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Yıl 2010, Yıl: 2010 Sayı: 2, 95 - 107, 01.07.2010

Öz

Antioxidants and Regulation of Antioxidant Enzymes by Cellular Redox Status

Yıl 2010, Yıl: 2010 Sayı: 2, 95 - 107, 01.07.2010

Öz

It has been well known that free radicals have numerous detrimental effects in both in vitro and in vivo in biological systems because of their unavoidable and tremendous reactivity against biological macromolecules especially proteins, carbohydrates and nucleic acids. They are produced in the biological systems continuously by various mechanisms and eliminated by cellular antioxidant systems. If not eliminated sufficiently, or there is a disturbance in their neutralization, inevitable cellular damage may occur. Activities or the presence of antioxidant enzymes in the cells are under strong regulation with transcriptional, translational and post translational mechanisms as a consequence of changes in cellular redox potential. Redox sensitive metabolic enzymes or proteins; such as protein phosphatases, NF-κB and AP-1, are capable of sensing the oxidant signals by reversible oxidation of their regulatory units which cause them to transduce the signal and adjust the cellular antioxidant metabolism. Redox sensitive proteins execute their functions via kinases, phosphatases, and transcription factors influencing the steady state levels of antioxidant enzymes. Therefore, cells may sense, transduce, and translate the oxidant signals into appropriate cellular responses depending on the cellular redox state. This rewiev focused on the basic definitions for the free radicals and the tissue defense mechanism and the possible regulation mechanisms of antioxidant enzymes in the situations undergoing reversible changes in cellular redox status

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Ayrıntılar

Diğer ID JA85AD33EE
Bölüm Araştırma Makalesi
Yazarlar

Gökhan Sadi Bu kişi benim

Özlem Sadi Bu kişi benim

Yayımlanma Tarihi 1 Temmuz 2010
Yayımlandığı Sayı Yıl 2010 Yıl: 2010 Sayı: 2

Kaynak Göster

APA Sadi, G., & Sadi, Ö. (2010). Antioxidants and Regulation of Antioxidant Enzymes by Cellular Redox Status. Türk Bilimsel Derlemeler Dergisi(2), 95-107.
AMA Sadi G, Sadi Ö. Antioxidants and Regulation of Antioxidant Enzymes by Cellular Redox Status. Turk.Bilimsel Derleme Derg. Temmuz 2010;(2):95-107.
Chicago Sadi, Gökhan, ve Özlem Sadi. “Antioxidants and Regulation of Antioxidant Enzymes by Cellular Redox Status”. Türk Bilimsel Derlemeler Dergisi, sy. 2 (Temmuz 2010): 95-107.
EndNote Sadi G, Sadi Ö (01 Temmuz 2010) Antioxidants and Regulation of Antioxidant Enzymes by Cellular Redox Status. Türk Bilimsel Derlemeler Dergisi 2 95–107.
IEEE G. Sadi ve Ö. Sadi, “Antioxidants and Regulation of Antioxidant Enzymes by Cellular Redox Status”, Turk.Bilimsel Derleme Derg., sy. 2, ss. 95–107, Temmuz 2010.
ISNAD Sadi, Gökhan - Sadi, Özlem. “Antioxidants and Regulation of Antioxidant Enzymes by Cellular Redox Status”. Türk Bilimsel Derlemeler Dergisi 2 (Temmuz 2010), 95-107.
JAMA Sadi G, Sadi Ö. Antioxidants and Regulation of Antioxidant Enzymes by Cellular Redox Status. Turk.Bilimsel Derleme Derg. 2010;:95–107.
MLA Sadi, Gökhan ve Özlem Sadi. “Antioxidants and Regulation of Antioxidant Enzymes by Cellular Redox Status”. Türk Bilimsel Derlemeler Dergisi, sy. 2, 2010, ss. 95-107.
Vancouver Sadi G, Sadi Ö. Antioxidants and Regulation of Antioxidant Enzymes by Cellular Redox Status. Turk.Bilimsel Derleme Derg. 2010(2):95-107.