Primer Dismenore Tedavisinde Vitamin D ile Randomize Kontrollü Bir Çalışma

Abstract

Amaç: Bu çalışmanın amacı primer dismenore tedavisinde D vitamininin etkinliğini değerlendirmektir.

Gereç ve Yöntemler: Bir üniversite hastanesine başvurmuş ve primer dismenore tanısı alan 16-35 yaş arası 142 hasta randomize kontrollü bir şekilde çalışmaya dahil edilmiştir. Olgular günde bir kez 667 IU D vitamini, günde bir kez 200 IU E vitamini ve günde iki kez 400 mg İbuprofen alacak şekilde üç gruba randomize edildi. Beklenen adet tarihinden iki gün önce ve adetin ilk üç gününde tedavi verildi. Ardışık iki siklüsde tedaviye devam edildi. Birincil sonuç olarak Vizüel Analog Skala (VAS) ile menstrüel ağrının şiddeti değerlendirildi. İkincil sonuç olarak ise iki aylık araştırma süresince Nonsteroidal anti-inflamatuar ilaç (NSAIDs) kullanma ihtiyacı değerlendirildi.

Bulgular: Gruplar arasında yaş, beden kitle indeksi ve bazal VAS skorları açısından anlamlı bir farklılık saptanmadı. Vitamin D grubunda tedavi sonrası ağrı şiddeti, İbuprofen grubundaki kadar düşük bulundu. Tedavi sonrası median VAS skoru D vitamini grubunda 5 (1-10), E vitamini grubunda 7 (1-10) ve ibuprofen grubunda ise 7 (2-10) olarak saptandı (p<0,001). NSAIDs kullanma gereksinimi ise D vitamini grubunda, E vitamini grubuna kıyasla anlamlı şekilde daha düşük olarak saptandı (%27,3 vs %65,9, p<0,001). Grupların hiç birisinde yan etkiye rastlanmadı.

Sonuç: Primer dismenorede ağrı kontrolünde hem D vitamini hem de E vitamini etkili bulunmuştur, bununla birlikte D vitaminin etkinliği daha açık görülmektedir.

Keywords

• Primer dismenore,D vitamini,menstrüel ağrı

A Randomized Controlled Study of Vitamin D in the Treatment of Primary Dysmenorrhea

Abstract

Aim: The aim of this study was evaluating the effectiveness of vitamin D in the treatment of primary dysmenorrhea.

Material and Methods: A total of 142 patients between 16 and 35 years of age who were admitted to a university hospital and diagnosed with primary dysmenorrhea were included in the study in a randomized controlled manner. Cases were randomized into three groups of 667 IU vitamin D once a day, 200 IU vitamin E once a day and 400 mg ibuprofen twice a day. The treatment was given two days before the expected date of menstruation and the first three days of menstruation. Treatment was continued in two consecutive cycles. Severity of menstrual pain was measured with Visual Analogue Scale (VAS), as the primary outcome. Need for using nonsteroidal anti-inflammatory drugs (NSAIDs) during two-month study period was evaluated as the secondary outcome.

Results: There were no significant difference in age, body mass index and baseline VAS scores between groups. Pain severity of vitamin D group after treatment was found as low as in the ibuprofen group. Median VAS scores of vitamin D, vitamin E and ibuprofen groups were 5 (1-10), 7 (1-10) and 7 (2-10), respectively after treatment (p<0.001). Requirement of NSAIDs was significantly less in vitamin D group than the vitamin E group (27.3% vs 65.9%, p<0.001). There were no side effects in groups.

Conclusion: Both vitamin D and E are effective in alleviation the pain of primary dysmenorrhea, however the effect of vitamin D is clearer.

Keywords

• Primary dysmenorrhoea,vitamin D,menstrual pain

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