Çocuk ve Erişkin Yaş Gruplarında Karaciğer Elastisitesinin Karaciğer Boyutu, Yaş, Cinsiyet ve Beden Kitle İndeksi ile İlişkisinin 2-D Shear Wave Elastografi ile Değerlendirilmesi

Abstract

Amaç: Bu çalışma çocuklarda ve erişkinlerde normal karaciğer elastisite değerinin (liver stiffness value, LSV) shear wave elastografi (SWE) ile değerlendirilmesini ve LSV ile yaş, cinsiyet, beden kitle indeksi (BKİ) ve karaciğer boyutu arasındaki ilişkinin ortaya koyulmasını amaçlamaktadır. Gereç ve Yöntemler: Bu çalışmaya yaşları 4 ve 50 yıl arasında olan, 92 kadın ve 81 erkek olmak üzere toplam 173 sağlıklı gönüllü dahil edilmiştir. LSV ölçümleri supin pozisyonda, normal nefes alma esnasında sağ interkostal aralıktan, akustik pencerenin en iyi olduğu aralıktan yapıldı. Beş güvenli ölçümün ortalaması ortalama LSV değeri olarak kabul edildi. Ortalama LSV ile yaş, cinsiyet, karaciğer boyutu ve BKİ arasındaki ilişki değerlendirildi. Bulgular: LSV ile yaş arasında (p<0,001; r=0,609), LSV ile BKİ arasında (p<0.001; r=0,512) ve LSV ile karaciğer boyutu arasında (p<0,001; r=0,485) pozitif yönlü orta dereceli bir ilişki saptanmıştır. Ancak multivariate lineer regresyon analizi karaciğer boyutunun ve cinsiyetin LSV üzerine etkisinin anlamlı olmadığını (sırasıyla p=0,091 ve p=0,759), yaş ve BKİ’nin etkisinin ise anlamlı olduğunu ortaya çıkarmıştır (sırasıyla p<0,001 ve p=0,019). Sonuç: 2-D SWE hem çocuklarda hem de erişkinlerde LSV’nin değerlendirilmesinde etkili bir görüntüleme yöntemidir. LSV yaş ve BKİ arttıkça artış göstermekte, bununla birlikte, cinsiyet ve karaciğer boyutundan etkilenmemektedir. Mevcut çalışmada elde edilen normal LSV çeşitli karaciğer hastalıklarının 2-D SWE ile değerlendirilmesinde referans değerler olarak kullanılabilir.

Keywords

• Karaciğer;
• elastografi
• ultrasonografi

The Relationship of Liver Stiffness with Liver Size, Age, Gender, and Body Mass Index in Child and Adult Age Groups by 2-D Shear Wave Elastography

Abstract

Aim: The study aimed to evaluate the normal liver stiffness value (LSV) with shear wave elastography (SWE) in children and adults, and reveal the relationship between LSV and age, gender, body mass index (BMI), and liver size. Material and Methods: A total of 173 healthy volunteers, 92 female and 81 male, aged between 4 and 50 years were included in this study. LSV measurements were performed in the supine position during normal breathing and from the right intercostal space where the acoustic window is best. The mean of the five valid measurements was accepted as the mean LSV. The relationship between the mean LSV and age, gender, liver size, and BMI was evaluated. Results: There was a moderate positive correlation between LSV and age (p<0.001, r=0.609), LSV and BMI (p<0.001, r=0.512), and LSV and liver size (p<0.001, r=0.485). However, the multivariate linear regression analysis revealed that the effects of liver size and gender on LSV were not significant (p=0.091, and p=0.759, respectively), while the effects of age and BMI were significant (p<0.001, and p=0.019, respectively). Conclusion: 2-D SWE is an effective imaging method to evaluate LSV both in children and adults. LSV increases with increasing age and BMI, however, it is not affected by gender and liver size. The normal LSV obtained in the present study can be used as reference values in the evaluation of various liver diseases with 2-D SWE.

Keywords

• : liver
• shear wave elastography
• ultrasonography

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