Research Article
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Year 2026, Volume: 28 Issue: 1 , 57 - 63 , 25.04.2026
https://doi.org/10.18678/dtfd.1825287
https://izlik.org/JA28FT28JN

Abstract

References

  • Moore AD, Anghelescu DL. Emergence delirium in pediatric anesthesia: complexities and clinical challenges. Paediatr Drugs. 2017;19(1):11-20. doi:10.1007/s40272-016-0201-5.
  • Chen YC, Foster J, Wang ML, Rohmah I, Tseng YH, Chiu HY. Global prevalence and risk factors of emergence delirium in pediatric patients undergoing general anesthesia: a systematic review and meta-analysis. J Pediatr Nurs. 2024;77:74-80. doi:10.1016/j.pedn.2024.03.010.
  • Vlajkovic GP, Sindjelic RP. Emergence delirium in children: many questions, few answers. Anesth Analg. 2007;104(1):84-91. doi:10.1213/01.ane.0000250914.91881.a8.
  • Dahmani S, Delivet H, Hilly J. Emergence delirium in children: an update. Curr Opin Anaesthesiol. 2014;27(3):309-15. doi:10.1097/ACO.0000000000000076.
  • Mason KP. Paediatric emergence delirium: a comprehensive review and interpretation of the literature. Br J Anaesth. 2017;118(3):335-43. doi:10.1093/bja/aew477.
  • Petre MA, Levin DN, Englesakis M, Maynes JT, Pechlivanoglou P, Aoyama K. Dexmedetomidine vs. total intravenous anaesthesia in paediatric emergence delirium: a network meta-analysis. Eur J Anaesthesiol. 2021;38(11):1111-23. doi:10.1097/EJA.0000000000001490.
  • Aoyama K, Furuta M, Ameye L, Petre MA, Englesakis M, Rana M, et al. Risk factors for pediatric emergence delirium: a systematic review. Can J Anaesth. 2025;72(3):384-96. doi:10.1007/s12630-024-02889-w.
  • Liao WW, Wang JJ, Wu GJ, Kuo CD. The effect of cerebral monitoring on recovery after sevoflurane anesthesia in ambulatory setting in children: a comparison among bispectral index, A-line autoregressive index, and standard practice. J Chin Med Assoc. 2011;74(1):28-36. doi:10.1016/j.jcma.2011.01.004.
  • Lim BG, Lee IO, Ahn H, Lee DK, Won YJ, Kim HJ, et al. Comparison of the incidence of emergence delirium and emergence times between desflurane and sevoflurane anesthesia in children: a systematic review and meta-analysis. Medicine (Baltimore). 2016;95(38):e4927. doi:10.1097/MD.0000000000004927.
  • Zhang Y, Zhang Q, Xu S, Zhang X, Gao W, Chen Y, et al. Association of volatile anesthesia exposure and depth with emergence agitation and delirium in children: prospective observational cohort study. Front Pediatr. 2023;11:1115124. doi:10.3389/fped.2023.1115124.
  • Bong CL, Balanza GA, Khoo CE, Tan JS, Desel T, Purdon PL. A narrative review illustrating the clinical utility of electroencephalogram-guided anesthesia care in children. Anesth Analg. 2023;137(1):108-23. doi:10.1213/ANE.0000000000006267.
  • Frelich M, Lečbychová K, Vodička V, Ekrtová T, Sklienka P, Jor O, et al. Effect of BIS-guided anesthesia on emergence delirium following general anesthesia in children: a prospective randomized controlled trial. Anaesth Crit Care Pain Med. 2024;43(1):101318. doi:10.1016/j.accpm.2023.101318.
  • Lee YJ, Hwang JW, Do SH, Na HS. The effect of anesthetic depth on the occurrence of emergence delirium in children undergoing strabismus surgery: a prospective observational study. Biomedicines. 2024;13(1):63. doi:10.3390/biomedicines13010063.
  • Davidson AJ, Huang GH, Rebmann CS, Ellery C. Performance of entropy and bispectral index as measures of anaesthesia effect in children of different ages. Br J Anaesth. 2005;95(5):674-9. doi:10.1093/bja/aei247.
  • Nair S, Wolf A. Emergence delirium after paediatric anaesthesia: new strategies in avoidance and treatment. BJA Educ. 2018;18(1):30-3. doi:10.1016/j.bjae.2017.07.001.
  • Bannister CF, Brosius KK, Sigl JC, Meyer BJ, Sebel PS. The effect of bispectral index monitoring on anesthetic use and recovery in children anesthetized with sevoflurane in nitrous oxide. Anesth Analg. 2001;92(4):877-81. doi:10.1097/00000539-200104000-00015.
  • Locatelli BG, Ingelmo PM, Sahillioglu E, Meroni V, Minardi C, Frawley G, et al. Emergence delirium in children: a comparison of sevoflurane and desflurane anesthesia using the Pediatric Anesthesia Emergence Delirium scale. Paediatr Anaesth. 2013;23(4):301-8. doi:10.1111/pan.12038.
  • Somaini M, Engelhardt T, Fumagalli R, Ingelmo PM. Emergence delirium or pain after anaesthesia--how to distinguish between the two in young children: a retrospective analysis of observational studies. Br J Anaesth. 2016;116(3):377-83. doi:10.1093/bja/aev552.
  • Peker K, Peker SA. The comparison of FLACC and OPS scales in differentiating pain and emergence delirium in the postoperative period in pediatric patients. Online Turkish Journal of Health Sciences. 2020;5(4):602-11. doi:10.26453/otjhs.777222.
  • Houben A, Ghamari S, Fischer A, Neumann C, Baehner T, Ellerkmann RK. Pediatric emergence delirium is linked to increased early postoperative negative behavior within two weeks after adenoidectomy: an observational study. Braz J Anesthesiol. 2024;74(5):744114. doi:10.1016/j.bjane.2021.03.008.
  • Sikich N, Lerman J. Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale. Anesthesiology. 2004;100(5):1138-45. doi:10.1097/00000542-200405000-00015.
  • Ringblom J, Wåhlin I, Proczkowska M, Korhonen L, Årestedt K. Measurement properties of the pediatric anesthesia emergence delirium scale: a confirmatory factor analysis-based study. Paediatr Anaesth. 2025;35(2):155-62. doi:10.1111/pan.15046.

The Effect of Bispectral Index Monitoring on Emergence Delirium in Pediatric Patients: A Retrospective Observational Study

Year 2026, Volume: 28 Issue: 1 , 57 - 63 , 25.04.2026
https://doi.org/10.18678/dtfd.1825287
https://izlik.org/JA28FT28JN

Abstract

Aim: Emergence delirium (ED) is a common behavioral disturbance during recovery from general anesthesia in pediatric patients. This retrospective observational study aimed to evaluate the effect of intraoperative bispectral index (BIS) monitoring on the incidence and severity of ED in children undergoing elective surgery. Material and Methods: Medical records of 160 pediatric patients aged 2-7 years who underwent elective surgery under general anesthesia were retrospectively reviewed. Patients were divided into two groups according to anesthetic depth monitoring: BIS-guided (n=80) and control (n=80). ED was assessed using the pediatric anesthesia emergence delirium (PAED) scale, and postoperative pain was evaluated using the face, legs, activity, cry, consolability (FLACC) scale. Results: The rate of ED was significantly lower in the BIS group compared with the control group (4 patients [5.0%] vs. 54 patients [67.5%], p=0.001). PAED (4.00±2.1 vs. 7.17±2.9) and FLACC (2.11±1.5 vs. 3.00±1.7) scores were also significantly reduced in the BIS-monitored group (p=0.001 for both). Recovery time (8.52±2.9 vs. 10.04±3.2 minutes, p=0.001) and PACU stay duration (44.68±11.2 vs. 59.76±14.5 minutes, p=0.001) were significantly shorter in the BIS group. In multivariate logistic regression analysis, BIS monitoring remained an independent protective factor against ED (OR=0.020, 95% CI: 0.010-0.080, p=0.001). Conclusion: Intraoperative BIS monitoring significantly reduces ED and improves recovery quality in pediatric patients. Objective monitoring of anesthetic depth may improve postoperative behavioral stability.

Ethical Statement

This study was approved by the Non-Invasive Clinical Research Ethics Committee of Gaziantep City Hospital (Date: 18.06.2025, Approval No: 247/2025).

References

  • Moore AD, Anghelescu DL. Emergence delirium in pediatric anesthesia: complexities and clinical challenges. Paediatr Drugs. 2017;19(1):11-20. doi:10.1007/s40272-016-0201-5.
  • Chen YC, Foster J, Wang ML, Rohmah I, Tseng YH, Chiu HY. Global prevalence and risk factors of emergence delirium in pediatric patients undergoing general anesthesia: a systematic review and meta-analysis. J Pediatr Nurs. 2024;77:74-80. doi:10.1016/j.pedn.2024.03.010.
  • Vlajkovic GP, Sindjelic RP. Emergence delirium in children: many questions, few answers. Anesth Analg. 2007;104(1):84-91. doi:10.1213/01.ane.0000250914.91881.a8.
  • Dahmani S, Delivet H, Hilly J. Emergence delirium in children: an update. Curr Opin Anaesthesiol. 2014;27(3):309-15. doi:10.1097/ACO.0000000000000076.
  • Mason KP. Paediatric emergence delirium: a comprehensive review and interpretation of the literature. Br J Anaesth. 2017;118(3):335-43. doi:10.1093/bja/aew477.
  • Petre MA, Levin DN, Englesakis M, Maynes JT, Pechlivanoglou P, Aoyama K. Dexmedetomidine vs. total intravenous anaesthesia in paediatric emergence delirium: a network meta-analysis. Eur J Anaesthesiol. 2021;38(11):1111-23. doi:10.1097/EJA.0000000000001490.
  • Aoyama K, Furuta M, Ameye L, Petre MA, Englesakis M, Rana M, et al. Risk factors for pediatric emergence delirium: a systematic review. Can J Anaesth. 2025;72(3):384-96. doi:10.1007/s12630-024-02889-w.
  • Liao WW, Wang JJ, Wu GJ, Kuo CD. The effect of cerebral monitoring on recovery after sevoflurane anesthesia in ambulatory setting in children: a comparison among bispectral index, A-line autoregressive index, and standard practice. J Chin Med Assoc. 2011;74(1):28-36. doi:10.1016/j.jcma.2011.01.004.
  • Lim BG, Lee IO, Ahn H, Lee DK, Won YJ, Kim HJ, et al. Comparison of the incidence of emergence delirium and emergence times between desflurane and sevoflurane anesthesia in children: a systematic review and meta-analysis. Medicine (Baltimore). 2016;95(38):e4927. doi:10.1097/MD.0000000000004927.
  • Zhang Y, Zhang Q, Xu S, Zhang X, Gao W, Chen Y, et al. Association of volatile anesthesia exposure and depth with emergence agitation and delirium in children: prospective observational cohort study. Front Pediatr. 2023;11:1115124. doi:10.3389/fped.2023.1115124.
  • Bong CL, Balanza GA, Khoo CE, Tan JS, Desel T, Purdon PL. A narrative review illustrating the clinical utility of electroencephalogram-guided anesthesia care in children. Anesth Analg. 2023;137(1):108-23. doi:10.1213/ANE.0000000000006267.
  • Frelich M, Lečbychová K, Vodička V, Ekrtová T, Sklienka P, Jor O, et al. Effect of BIS-guided anesthesia on emergence delirium following general anesthesia in children: a prospective randomized controlled trial. Anaesth Crit Care Pain Med. 2024;43(1):101318. doi:10.1016/j.accpm.2023.101318.
  • Lee YJ, Hwang JW, Do SH, Na HS. The effect of anesthetic depth on the occurrence of emergence delirium in children undergoing strabismus surgery: a prospective observational study. Biomedicines. 2024;13(1):63. doi:10.3390/biomedicines13010063.
  • Davidson AJ, Huang GH, Rebmann CS, Ellery C. Performance of entropy and bispectral index as measures of anaesthesia effect in children of different ages. Br J Anaesth. 2005;95(5):674-9. doi:10.1093/bja/aei247.
  • Nair S, Wolf A. Emergence delirium after paediatric anaesthesia: new strategies in avoidance and treatment. BJA Educ. 2018;18(1):30-3. doi:10.1016/j.bjae.2017.07.001.
  • Bannister CF, Brosius KK, Sigl JC, Meyer BJ, Sebel PS. The effect of bispectral index monitoring on anesthetic use and recovery in children anesthetized with sevoflurane in nitrous oxide. Anesth Analg. 2001;92(4):877-81. doi:10.1097/00000539-200104000-00015.
  • Locatelli BG, Ingelmo PM, Sahillioglu E, Meroni V, Minardi C, Frawley G, et al. Emergence delirium in children: a comparison of sevoflurane and desflurane anesthesia using the Pediatric Anesthesia Emergence Delirium scale. Paediatr Anaesth. 2013;23(4):301-8. doi:10.1111/pan.12038.
  • Somaini M, Engelhardt T, Fumagalli R, Ingelmo PM. Emergence delirium or pain after anaesthesia--how to distinguish between the two in young children: a retrospective analysis of observational studies. Br J Anaesth. 2016;116(3):377-83. doi:10.1093/bja/aev552.
  • Peker K, Peker SA. The comparison of FLACC and OPS scales in differentiating pain and emergence delirium in the postoperative period in pediatric patients. Online Turkish Journal of Health Sciences. 2020;5(4):602-11. doi:10.26453/otjhs.777222.
  • Houben A, Ghamari S, Fischer A, Neumann C, Baehner T, Ellerkmann RK. Pediatric emergence delirium is linked to increased early postoperative negative behavior within two weeks after adenoidectomy: an observational study. Braz J Anesthesiol. 2024;74(5):744114. doi:10.1016/j.bjane.2021.03.008.
  • Sikich N, Lerman J. Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale. Anesthesiology. 2004;100(5):1138-45. doi:10.1097/00000542-200405000-00015.
  • Ringblom J, Wåhlin I, Proczkowska M, Korhonen L, Årestedt K. Measurement properties of the pediatric anesthesia emergence delirium scale: a confirmatory factor analysis-based study. Paediatr Anaesth. 2025;35(2):155-62. doi:10.1111/pan.15046.
There are 22 citations in total.

Details

Primary Language English
Subjects Anaesthesiology
Journal Section Research Article
Authors

Bahar Uslu Bayhan 0009-0009-3052-2604

Tuğçe Gazioğlu Kişi 0009-0002-2336-1848

Şevki Sarı 0000-0002-4934-9399

Bekir Suat Kürkçüoğlu 0009-0000-9987-1612

Submission Date November 17, 2025
Acceptance Date March 29, 2026
Publication Date April 25, 2026
DOI https://doi.org/10.18678/dtfd.1825287
IZ https://izlik.org/JA28FT28JN
Published in Issue Year 2026 Volume: 28 Issue: 1

Cite

APA Uslu Bayhan, B., Gazioğlu Kişi, T., Sarı, Ş., & Kürkçüoğlu, B. S. (2026). The Effect of Bispectral Index Monitoring on Emergence Delirium in Pediatric Patients: A Retrospective Observational Study. Duzce Medical Journal, 28(1), 57-63. https://doi.org/10.18678/dtfd.1825287
AMA 1.Uslu Bayhan B, Gazioğlu Kişi T, Sarı Ş, Kürkçüoğlu BS. The Effect of Bispectral Index Monitoring on Emergence Delirium in Pediatric Patients: A Retrospective Observational Study. Duzce Med J. 2026;28(1):57-63. doi:10.18678/dtfd.1825287
Chicago Uslu Bayhan, Bahar, Tuğçe Gazioğlu Kişi, Şevki Sarı, and Bekir Suat Kürkçüoğlu. 2026. “The Effect of Bispectral Index Monitoring on Emergence Delirium in Pediatric Patients: A Retrospective Observational Study”. Duzce Medical Journal 28 (1): 57-63. https://doi.org/10.18678/dtfd.1825287.
EndNote Uslu Bayhan B, Gazioğlu Kişi T, Sarı Ş, Kürkçüoğlu BS (April 1, 2026) The Effect of Bispectral Index Monitoring on Emergence Delirium in Pediatric Patients: A Retrospective Observational Study. Duzce Medical Journal 28 1 57–63.
IEEE [1]B. Uslu Bayhan, T. Gazioğlu Kişi, Ş. Sarı, and B. S. Kürkçüoğlu, “The Effect of Bispectral Index Monitoring on Emergence Delirium in Pediatric Patients: A Retrospective Observational Study”, Duzce Med J, vol. 28, no. 1, pp. 57–63, Apr. 2026, doi: 10.18678/dtfd.1825287.
ISNAD Uslu Bayhan, Bahar - Gazioğlu Kişi, Tuğçe - Sarı, Şevki - Kürkçüoğlu, Bekir Suat. “The Effect of Bispectral Index Monitoring on Emergence Delirium in Pediatric Patients: A Retrospective Observational Study”. Duzce Medical Journal 28/1 (April 1, 2026): 57-63. https://doi.org/10.18678/dtfd.1825287.
JAMA 1.Uslu Bayhan B, Gazioğlu Kişi T, Sarı Ş, Kürkçüoğlu BS. The Effect of Bispectral Index Monitoring on Emergence Delirium in Pediatric Patients: A Retrospective Observational Study. Duzce Med J. 2026;28:57–63.
MLA Uslu Bayhan, Bahar, et al. “The Effect of Bispectral Index Monitoring on Emergence Delirium in Pediatric Patients: A Retrospective Observational Study”. Duzce Medical Journal, vol. 28, no. 1, Apr. 2026, pp. 57-63, doi:10.18678/dtfd.1825287.
Vancouver 1.Bahar Uslu Bayhan, Tuğçe Gazioğlu Kişi, Şevki Sarı, Bekir Suat Kürkçüoğlu. The Effect of Bispectral Index Monitoring on Emergence Delirium in Pediatric Patients: A Retrospective Observational Study. Duzce Med J. 2026 Apr. 1;28(1):57-63. doi:10.18678/dtfd.1825287