İn Vitro Fertilizasyon/İntrasitoplazmik Sperm Enjeksiyonu Uygulanan Çiftlerde Paternal Yaşın Düşük Oranlarına Etkisi

Abstract

Amaç: Bu çalışmanın amacı in vitro fertilizasyon/intrasitoplazmik sperm enjeksiyonu tedavi siklusları uygulanan çiftlerde paternal yaşın düşük oranları üzerindeki etkisini belirlemektir. Gereç ve Yöntemler: Hastalar iki gruba ayrıldı. Gebeliği düşükle sonuçlanan hastalar (n=73) çalışma grubunu ve canlı tekil doğum yapan hastalar (n=256) ise kontrol grubunu oluşturdu. Demografik özellikler, tedavi endikasyonları, infertilite süresi, adetin 3. günü folikül uyarıcı hormon, östradiol, lüteinize edici hormon, toplam antral folikül sayısı, anti-Müllerian hormon seviyeleri ve kontrollü ovaryan stimülasyon parametreleri, tetikleme günü, tetikleme gününde östradiol ve progesteron seviyeleri, toplanan toplam oosit sayısı, matur oosit sayısı, embriyo sayısı ve kalitesi, tetikleme, oosit pick-up ve embriyo transfer gününde endometrial kalınlık, embriyo-fundus mesafesi ve embriyo transfer günü kaydedildi. Bulgular: Bu çalışmaya toplam 329 kadın dahil edildi. Açıklanamayan infertilite tanısı alan hasta sayısı çalışma grubunda kontrol grubuna göre istatistiksel olarak anlamlı derecede daha yüksek idi (p=0,020). Anne yaşının, çalışma grubunda kontrol grubuna göre istatistiksel olarak anlamlı derecede daha yüksek olduğu bulundu (p=0,025). Anne yaşı 1 birim arttığında, düşük yapma riskinin de %8,7 oranında arttığı ve açıklanamayan infertilitesi olanların açıklanamayan infertilitesi olmayanlara göre ise %75,6 oranında daha yüksek oranda düşük yapma riskine sahip olduğu görüldü. Sonuç: Paternal yaş düşük yapma ile ilişkili olarak bulunmazken, anne yaşı ve açıklanamayan infertilite ile düşük oranı arasında pozitif bir korelasyon olduğu görüldü.

Keywords

• Paternal yaş
• düşük oranı
• açıklanamayan infertilite
• anne yaşı
• IVF/ICSI

Effect of Paternal Age on Miscarriage Rates in Couples Undergoing In Vitro Fertilization/Intracytoplasmic Sperm Injection

Abstract

Aim: The aim of this study was to determine the effect of paternal age on miscarriage rates in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment cycles. Material and Methods: Patients were classified into two groups. The study group consisted of the patients whose pregnancy resulted in a miscarriage (n=73) and a control group in which the patients had a live singleton birth (n=256). Demographic characteristics, treatment indications, duration of infertility, menstruation day 3 follicle stimulating hormone, estradiol, luteinizing hormone, total antral follicle count, anti-Mullerian hormone levels and controlled ovarian stimulation parameters, day of trigger, estradiol and progesterone levels on the day of trigger, the total number of oocytes retrieved, the number of mature oocytes, the number and quality of the embryo, endometrial thickness on the day of trigger, oocyte pick up and embryo transfer, the distance of embryo-fundus and the day of embryo transfer were recorded. Results: Totally 329 women were included in the present study. The number of patients with the diagnosis of unexplained infertility was statistically significantly higher in the study group than in the control group (p=0.020). Maternal age was found statistically significantly higher in the study group than in the control group (p=0.025). When maternal age increased by 1 unit, the risk of miscarriage increased by 8.7% and those with unexplained infertility had a 75.6% higher risk of miscarriage than those without unexplained infertility. Conclusion: Paternal age was not associated with miscarriage whereas maternal age and unexplained infertility had a positive correlation with miscarriage rate.

Keywords

• Paternal age
• miscarriage rate
• unexplained infertility
• maternal age
• IVF/ICSI

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