Abstract

Amaç: Bu çalışmanın amacı, serbest diş eti grefti (FGG) alınmasını takiben damak donör yaralarında hastalar tarafından algılanan postoperatif morbidite üzerindeki hyaluronik asit (HA) ve ozon tedavisinin etkilerini değerlendirmektir. Materyaller ve Yöntemler: Bu prospektif gözlemsel klinik çalışmaya toplam 60 FGG ameliyatı geçiren hasta dahil edilmiştir. Hastalar, kullanılan postoperatif yaklaşıma göre üç gruba ayrılmıştır: kontrol (n=20), HA (n=20) ve ozon (n=20). Ozon grubunda damak yara yüzeyine ozon gazı uygulanırken, HA grubunda %0,8 hyaluronik asit içeren oral jel kullanılmıştır. Kontrol grubunda herhangi bir ek tedavi uygulanmamıştır. Postoperatif morbidite, ağrı, konuşma güçlüğü, yemek yeme güçlüğü, yutma güçlüğü ve ağız kuruluğu için 0-10 arası sayısal derecelendirme ölçeği kullanılarak postoperatif 1, 3, 5 ve 14. günlerde değerlendirilmiştir. Sonuçlar: Ameliyat sonrası 3. günde gruplar arasında anlamlı farklılıklar sadece konuşma güçlüğü ve yutma zorluğu açısından tespit edildi. Hyaluronik asit veya ozon tedavisi alan katılımcılar, kontrol grubundakilere göre her iki parametre için de daha düşük puanlar bildirdi (p<0,05). Ağrı açısından, 1. günde sadece ozon grubunda bir azalma gözlemlenirken, 3. günde her iki ek tedavi grubunda da kontrol grubuna göre ağrı düzeylerinde azalma görüldü (p<0,05). Ağız kuruluğu, ameliyat sonrası 1. ve 3. günlerde ozon tedavisi alan katılımcılarda daha az belirgindi (p<0,05). Tüm çalışma popülasyonunda, tüm morbidite ölçütleri takip süresi boyunca kademeli olarak azaldı (p<0,001). Sonuç: Hem hyaluronik asit hem de ozon uygulamaları, FGG ameliyatından sonraki erken ameliyat sonrası dönemde hastanın algıladığı morbiditeyi azaltarak hasta konforunu iyileştirdi. Ozon uygulaması, özellikle ağrı ve ağız kuruluğu üzerinde daha erken faydalı etkiler gösterdi. Bununla birlikte, iki tedavi yöntemi arasında istatistiksel olarak anlamlı bir üstünlük tespit edilmedi.

Keywords

• Hasta konforu
• Palatal yara
• Diş eti grefti

Project Number

2026/1-3

Ethical Statement

Çalışma protokolü Adıyaman Üniversitesi Girişimsel Olmayan Klinik Araştırmalar Etik Kurulu tarafından onaylanmıştır.

Palatal donor site morbidity following free gingival graft harvesting: effects of ozone therapy and hyaluronic acid gel application

Abstract

Aim: The aim of this study was to evaluate the effects of hyaluronic acid (HA) and ozone therapy on patient-perceived postoperative morbidity at palatal donor wounds following free gingival graft (FGG) harvesting. Materials and Methods: A total of 60 patients who underwent FGG surgery were included in this prospective observational clinical study. Patients were allocated into three groups according to the postoperative approach used: control (n=20), HA (n=20), and ozone (n=20). Ozone gas was applied to the palatal wound surface in the ozone group, whereas an oral gel containing 0.8% hyaluronic acid was used in the HA group. No adjunctive treatment was applied in the control group. Postoperative morbidity was assessed on postoperative days 1, 3, 5, and 14 using a 0–10 Numerical Rating Scale for pain, speech discomfort, eating discomfort, swallowing difficulty, and oral dryness. Results: Significant between-group differences were identified only for speech discomfort and swallowing difficulty on postoperative day 3. Participants receiving HA or ozone therapy reported lower scores for both parameters than those in the control group (p<0.05). For pain, a reduction was evident exclusively in the ozone group on day 1, whereas by day 3 both adjunctive treatment groups exhibited reduced pain levels relative to the control group (p<0.05). Oral dryness was less pronounced in the ozone-treated participants on postoperative days 1 and 3 (p<0.05). Across the entire study population, all morbidity measures progressively decreased throughout the follow-up period (p<0.001). Conclusion: Both hyaluronic acid and ozone applications improved patient comfort by reducing patient-perceived morbidity during the early postoperative period following FGG surgery. Ozone application demonstrated earlier beneficial effects, particularly on pain and oral dryness. However, no statistically significant superiority was detected between the two treatment modalities.

Keywords

• Patient comfort
• Palatal wound
• Gingival grafting

Project Number

2026/1-3

Ethical Statement

The study protocol was approved by the Adıyaman University Non-Interventional Clinical Research Ethics Committee

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