Dikkat Eksikliği ve Hiperaktivite Bozukluğu Olan Çocuk ve Ergenlerde İnflamasyon Göstergelerinin Değerlendirilmesi: Cinsiyet ve Alt Tipin Etkisi

Abstract

Amaç: Bu çalışmada, tedavi almayan ve komorbiditesi olmayan dikkat eksikliği hiperaktivite bozukluğu (DEHB) tanılı çocuk ve ergenlerde hematolojik inflamatuar biyobelirteçlerin değerlendirilmesi amaçlanmıştır.

Gereç ve Yöntemler: Bu çalışmaya DSM-5 kriterlerine göre DEHB tanısı alan 6-18 yaş arası 169 çocuk dahil edildi. Yaş ve cinsiyet açısından eşleştirilmiş psikiyatrik ve/veya tıbbi hastalığı olmayan 59 sağlıklı çocuk kontrol grubu olarak alındı. Anlıksal yeti yitimi ve/veya otizm spektrum bozukluğu, akut, kronik veya inflamatuar bir hastalığı olan çocuklar çalışma dışı bırakıldı. Sigara kullanımı, obezite, psikotrop ilaçların kullanımı ve kayıt bilgilerinin yetersiz olması diğer dışlama kriterleri idi. DEHB ve kontrol grupları sosyodemografik özellikler, inflamatuar belirteçler ve hematolojik parametreler açısından karşılaştırıldı.

Bulgular: Ortalama platelet volümü (MPV) ve bazofil (BASO) düzeyleri DEHB grubunda kontrol grubuna göre anlamlı düzeyde yüksek idi ve bu fark sadece erkeklerde görüldü. Hiperaktif grupta eritrosit dağılım genişliği (RDW), lenfosit (LYMPH)ve monosit (MONO) daha yüksekti; dikkat eksikliği grubunda ortalama platelet volümü/lenfosit oranı (MPVLR) diğer tüm alt gruplardan ve kontrol grubundan daha yüksek idi. MPV ise üç alt grupta benzerdi ve bu grupların tümünde kontrol grubundan daha yüksekti.

Sonuç: Bu çalışma MPV ve BASO düzeylerinin DEHB grubunda, özellikle erkek çocuklarda daha yüksek olma eğiliminde olduğunu ortaya koymaktadır. Hematolojik biyobelirteçler DEHB tanısında ve DEHB alt tiplerinin belirlenmesinde faydalı olabilir ancak bu konudaki veriler henüz yetersizdir ve daha kapsamlı çalışmalara ihtiyaç vardır.

Keywords

• DEHB
• biyobelirteçler
• çocuk
• inflamasyon
• cinsiyet

Evaluation of the Indicators of Inflammation in Children and Adolescents with Attention Deficit and Hyperactivity Disorder: Effect of Sex and Subtype

Abstract

Aim: It was aimed to evaluate the hematological inflammatory markers in treatment-naive and comorbidity-free children and adolescents with attention deficit and hyperactivity disorder (ADHD) in this study.

Material and Methods: One hundred sixty-nine children aged 6-18, who were diagnosed with ADHD according to DSM-5 criteria were included in the study. Age and sex-matched 59 healthy children without any psychiatric and/or medical disorder were included as a control group. The children who had an intellectual disability and/or autism spectrum disorder, acute, chronic or inflammatory diseases were excluded from the study. Smoking, obesity and using psychotropic medications and lack of data in records were other exclusion criteria. ADHD and control groups were compared in terms of sociodemographic characteristics, inflammatory markers and hematological parameters.

Results: Mean platelet volume (MPV) and Basophil (BASO) levels were significantly higher in the ADHD group compared to the control group and this statistical difference was only observed for boys. In hyperactivity subtype, red cell distribution width (RDW), lymphocyte (LYMPH) and monocytes (MONO) were higher; in attention deficit subtype mean platelet volume-to-lymphocyte ratio (MPVLR) was higher than all other subtypes and control group. MPV was similar in three subtypes, and were higher in all of them than the control group.

Conclusion: This study revealed that MPV and BASO tend to be higher in the ADHD group especially in boys. Hematological biomarkers may be useful for diagnosis of ADHD and determination of ADHD subtypes but data on this subject are insufficient and more comprehensive studies are needed.

Keywords

• ADHD
• biomarkers
• child
• inflammation
• sex

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