Yüksek Dereceli Primer Beyin Tümörleri ile Metastatik Beyin Tümörlerinin Difüzyon MR Bulgularının Karşılaştırılması

Abstract

Amaç: Glioblastomalar en yüksek dereceli ve en ölümcül primer beyin tümörleridir. Beyin dışı dokulardaki kanserlerin beyne metastazı ile ortaya çıkan beyin kitleleri glioblastomaların ayırıcı tanısında yer almaktadır. Bu çalışmada, primer ve metastatik beyin kitlelerinin difüzyon ağırlıklı görüntüleme sinyal özelliklerinin karşılaştırılması ve ayırıcı tanıda faydalı olabilecek bulguların tanımlanması amaçlandı. Gereç ve Yöntemler: Çalışmaya patolojik olarak glioblastoma tanısı almış hastalar ile patolojik olarak metastaz tanısı almış veya radyolojik olarak beyin metastazı tanısı almış hastalar dahil edildi. 1,5 Tesla tarayıcı ile elde edilen manyetik rezonans görüntüleme incelemelerindeki difüzyon ağırlıklı görüntüleme sinyal özellikleri geriye dönük olarak analiz edildi. Her iki hasta grubunda lezyonların sinyal özellikleri ile kısa ve uzun çapları ölçüldü ve karşılaştırıldı. Bulgular: Bu çalışmaya 24 glioblastoma ve 30 beyin metastazı olmak üzere toplam 54 hasta dahil edildi. Glioblastoma grubunda difüzyon ağırlıklı görüntülemenin en yaygın sinyal özelliği 20 (%83,3) heterojen hiper ve hipointens alanlar olarak saptandı. Metastaz grubunda en sık görülen sinyal özelliği 16 (%53,3) hastada periferik hiperintens halka ve santral hipointens sinyal olarak saptandı. Lezyon sayısı ile primer beyin tümörü ve metastazlar arasında anlamlı bir ilişki bulunamadı. Sonuç: Difüzyon ağırlıklı görüntülemede kantitatif değerlendirme yapılmadan sadece sinyal özellikleri kullanılsa da primer ve metastatik beyin kitlelerinin ayırıcı tanısında yardımcı olabilir. İki gruptaki kitlelerin karşılaştırılabilir sinyal özelliklerine sahip olabileceğini unutmamak önemlidir.

Keywords

• Difüzyon ağırlıklı görüntüleme
• Glioblastoma
• beyin metastazı
• sinyal özellikleri

Comparison of Diffusion MRI Findings of High-Graded Primary Brain Tumors and Metastatic Brain Tumors

Abstract

Aim: Glioblastomas are the highest grade and most mortal primary brain tumors. Cerebral masses that occur with the metastasis of cancers of tissues other than brain are included in the differential diagnosis of glioblastomas. This study aimed to compare the diffusion-weighted imaging signal characteristics of primary and metastatic brain masses and to describe the findings that may be useful in the differential diagnosis. Material and Methods: Patients with pathologically diagnosed glioblastoma and patients with pathologically diagnosed metastases or radiologically diagnosed brain metastases were included in the study. Diffusion-weighted imaging signal properties in magnetic resonance imaging examinations obtained with a 1.5 Tesla scanner were retrospectively analyzed. The signal features and short and long diameters of the lesions were measured and compared in both patient groups. Results: A total of 54 patients, 24 glioblastomas, and 30 brain metastases were included in the study. The most common signal feature of diffusion-weighted imaging in the glioblastoma group was heterogeneous hyper- and hypointense areas observed in 20 (83.3%) patients. The most common signal feature in the metastasis group was the peripheral hyperintense ring and central hypointense signal in 16 (53.3%) patients. There was no significant relation found between the number of lesions and the primary brain tumor and metastases. Conclusion: Although only signal characteristics are used without quantitative assessment in diffusion-weighted imaging, it may be helpful in the differential diagnosis of primary and metastatic brain masses. It is important to remember that the masses in the two groups can have comparable signal properties.

Keywords

• Diffusion-weighted imaging
• Glioblastoma
• brain metastasis
• signal properties

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