Serum Uric Acid Level and Cardiovascular Disease Development Risk in Stage 3-5 Chronic Kidney Disease Patients

Year 2020, , 171 - 174, 30.12.2020

Suleyman Karakose

https://doi.org/10.18678/dtfd.767731

Cited By: 1

Abstract

Aim: The patients with chronic kidney disease (CKD) have higher risk of cardiovascular disease (CVD) than the general population and this risk increases in advanced CKD stages. The data about the association between CVD and uric acid level in stage 3-5 CKD patients are limited in the literature. The aim of this study is to investigate whether uric acid levels are associated with cardiovascular events and mortality in the CKD patients.
Material and Methods: Patients who were followed up with the diagnosis of stage 3-5 CKD between June 2014 and December 2019 were evaluated retrospectively. A hundred stage 3-5 CKD cases above the age of eighteen were included in the study. The patients were divided into two groups according to average serum uric acid levels; <7 mg/dL and ≥7 mg/dL. Any confirmed diagnosis of stroke, myocardial infarction, coronary heart disease or heart failure was accepted positive for the history of CVD.
Results: Cardiovascular event development was observed in 15 patients and mortality in 1 patient. CVD were seen in 10 (21.3%) patients in group 1 while 5 (9.4%) patients in group 2. Although the cardiovascular events were seen more in the group 1, this difference was not statistically significant (p=0.098).
Conclusion: Although CVD is seen higher in the low uric acid (<7 mg/dL) group, no significant association was found between serum uric acid level and development of CVD in stage 3-5 CKD patients, in this study. Prospective studies with larger sample sizes may provide better evidence regarding possible relationship.

Keywords

hyperuricemia, chronic kidney disease, cardiovascular disease

Supporting Institution

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Project Number

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Thanks

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Evre 3-5 Kronik Böbrek Hastalarında Serum Ürik Asit Seviyesi ve Kardiyovasküler Hastalık Gelişim Riski

Abstract

Amaç: Kronik böbrek hastalığı (KBH) olanlarda kardiyovasküler hastalık (KVH) riski genel popülasyondan daha yüksektir ve bu risk ileri KBH evrelerinde artmaktadır. Evre 3-5 KBH hastalarında KVH ve ürik asit seviyesi arasındaki ilişki hakkındaki veriler literatürde sınırlıdır. Bu çalışmanın amacı, KBH hastalarında ürik asit düzeyinin kardiyovasküler olaylar ve mortalite ile ilişkili olup olmadığının incelenmesidir.
Gereç ve Yöntemler: Haziran 2014 ve Aralık 2019 tarihleri arasında evre 3-5 KBH tanısı ile takip edilen hastalar geriye dönük olarak değerlendirildi. On sekiz yaş üstü 100 evre 3-5 KBH olgusu çalışmaya dahil edildi. Hastalar ortalama serum ürik asit düzeylerine göre <7 mg/dL ve ≥7 mg/dL olmak üzere iki gruba ayrıldı. Doğrulanmış inme, miyokard enfarktüsü, koroner kalp hastalığı veya kalp yetmezliği tanısı olması KVH öyküsü için pozitif kabul edildi.
Bulgular: On beş hastada kardiyovasküler olay gelişimi, 1 hastada mortalite izlendi. Grup 1'deki 10 (%21,3) hastada ve grup 2'deki 5 (%9,4) hastada KVH görüldü. Grup 1’de kardiyovasküler olaylar daha fazla görülmesine rağmen, bu fark istatistiksel olarak anlamlı değildi (p=0.098).
Sonuç: Bu çalışmada, düşük ürik asit (<7 mg/dL) grubunda KVH daha yüksek görülmekle birlikte, evre 3-5 KBH hastalarında serum ürik asit düzeyi ile KVH gelişimi arasında anlamlı bir ilişki bulunamamıştır. Daha fazla örneklem büyüklükleri ile ileriye dönük çalışmalar, olası ilişki hakkında daha iyi kanıt sağlayabilir.

Keywords

Hiperürisemi, kronik böbrek hastalığı, kardiyovasküler hastalık

Project Number

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