Diabetes Mellitus ve COVID-19 Salgını Hakkında Bir Olgu Sunumu

Öz

Koronavirüs hastalığı 2019 (coronavirüs disease 2019, COVID-19) salgını, dünyanın dört bir yanında, toplumlarda sağlık sistemini nerdeyse çökertmiştir. Vaka sayısının çok hızlı bir şekilde artışı bu virüsü gündemin en üstüne taşımış ve virüsün bulaş şekli, ne kadar süre canlı kaldığı, nasıl korunulması gerektiği gibi birçok konu son bir yılın en çok araştırılan konuları olmuştur. Özellikle kronik hastalıkları olan ve ileri yaştaki hastalarda mortalitenin yüksek olduğu gözlenmektedir. Kronik hastalıklardan biri olan diyabetes mellitusta da COVID-19 nedeni ile morbidite ve mortalite riski yüksektir. Olgu sunumumuz, COVID-19 enfeksiyonu nedeni ile hastaneye yatırılan diyabetes mellitus tanılı hastaların takiplerinde kan şekeri regülasyonunda bozulmalar olduğunu ve bunlarla baş edilmesi gerektiğini ve COVID-19 enfeksiyonunun kötü prognozla gidişatını göstermektedir.

Anahtar Kelimeler

• Diabetes mellitus
• koronavirüs
• patogenez
• SARS-CoV-2

A Case Report about Diabetes Mellitus and COVID-19 Outbreak

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has almost collapsed most of the health systems of communities around the world. The rapid increase in the number of cases has brought this virus to the top of the agenda, and many issues such as the mode of transmission of the virus, how long it remains alive, how it should be protected have been the most researched topics in the last year. It is observed that mortality is high especially in patients with chronic diseases and elderly patients. In also diabetes mellitus, one of the chronic diseases, the risk of morbidity and mortality is high due to COVID-19. Our case report states that there are impairments in blood glucose regulation in the follow-up of patients with diabetes mellitus hospitalized due to COVID-19 infection and that they should be dealt with, and the course of COVID-19 infection with poor prognosis.

Keywords

• Diabetes mellitus
• coronavirus
• pathogenesis
• SARS-CoV-2

References

1. Muniyappa R, Gubbi S. COVID-19 pandemic, coronaviruses, and diabetes mellitus. Am J Physiol Endocrinol Metab. 2020;318(5):E736-41.
2. Baud D, Qi X, Nielsen-Saines K, Musso D, Pomar L, Favre G. Real estimates of mortality following COVID-19 infection. Lancet Infect Dis. 2020;20(7):773.
3. Tadic M, Cuspidi C, Sala C. COVID-19 and diabetes: Is there enough evidence? J Clin Hypertens (Greenwich). 2020;22(6):943-8.
4. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-20.
5. Fadini GP, Morieri ML, Longato E, Avogaro A. Prevalence and impact of diabetes among people infected with SARS-CoV-2. J Endocrinol Invest. 2020;43(6):867-9.
6. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9.
7. Guo W, Li M, Dong Y, Zhou H, Zhang Z, Tian C, et al. Diabetes is a risk factor for the progression and prognosis of COVID-19. Diabetes Metab Res Rev. 2020;[Epub ahead of print]. doi: 10.1002/dmrr.3319.
8. Guan W, Ni ZY, Hu Y, Liang WH, Ou C, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-20.

9. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239-42.
10. Yang JK, Feng Y, Yuan MY, Yuan SY, Fu HJ, Wu BY, et al. Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARS. Diabet Med. 2006;23(6):623-8.
11. Badawi A, Ryoo SG. Prevalence of diabetes in the 2009 influenza A (H1N1) and the Middle East respiratory syndrome coronavirus: a systematic review and meta-analysis. J Public Health Res. 2016;5(3):733.
12. Li XC, Zhang J, Zhuo JL. The vasoprotective axes of the renin-angiotensin system: physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases. Pharmacol Res. 2017;125(Pt A):21-38.
13. Yang P, Gu H, Zhao Z, Wang W, Cao B, Lai C, et al. Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury. Sci Rep. 2014;4:7027.
14. Henry C, Zaizafoun M, Stock E, Ghamande S, Arroliga AC, White HD. Impact of angiotensin-converting enzyme inhibitors and statins on viral pneumonia. Proc (Bayl Univ Med Cent). 2018;31(4):419-23.