/dahudermj.1886504 |
| IZ | https://izlik.org/JA53JU56WH |
| Published in Issue | Year 2026 Issue: Advanced Online Publication |
DAHUDER Medical Journal (DAHUDER MJ) is an international, independent, double-blind peer-reviewed, open access, and online publishing journal dedicated to publishing high-quality scientific papers in all areas of clinical medicine. Manuscripts must present original data that have not been published previously and are not under consideration elsewhere.
All submissions are evaluated by at least two independent reviewers who are specialists in the relevant field, and the final decision rests with the Editor-in-Chief. The Editorial Board follows the principles of the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE).
The journal is published quarterly in March, June, September, and December and accepts manuscripts in English, including original articles, case reports, invited reviews, and letters to the editor.
Subject areas covered by DAHUDER MJ include, but are not limited to:
General information
Article Submission Phase
Required files to be uploaded when submitting an article:
1- An Article Format file of the article prepared in accordance with the editorial guidelines (No information about the authors should be included. This file will be sent to the reviewers in accordance with the double-blind review policy.)
2- The "Title Page" must be completely filled out and uploaded to the system.
3- Copyright Agreement and Author Acknowledgement Form
4- A similarity report must be uploaded to the system.
5- The approved version of the Ethics Committee Permit must be uploaded to the system. If the study does not require ethics committee approval, upload a file indicating this. In addition, this approval (name, date, and number of the committee) must be stated in the "Article Information Form" at the end of the study.
Institutional review board/ethics committee approval (IRB)
If a study involves either human subjects, human-derived materials, and/or medical records, authors must include in the Methods section either a statement that an Institutional Review Board (IRB)/Ethics Committee approval has been obtained or a statement that the IRB/Ethics Committee has ruled that approval was not required for the study. When reporting experiments conducted with humans, it is indicated that the procedures were in accordance with ethical standards set forth by the committee that oversees human experimentation. Approval of research protocols by the relevant ethics committee, in accordance with international agreements (Helsinki Declaration of 1975, revised 2024, available at https://www.wma.net/policies-post/wma-declaration-of-helsinki/, “Guide for the Care and Use of Laboratory Animals” www.nap.edu/catalog/5140.html/), is required for all experimental, clinical, and drug studies. Patient names, initials, and hospital identification numbers should not be used. Manuscripts reporting the results of experimental investigations conducted with humans must state that the study protocol received institutional review board approval and that the participants provided informed consent.
Permissions
Authors who wish to include figures, tables, or text fragments that have been previously published elsewhere should definitely cite the relevant place in the article. If not cited, they must obtain permission from the copyright holder(s) for the relevant portion and include proof of such permission when submitting their manuscript. Without such proof, any material cited will be assumed to belong to the authors. No material, such as clinical images or charts, photos, and graphs, as well as images of devices that may have been obtained from their producers, can be published without such permission.
Types of Papers
Original Article: An article is a full-length report on original primary research that will interest the journal's readers. They must describe significant and original observations.
Review Article: The review article is a comprehensive analysis of specific topics and recent developments in a particular area. A review should focus on recent research and issues. It should also include the authors' opinions on how to approach the topic/situation under discussion and what is needed to advance the field in the future.
Communications: Short (brief) communications are short papers that focus on a particular aspect of a problem or a new finding that is expected to have a significant impact and present original and important material. Short communication is not intended to publish preliminary results. They may be given rapid publication. Short communication should not be subdivided. The paper should include an abstract, main body of text (combined methods, results, and discussion in a single section), and references.
Rapid communications are similar to short communications. These are usually articles used to disseminate preliminary results that are original, of high interest, and likely to have a significant impact on the relevant scientific community. In the healthcare field, this can include information that is urgent from a public health perspective or findings in a rapidly changing specialty. Their format is similar to short communications.
Case Report: Case reports and case studies should present significant new insights or cases with an unusual and noteworthy course. It is recommended that case reports include an up-to-date review of all previous cases in the field. The novelty of the case(s) may lie in the phenotype, the presentation, the investigation, and/or the management. A case report must be strictly limited to 2000 words, excluding the abstract, references, and article information form, and have minimal figures, tables, and references.
Letter to the Editor: Formal commentary on published articles may take the form of critiques, requests for clarification, or—on occasion—replication efforts. After peer review, these contributions may be posted online as Letters to the Editor, typically accompanied by a response from the original authors. Letters to the Editor and replies are bidirectionally linked with the original published paper. The journal will not consider Letters about work published elsewhere. Submissions that do not meet our guidelines will not be taken forward. Letters to the Editor should be roughly 1000 words in length, not counting references and article information form. They must be written in a neutral register, and all points raised should pertain directly to the original article. All such submissions are peer reviewed, and the Editor retains sole discretion over acceptance or rejection.
Manuscript preparation
Download the Article Format file for the sample file.
Title: A title that describes the article and is not too long is preferred. Only the first letter of each word in the title should be capitalized.
Authors: Author names must be clearly written. Abbreviations must not be used. Each author's ORCID ID number must be written. Each author's institution must be listed in the order Department, Faculty, University, City, and Country. If the institution is present, its ROR ID must be written after the address.
Abstracts: A structured abstract of no more than 300 words is required. The Abstract for all manuscripts except case reports and review articles should be divided into Objective, Methods, Results, and Conclusion.
Keywords: Keywords are required for indexing and abstracting services. Up to ten words should be listed.
Main text: The main text of an original article should be divided into INTRODUCTION, METHODS, RESULTS, DISCUSSION, and CONCLUSION sections. The case report should include an abstract, introduction, case report, discussion, and references. Abbreviations must be defined following their first use in the Abstract as well as in the main text and in the figures and tables. Only commonly accepted abbreviations should be used. Drug and chemical names should be stated using generic or standard chemical nomenclature. Units of measurement should conform to the International System (SI); however, clinical data may be presented in conventional units where deemed more appropriate.
Headings and subheadings: Main headings (INTRODUCTION, METHODS, RESULTS, DISCUSSION, etc.) and the word REFERENCES should be written in capital letters. In subheadings, only the first letter of each word should be capitalized.
Footnotes: Footnotes may be used to give additional information, but should not consist of a reference citation, which is not included in the reference list at the end of the manuscript, and must not contain figures or tables. Footnotes should be numbered consecutively and separately for the title page, the main text, and each table. Footnotes should be indicated by superscript lowercase letters or numbers, or by asterisks for significance values and other statistical data. Footnotes should be positioned at the bottom of the page or table in which they appear.
Tables, Graphics, and Illustrations
Tables, graphics, and illustrations should be numbered in Arabic numerals in the text. The places of the illustrations should be signed in the text.
Tables
Illustrations (Figures)
Legends for Illustrations (Figures)
Article Information Form
The article information form should be written after the text, before the references. Explain the following headings in detail.
Acknowledgments:
Financial Disclosure:
Conflicts of interest:
Ethical Declaration:
Artificial Intelligence Statement:
Author Contributions: (The statement "Authors' contribution to the article is equal" is not accepted.) To be considered as an author of an article, a writer must have contributed to at least 3 of the following. If any of the following headings are not relevant to your work, please mark them as "None".
Conceptualization: FA, SA;
Methodology: FA, SA;
Software: TA;
Validation: FA, TA;
Formal analysis: SA;
Investigation: FA;
Resources: TA;
Data curation: FA;
Writing – original draft: SA;
Writing – review & editing: FA;
Visualization: SA;
Supervision: None;
Project administration: FA, SA;
Funding acquisition: None;
Reference Style and Format
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For books and other monographs
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Homepage/Website
Proofreading
After DAHUDER MJ has prepared the layout of the article, it is sent to all authors for proofreading. All authors must view the pre-publication version of the article and approve its publication.
Multicenter clinical trials
DAHUDER MJ welcomes the submission of manuscripts reporting results of multicenter clinical trials. These manuscripts may be submitted with authorship in one of the following styles:
In each case, one individual must serve as the corresponding author, and the names of all individuals specifically involved in the preparation of the manuscript should be listed under the heading Writing Committee following the Acknowledgments section. This should be followed by a list of investigators from each institution under the heading Study Group Investigators. Each author and each Writing Committee member must sign the Copyright Agreement and Author Acknowledgement Form.
Content responsibility
Content and scientific accuracy of all manuscripts, as well as of any electronic supplementary material, are the sole responsibility of the authors. No responsibility will be assumed by DAHUDER MJ for any legal claim arising from injury and/or damage to persons or property as a matter of product liability, negligence, or other circumstances; nor from any use or operation of any methods, products, instructions, or ideas contained in the published material. No test or procedure should be carried out unless the reader judges it to be safe. Independent verification of all diagnoses and drug dosages should be performed. Discussions, views, and recommendations regarding medical procedures, drug choices, and dosages are the sole responsibility of the authors.
Disclaimer
DAHUDER MJ does not accept or publish advertisements. Any mention of commercial products, if it occurs within scholarly content, does not imply endorsement by the journal.
Dahuder Medical Journal (Dahuder MJ) is an international, peer-reviewed academic journal dedicated to internal medicine, clinical medicine, and related health sciences. The journal publishes articles in English, operates a double-blind peer-review system, and adopts a continuous publication model, whereby accepted manuscripts are published online once all editorial and production procedures have been completed. Dahuder Medical Journal is committed to the highest standards of scientific quality, publication ethics, and academic integrity, and follows the principles and recommendations of COPE, ICMJE, the Declaration of Helsinki, and WAME.
Author Responsibilities
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Research Ethics
Data Transparency
Conflict of Interest
Artificial Intelligence (AI) Use Policy
Retraction
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Handling of Ethical Misconduct
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