Kalp Hastalıklarında Deney Hayvanı Modelleri

Year 2024, , 79 - 86, 30.06.2024

Ali Gök , Ersin Beyazçiçek

https://doi.org/10.18678/dtfd.1489656

Abstract

Kalp hastalıkları, dünya çapında önemli bir ölüm ve hastalık yükünü oluşturur. Bu genel terim, koroner arter hastalığı, kalp yetmezliği, miyokard enfarktüsü ve kapakçık kalp hastalığı gibi çeşitli durumları kapsar. Bu hastalıkları anlama ve ele alma gerekliliği göz önüne alındığında, deneysel çalışmalar kaçınılmazdır. Deneysel hayvan modelleri, kalp hastalıklarının mekanizmalarını açıklamada vazgeçilmez araçlar olarak hizmet eder. Yeni tedaviler geliştirmek ve mevcut tedavilerin etkinliğini değerlendirmek için kilit öneme sahiptirler. Kalp hastalığı araştırmalarında yaygın olarak kullanılan hayvan modelleri arasında fareler, sıçanlar, tavşanlar, köpekler ve domuzlar bulunmaktadır. Her model, araştırmacıların kalp patolojisinin belirli yönlerini incelemesine ve kalp hastalığında rol alan karmaşık mekanizmaları çözmesine olanak tanıyan farklı avantajlar ve kısıtlamalar sunar. Bu kapsamlı incelemede, kalp hastalığı araştırmalarında kullanılan çeşitli hayvan modellerinin kısa bir özetinin sunulması amaçlanmıştır. Her bir modelin avantajları ve dezavantajları belirlenmiş, insan kalp hastalığını taklit ettikleri yönleri açıklanmış ve kullanımlarına olanak tanıyan önemli araştırma bulguları vurgulanmıştır. Bu bilgileri sentezleyerek, araştırmacıların ve klinisyenlerin kalp hastalıklarını araştırmak için mevcut çeşitli hayvan modellerine sağladığı değerli bilgilerle, bu rahatsız edici durumların anlaşılmasının ve tedavisinin geliştirilmesine katkıda bulunmak amaçlanmıştır.

Keywords

Koroner arter hastalığı, kalp yetmezliği, miyokard enfarktüsü, kemirgenler, iskemi

Experimental Animal Models in Heart Disease

Abstract

Heart diseases constitute a significant global burden of mortality and morbidity. This encompassing word refers to a variety of illnesses, including coronary artery disease, heart failure, myocardial infarction, and valvular heart disease. Given the imperative need to comprehend and address these ailments, experimental studies are indispensable. Experimental animal models serve as indispensable tools in elucidating the mechanisms of heart disease. They are pivotal for developing novel treatments and assessing the efficacy of existing therapies. Among the commonly utilized animal models in heart disease research are mice, rats, rabbits, dogs, and pigs. Each model offers distinct advantages and limitations, allowing researchers to probe specific facets of cardiac pathology and unravel the intricate mechanisms involved in heart disease. In this comprehensive review, it was aimed to provide a succinct overview of the various animal models employed in heart disease research. The advantages and drawbacks of each model were delineated, the aspects of human heart disease they emulate were elucidated, and pivotal research findings facilitated by their utilization were highlighted. By synthesizing this information, it was the endeavor to provide researchers and clinicians with valuable insights into the diverse array of animal models available for investigating heart diseases, ultimately paving the way for enhanced understanding and treatment of these debilitating conditions.

Keywords

Coronary artery disease, heart failure, myocardial infarction, rodents, ischemia

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