Evaluation of Sense of Smell in Onychomycosis Patients Receiving Terbinafine Treatment

Abstract

Aim: The most common side effects of terbinafine are gastrointestinal symptoms. Loss of taste and smell side effects are presented in a small number of case reports. We aimed to measure the effect of terbinafine on the sense of smell and the degree of change in the sense of smell in this study. Material and Methods: Odor identification test (OIT), odor threshold test (OTT), and odor discrimination test (ODT) were applied to the patients treated with terbinafine and the control group. It was applied with “Sniffin Sticks” test pens. Smell test was performed on the patient group just before the start of terbinafine treatment and at the end of 3 months of treatment. Results: There was no statistical difference between the patient and control groups in terms of age (p=0.991) and gender (p=0.811). There was no statistical difference when the initial odor tests of the patient group and the control group were compared. The OIT value of the patient group was 10.15±1.43 at the beginning and 10.10±1.15 at the end of the treatment (p=0.743). The OTT values were 6.23±1.08 at the beginning and 6.21±0.85 at the end of the treatment (p=0.811). The ODT values were 9.71±1.44 at the beginning and 9.69±1.34 at the end of the treatment (p=0.767). There was no statistical difference in the results of the tests performed at the beginning and end of the treatment. Conclusion: There was no adverse effect on the sense of smell associated with the use of systemic terbinafine treatment for 3 months.

Keywords

• Terbinafine
• onychomycosis
• Sniffin’Sticks test
• odor

Terbinafin Tedavisi Alan Onikomikoz Hastalarında Koku Duyusunun Değerlendirilmesi

Abstract

Amaç: Terbinafinin en sık karşılaşılan yan etkileri gastrointestinal şikayetlerdir. Tat ve koku kaybı yan etkisi ise az sayıda vaka sunumunda bildirilmiştir. Bu çalışmadaki amacımız terbinafinin koku duyusu üzerine etkisini ve koku duyusundaki değişimin derecesini ölçmektir. Gereç ve Yöntemler: Terbinafin tedavisi başlanan hastalara ve kontrol grubuna koku tanımlama testi (KTT; odor identification test, OIT), koku duyarlılık testi (KDT; odor threshold test, OTT) ve koku ayırım testi (KAT; odor discrimination test, ODT) uygulandı. Koku testi “Sniffin Sticks” test kalemleri ile yapıldı. Hasta grubuna koku testi terbinafin tedavisi başlamadan hemen önce ve 3 aylık tedavi süresinin sonunda yapıldı. Bulgular: Hasta ve kontrol grupları arasında yaş (p=0,991) ve cinsiyet (p=0,811) açısından istatistiksel olarak anlamlı bir fark saptanmadı. Hasta grubunun başlangıç koku testleri ve kontrol grubunun koku testleri karşılaştırıldığında da aralarında istatistiksel olarak anlamlı bir fark yoktu. Hasta grubunun KTT değeri tedavi başlangıcında 10,15±1,43 ve tedavi sonunda ise 10,10±1,15 olarak saptandı (p=0,743). KDT değerleri tedavi başlangıcında 6,23±1,08 ve tedavi sonunda ise 6,21±0,85 olarak tespit edildi (p=0,811). KAT değerleri tedavi başlangıcında 9,71±1,44 ve tedavi sonunda ise 9,69±1,34 olarak saptandı (p=0,767). Tedavi başında ve sonunda yapılan test sonuçlarında istatistiksel olarak anlamlı bir fark yoktu. Sonuç: Sistemik terbinafin tedavisinin 3 ay süreyle kullanımına bağlı olarak koku duyusu üzerinde herhangi bir yan etki tespit edilmemiştir.

Keywords

• Terbinafin
• onikomikoz
• Sniffin’Sticks test
• koku

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