The Relation Between Vaginal Mycoplasma Colonization and Bacterial Vaginosis

Yıl 2007, Cilt: 9 Sayı: 2, 14 - 18, 01.07.2007

Oguz Karabay Ata Topçuoglu Sebahat Atar Gürel Esra Koçoglu Nevin Koç Ince Hulusi Gürel

Öz

Purpose: This study was aimed to invastigate the relation between bacterial vaginosis (BV) and the colonizasion of vaginal mycoplasmas (Mycoplasma homi nis, Ureaplasma urealyticum). Methods: The culture results of 173 vaginal samples received in the Microbiology Laboratory of The Medical Faculty of Abant Izzet Baysal University between March 2004 and December 2004 were assessed in this retrospective - cross-sectional study. Only the samples from adequately described patients were included. The diagnosis of BV was based on the Amsel criteria. The isolation of Mycoplasma was made in commercial media ( Mycoplasma IST- bioMerieux, Marcy L’etoil, France). The core lation between vajinosis and the colonisation of mycoplasmae (M..hominis ve U. urealyticum) was investigated. Results: BV was detected in 55 (32%) of cultures. Ten (6%) cultures revealed Mycoplasma hominis, and 62 (36%) cultures revealed Ureaplasma urealyticum. Eight of 10 patients (80%) with M.hominis had BV (p0.05). A statistically significant corelation was detected between vaginal M.hominis colonization and BV. BV and U.urealyticum colonization was not found to be associated with each other. Conclusion: BV was found to be associated with M.hominis colonization in this study although the effect of colonisation on the occurence of BV is not clear. We conclude that further studies are necessary to invastigate the possible role of M. hominis in the etiology of BV

Anahtar Kelimeler

Bacterial vaginosis, Mycoplasma hominis, Ureaplasma urealyticum

Vajinal Mikoplazma Kolonizasyonunun Bakteriyel Vajinozis Ile Iliskisinin Arastirilmasi

Öz

Amaç: Bu kesitsel, geriye dönük çalismada bakteriyel vajinozis (BV) ile vajinal mikoplazmalarin (Mycoplasma hominis ve Ureaplasma urealyticum) kolonizasyonu arasindaki iliskinin arastirilmasi amaçlandi. Gereç ve Yöntem: Mart 2004 -Aralik 2004 tarihleri arasinda Abant Izzet Baysal Üniversitesi Tip Fakültesi Mikrobiyoloji laboratuvarina vajen kültürü istemiyle gönderilen örnekler retrospektif olarak incelendi. Çalisma dönemi içinde verileri eksiksiz olarak elde edilebilen 173 örnek degerlendirmeye alindi. Bakteriyel vajinozis tanisi Amsel kriterlerine göre yapildi. Vajinal mikoplazmalarin izolasyonu için hazir ticari besiyeri kullanildi. Vajinozis tanisi alan olgularin kültür sonuçlari degerlendirilerek Mycoplasma hominis ve Ureaplasma urealyticum kolonizasyonu ile vajinozis arasindaki korelasyon arastirildi. Bulgular: Toplam 173 vajinal örnegin 55’inde (% 32) BV saptanmisken 10’unda (% 6) M. hominis ve 62’sinde (% 36) U.urealyticum saptanmistir. M. hominis kolonizasyonu olan 10 olgunun 8’inde (% 80) BV saptanmisken (p0.05). Vajendeki M.hominis kolonizasyonu ile BV arasinda anlamli bir korelasyon bulunmusken, U. urealyticum kolonizasyonu ile BV arasinda anlamli iliski saptanmamistir. Sonuç: Bu çalismada BV M. hominis kolonizasyonu ile iliskili bulunmus, ancak BV olusumundaki rolü belirlenememistir. Mycoplasma hominis’in BV etiyolojisindeki rolünü ortaya koyabilecek daha kapsamli arastirmalara ihtiyaç oldugu kanisina varilmistir

Anahtar Kelimeler

Bakteriyel vajinozis, Mycoplasma homi nis, Ureaplasma urealyticum

Kaynakça

• Owen MK, Clenney TL: Management of vaginitis. Am Fam Physician. 70: 2125–2132, 2002.
• Ünal S, Zarakolu P: Cinsel yolla bulasan hastaliklar. In: “Topçu AW, Söyletir G, Doganay M (eds): Infeksiyon Hastaliklari ve Mikrobiyolojisi. 2.basim. Istanbul. Nobel Tip Kitabevi. pp:1111–1115, 2002.
• Günay T, Aksakoglu G: Bakteriyel vaginozis, STED. 11: 369–370, 2002.
• Smayevsky J, Canigia LF, Lanza A, Bianchini H: Vaginal microflora associated with bacterial vaginosis in nonpregnant women: reliability of sialidase detection. Infect Dis Obstet Gynecol. 9: 17–22, 2001.
• Spiegel CA: Bacterial vaginosis: changes in laboratory practice. Clin Microbiol Newslett. 21: 33–37, 1999.
• Taylor-Robinson D, Furr PM: Update on sexually transmitted mycoplasmas. Lancet. 351: 12–15, 1998.
• Arya OP, Tong CY, Hart CA, Pratt BC, Hughes S, Roberts P, Kirby P, Howel J, McCormick A, Goddard AD: Is Mycoplasma hominis a vaginal pathogen? Sex Transm Infect. 77: 58– 62, 2001.
• Amsel R, Totten PA, Spiegel CA, Chen KC, Eschenbach D, Holmes KK: Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med. 74: 14–22, 1983.
• Miller KE, Graves JC: Update on the prevention and treatment of sexually transmitted diseases. Am Fam Physician. 61: 379–386, 2000.
• Waites KB, Canupp KC, Kenny, GE: In vitro susceptibilities of Mycoplasma hominis to six fluoroquinolones determined by E-test. Antimicrob Agents Chemother. 438: 2571–2573, 1999.
• Meyer RD, Clough W: Extragenital Mycopla sma hominis infections in adults: emphasis on immunosuppression. Clin Infect Dis. 17: 243–249, 1993.
• Marrazzo JM: Evolving issues in understanding and treating bacterial vaginosis. Expert Rev Anti Infect Ther. 2: 913–922, 2004.
• Çamli L, Yorulmaz ES, Danis N, Bostanci A, Gökmen B: Asemptomatik vaginal enfeksiyonlarin gebelik prognozuna etkileri. Jinekoloji ve Obstetri'de Yeni Görüs ve Gelismeler. 6: 48–52, 1995.
• Mutlu G, Pamukçu M, Numarasli S, Çolak D: Bacteriyel vaginozis olgularinda Gardnerella vaginalis’in rolü. Infeksiyon Derg. 6: 103–108, 1992. 15. Wang EE, Matlow AG, Ohlsson A, Nelson SC: Ureaplasma urealyticum infection in the perinatal period. Clin Perinatol. 24: 91–105, 1997. 16. Paul VK, Gupta U, Singh M, Nag VL, Takkar D, Bhan MK: Association of genital Mycoplasma colonization with low birth weight. Int J Gynaecol Obstet. 63: 109–114, 1998. 17. Pheifer TA, Forsyth PS, Durfee MA
• Pallock HM, Holmes KK: Nonspecific vaginitis: role of Haemophilus vaginalis and treatment with metronidazole. N Engl J Med. 298: 1429–1434, 1978. .