Interplay between IL-17 cytokines and gut microbiota in colon inflammation

Ayşe Naz Özabacı

doi:10.18614/dehm.1813858

Interplay between IL-17 cytokines and gut microbiota in colon inflammation

Abstract

This review aims to investigate the relationship between the gut microbiota and the interleukin-17 (IL-17) cytokine family, focusing on the effects of these interactions on immune homeostasis and disease pathogenesis. Based on recent findings, the role of IL-17 in maintaining gut integrity and regulating microbial composition has been examined. It explores how IL-17 influences the balance of gut microbiota and how microbiota-derived metabolites, such as short-chain fatty acids (SCFAs), regulate IL-17 activity. The interaction between IL-17 and the gut microbiota has been addressed in the context of immune modulation across various mucosal sites. The results demonstrate that IL-17 plays a central role in maintaining mucosal defenses and shaping systemic immune responses. Disruption of this relationship may lead to autoimmune and inflammatory diseases, suggesting that targeting IL-17-microbiota interactions could offer new therapeutic approaches. This study seeks to shed light on the regulatory dynamics between IL-17 and the gut microbiota, extending beyond the functions of the immune system to inspire the development of novel therapeutic strategies for restoring homeostasis and alleviating inflammatory disorders.

Keywords

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Details

Primary Language

English

Subjects

Clinical Sciences (Other)

Journal Section

Review

Authors

Ayşe Naz Özabacı
0009-0008-2802-027X
Türkiye

Publication Date

October 30, 2025

Submission Date

November 28, 2024

Acceptance Date

May 29, 2025

Published in Issue

Year 2025 Volume: 39 Number: 4

DOI

https://doi.org/10.18614/dehm.1813858

IZ

https://izlik.org/JA97MG72UN

Cite

RIS / Bibtex

APA

Özabacı, A. N. (2025). Interplay between IL-17 cytokines and gut microbiota in colon inflammation. Developments and Experiments in Health and Medicine, 39(4), 329-338. https://doi.org/10.18614/dehm.1813858

AMA

1.Özabacı AN. Interplay between IL-17 cytokines and gut microbiota in colon inflammation. Dev Exp Health Med. 2025;39(4):329-338. doi:10.18614/dehm.1813858

Chicago

Özabacı, Ayşe Naz. 2025. “Interplay Between IL-17 Cytokines and Gut Microbiota in Colon Inflammation”. Developments and Experiments in Health and Medicine 39 (4): 329-38. https://doi.org/10.18614/dehm.1813858.

EndNote

Özabacı AN (October 1, 2025) Interplay between IL-17 cytokines and gut microbiota in colon inflammation. Developments and Experiments in Health and Medicine 39 4 329–338.

IEEE

[1]A. N. Özabacı, “Interplay between IL-17 cytokines and gut microbiota in colon inflammation”, Dev Exp Health Med, vol. 39, no. 4, pp. 329–338, Oct. 2025, doi: 10.18614/dehm.1813858.

ISNAD

Özabacı, Ayşe Naz. “Interplay Between IL-17 Cytokines and Gut Microbiota in Colon Inflammation”. Developments and Experiments in Health and Medicine 39/4 (October 1, 2025): 329-338. https://doi.org/10.18614/dehm.1813858.

JAMA

1.Özabacı AN. Interplay between IL-17 cytokines and gut microbiota in colon inflammation. Dev Exp Health Med. 2025;39:329–338.

MLA

Özabacı, Ayşe Naz. “Interplay Between IL-17 Cytokines and Gut Microbiota in Colon Inflammation”. Developments and Experiments in Health and Medicine, vol. 39, no. 4, Oct. 2025, pp. 329-38, doi:10.18614/dehm.1813858.

Vancouver

1.Ayşe Naz Özabacı. Interplay between IL-17 cytokines and gut microbiota in colon inflammation. Dev Exp Health Med. 2025 Oct. 1;39(4):329-38. doi:10.18614/dehm.1813858