Alfa 2 Delta(α2δ)LigandlarınınAnksiyolitik Etkisinin Hayvan Anksiyete Testleri ile İncelenmesi

Yıl 2017, Cilt: 10 Sayı: 1, 13 - 15, 01.06.2017

Hasan Çalışkan Koray Hamza Cihan Nezahat Zaloğlu

Öz

Anksiyete çok farklı emosyonları içeren psikolojik bir rahatsızlıktır. Anksiyete tedavisinde son yıllarda antikonvülsan ajanlarda kullanılmaktadır. Bu derlemede antikonvülsan özelliğe sahip, voltaj bağımlı kalsiyum kanallarının ligandı olan Gabapentin ve Pregabalinin hayvan anksiyete testlerindeki anksiyolitik etkisi incelenmiştir.

Anahtar Kelimeler

Anksiyete, Gabapentin, Pregabalin

Kaynakça

• Stahl SM. 2015. Stahl’ın Temel Psikofarmokolojisi, Sinirsel Temeli ve Pratik Uygulaması. Ed: Prof.Dr. Tunç Alkın. S: 388-420.
• Goldlust A, Su TZ, Welty DF, Taylor CP, Oxender DL. 1995. Effects of anticonvulsantdruggabapentin on theenzymes in metabolicpathways of glutamateand GABA. EpilepsyRes. 22(1):1-11.
• Petroff OA, Rothman DL, Behar KL, Lamoureux D, Mattson RH. 1996. Theeffect of gabapentin on brain gamma-aminobutyricacid in patientswithepilepsy. AnnNeurol. 39(1):95-9.
• Schwan S, Sundström A, Stjernberg E, Hallberg E, Hallberg P. 2010. Signalfor an abuseliabilityforpregabalinresultsfromtheSwedishspontaneousadversedrugreactionreportingsystem. Eur J ClinPharmacol. 66(9):947-953.
• Amin B, Hosseinzadeh H. 2012. Evaluation of aqueousandethanolicextracts of saffron, Crocussativus L.,anditsconstituents, safranalandcrocin in allodyniaandhyperalgesiainducedbychronicconstrictioninjury model of neuropathicpain in rats. Fitoterapia. 83(5):888-95.
• Young LT, Robb JC, Hasey GM, MacQueen GM, PatelisSiotis I, Marriott M, Joffe RT. 1999. Gabapentin as an adjunctivetreatment in bipolardisorder. J AffectDisord. 55(1):73-7.
• Rosenberg JM, Harrell C, Ristic H, Werner RA, de Rosayro AM. 1997. Theeffect of gabapentin on neuropathicpain. Clin J Pain. 13(3):251-5.
• Gahr M, Freudenmann RW, Hiemke C, Kölle MA, Schönfeldt-Lecuona C. 2013. Pregabalinabuseanddependence in Germany: resultsfrom a databasequery. Eur J ClinPharmacol. 69(6):1335-42.
• Montgomery KC. 1955. Therelationbetweenfearinducedbynovelstimulationandexploratorybehavior. J CompPhysiolPsychol. 48(4): 254-260.
• Handley SL, Mithani S. 1984. Effects of alpha-adrenoceptoragonistsandantagonists in a maze-exploration model of ’fear’-motivatedbehaviour. NaunynSchmiedebergsArch. Pharmacol. 327:1–5.
• Pellow S, Chopin P, File SE, Briley M. 1985. Validation of open: closedarmentries in an elevatedplus-maze as a measure of anxiety in therat. J. NeurosciMethods. 14: 149-167.
• Watson WP, Robinson E, Little HJ. 1997. Thenovelanticonvulsant, gabapentin, protectsagainstbothconvulsantandanxiogenicaspects of theethanolwithdrawalsyndrome. Neuropharmacology. 36(10):1369-75.
• de-Paris F, Busnello JV, Vianna MR, Salgueiro JB, Quevedo J, Izquierdo I, Kapczinski F. 2000. Theanticonvulsantcompoundgabapentinpossessesanxiolytic but not amnesiceffects in rats. BehavPharmacol. 11(2):169-73.
• Kulkarni SK, Singh K, Bishnoi M. 2008. Comparativebehaviouralprofile of newerantianxietydrugs on differentmazes. Indian J ExpBiol. 46(9):633-8.
• Celikyurt IK, Mutlu O, Ulak G, Akar FY, Erden F. 2011. Gabapentin, A GABA analogue, enhancescognitiveperformance in mice. NeurosciLett. 492(2):124-8.
• Kilic FS, Ismailoglu S, Kaygisiz B, Oner S. 2014. Effects of singleandcombinedgabapentinuse in elevatedplusmazeandforcedswimmingtests. ActaNeuropsychiatr. 26(5):307-14.
• Field MJ, Oles RJ, Singh L. 2001. Pregabalinmayrepresent a novelclass of anxiolyticagentswith a broadspectrum of activity. Br J Pharmacol. 132(1):1-4.
• Zohar J, Matar MA, Ifergane G, Kaplan Z, Cohen H. 2008. Brief post-stressortreatmentwithpregabalin in an animal model for PTSD: short-termanxiolyticeffectswithoutlong-termanxiogeniceffect. EurNeuropsychopharmacol. 18(9):653-666.
• Hall CS. 1934. Emotionalbehavior in rat: Defactionandurination as measure of individualdiffirences in emotionality. Journal of comparativePsychology. 18: 385-403.
• Cilio MR, Bolanos AR, Liu Z, Schmid R, Yang Y, Stafstrom CE, Mikati MA, Holmes GL. 2001. Anticonvulsantactionandlong-termeffects of gabapentin in theimmaturebrain. Neuropharmacology. 40(1):139-47.
• Lau W, Dykstra C, Thevarkunnnel S, Silenieks LB, de Lannoyy IA, Lee DK, Higgins GA. 2013. A backtranslation of pregabalinandcarbamazepineagainstevokedandnon-evokedendpoints in theratsparednerveinjury model of neuropathicpain. Neuropharmacology. 73: 204-215.
• Avila-Martin G, Galan-Arriero I, Ferrer-Donato A, Busquets X, Gomez-Soriano J, Escribá PV, Taylor J. 2015. Oral 2-hydroxyoleic acidinhibitsreflexhypersensitivityandopen-field-inducedanxietyaftersparednerveinjury. Eur J Pain. 19(1):111-22.
• Galan-Arriero I, Avila-Martin G, Ferrer-Donato A, Gomez-Soriano J, Piazza S, Taylor J. 2015. Earlytreatmentwith UR13870, a novelinhibitor of p38α mitogenousactivated protein kinase, preventshyperreflexiaandanxietybehaviors, in thesparednerveinjury model of neuropathicpain. NeurosciLett. 604: 69-74.
• Crawley J, Goodwin FK. 1980. Preliminary report of a simpleanimalbehavior model fortheanxiolyticeffects of benzodiazepines. PharmacolBiochemBehav. 13(2):167-70.
• Navarrete F, Pérez-Ortiz JM, Manzanares J. 2012. Pregabalin- andtopiramate-mediatedregulation of cognitiveand motor impulsivity in DBA/2 mice. Br J Pharmacol. 167(1): 183-195.