BibTex RIS Kaynak Göster

The studies about diseases concerning with contemplated MTHFR 677 C>T polymorphism

Yıl 2014, Cilt: 41 Sayı: 1, 244 - 256, 01.03.2014

Müzeyyen İzmirli Özgür Aldemir Bülent Gögebakan Davut Alptekin

https://doi.org/10.5798/diclemedj.0921.2014.01.0411
Cited By: 1

Öz

5,10-Methlenetetrahydrofolate reductase (MTHFR) is one of the most important enzymes for folic acid metabolism. This protein\'s gene is mapped on chromosome 1, which is located at the end of the short arm (1p36.3). MTHFR enzyme plays a key role in cell metabolism including folic acid and nucleotide synthesis (DNA, RNA). Polymorphism is also a factor in biodiversity, and is different according to ethnic heritage and racial. The 677 C>T is also MTHFR polymorphisms that decrease MTHFR enzyme activity. The aim of this study is to compile studies are associated with MTHFR C677T polymorphism. PUBMED, Turk Biochemistry and Jornal of Clinical & Experimental Investigations were searched to develop an investigatory pursuit strategy. MTHFR, Turkish population, 677 C>T and polymorphisms were key words including “MTHFR”, “Türk popülasyonu: Turkish population”, “677 C>T” “polimorfizm: polymorphism” used to focus the search. The literature review included all published relevant Turkish population and MTHFR polymorphisms for that all of study. The data of selected polymorphism for Turkish population was listed in tables for easy access and retrieval.

Anahtar Kelimeler

MTHFR Turkish population 677 C>T polymorphism

Kaynakça

  • Schwann B, Rozen R. Polymorphisms in the methylenetet- rahydrofolate reductase gene: clinical consequences. Am J Pharmacogenomics 2001;1:189-201.
  • İzmirli M, Tufan T, Alptekin D. DNA metilasyonu. Arşiv Kaynak Tarama Dergisi 2012;21:274-282.
  • Goyette P, Pai A, Milos R, et al. Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR). Mamm Genome 1998;9:571-582.
  • Goyette P, Rozen R. The thermolabile variant 677CT can further reduce activity when expressed in cis with severe mutations for human methylenetetrahydrofolate reductase. Hum Mutat 2000;16:132-138.
  • Ueland PM, Refsum H, Stabler SP, et al. Total homocysteine in plasma or serum: methods and clinical applications. Clin Chem 1993;39:1764-1779.
  • Yang QH, Botto LD, Gallagher M, et al. Prevalence and ef- fects of gene–gene and gene-nutrient interactions on serum folate and serum total homocysteine concentrations in the United States: findings from the third National Health and Nutrition Examination Survey DNA Bank. Am J Clin Nutr 2008;88:232-246.
  • Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 1995;274:1049-1057.
  • Ozarda Y, Sucu DK, Hizli B, Aslan D. Rate of T alleles and TT genotype at MTHFR 677C>T locus or C alleles and CC genotype atMTHFR 1298A>C locus among healthy subjects in Turkey: impact on homocysteine and folic acid status and reference intervals. Cell Biochem Funct 2009;27:568-577.
  • Robien K, Ulrich CM. 5,10-Methylenetetrahydrofolate re- ductase polymorphisms and leukemia risk: a HuGE minire- view. Am J Epidemiol 2003;157:571-582.
  • Yilmaz H, Agachan B, Isbir T, Akoglu E. Is there additional effect of MTHFR C677T mutation on lipid abnormalities in renal allograft recipients? Transplant Proc 2003;35:1390- 1392.
  • Sazci A, Ergul E, Guzelhan Y, et al. Methylenetetrahydrofo- late reductase gene polymorphisms in patients with schizo- phrenia. Brain Res Mol Brain Res 2003;117:104-107.
  • Kupferminc MJ, Eldor A, Steinman N, et al. Increased fre- quency of genetic thrombophilia in women with complica- tions of pregnancy. N Engl J Med 1999;340:9-13.
  • Mills JL, Kirke PN, Molloy AM, et al. Methylenetetrahy- drofolate reductase thermolabile variant and oral clefts. Am J Med Genet 1999;86:71-74.
  • Wenstrom KD, Johanning GL, Johnston KE, DuBard M. Association of the C677T methylenetetrahydrofolate re- ductase mutation and elevated homocysteine levels with congenital cardiac malformations. Am J Obstet Gynecol
  • Ozdemir S, Silan F, Hasbek Z, et al. Increased T-allele fre- quency of 677 C>T polymorphism in the methylenetetra- hydrofolatereductase gene in differentiated thyroid carci- noma. Genet Test Mol Biomarkers 2012;16:780-784.
  • Ergul E, Sazci A, Utkan Z, Canturk NZ. Polymorphisms in the MTHFR gene are associated with breast cancer. Tu- mour Biol 2003;24:286-290.
  • Hekim N, Ergen A, Yaylim I, et al. No associaiton between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer. Cell Biochem Funt 2007;25:115-117.
  • Küçükhüseyin Ö, Kurnaz Ö, Akadam-Teker AB, et al. Ef- fects of the MTHFR C677T polymorphism on prostate spe- cific antigen and prostate cancer. Asian Pac J Cancer Prev 2011;12:2275-2278.
  • Ozger H, Kilioglu O, Yilmaz H, et al. Methylenetetrahydro- folate reductase C677T polymorphism in osteosarcoma and chondrosarcoma patients. Folia Biol (Praha) 2008;54:53- 57.
  • Zeybek U, Yaylim I, Yilmaz H, et al. Methylenetetra- hydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer. Cell Biochem Funct
  • Kafadar AM; Yilmaz H, Kafadar D, et al. C677T gene poly- morphism of methylenetetrahydrofolate reductase (MTH- FR) in meningiomas and high grade gliomas. Anticancer Res 2006;26(3B):2445-2449.
  • Deligezer U, Akisik E, Dalay N. Genotyping of the MTHFR gene polymorphism, C677T in patients with leukemia by melting curve analysis. Mol Diagn 2003;7:181-185.
  • Deligezer U, Akisik EE, Dalay N. Homozygosity at the C677T of the MTHFR gene is associated with increased breast cancer risk in the Turkish population. In Vivo
  • Sazci A, Ozel MD, Emel E, Idrisoglu HA. Gender-specific association of methylenetetrahydrofolate reductase gene polymorphisms with sporadic amyotrophic lateral sclero- sis. Genet Test Mol Biomarkers 2012;16:716-721.
  • Taymaz H, Erarslan S, Oner ET, et al. Sequence variations within the genes related to hemostatic imbalance and their impact on coronary artery disease in Turkish population. Thromb Res 2007;119:55-62.
  • Yilmaz H, Agachan B, Ergen A, et al. Methylenetetrahydro- folate reductase C677T mutation and left ventricular hyper- trophy in Turkish patients with type II diabetes mellitus. J Biochem Mol Biol 2004;37:234-238.
  • Tug E, Aydin H, Kaplan E, Dogruer D. Frequency of ge- netic mutations associated with thromboembolism in the Western Black Sea Region. Intern Med 2011;50:17-21.
  • Sazci A, Ergul E, Tuncer N, et al. Methylenetetrahydro- folate reductase gene polymorphisms are associated with ischemic and hemorrhagic stroke: Dual effect of MTHFR polymorphisms C677T and A1298C. Brain Res Bull. 2006;71:45-50.
  • Yilmaz H, Isbir S, Agachan B, et al. C677T mutation of methylenetetrahydrofolate reductase gene and serum ho- mocysteine levels in Turkish patients with coronary artery disease. Cell Biochem Funct 2006;24:87-90.
  • Agirbasli M, Guney AI, Ozturhan HS, et al. Multifactor di- mensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease. Eur J Cardiovasc Prev Rehabil 2011;18:803-809.
  • Dölek B, Eraslan S, Eroğlu S, et al. Molecular analysis of factor V Leiden, factor V Hong Kong, factor II G20210A ,methylenetetrahydrofolate reductase C677T, and A1298C mutations related to Turkish thrombosis patients. Clin Appl Thromb Hemost 2007;13:435-438.
  • Kucukhuseyin O, Kurnaz O, Akadam-Teker AB, et al. The Association of MTHFR C677T Gne Variants and Lipid Profile sor Body Mass Index in Patients with Diabetic and Nondiabetic Coronary Heart Disease. J Clin Lab Anal 2013;27:427-434.
  • Aydin M, Gokkusu C, Ozkok E, et al. Association of ge- netic variants in methylenetetrahydrofolate reductase and paraoxonase-1 genes with homocysteine, folate and vi- tamin B12 in coronary artery disease. Mol Cell Biochem 2009;325:199-208.
  • Karata S, Aydin Y, Ocer F, et al. Hereditary thrombophilia, anti-beta2 glycoprotein 1 IgM, and anti-annexin V anti- bodies in recurrent pregnancy loss. Am J Reprod Immunol 2012;67:251-255.
  • Yilmaz H, Unlüçerçi Y, Gürdöl F, et al. Association of pre-eclampsia with hyperhomocysteinaemia and methy- lenetetrahydrofolate reductase gene C677T polymorphism in a Turkish population. Aust N Z J Obstet Gynaecol 2004;44:423-427.
  • Ozdemir O, Yenicesu GI, Silan F, et al. Recurrent pregnan- cy loss and its relation to combined parental thrombophilic gene mutations. Genet Test Mol Biomarkers 2012;16:279- 286.
  • Deligezer U, Akisik EE, Yaman F, et al. MTHFR C677 T gene polymorphism in lymphoproliferative diseases. J Clin Lab Anal 2006;20:37-41.
  • Emre S, Sirin A, Ergen A, et al. Methylenetetrahydrofolate reductase C677T polymorphism in patients with Henoch- Schönlein purpura. Pediatr Int 2011;53:358-362.
  • Ar MC, Baykara O, Buyru AN, Baslar Z. The impact of prothrombotic mutations on factor consumption in adult pa- tients with severe hemophilia. Clin Appl Thromb Hemost 2009;15:660-665.
  • Ergul E, Sazci A, Kara I. Methylenetetrahydrofolate re- ductase gene polymorphisms in Turkish children with at- tention-deficit/hyperactivity disorder. Genet Test Mol Bio- markers 2012;16:67-69.
  • Ukinc K, Ersoz HO, Karahan C, et al. Methyltetrahydro- folate reductase C677T gene mutation and hyperhomocys- teinemia as a novel risk factor for diabetic nephropathy. Endocrine 2009;36:255-261.
  • Demirel Y, Dogan S, Uludag A, et al. Combined effect of Factor V Leiden, MTHFR, and angiotensin-converting enzyme (insertion/deletion) gene mutations in hyperten- sive adult individuals: a population-based study from Si- vas and Canakkale, Turkey. Genet Test Mol Biomarkers
  • Sazci A, Ergül E, Güzelhan Y, et al. Methylenetetrahydrofo- late reductase gene polymorphisms in patients with schizo- phrenia. Brain Res Mol Brain Res 2003;117:104-107.
  • Sazci A, Ergul E, Kucukali I, et al. Association of the C677T and A1298C polymorphisms of methylenetetrahy- drofolate reductase gene with schizophrenia: association is significant in men but not in women. Prog Neuropsycho- pharmacol Biol Psychiatry 2005;29:1113-1123.
  • Yilmaz H, Agachan B, Isbir T, Akoglu E. Is there additional effect of MTHFR C677T mutation on lipid abnormalties in renal allograft recipients? Transplant Proc 2003;35:1390- 1392.
  • Kara I, Sazci A, Ergul E, et al. Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydro- folate reductase gene in patients with migraine risk. Brain Res Mol Brain Res 2003;111:84-90.
  • Bahadir A, Eroz R, Dikici S. Investigation of MTHFR C677T gene polymorphism, biochemical and clinical pa- rameters in Turkish migraine patients: Association with allodynia and fatigue. Cell Mol Neurobiol 2013;33:1055- 1063.
  • Sazci A, Ergul E, Bayulkem K. Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene in patients with essential tremor in Turkey. Mov Disord 2004;19:1472-1476.
  • Ozbek Z, Kucukali CI, Ozkok E, et al. Effect of the methy- lenetetrahydrofolate reductase gene polymorphisms on ho- mocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:1331-1337.
  • Sazci A, Ergul E, Aygun C, et al. Methylenetetrahydrofo- late reductase gene polymorphisms in patients with non- alcoholic steatohepatitis (NASH). Cell Biochem Funct
  • Ozarda Y, Sucu DK, Hizli B, Aslan D. Rate of T alleles and TT genotype at MTHFR 677C>T locus or C alleles and CC genotype at MTHFR 1298 A>C locus among healthy subjects in Turkey: impact on homocysteine and folic acid status and reference intervals. Cell Biochem Funct 2009;27:568-577.
  • Sazci A, Ergul E, Kaya G, Kara I. Genotype and allele fre- quencies of the polymorphic methylenetetrahydrofolate reductase gene in Turkey. Cell Biochem Funct 2005;23:51- 54.
  • Kantar M, Kosova B, Cetingul N, et al. Methylenetetra- hydrofolate reductase C677T and A1298C gene polymor- phisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lympho- ma. Leuk Lymphoma 2009;50:912-917.
  • Onur E, Kurdal AT, Tugrul B, et al. Is genetic screen- ing necessary for determining the possibility of venous thromboembolism in cancer patients? Med Princ Pract
  • Alioglu E, Turk U, Cam S, et al. Polymorphisms of the methylenetetrahydrofolate reductase, vascular endothelial growth factor, endothelial nitric oxide synthase, monocyte chemoattractant protein-1 and apolipoprotein E genes are not associated with carotid intima-media thickness. Can J Cardiol 2009;25:e1-5.
  • Var A, Utük O, Akçali S, et al. Impact of hemostatic gene single point mutations in patients with non-diabetic coro- nary artery disease. Mol Biol Rep 2009;36:2235-2243.
  • Bolaman Z, Ozkul A, Kiylioglu N, et al. Hereditary throm- bophilic factors in stroke due to cerebral infarct. Am J Med Sci 2009;337:11-13.
  • Onur E, Kurdal AT, Tugrul B, et al. Is genetic screen- ing necessary for determining the possibility of veneous thromboembolism in cancer patients? Med Princ Pract 2012;21:160-163.
  • Onrat ST, Akci O, Söylemez Z, et al. Prevalence of myocar- dial infarction polymorphisms in Afyonkarahisar, Western Turkey. Mol Biol Rep 2012;39:9257-9264.
  • Yildiz G, Yavuzcan A, Yildiz P, et al. Inherited thrombo- philia with recurrent pregnancy loss in Turkish women a real phenomenon? Ginekol Pol 2012;83:598-603.
  • Karadeniz M, Erdogan M, Zengi A, et al. Methylenetetra- hydrofolate reductase C677T gene polymorphism in Turk- ish patients with polycystic ovary syndrome. Endocrine 2010;38:127-133.
  • Habibovic Z, Zeybek B, Sanhal C, et al. Effects of inherited trombophilia in women with recurrent pregnancy loss. Clin Exp Obstet Gynecol 2011;38:347-350.
  • Canda MT, Demir N, Sezer O. Impact of Factor V Leiden, prothrombin and methylenetetrahydrofolate reductase gene mutations on infant birth weight in women with recurrent fetal loss and women with successful pregnancies. Clin Exp Obstet Gynecol 2012;39:359-361.
  • Yasa MH, Bolaman Z, Yukselen V, et al. Factor V Leiden G1691A, prothrombin G20210A, and MTHFR C677T mutations in Turkish inflammatory bowel disease patients. Hepatogastroenterology 2007;54:1438-1442.
  • Sensoy N, Şoysal Y, Kahraman A, et al. Modulator effects of the methylenetetrahydrofolate reductase C677T poly- morphism on response to vitamin B12 therapy and homo- cysteine metabolism. DNA Cell Biol 2012;31:820-825.
  • Erdogan MO, Yildiz SH, Solak M, et al. C677T polymor- phism of the methylenetetrahydrofolate reductase gene does not affect folic acid, vitamin B12, and homocysteine serum levels in Turkish children with neural tube defects. Genet Mol Res 2010;9:1197-1203.
  • Yasar A, Gunduz K, Onur E, Calkan M. Serum homocys- teine, vitamin B12, folic acid levels and methylenetetrahy- drofolate reductase (MTHFR) gene polymorphism in vit- iligo. Dis Markers 2012;33:85-89.
  • Kabukcu S, Keskin N, Keskin A, Atalay E. The frequency of factor V Leiden and concomitance of factor V Leiden with prothrombin G20210A mutation and methylene tet- rahydrofolate reductase C677T gene mutation in healthy population of Denizli, Aegean region of Turkey. Clin Appl Thromb Hemost 2007;13:166-171.
  • Eroglu Z, Erdogan M, Tetik A, et al. The relationship of the methylenetetrahydrofolate reductase C677T gene polymor- phism in Turkish type 2 diabetic patients with and without nephropathy. Diabetes Metab Res Rev 2007;23:621-624.
  • Celik A, Tekis D, Saglam F, et al. Association of corticoste- roids and factor V, prothrombin, and MTHFR gene muta- tions with a vascular osteonecrosis in renal allograft recipi- ents. Transplant Proc 2006;38:512-516.
  • Izmirli M, Inandiklioglu N, Abat D, et al. MTHFR gene polymorphisms in bladder cancer in the Turkish population. Asian Pac J Cancer Prev 2011;12:1833-1835.
  • Mendilcioglu I, Bilgen T, Arikan Y, et al. The associa- tion between inherited thrombophilias and pregnancy- related hypertension recurrence. Arch Gynecol Obstet
  • Izmirli M, Alptekin D, Topcuoglu MS, Guzel MD. Investi- gation of methylene tetrahydrofolate reductase gene poly- morphisms in coronary by-passed patients due to coronary atherosclerosis etiology. Turkiye Klinikleri J Cardiovasc Sci 2009;21:303-308.
  • Hanta I, Soydas Y, Karatasli M, et al. Plasma homocys- teine level and 677C>T mutation on the MTHFR gene in patients with venous thromboembolism. Bratisl Lek Listy 2010;111:70-73.
  • Dundar-Yenilmez E, Tuli A, Bozkurt A, Acartürk E. The effects of factor V leiden, prothrombin G20210A, MTHFR C677T, MTHFR A1298C, factor XIIIA Val34Leu, factor XIIIB His95Arg and apolipoprotein E genotypes on coro- nary artery disease. Turk J Biochem 2012;37:424-430.
  • Demir SC, Evruke C, Ozgunen T, et al. The relationship between pregnancy induced hypertension and congenital thrombophilia. Saudi Med J 2006;27:1161-1166.
  • Timuragaoglu A, Dizlek S, Uysalgil N, et al. Methylenetet- rahydrofolate reductase C677T polymorphism in adult pa- tients with lymphoproliferative disorders and its effect on chemotherapy. Ann Hematol 2006;85:863-868.
  • Canataroglu A, Tanriverdi K, Inal T, et al. Methylenetet- rahydrofolate reductase gene C677T mutation and plasma homocysteine level in Behçet’s disease. Rheumatol Int
  • Sipahi T, Kara A, Kuybulu A, et al. Congenital thrombotic risk factors in beta-thalassemia. Clin Appl Thromb Hemost 2009;15:581-584.
  • Serin E, Güçlü M, Ataç FB, et al. Methylenetetrahydrofo- late reductase C677T mutation and nonalcoholic fatty liver disease. Dig Dis Sci 2007;52:1183-1186.
  • Ozen F, Erdis E, Sik E, et al. Germ-line MTHFR C677T, FV H1299R and PAI-1 5G/4G Variations in Breast Carcinoma. Asian Pac J Cancer Prev 2013;14:2903-2908.
  • Ozkan M, Sivgin S, Kocyigit I, et al. Do thrombophilic gene mutations have a role on thromboembolic events in cancer patients? Asia Pac J Clin Oncol 2012;8:e34-41.
  • Ekiz F, Ormeci N, Coban S, et al. Association of methylene- tetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett’s esopha- gus, and reflux esophagitis. Dis Esophagus 2012;25:437- 441.
  • Torun YA, Patiroglu T, Ozdemir MA, et al. Inherited pro- thrombotic risk factors in Turkish children with acute lym- phoblastic leukemia: significance of concomitant genetic mutation. Clin Appl Thromb Hemost 2012;18:218-221.
  • Arslan S, Manduz S, Epöztürk K, et al. Association of deep venous thrombosis with prothrombotic gene poly- morphism identified in lung cancer cases. Mol Biol Rep 2011;38:2395-400.
  • Arslan S, Karadayi S, Yildirim ME, et al. The association between methylene-tetrahydrofolate reductase gene poly- morphism and lung cancer risk. Mol Biol Rep 2011;38:991- 996.
  • Ozen F, Polat F, Arslan S, Ozdemir O. Combined germline variations of thrombophilic genes promote genesis of lung cancer. Asian Pac J Cancer Prev 2013;14:5449-5454.
  • Muslumanoglu MH, Tepeli E, Demir S, et al. The analysis of the relationship between A1298C and C677T polymor- phisms of the MTHFR gene with prostate cancer in Eskise- hir population. Genet Test Mol Biomarkers 2009;13:641- 645.
  • Eroglu A, Egin Y, Cam R, Akar N. The 19-bp deletion of di- hydrofolate reductase (DHFR), methylenetetrahydrofolate reductase (MTHFR) C677T, Factor V Leiden, prothrombin G20210A polymorphisms in cancer patients with and with- out thrombosis. Ann Hematol 2009;88:73-76.
  • Balta G, Yuksek N, Ozyurek E, et al. Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia. Am J Hematol 2003;73:154-160.
  • Eroğlu A, Karabıyık A, Akar N. The association of protease activated receptor 1 gene 506 I/D polymorphism with dis- ease-free survival in breast cancer patients. Ann Surg Oncol 2012;19:1365-1369.
  • Geçene M, Tuncay F, Borman P, et al. Atherosclerosis in male patients with ankylosing spondylitis: the relation with methylenetetrahydrofolate reductase (C677T) gene poly- morphism and plasma homocysteine levels. Rheumatol Int 2013;33:1519-1524.
  • Yildiz OK, Cevik S, Cil G, et al. Cerebral venous sinüs thrombosis presenting as transient ischemic attacks in a case with homozygous mutations of MTHFR A1298C and C677T. J Stroke Cerebrovasc Dis 2012;21:75-77.
  • Kupeli E, Verdi H, Simsek A, et al. Genetic mutations in Turkish population with pulmonary embolism and deep ve- nous thrombosis. Clin Appl Thromb Hemost 2011;17:E87- 94.
  • Ozmen F, Ozmen MM, Ozalp N, Akar N. The prevalence of factor V (G1691A), MTHFR (C677T) and PT (G20210A) gene mutations in arterial thrombosis. Ulus Travma Acil Cerrahi Derg 2009;15:113-119.
  • Ozbek N, Alioglu B, Avci Z, et al. Incidence of and risk fac- tors for childhood thrombosis: a single-center experience in Ankara, Turkey. Pediatr Hematol Oncol 2009;26:11-29.
  • Küpeli E, Cengiz C, Cila A, Karnak D. Hyperhomocystein- emia due to pernicious anemia leading to pulmonary throm- boembolism in a heterozygous mutation carrier. Clin Appl Thromb Hemost 2008;14:365-368.
  • Balta G, Gürgey A. Methylenetetrahydrofolate reductase (MTHFR) C677T mutation in Turkish patients with throm- bosis. Turk J Pediatr 1999;41:197-199.
  • Ozyurek E, Balta G, Degerliyurt A, et al. Significance of factor V, prothrombin, MTHFR, and PAI-1 genotypes in childhood cerebral thrombosis. Clin Appl Thromb Hemost
  • Alioglu B, Ozyurek E, Tarcan A, et al. Heterozygous meth- ylenetetrahydrofolate reductase 677C-T gene mutation with mild hyperhomocysteinemia associated with intrauterine iliofemoral artery thrombosis. Blood Coagul Fibrinolysis 2006;17:495-498.
  • Dikmen M, Ozbabalik D, Gunes HV, et al. Acute stroke in relation to homocysteine and methylenetetrahydrofo- late reductase gene polymorphisms. Acta Neurol Scand
  • Akman B, Afsar B, Ataç FB, et al. Predictors of vascular access thrombosis among patients on the cadaveric renal transplantation waiting list. Transplant Proc 2006;38:413- 415.
  • Akar N, Akar E, Ozel D, et al. Common mutations at the homocysteine metabolism pathway and pediatric stroke. Thromb Res 2001;102:115-120.
  • Gülec S, Aras O, Akar E, et al. Methylenetetrahydrofolate reductase gene polymorphism and risk of premature myo- cardial infarction. Clin Cardiol 2001;24:281-284.
  • Ozyürek E, Balta G, Degerliyurt A, et al. Significance of factor V, prothrombin, MTHFR, and PAI-1 genotypes in childhood cerebral thrombosis. Clin Appl Thromb Hemost
  • Akar N, Akar E, Akçay R, et al. Effect of methylenetet- rahydrofolate reductase 677 C-T, 1298 A-C, and 1317 T-C on factor V 1691 mutation in Turkish deep vein thrombosis patients. Thromb Res 2000;97:163-167.
  • Akar N, Akar E, Deda G, et al. Factor V1691 G-A, pro- thrombin 20210 G-A, and methylenetetrahydrofolate re- ductase 677 C-T variants in Turkish children with cerebral infarct. J Child Neurol 1999;14:749-751.
  • Tokgözoğlu SL, Alikaşifoğlu M, Unsal-Atalar E, et al. Methylenetetrahydrofolate reductase genotype and the risk and extent of coronary artery disease in a population with low plasma folate. Heart 1999;81:518-522.
  • Ozyurek E, Balta G, Degerliyurt A, et al. Significance of factor V, prothrombin, MTHFR, and PAI-1 genotypes in childhood cerebral thrombosis. Clin Appl Thromb Hemost 2007;13:154-160.
  • Ozkurt S, Temiz G, Saylisoy S, Soydan M. Cerebral sinovenous thrombosis associated with factor V Leiden and methylenetetrahydrofolatereductase A1298C muta- tion in adult membranous glomerulonephritis. Ren Fail 2011;33:524-527.
  • Nazli Y, Colak N, Aksoy ON, Cakir O. Thyroid vein thrombosis in a young woman with methylenetetrahydrofo- late reductase gene mutation receiving cyproterone acetate/ ethinylestradiol treatment for polycystic ovary syndrome: a case report. Blood Coagul Fibrinolysis 2011;22:331-333.
  • Uvuz F, Kilic S, Yilmaz N, et al. Relationship between preterm labor and thrombophilic gene polymorphism: A prospective sequential cohort study. Gynecol Obstet Invest
  • Boduroğlu K, Alanay Y, Koldan B, Tunçbilek E. Methy- lenetetrahydrofolate reductase enzyme polymorphisms as maternal risk for Down syndrome among Turkish women. Am J Med Genet 2004;127A:5-10.
  • Yenicesu GI, Cetin M, Ozdemir O, et al. A prospective case-control study analyzes 12 thrombophilic gene muta- tions in Turkish couples with recurrent pregnancy loss. Am J Reprod Immunol 2010;63:126-136.
  • Yokuş O, Balçık ÖŞ, Albayrak M, et al. Thrombophilic risk factors in women with recurrent abortion. J Clin Exp Invest 2010;1:168-172.
  • Inanir A, Yigit S, Tural S, et al. MTHFR gene C677T mu- tation and ACE gene I/D polymorphism in Turkish patients with osteoarthritis. Dis Markers 2013;34:17-22.
  • Inanir A, Yigit S, Tekcan A, et al. IL-4 and MTHFR gene polymorphism in rheumatoid artritis and their effects. Im- munol Lett 2013;152:104-108.
  • Taşbaş O, Borman P, Gürhan Karabulut H, et al. The Frequency of A1298C and C677T Polymorphisms of the Methylentetrahydrofolate Gene in Turkish Patients with Rheumatoid Arthritis: Relationship with Methotrexate Tox- icity. Open Rheumatol J 2011;5:30-35.
  • Ozkul Y, Evereklioglu C, Borlu M, et al. 5,10-methylene- tetrahydrofolate reductase C677T gene polymorphism in Behcet’s patients with or without ocular involvement. Br J Ophthalmol 2005;89:1634-1637.
  • Toydemir PB, Elhan AH, Tükün A, et al. Effects of factor V gene G1691A, methylenetetrahydrofolate reductase gene C677T, and prothombin gene G20210A mutations on deep venous thrombogenesis in Behçet’s disease. J Rheumatol 2000;27:2849-2854.
  • Törüner M, Erkan O, Soykan I, et al. Factor V Leiden, pro- thrombin G20210A and MTHFR gene mutations in inflam- matory bowel disease. Turk J Gastroenterol 2004;15:250- 252.
  • Eser B, Cosar M, Eser O, et al. 677C>T and 1298A>C polymorphisms of methylenetetrahydropholate reductase gene and biochemical parameters in Turkish population with spina bifida occulta. Turk Neurosurg 2010;20:9-15.
  • Aşlar D, Ozdiler E, Altuğ AT, Taştan H. Determination of methylenetetrahydrofolate reductase (MTHFR) gene poly- morphism in Turkish patients with nonsyndromic cleft lip and palate. Int J Pediatr Otorhinolaryngol 2013;77:1143- 1146.
  • Boduroğlu K, Alikaşifoğlu M, Anar B, Tunçbilek E. As- sociation of the 677CT mutation on the methylenetetra- hydrofolate reductase gene in Turkish patients with neural tube defects. J Child Neurol 1999;14:159-161.
  • Ceyhan ST, Beyan C, Bahce M, et al. Thrombophilia-as- sociated gene mutations in women with pregnancies com- plicated by fetal neural tube defects. Int J Gynaecol Obstet 2008;101:188-189.
  • Boduroğlu K, Alanay Y, Alikaşifoğlu M, et al. Analysis of MTHFR 1298A>C in addition to MTHFR 677C>T poly- morphism as a risk factor for neural tube defects in the Turkish population. Turk J Pediatr 2005;47:327-333.
  • Kosar A, Kasapoglu B, Kalyoncu S, et al. Treatment of adverse perinatal outcome in inherited thrombophilias: a clinical study. Blood Coagul Fibrinolysis 2011;22:14-18.
  • Boduroğlu K, Alikaşifoğlu M, Anar N, Tunçbilek E. As- sociaition of the 677 CT mutation on the methylenetetra- hydrofolate reductase gene in Turkish patients with neural tube defects. J Child Neurol 1999;14:159-161.
  • Sahiner UM, Alanay Y, Alehan D, et al. Investigation methylenetetrahydrofolate reductase polymorphisms and homocysteine levels in heart defects. Pediatr Int 2013;DOI:10.1111/ped.12222.
  • Ozbek N, Ataç FB, Yildirim SV, et al. Analysis of pro- thrombotic mutations and polymorphism in children who developed thrombosis in the perioperative period of con- genital cardiac surgery. Cardiol Young 2005;15:19-25.
  • Kalkan G, Karakus N, Yigit S. Association of MTH- FR gene C677T mutation with recurrent aphthous sto- matitis and number of oral ulcers. Clin Oral Investig 2013;DOI:10.1007/s00784-013-0997-0.
  • Bekci TT, Kocak N, Kesli R. Distribution of common methylenetetrahydrofolate reductase gene mutations in patients with obstructive sleep apnoea. J Int Med Res 2009;37:1718-1724.
  • Vurucu S, Demirkaya E, Kul M, et al. Evaluation of the relationship between C677T variants of methylenetetra- hydrofolate reductase gene and hyperhomocysteinemia in children receiving antiepileptic drug therapy. Prog Neuro- psychopharmacol Biol Psychiatry 2008;32:844-848.
  • Turaçli ME, Tekeli O, Ozdemir F, Akar N. Methylenetetra- hydrofolate reductase 677 C-T and homocysteine levels in Turkish patients with pseudoexfoliation. Clin Experiment Ophthalmol 2005;33:505-508.
  • Sırmalı R, Koca Y, Erden G, et al. Evaluation of the Asso- ciation of Mthfr C677T and A1298C Gene Polymorphisms with Diabetic Retinopathy in Type 2 Diabetes Patients. Turk J Biochem 2008;33:71-76.
  • Dinleyici EC, Kirel B, Alatas O, et al. Plasma total homo- cysteine levels in children with type 1 diabetes: relationship with vitamin status, methylenetetrahydrofolate reductase genotype, disease parameters and coronary risk factors. J Trop Pediatr 2006;52:260-266.
  • Yildiz B, Cetin N, Kural N, et al. Co-existence of renovas- cular hypertension, polyarteritis nodosa, antiphospholipid syndrome and methylenetetrahydrofolate reductase muta- tion. Pediatr Int 2013;55:e107-110.
  • Yildiz Z, Ulu A, Incesulu A, et al. The importance of throm- botic risc factors in the development of idiopathic sudden hearing loss. Clin Appl Thromb Hemost 2008;14:356-359.
  • Vurucu S, Demirkaya E, Kul M, et al. Evaluation of the relationship between C677T variants of methylenetetra- hydrofolate reductase gene and hyperhomocysteinemia in children receiving antiepileptic drug therapy. Prog Neuro- psychopharmacol Biol Psychiatry 2008;32:844-848.
  • Yigit S, Karakus N, Inanir A. Association of MTHFR gene C677T mutation with diabetic peripheral neuropathy and diabetic retinopathy. Mol Vis 2013;19:1626-1630.
  • Kalkan G, Yigit S, Karakuş N, et al. Methylenetetrahydro- folate reductase C677T mutation in patients with alopecia areata in Turkish population. Gene 2013;530:109-112.
  • Uğuz N, Erden G, Güngör O, et al. Determination of the frequency of MTHFR C677T and MTHFR A1298C poly- morphisms in persons with polymorphic MTHFR gene. J Clin Exp Invest 2012;3:472-476.
  • Uçar F, Celik S, Yücel B, et al. MTHFR C677T poly- morphism and its relationship to myocardial infarction in the Eastern Black Sea region of Turkey. Arch Med Res 2011;42:709-712.
  • Ağaoğlu N, Türkyilmaz S, Ovali E, et al. Prevalence of prothrombotic abnormalities in patients with acute mesen- teric ischemia. World J Surg 2005;29:1135-1138.
  • Uçar F, Sönmez M, Ovali E, et al. MTHFR C677T poly- morphism and its relation to ischemic stroke in the Black Sea Turkish population. Am J Hematol 2004;76:40-43.
  • Uçar F, Celik S, Ovali E, et al. Coexistence of prothrombic risk factors and its relation to left ventricular thrombus in acute myocardial infarction. Acta Cardiol 2004;59:33-39.
  • Karakaus N, Yigit S, Kalkan G, et al. Association between the methylenetetrahydrofolate reductase gene C677T muta- tion and colchicine unresponsiveness in Behcet’s disease. Mol Vis 2012;18:1696-700.
  • Hakimoglu S, Hanci V, Hakimoglu Y, et al. The effects of nitrous oxide on vitamin B12 and homocysteine levels in methylenetetrahydrofolate reductase gene mutation. Bratisl Lek Listy 2013;114:317-322.
  • Ilhan N, Kucuksu M, Kaman D, et al. The 677 C/T MTH- FR polymorphism is associated with essential hyperten- sion, coronary artery disease, and higher homocysteine levels. Arch Med Res 2008;39:125-130.
  • Varoglu AO. Na VPA-induced acute ischemic stroke in an epileptic patient with methylenetetrahydrofolatereductase gene polymorphism. Epilepsy Res 2009;86:232-236.
  • 1 Uzar E, Ekici F, Acar A, et al. Cerebral venous sinus thrombosis: an analyses of 47 patients. Eur Rev Med Phar- macol Sci 2012;16:1499-1505.
  • 1 Gokalp D, Tuzcu A, Bahceci M, et al. Analysis of throm- bophilic genetic mutations in patients with Sheehan’s syn- drome: is thrombophilia responsible for the pathogenesis of Sheehan’s syndrome? Pituitary 2011;14:168-173.
  • 1 Yalinkaya A, Erdemoglu M, Akdeniz N, Kale A, Kale E. The relationship between thrombophilic mutations and preeclampsia: a prospective case-control study. Ann Saudi Med 2006;26:105-109.
  • 1 Yilmaz S, Bayan K, Tüzün Y, et al. A comprehensive anal- ysis of 12 thrombophilic mutations and related parameters in patients with inflammatory bowel disease: data from Tur- key. J Thromb Thrombolysis 2006;22:205-212.
  • 1 Bayan K, Tüzün Y, Yilmaz S, et al. Analysis of inherited thrombophilic mutations and natural anticoagulant defi- ciency in patients with idiopathic portal hypertension. J Thromb Thrombolysis 2009;28:57-62.
  • 1 Büyükçelik M, Karakök M, Başpinar O, Balat A. Arte- rial thrombosis associated with factor V Leiden and methy- lenetetrahydrofolate reductase C677T mutation in child- hood membranous glomerulonephritis. Pediatr Nehrol 2008;23:491-494.
  • 1 Gokcen C, Kocak N, Pekgor A. Methylenetetrahydrofo- late reductase gene polymorphi polymorphisms in children with attention deficit hyperactivity disorder. Int J Med Sci 2011;8:523-528.
  • 1 Izmirli M. A literature review of MTHFR (C677T and A1298C polymorphisms) and cancer risk. Mol Biol Rep 2013;40:625-637.
  • 1 Dikmen M. Molecular biology of methylenetetrahydrofo- late reductase enzyme and association with diseases. Ko- catepe Tıp Dergisi 2004;5:9-16.

The studies about diseases concerning with contemplated MTHFR 677 C>T polymorphism

Yıl 2014, Cilt: 41 Sayı: 1, 244 - 256, 01.03.2014

Müzeyyen İzmirli Özgür Aldemir Bülent Gögebakan Davut Alptekin

https://doi.org/10.5798/diclemedj.0921.2014.01.0411
Cited By: 1

Öz

5,10-Metilentetrahidrofolat redüktaz (MTHFR) folik asit metabolizması için en önemli enzimlerden biridir. Bu proteinin geni 1 numaralı kromozomun kısa kolunda (1p36.3) haritalanmıştır. MTHFR enzimi, folik asit, nükleotid sentezi (DNA, RNA) gibi pek çok reaksiyonu içeren hücre metabolizmasında, kilit rol oynar. Polimorfizmler etnik kökene ve ırklara göre farklılık gösteren ve biyoçeşitlilikte rol oynayan bir faktördür. MTHFR 677 C>T polimorfizmi enzim aktivitesini azaltan bir polimorfizmdir. Çalışmanın amacı, Türkiye\'de MTHFR C677T polimorfizmi ile ilgili olan çalışmaları derlemektir. Bu nedenle, Türkiye\'de yapılmış MTHFR 677 C>T polimorfizmi ile ilgili PUBMED, Türk Biyokimya ve Klinik & Deneysel Araştırmalar dergisinde yayınlanmış bütün çalışmalar derlenmiştir. Araştırma yapılırken “MTHFR”, “Türk popülasyonu: Turkish population”, “677 C>T” “polimorfizm: polymorphism” anahtar kelimeleri kullanılmıştır. Bu çalışmalar, belli başlı hastalık gruplarına göre sınıflandırılmış ve tablolar halinde okuyucunun değerlendirmesine sunulmuştur.

Anahtar Kelimeler

MTHFR Türk populasyonu 677 C>T polimorfizmi

Kaynakça

  • Schwann B, Rozen R. Polymorphisms in the methylenetet- rahydrofolate reductase gene: clinical consequences. Am J Pharmacogenomics 2001;1:189-201.
  • İzmirli M, Tufan T, Alptekin D. DNA metilasyonu. Arşiv Kaynak Tarama Dergisi 2012;21:274-282.
  • Goyette P, Pai A, Milos R, et al. Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR). Mamm Genome 1998;9:571-582.
  • Goyette P, Rozen R. The thermolabile variant 677CT can further reduce activity when expressed in cis with severe mutations for human methylenetetrahydrofolate reductase. Hum Mutat 2000;16:132-138.
  • Ueland PM, Refsum H, Stabler SP, et al. Total homocysteine in plasma or serum: methods and clinical applications. Clin Chem 1993;39:1764-1779.
  • Yang QH, Botto LD, Gallagher M, et al. Prevalence and ef- fects of gene–gene and gene-nutrient interactions on serum folate and serum total homocysteine concentrations in the United States: findings from the third National Health and Nutrition Examination Survey DNA Bank. Am J Clin Nutr 2008;88:232-246.
  • Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 1995;274:1049-1057.
  • Ozarda Y, Sucu DK, Hizli B, Aslan D. Rate of T alleles and TT genotype at MTHFR 677C>T locus or C alleles and CC genotype atMTHFR 1298A>C locus among healthy subjects in Turkey: impact on homocysteine and folic acid status and reference intervals. Cell Biochem Funct 2009;27:568-577.
  • Robien K, Ulrich CM. 5,10-Methylenetetrahydrofolate re- ductase polymorphisms and leukemia risk: a HuGE minire- view. Am J Epidemiol 2003;157:571-582.
  • Yilmaz H, Agachan B, Isbir T, Akoglu E. Is there additional effect of MTHFR C677T mutation on lipid abnormalities in renal allograft recipients? Transplant Proc 2003;35:1390- 1392.
  • Sazci A, Ergul E, Guzelhan Y, et al. Methylenetetrahydrofo- late reductase gene polymorphisms in patients with schizo- phrenia. Brain Res Mol Brain Res 2003;117:104-107.
  • Kupferminc MJ, Eldor A, Steinman N, et al. Increased fre- quency of genetic thrombophilia in women with complica- tions of pregnancy. N Engl J Med 1999;340:9-13.
  • Mills JL, Kirke PN, Molloy AM, et al. Methylenetetrahy- drofolate reductase thermolabile variant and oral clefts. Am J Med Genet 1999;86:71-74.
  • Wenstrom KD, Johanning GL, Johnston KE, DuBard M. Association of the C677T methylenetetrahydrofolate re- ductase mutation and elevated homocysteine levels with congenital cardiac malformations. Am J Obstet Gynecol
  • Ozdemir S, Silan F, Hasbek Z, et al. Increased T-allele fre- quency of 677 C>T polymorphism in the methylenetetra- hydrofolatereductase gene in differentiated thyroid carci- noma. Genet Test Mol Biomarkers 2012;16:780-784.
  • Ergul E, Sazci A, Utkan Z, Canturk NZ. Polymorphisms in the MTHFR gene are associated with breast cancer. Tu- mour Biol 2003;24:286-290.
  • Hekim N, Ergen A, Yaylim I, et al. No associaiton between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer. Cell Biochem Funt 2007;25:115-117.
  • Küçükhüseyin Ö, Kurnaz Ö, Akadam-Teker AB, et al. Ef- fects of the MTHFR C677T polymorphism on prostate spe- cific antigen and prostate cancer. Asian Pac J Cancer Prev 2011;12:2275-2278.
  • Ozger H, Kilioglu O, Yilmaz H, et al. Methylenetetrahydro- folate reductase C677T polymorphism in osteosarcoma and chondrosarcoma patients. Folia Biol (Praha) 2008;54:53- 57.
  • Zeybek U, Yaylim I, Yilmaz H, et al. Methylenetetra- hydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer. Cell Biochem Funct
  • Kafadar AM; Yilmaz H, Kafadar D, et al. C677T gene poly- morphism of methylenetetrahydrofolate reductase (MTH- FR) in meningiomas and high grade gliomas. Anticancer Res 2006;26(3B):2445-2449.
  • Deligezer U, Akisik E, Dalay N. Genotyping of the MTHFR gene polymorphism, C677T in patients with leukemia by melting curve analysis. Mol Diagn 2003;7:181-185.
  • Deligezer U, Akisik EE, Dalay N. Homozygosity at the C677T of the MTHFR gene is associated with increased breast cancer risk in the Turkish population. In Vivo
  • Sazci A, Ozel MD, Emel E, Idrisoglu HA. Gender-specific association of methylenetetrahydrofolate reductase gene polymorphisms with sporadic amyotrophic lateral sclero- sis. Genet Test Mol Biomarkers 2012;16:716-721.
  • Taymaz H, Erarslan S, Oner ET, et al. Sequence variations within the genes related to hemostatic imbalance and their impact on coronary artery disease in Turkish population. Thromb Res 2007;119:55-62.
  • Yilmaz H, Agachan B, Ergen A, et al. Methylenetetrahydro- folate reductase C677T mutation and left ventricular hyper- trophy in Turkish patients with type II diabetes mellitus. J Biochem Mol Biol 2004;37:234-238.
  • Tug E, Aydin H, Kaplan E, Dogruer D. Frequency of ge- netic mutations associated with thromboembolism in the Western Black Sea Region. Intern Med 2011;50:17-21.
  • Sazci A, Ergul E, Tuncer N, et al. Methylenetetrahydro- folate reductase gene polymorphisms are associated with ischemic and hemorrhagic stroke: Dual effect of MTHFR polymorphisms C677T and A1298C. Brain Res Bull. 2006;71:45-50.
  • Yilmaz H, Isbir S, Agachan B, et al. C677T mutation of methylenetetrahydrofolate reductase gene and serum ho- mocysteine levels in Turkish patients with coronary artery disease. Cell Biochem Funct 2006;24:87-90.
  • Agirbasli M, Guney AI, Ozturhan HS, et al. Multifactor di- mensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease. Eur J Cardiovasc Prev Rehabil 2011;18:803-809.
  • Dölek B, Eraslan S, Eroğlu S, et al. Molecular analysis of factor V Leiden, factor V Hong Kong, factor II G20210A ,methylenetetrahydrofolate reductase C677T, and A1298C mutations related to Turkish thrombosis patients. Clin Appl Thromb Hemost 2007;13:435-438.
  • Kucukhuseyin O, Kurnaz O, Akadam-Teker AB, et al. The Association of MTHFR C677T Gne Variants and Lipid Profile sor Body Mass Index in Patients with Diabetic and Nondiabetic Coronary Heart Disease. J Clin Lab Anal 2013;27:427-434.
  • Aydin M, Gokkusu C, Ozkok E, et al. Association of ge- netic variants in methylenetetrahydrofolate reductase and paraoxonase-1 genes with homocysteine, folate and vi- tamin B12 in coronary artery disease. Mol Cell Biochem 2009;325:199-208.
  • Karata S, Aydin Y, Ocer F, et al. Hereditary thrombophilia, anti-beta2 glycoprotein 1 IgM, and anti-annexin V anti- bodies in recurrent pregnancy loss. Am J Reprod Immunol 2012;67:251-255.
  • Yilmaz H, Unlüçerçi Y, Gürdöl F, et al. Association of pre-eclampsia with hyperhomocysteinaemia and methy- lenetetrahydrofolate reductase gene C677T polymorphism in a Turkish population. Aust N Z J Obstet Gynaecol 2004;44:423-427.
  • Ozdemir O, Yenicesu GI, Silan F, et al. Recurrent pregnan- cy loss and its relation to combined parental thrombophilic gene mutations. Genet Test Mol Biomarkers 2012;16:279- 286.
  • Deligezer U, Akisik EE, Yaman F, et al. MTHFR C677 T gene polymorphism in lymphoproliferative diseases. J Clin Lab Anal 2006;20:37-41.
  • Emre S, Sirin A, Ergen A, et al. Methylenetetrahydrofolate reductase C677T polymorphism in patients with Henoch- Schönlein purpura. Pediatr Int 2011;53:358-362.
  • Ar MC, Baykara O, Buyru AN, Baslar Z. The impact of prothrombotic mutations on factor consumption in adult pa- tients with severe hemophilia. Clin Appl Thromb Hemost 2009;15:660-665.
  • Ergul E, Sazci A, Kara I. Methylenetetrahydrofolate re- ductase gene polymorphisms in Turkish children with at- tention-deficit/hyperactivity disorder. Genet Test Mol Bio- markers 2012;16:67-69.
  • Ukinc K, Ersoz HO, Karahan C, et al. Methyltetrahydro- folate reductase C677T gene mutation and hyperhomocys- teinemia as a novel risk factor for diabetic nephropathy. Endocrine 2009;36:255-261.
  • Demirel Y, Dogan S, Uludag A, et al. Combined effect of Factor V Leiden, MTHFR, and angiotensin-converting enzyme (insertion/deletion) gene mutations in hyperten- sive adult individuals: a population-based study from Si- vas and Canakkale, Turkey. Genet Test Mol Biomarkers
  • Sazci A, Ergül E, Güzelhan Y, et al. Methylenetetrahydrofo- late reductase gene polymorphisms in patients with schizo- phrenia. Brain Res Mol Brain Res 2003;117:104-107.
  • Sazci A, Ergul E, Kucukali I, et al. Association of the C677T and A1298C polymorphisms of methylenetetrahy- drofolate reductase gene with schizophrenia: association is significant in men but not in women. Prog Neuropsycho- pharmacol Biol Psychiatry 2005;29:1113-1123.
  • Yilmaz H, Agachan B, Isbir T, Akoglu E. Is there additional effect of MTHFR C677T mutation on lipid abnormalties in renal allograft recipients? Transplant Proc 2003;35:1390- 1392.
  • Kara I, Sazci A, Ergul E, et al. Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydro- folate reductase gene in patients with migraine risk. Brain Res Mol Brain Res 2003;111:84-90.
  • Bahadir A, Eroz R, Dikici S. Investigation of MTHFR C677T gene polymorphism, biochemical and clinical pa- rameters in Turkish migraine patients: Association with allodynia and fatigue. Cell Mol Neurobiol 2013;33:1055- 1063.
  • Sazci A, Ergul E, Bayulkem K. Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene in patients with essential tremor in Turkey. Mov Disord 2004;19:1472-1476.
  • Ozbek Z, Kucukali CI, Ozkok E, et al. Effect of the methy- lenetetrahydrofolate reductase gene polymorphisms on ho- mocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:1331-1337.
  • Sazci A, Ergul E, Aygun C, et al. Methylenetetrahydrofo- late reductase gene polymorphisms in patients with non- alcoholic steatohepatitis (NASH). Cell Biochem Funct
  • Ozarda Y, Sucu DK, Hizli B, Aslan D. Rate of T alleles and TT genotype at MTHFR 677C>T locus or C alleles and CC genotype at MTHFR 1298 A>C locus among healthy subjects in Turkey: impact on homocysteine and folic acid status and reference intervals. Cell Biochem Funct 2009;27:568-577.
  • Sazci A, Ergul E, Kaya G, Kara I. Genotype and allele fre- quencies of the polymorphic methylenetetrahydrofolate reductase gene in Turkey. Cell Biochem Funct 2005;23:51- 54.
  • Kantar M, Kosova B, Cetingul N, et al. Methylenetetra- hydrofolate reductase C677T and A1298C gene polymor- phisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lympho- ma. Leuk Lymphoma 2009;50:912-917.
  • Onur E, Kurdal AT, Tugrul B, et al. Is genetic screen- ing necessary for determining the possibility of venous thromboembolism in cancer patients? Med Princ Pract
  • Alioglu E, Turk U, Cam S, et al. Polymorphisms of the methylenetetrahydrofolate reductase, vascular endothelial growth factor, endothelial nitric oxide synthase, monocyte chemoattractant protein-1 and apolipoprotein E genes are not associated with carotid intima-media thickness. Can J Cardiol 2009;25:e1-5.
  • Var A, Utük O, Akçali S, et al. Impact of hemostatic gene single point mutations in patients with non-diabetic coro- nary artery disease. Mol Biol Rep 2009;36:2235-2243.
  • Bolaman Z, Ozkul A, Kiylioglu N, et al. Hereditary throm- bophilic factors in stroke due to cerebral infarct. Am J Med Sci 2009;337:11-13.
  • Onur E, Kurdal AT, Tugrul B, et al. Is genetic screen- ing necessary for determining the possibility of veneous thromboembolism in cancer patients? Med Princ Pract 2012;21:160-163.
  • Onrat ST, Akci O, Söylemez Z, et al. Prevalence of myocar- dial infarction polymorphisms in Afyonkarahisar, Western Turkey. Mol Biol Rep 2012;39:9257-9264.
  • Yildiz G, Yavuzcan A, Yildiz P, et al. Inherited thrombo- philia with recurrent pregnancy loss in Turkish women a real phenomenon? Ginekol Pol 2012;83:598-603.
  • Karadeniz M, Erdogan M, Zengi A, et al. Methylenetetra- hydrofolate reductase C677T gene polymorphism in Turk- ish patients with polycystic ovary syndrome. Endocrine 2010;38:127-133.
  • Habibovic Z, Zeybek B, Sanhal C, et al. Effects of inherited trombophilia in women with recurrent pregnancy loss. Clin Exp Obstet Gynecol 2011;38:347-350.
  • Canda MT, Demir N, Sezer O. Impact of Factor V Leiden, prothrombin and methylenetetrahydrofolate reductase gene mutations on infant birth weight in women with recurrent fetal loss and women with successful pregnancies. Clin Exp Obstet Gynecol 2012;39:359-361.
  • Yasa MH, Bolaman Z, Yukselen V, et al. Factor V Leiden G1691A, prothrombin G20210A, and MTHFR C677T mutations in Turkish inflammatory bowel disease patients. Hepatogastroenterology 2007;54:1438-1442.
  • Sensoy N, Şoysal Y, Kahraman A, et al. Modulator effects of the methylenetetrahydrofolate reductase C677T poly- morphism on response to vitamin B12 therapy and homo- cysteine metabolism. DNA Cell Biol 2012;31:820-825.
  • Erdogan MO, Yildiz SH, Solak M, et al. C677T polymor- phism of the methylenetetrahydrofolate reductase gene does not affect folic acid, vitamin B12, and homocysteine serum levels in Turkish children with neural tube defects. Genet Mol Res 2010;9:1197-1203.
  • Yasar A, Gunduz K, Onur E, Calkan M. Serum homocys- teine, vitamin B12, folic acid levels and methylenetetrahy- drofolate reductase (MTHFR) gene polymorphism in vit- iligo. Dis Markers 2012;33:85-89.
  • Kabukcu S, Keskin N, Keskin A, Atalay E. The frequency of factor V Leiden and concomitance of factor V Leiden with prothrombin G20210A mutation and methylene tet- rahydrofolate reductase C677T gene mutation in healthy population of Denizli, Aegean region of Turkey. Clin Appl Thromb Hemost 2007;13:166-171.
  • Eroglu Z, Erdogan M, Tetik A, et al. The relationship of the methylenetetrahydrofolate reductase C677T gene polymor- phism in Turkish type 2 diabetic patients with and without nephropathy. Diabetes Metab Res Rev 2007;23:621-624.
  • Celik A, Tekis D, Saglam F, et al. Association of corticoste- roids and factor V, prothrombin, and MTHFR gene muta- tions with a vascular osteonecrosis in renal allograft recipi- ents. Transplant Proc 2006;38:512-516.
  • Izmirli M, Inandiklioglu N, Abat D, et al. MTHFR gene polymorphisms in bladder cancer in the Turkish population. Asian Pac J Cancer Prev 2011;12:1833-1835.
  • Mendilcioglu I, Bilgen T, Arikan Y, et al. The associa- tion between inherited thrombophilias and pregnancy- related hypertension recurrence. Arch Gynecol Obstet
  • Izmirli M, Alptekin D, Topcuoglu MS, Guzel MD. Investi- gation of methylene tetrahydrofolate reductase gene poly- morphisms in coronary by-passed patients due to coronary atherosclerosis etiology. Turkiye Klinikleri J Cardiovasc Sci 2009;21:303-308.
  • Hanta I, Soydas Y, Karatasli M, et al. Plasma homocys- teine level and 677C>T mutation on the MTHFR gene in patients with venous thromboembolism. Bratisl Lek Listy 2010;111:70-73.
  • Dundar-Yenilmez E, Tuli A, Bozkurt A, Acartürk E. The effects of factor V leiden, prothrombin G20210A, MTHFR C677T, MTHFR A1298C, factor XIIIA Val34Leu, factor XIIIB His95Arg and apolipoprotein E genotypes on coro- nary artery disease. Turk J Biochem 2012;37:424-430.
  • Demir SC, Evruke C, Ozgunen T, et al. The relationship between pregnancy induced hypertension and congenital thrombophilia. Saudi Med J 2006;27:1161-1166.
  • Timuragaoglu A, Dizlek S, Uysalgil N, et al. Methylenetet- rahydrofolate reductase C677T polymorphism in adult pa- tients with lymphoproliferative disorders and its effect on chemotherapy. Ann Hematol 2006;85:863-868.
  • Canataroglu A, Tanriverdi K, Inal T, et al. Methylenetet- rahydrofolate reductase gene C677T mutation and plasma homocysteine level in Behçet’s disease. Rheumatol Int
  • Sipahi T, Kara A, Kuybulu A, et al. Congenital thrombotic risk factors in beta-thalassemia. Clin Appl Thromb Hemost 2009;15:581-584.
  • Serin E, Güçlü M, Ataç FB, et al. Methylenetetrahydrofo- late reductase C677T mutation and nonalcoholic fatty liver disease. Dig Dis Sci 2007;52:1183-1186.
  • Ozen F, Erdis E, Sik E, et al. Germ-line MTHFR C677T, FV H1299R and PAI-1 5G/4G Variations in Breast Carcinoma. Asian Pac J Cancer Prev 2013;14:2903-2908.
  • Ozkan M, Sivgin S, Kocyigit I, et al. Do thrombophilic gene mutations have a role on thromboembolic events in cancer patients? Asia Pac J Clin Oncol 2012;8:e34-41.
  • Ekiz F, Ormeci N, Coban S, et al. Association of methylene- tetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett’s esopha- gus, and reflux esophagitis. Dis Esophagus 2012;25:437- 441.
  • Torun YA, Patiroglu T, Ozdemir MA, et al. Inherited pro- thrombotic risk factors in Turkish children with acute lym- phoblastic leukemia: significance of concomitant genetic mutation. Clin Appl Thromb Hemost 2012;18:218-221.
  • Arslan S, Manduz S, Epöztürk K, et al. Association of deep venous thrombosis with prothrombotic gene poly- morphism identified in lung cancer cases. Mol Biol Rep 2011;38:2395-400.
  • Arslan S, Karadayi S, Yildirim ME, et al. The association between methylene-tetrahydrofolate reductase gene poly- morphism and lung cancer risk. Mol Biol Rep 2011;38:991- 996.
  • Ozen F, Polat F, Arslan S, Ozdemir O. Combined germline variations of thrombophilic genes promote genesis of lung cancer. Asian Pac J Cancer Prev 2013;14:5449-5454.
  • Muslumanoglu MH, Tepeli E, Demir S, et al. The analysis of the relationship between A1298C and C677T polymor- phisms of the MTHFR gene with prostate cancer in Eskise- hir population. Genet Test Mol Biomarkers 2009;13:641- 645.
  • Eroglu A, Egin Y, Cam R, Akar N. The 19-bp deletion of di- hydrofolate reductase (DHFR), methylenetetrahydrofolate reductase (MTHFR) C677T, Factor V Leiden, prothrombin G20210A polymorphisms in cancer patients with and with- out thrombosis. Ann Hematol 2009;88:73-76.
  • Balta G, Yuksek N, Ozyurek E, et al. Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia. Am J Hematol 2003;73:154-160.
  • Eroğlu A, Karabıyık A, Akar N. The association of protease activated receptor 1 gene 506 I/D polymorphism with dis- ease-free survival in breast cancer patients. Ann Surg Oncol 2012;19:1365-1369.
  • Geçene M, Tuncay F, Borman P, et al. Atherosclerosis in male patients with ankylosing spondylitis: the relation with methylenetetrahydrofolate reductase (C677T) gene poly- morphism and plasma homocysteine levels. Rheumatol Int 2013;33:1519-1524.
  • Yildiz OK, Cevik S, Cil G, et al. Cerebral venous sinüs thrombosis presenting as transient ischemic attacks in a case with homozygous mutations of MTHFR A1298C and C677T. J Stroke Cerebrovasc Dis 2012;21:75-77.
  • Kupeli E, Verdi H, Simsek A, et al. Genetic mutations in Turkish population with pulmonary embolism and deep ve- nous thrombosis. Clin Appl Thromb Hemost 2011;17:E87- 94.
  • Ozmen F, Ozmen MM, Ozalp N, Akar N. The prevalence of factor V (G1691A), MTHFR (C677T) and PT (G20210A) gene mutations in arterial thrombosis. Ulus Travma Acil Cerrahi Derg 2009;15:113-119.
  • Ozbek N, Alioglu B, Avci Z, et al. Incidence of and risk fac- tors for childhood thrombosis: a single-center experience in Ankara, Turkey. Pediatr Hematol Oncol 2009;26:11-29.
  • Küpeli E, Cengiz C, Cila A, Karnak D. Hyperhomocystein- emia due to pernicious anemia leading to pulmonary throm- boembolism in a heterozygous mutation carrier. Clin Appl Thromb Hemost 2008;14:365-368.
  • Balta G, Gürgey A. Methylenetetrahydrofolate reductase (MTHFR) C677T mutation in Turkish patients with throm- bosis. Turk J Pediatr 1999;41:197-199.
  • Ozyurek E, Balta G, Degerliyurt A, et al. Significance of factor V, prothrombin, MTHFR, and PAI-1 genotypes in childhood cerebral thrombosis. Clin Appl Thromb Hemost
  • Alioglu B, Ozyurek E, Tarcan A, et al. Heterozygous meth- ylenetetrahydrofolate reductase 677C-T gene mutation with mild hyperhomocysteinemia associated with intrauterine iliofemoral artery thrombosis. Blood Coagul Fibrinolysis 2006;17:495-498.
  • Dikmen M, Ozbabalik D, Gunes HV, et al. Acute stroke in relation to homocysteine and methylenetetrahydrofo- late reductase gene polymorphisms. Acta Neurol Scand
  • Akman B, Afsar B, Ataç FB, et al. Predictors of vascular access thrombosis among patients on the cadaveric renal transplantation waiting list. Transplant Proc 2006;38:413- 415.
  • Akar N, Akar E, Ozel D, et al. Common mutations at the homocysteine metabolism pathway and pediatric stroke. Thromb Res 2001;102:115-120.
  • Gülec S, Aras O, Akar E, et al. Methylenetetrahydrofolate reductase gene polymorphism and risk of premature myo- cardial infarction. Clin Cardiol 2001;24:281-284.
  • Ozyürek E, Balta G, Degerliyurt A, et al. Significance of factor V, prothrombin, MTHFR, and PAI-1 genotypes in childhood cerebral thrombosis. Clin Appl Thromb Hemost
  • Akar N, Akar E, Akçay R, et al. Effect of methylenetet- rahydrofolate reductase 677 C-T, 1298 A-C, and 1317 T-C on factor V 1691 mutation in Turkish deep vein thrombosis patients. Thromb Res 2000;97:163-167.
  • Akar N, Akar E, Deda G, et al. Factor V1691 G-A, pro- thrombin 20210 G-A, and methylenetetrahydrofolate re- ductase 677 C-T variants in Turkish children with cerebral infarct. J Child Neurol 1999;14:749-751.
  • Tokgözoğlu SL, Alikaşifoğlu M, Unsal-Atalar E, et al. Methylenetetrahydrofolate reductase genotype and the risk and extent of coronary artery disease in a population with low plasma folate. Heart 1999;81:518-522.
  • Ozyurek E, Balta G, Degerliyurt A, et al. Significance of factor V, prothrombin, MTHFR, and PAI-1 genotypes in childhood cerebral thrombosis. Clin Appl Thromb Hemost 2007;13:154-160.
  • Ozkurt S, Temiz G, Saylisoy S, Soydan M. Cerebral sinovenous thrombosis associated with factor V Leiden and methylenetetrahydrofolatereductase A1298C muta- tion in adult membranous glomerulonephritis. Ren Fail 2011;33:524-527.
  • Nazli Y, Colak N, Aksoy ON, Cakir O. Thyroid vein thrombosis in a young woman with methylenetetrahydrofo- late reductase gene mutation receiving cyproterone acetate/ ethinylestradiol treatment for polycystic ovary syndrome: a case report. Blood Coagul Fibrinolysis 2011;22:331-333.
  • Uvuz F, Kilic S, Yilmaz N, et al. Relationship between preterm labor and thrombophilic gene polymorphism: A prospective sequential cohort study. Gynecol Obstet Invest
  • Boduroğlu K, Alanay Y, Koldan B, Tunçbilek E. Methy- lenetetrahydrofolate reductase enzyme polymorphisms as maternal risk for Down syndrome among Turkish women. Am J Med Genet 2004;127A:5-10.
  • Yenicesu GI, Cetin M, Ozdemir O, et al. A prospective case-control study analyzes 12 thrombophilic gene muta- tions in Turkish couples with recurrent pregnancy loss. Am J Reprod Immunol 2010;63:126-136.
  • Yokuş O, Balçık ÖŞ, Albayrak M, et al. Thrombophilic risk factors in women with recurrent abortion. J Clin Exp Invest 2010;1:168-172.
  • Inanir A, Yigit S, Tural S, et al. MTHFR gene C677T mu- tation and ACE gene I/D polymorphism in Turkish patients with osteoarthritis. Dis Markers 2013;34:17-22.
  • Inanir A, Yigit S, Tekcan A, et al. IL-4 and MTHFR gene polymorphism in rheumatoid artritis and their effects. Im- munol Lett 2013;152:104-108.
  • Taşbaş O, Borman P, Gürhan Karabulut H, et al. The Frequency of A1298C and C677T Polymorphisms of the Methylentetrahydrofolate Gene in Turkish Patients with Rheumatoid Arthritis: Relationship with Methotrexate Tox- icity. Open Rheumatol J 2011;5:30-35.
  • Ozkul Y, Evereklioglu C, Borlu M, et al. 5,10-methylene- tetrahydrofolate reductase C677T gene polymorphism in Behcet’s patients with or without ocular involvement. Br J Ophthalmol 2005;89:1634-1637.
  • Toydemir PB, Elhan AH, Tükün A, et al. Effects of factor V gene G1691A, methylenetetrahydrofolate reductase gene C677T, and prothombin gene G20210A mutations on deep venous thrombogenesis in Behçet’s disease. J Rheumatol 2000;27:2849-2854.
  • Törüner M, Erkan O, Soykan I, et al. Factor V Leiden, pro- thrombin G20210A and MTHFR gene mutations in inflam- matory bowel disease. Turk J Gastroenterol 2004;15:250- 252.
  • Eser B, Cosar M, Eser O, et al. 677C>T and 1298A>C polymorphisms of methylenetetrahydropholate reductase gene and biochemical parameters in Turkish population with spina bifida occulta. Turk Neurosurg 2010;20:9-15.
  • Aşlar D, Ozdiler E, Altuğ AT, Taştan H. Determination of methylenetetrahydrofolate reductase (MTHFR) gene poly- morphism in Turkish patients with nonsyndromic cleft lip and palate. Int J Pediatr Otorhinolaryngol 2013;77:1143- 1146.
  • Boduroğlu K, Alikaşifoğlu M, Anar B, Tunçbilek E. As- sociation of the 677CT mutation on the methylenetetra- hydrofolate reductase gene in Turkish patients with neural tube defects. J Child Neurol 1999;14:159-161.
  • Ceyhan ST, Beyan C, Bahce M, et al. Thrombophilia-as- sociated gene mutations in women with pregnancies com- plicated by fetal neural tube defects. Int J Gynaecol Obstet 2008;101:188-189.
  • Boduroğlu K, Alanay Y, Alikaşifoğlu M, et al. Analysis of MTHFR 1298A>C in addition to MTHFR 677C>T poly- morphism as a risk factor for neural tube defects in the Turkish population. Turk J Pediatr 2005;47:327-333.
  • Kosar A, Kasapoglu B, Kalyoncu S, et al. Treatment of adverse perinatal outcome in inherited thrombophilias: a clinical study. Blood Coagul Fibrinolysis 2011;22:14-18.
  • Boduroğlu K, Alikaşifoğlu M, Anar N, Tunçbilek E. As- sociaition of the 677 CT mutation on the methylenetetra- hydrofolate reductase gene in Turkish patients with neural tube defects. J Child Neurol 1999;14:159-161.
  • Sahiner UM, Alanay Y, Alehan D, et al. Investigation methylenetetrahydrofolate reductase polymorphisms and homocysteine levels in heart defects. Pediatr Int 2013;DOI:10.1111/ped.12222.
  • Ozbek N, Ataç FB, Yildirim SV, et al. Analysis of pro- thrombotic mutations and polymorphism in children who developed thrombosis in the perioperative period of con- genital cardiac surgery. Cardiol Young 2005;15:19-25.
  • Kalkan G, Karakus N, Yigit S. Association of MTH- FR gene C677T mutation with recurrent aphthous sto- matitis and number of oral ulcers. Clin Oral Investig 2013;DOI:10.1007/s00784-013-0997-0.
  • Bekci TT, Kocak N, Kesli R. Distribution of common methylenetetrahydrofolate reductase gene mutations in patients with obstructive sleep apnoea. J Int Med Res 2009;37:1718-1724.
  • Vurucu S, Demirkaya E, Kul M, et al. Evaluation of the relationship between C677T variants of methylenetetra- hydrofolate reductase gene and hyperhomocysteinemia in children receiving antiepileptic drug therapy. Prog Neuro- psychopharmacol Biol Psychiatry 2008;32:844-848.
  • Turaçli ME, Tekeli O, Ozdemir F, Akar N. Methylenetetra- hydrofolate reductase 677 C-T and homocysteine levels in Turkish patients with pseudoexfoliation. Clin Experiment Ophthalmol 2005;33:505-508.
  • Sırmalı R, Koca Y, Erden G, et al. Evaluation of the Asso- ciation of Mthfr C677T and A1298C Gene Polymorphisms with Diabetic Retinopathy in Type 2 Diabetes Patients. Turk J Biochem 2008;33:71-76.
  • Dinleyici EC, Kirel B, Alatas O, et al. Plasma total homo- cysteine levels in children with type 1 diabetes: relationship with vitamin status, methylenetetrahydrofolate reductase genotype, disease parameters and coronary risk factors. J Trop Pediatr 2006;52:260-266.
  • Yildiz B, Cetin N, Kural N, et al. Co-existence of renovas- cular hypertension, polyarteritis nodosa, antiphospholipid syndrome and methylenetetrahydrofolate reductase muta- tion. Pediatr Int 2013;55:e107-110.
  • Yildiz Z, Ulu A, Incesulu A, et al. The importance of throm- botic risc factors in the development of idiopathic sudden hearing loss. Clin Appl Thromb Hemost 2008;14:356-359.
  • Vurucu S, Demirkaya E, Kul M, et al. Evaluation of the relationship between C677T variants of methylenetetra- hydrofolate reductase gene and hyperhomocysteinemia in children receiving antiepileptic drug therapy. Prog Neuro- psychopharmacol Biol Psychiatry 2008;32:844-848.
  • Yigit S, Karakus N, Inanir A. Association of MTHFR gene C677T mutation with diabetic peripheral neuropathy and diabetic retinopathy. Mol Vis 2013;19:1626-1630.
  • Kalkan G, Yigit S, Karakuş N, et al. Methylenetetrahydro- folate reductase C677T mutation in patients with alopecia areata in Turkish population. Gene 2013;530:109-112.
  • Uğuz N, Erden G, Güngör O, et al. Determination of the frequency of MTHFR C677T and MTHFR A1298C poly- morphisms in persons with polymorphic MTHFR gene. J Clin Exp Invest 2012;3:472-476.
  • Uçar F, Celik S, Yücel B, et al. MTHFR C677T poly- morphism and its relationship to myocardial infarction in the Eastern Black Sea region of Turkey. Arch Med Res 2011;42:709-712.
  • Ağaoğlu N, Türkyilmaz S, Ovali E, et al. Prevalence of prothrombotic abnormalities in patients with acute mesen- teric ischemia. World J Surg 2005;29:1135-1138.
  • Uçar F, Sönmez M, Ovali E, et al. MTHFR C677T poly- morphism and its relation to ischemic stroke in the Black Sea Turkish population. Am J Hematol 2004;76:40-43.
  • Uçar F, Celik S, Ovali E, et al. Coexistence of prothrombic risk factors and its relation to left ventricular thrombus in acute myocardial infarction. Acta Cardiol 2004;59:33-39.
  • Karakaus N, Yigit S, Kalkan G, et al. Association between the methylenetetrahydrofolate reductase gene C677T muta- tion and colchicine unresponsiveness in Behcet’s disease. Mol Vis 2012;18:1696-700.
  • Hakimoglu S, Hanci V, Hakimoglu Y, et al. The effects of nitrous oxide on vitamin B12 and homocysteine levels in methylenetetrahydrofolate reductase gene mutation. Bratisl Lek Listy 2013;114:317-322.
  • Ilhan N, Kucuksu M, Kaman D, et al. The 677 C/T MTH- FR polymorphism is associated with essential hyperten- sion, coronary artery disease, and higher homocysteine levels. Arch Med Res 2008;39:125-130.
  • Varoglu AO. Na VPA-induced acute ischemic stroke in an epileptic patient with methylenetetrahydrofolatereductase gene polymorphism. Epilepsy Res 2009;86:232-236.
  • 1 Uzar E, Ekici F, Acar A, et al. Cerebral venous sinus thrombosis: an analyses of 47 patients. Eur Rev Med Phar- macol Sci 2012;16:1499-1505.
  • 1 Gokalp D, Tuzcu A, Bahceci M, et al. Analysis of throm- bophilic genetic mutations in patients with Sheehan’s syn- drome: is thrombophilia responsible for the pathogenesis of Sheehan’s syndrome? Pituitary 2011;14:168-173.
  • 1 Yalinkaya A, Erdemoglu M, Akdeniz N, Kale A, Kale E. The relationship between thrombophilic mutations and preeclampsia: a prospective case-control study. Ann Saudi Med 2006;26:105-109.
  • 1 Yilmaz S, Bayan K, Tüzün Y, et al. A comprehensive anal- ysis of 12 thrombophilic mutations and related parameters in patients with inflammatory bowel disease: data from Tur- key. J Thromb Thrombolysis 2006;22:205-212.
  • 1 Bayan K, Tüzün Y, Yilmaz S, et al. Analysis of inherited thrombophilic mutations and natural anticoagulant defi- ciency in patients with idiopathic portal hypertension. J Thromb Thrombolysis 2009;28:57-62.
  • 1 Büyükçelik M, Karakök M, Başpinar O, Balat A. Arte- rial thrombosis associated with factor V Leiden and methy- lenetetrahydrofolate reductase C677T mutation in child- hood membranous glomerulonephritis. Pediatr Nehrol 2008;23:491-494.
  • 1 Gokcen C, Kocak N, Pekgor A. Methylenetetrahydrofo- late reductase gene polymorphi polymorphisms in children with attention deficit hyperactivity disorder. Int J Med Sci 2011;8:523-528.
  • 1 Izmirli M. A literature review of MTHFR (C677T and A1298C polymorphisms) and cancer risk. Mol Biol Rep 2013;40:625-637.
  • 1 Dikmen M. Molecular biology of methylenetetrahydrofo- late reductase enzyme and association with diseases. Ko- catepe Tıp Dergisi 2004;5:9-16.
Toplam 159 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Derlemeler
Yazarlar

Müzeyyen İzmirli Bu kişi benim

Özgür Aldemir Bu kişi benim

Bülent Gögebakan Bu kişi benim

Davut Alptekin Bu kişi benim

Yayımlanma Tarihi 1 Mart 2014
Gönderilme Tarihi 2 Mart 2015
Yayımlandığı Sayı Yıl 2014 Cilt: 41 Sayı: 1

Kaynak Göster

APA İzmirli, M., Aldemir, Ö., Gögebakan, B., Alptekin, D. (2014). The studies about diseases concerning with contemplated MTHFR 677 C>T polymorphism. Dicle Medical Journal, 41(1), 244-256. https://doi.org/10.5798/diclemedj.0921.2014.01.0411
AMA İzmirli M, Aldemir Ö, Gögebakan B, Alptekin D. The studies about diseases concerning with contemplated MTHFR 677 C>T polymorphism. diclemedj. Mart 2014;41(1):244-256. doi:10.5798/diclemedj.0921.2014.01.0411
Chicago İzmirli, Müzeyyen, Özgür Aldemir, Bülent Gögebakan, ve Davut Alptekin. “The Studies about Diseases Concerning With Contemplated MTHFR 677 C>T Polymorphism”. Dicle Medical Journal 41, sy. 1 (Mart 2014): 244-56. https://doi.org/10.5798/diclemedj.0921.2014.01.0411.
EndNote İzmirli M, Aldemir Ö, Gögebakan B, Alptekin D (01 Mart 2014) The studies about diseases concerning with contemplated MTHFR 677 C>T polymorphism. Dicle Medical Journal 41 1 244–256.
IEEE M. İzmirli, Ö. Aldemir, B. Gögebakan, ve D. Alptekin, “The studies about diseases concerning with contemplated MTHFR 677 C>T polymorphism”, diclemedj, c. 41, sy. 1, ss. 244–256, 2014, doi: 10.5798/diclemedj.0921.2014.01.0411.
ISNAD İzmirli, Müzeyyen vd. “The Studies about Diseases Concerning With Contemplated MTHFR 677 C>T Polymorphism”. Dicle Medical Journal 41/1 (Mart 2014), 244-256. https://doi.org/10.5798/diclemedj.0921.2014.01.0411.
JAMA İzmirli M, Aldemir Ö, Gögebakan B, Alptekin D. The studies about diseases concerning with contemplated MTHFR 677 C>T polymorphism. diclemedj. 2014;41:244–256.
MLA İzmirli, Müzeyyen vd. “The Studies about Diseases Concerning With Contemplated MTHFR 677 C>T Polymorphism”. Dicle Medical Journal, c. 41, sy. 1, 2014, ss. 244-56, doi:10.5798/diclemedj.0921.2014.01.0411.
Vancouver İzmirli M, Aldemir Ö, Gögebakan B, Alptekin D. The studies about diseases concerning with contemplated MTHFR 677 C>T polymorphism. diclemedj. 2014;41(1):244-56.

Cited By

Güneydoğu Anadolu Bölgesi’ndeki Tekrarlayan Abortus Olgularında Protrombin, MTHFR, FV Leiden ve PAI-1 Polimorfizmlerinin Retrospektif Olarak İncelenmesi
Dicle Tıp Dergisi
Evren Gumus
https://doi.org/10.5798/dicletip.457243