Abstract
Primary Epstein-Barr virus (EBV) infection is a herpes virus characterized by sore throat, fever, and lymphadenopathy. Liver involvement is characterized by moderate elevation of aminotransferases and hepatosplenomegaly, which regresses spontaneously. Cholestatic hepatitis in patients is a rare presentation of primary EBV infection. A 19-year-old male patient presented to the emergency department with complaints of nausea, vomiting, right upper quadrant pain, and mild sore throat for 2 days. Acute EBV infection was diagnosed based on serology results and no dilating lesions detected on radiological imaging. Healthcare professionals should keep in mind that EBV may also be involved in the etiology of cholestatic hepatitis.
Keywords
Project Number
no
References
- Shaw N, Evans J. Liver failure and Epstein-Barr virus infection. Arch Dis Child. 1988;63:432–3. doi: 10.1136/adc.63.4.432
- Primary Ebstain-Barr Virüs hepatitis complicated by ascites with Ebstein Barr Virüs reactivation during primary Cytomegalovirüs infection. J of Pediatric Gastroenterology 2003;37:87-90. doi: 10.1097/00005176-200307000-00016
- Kofteridis D, Koulentaki M, Valachis A, Christofaki M, Mazokopakis E, Papazoglou G, et al. Eur J Intern Med. 2011;22(1):73–6. doi: 10.1016/j.ejim.2010.07.016
- Ebstein-Barr Virüs virüs: an unusual cause of cholestatic hepatitis in older adults. Gastroenterology Hepatology 2007;3(2):101-105.
- Cameron B, Flamand L, Juwana H, Middeldorp J, Naing Z, Rawlinson W, et al. Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome. J Med Virol. 2010;82(10):1684–8. doi: 10.1002/jmv.21873
- Levitskaya J, Coram M, Levitsky V, Imreh S, Steigerwald-Mullen PM, Klein G, Kurilla MG, Masucci MG. Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1. Nature. 1995 Jun 22;375(6533):685-8. doi: 10.1038/375685a0.
- Epstein Barr virus hepatitis. Kofteridis DP, Koulentaki M, Valachis A, Christofaki M, Mazokopakis E, Papazoglou G, Samonis G. Eur J Intern Med. 2011;22:73–76. doi: 10.1016/j.ejim.2010.07.016.
- Markin R. Manifestations of Epstein-Barr virus-associated disorders in liver. Liver. 1994;14(1):1–13. doi: 10.1111/j.1600-0676.1994.tb00001.x
- Joshi A, Jha D, Wari E, Saeed M, Hussain M, Hiatt TK. Cholestatic hepatitis in acute Epstein–Barr virus infection: A case report. Clin Case Rep. 2024; 12:e9357. doi:10.1002/ccr3.9357
- Mellinger J, Rossaro L, Naugler W, Nadig S, Appelman H, Lee W, et al. Epstein-Barr virus (EBV) related acute liver failure: a case series from the US Acute Liver Failure Study Group. Dig Dis Sci. 2014;59(7):1630–7. doi: 10.1007/s10620-014-3029-2
- M Abdel-Aziz, H El-Hoshy, M Rashed, M Qotb, S Awad, N Naguib. Epstein–Barr virus infection as a cause of cervical lymphadenopathy in children. Int J Paediatr Otorhinolaryngol. 2011;75(4):564–67. doi: 10.1016/j.ijporl.2011.01.020.
- Womack J, Jimenez M. Common questions about infectious mononucleosis. Am Fam Physician. 2015;91(6):372-376
Abstract
Primer Epstein-Barr virüsü (EBV) enfeksiyonu boğaz ağrısı, ateş ve lenfadenopati ile karakterize bir herpes virüsüdür. Karaciğer tutulumu aminotransferazların orta düzeyde yükselmesi ve kendiliğinden gerileyen hepatosplenomegali ile karakterizedir. Hastalarda kolestatik hepatit primer EBV enfeksiyonunun nadir görülen bir sunumudur. 19 yaşında erkek hasta 2 gündür devam eden mide bulantısı, kusma, sağ üst kadran ağrısı ve hafif boğaz ağrısı şikayetleriyle acil servise başvurdu. Akut EBV enfeksiyonu seroloji sonuçlarına ve radyolojik görüntülemede genişleyen lezyon saptanmamasına dayanarak teşhis edildi. Sağlık çalışanları EBV'nin kolestatik hepatitin etiyolojisinde de rol oynayabileceğini akılda tutmalıdır.
Keywords
Project Number
no
References
- Shaw N, Evans J. Liver failure and Epstein-Barr virus infection. Arch Dis Child. 1988;63:432–3. doi: 10.1136/adc.63.4.432
- Primary Ebstain-Barr Virüs hepatitis complicated by ascites with Ebstein Barr Virüs reactivation during primary Cytomegalovirüs infection. J of Pediatric Gastroenterology 2003;37:87-90. doi: 10.1097/00005176-200307000-00016
- Kofteridis D, Koulentaki M, Valachis A, Christofaki M, Mazokopakis E, Papazoglou G, et al. Eur J Intern Med. 2011;22(1):73–6. doi: 10.1016/j.ejim.2010.07.016
- Ebstein-Barr Virüs virüs: an unusual cause of cholestatic hepatitis in older adults. Gastroenterology Hepatology 2007;3(2):101-105.
- Cameron B, Flamand L, Juwana H, Middeldorp J, Naing Z, Rawlinson W, et al. Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome. J Med Virol. 2010;82(10):1684–8. doi: 10.1002/jmv.21873
- Levitskaya J, Coram M, Levitsky V, Imreh S, Steigerwald-Mullen PM, Klein G, Kurilla MG, Masucci MG. Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1. Nature. 1995 Jun 22;375(6533):685-8. doi: 10.1038/375685a0.
- Epstein Barr virus hepatitis. Kofteridis DP, Koulentaki M, Valachis A, Christofaki M, Mazokopakis E, Papazoglou G, Samonis G. Eur J Intern Med. 2011;22:73–76. doi: 10.1016/j.ejim.2010.07.016.
- Markin R. Manifestations of Epstein-Barr virus-associated disorders in liver. Liver. 1994;14(1):1–13. doi: 10.1111/j.1600-0676.1994.tb00001.x
- Joshi A, Jha D, Wari E, Saeed M, Hussain M, Hiatt TK. Cholestatic hepatitis in acute Epstein–Barr virus infection: A case report. Clin Case Rep. 2024; 12:e9357. doi:10.1002/ccr3.9357
- Mellinger J, Rossaro L, Naugler W, Nadig S, Appelman H, Lee W, et al. Epstein-Barr virus (EBV) related acute liver failure: a case series from the US Acute Liver Failure Study Group. Dig Dis Sci. 2014;59(7):1630–7. doi: 10.1007/s10620-014-3029-2
- M Abdel-Aziz, H El-Hoshy, M Rashed, M Qotb, S Awad, N Naguib. Epstein–Barr virus infection as a cause of cervical lymphadenopathy in children. Int J Paediatr Otorhinolaryngol. 2011;75(4):564–67. doi: 10.1016/j.ijporl.2011.01.020.
- Womack J, Jimenez M. Common questions about infectious mononucleosis. Am Fam Physician. 2015;91(6):372-376
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences (Other) |
| Journal Section | Case Reports |
| Authors | |
| Project Number | no |
| Publication Date | July 29, 2025 |
| Submission Date | February 5, 2025 |
| Acceptance Date | March 3, 2025 |
| Published in Issue | Year 2025 Volume: 5 Issue: 3 |
