A Case Report of Mumps Orchiepididymitis Treated Successfully With Alpha Interferon

Yıl 2007, Cilt: 9 Sayı: 3, 31 - 33, 01.12.2007

Erdal Peker

Öz

Although mumps is known to be a self-limiting disease, it can result in testicular atrophy and infertility when it causes orchiepididymitis as a complication in adolescents and young adults. Although not commonly accepted treatment choices, generally used therapies include broad-spectrum antibiotics, analgesic-anti-inflammatory drugs, elevation of testicles and rest. But since these therapies can not prevent the occurrence of testicular atrophy, it is reported that additional interferon therapy may prevent testicular atrophy (1). In this case report, a 14 years old boy having developed orchiepididymitis one week after mumps infection was presented who was treated with interferon alpha (Roferon, Roche) for 7 days successfully and had no side effects

Anahtar Kelimeler

Mumps, orchiepididymitis, treatment, interferon

Interferon Tedavisi Ile Basarili Bir Sekilde Tedavi Edilen Bir Kabakulak Orsiepididimit Olgusu

Öz

Kabakulak genellikle kendi kendini sinirlayan bir hastalik olarak bilinmesine karsin özellikle adölesan ve genç eriskinlerde orsiepididimite neden oldugunda testiküler atrofi ve dolayisiyla infertilite ile sonuçlanabilmektedir. Yaygin kabul gören bir tedavi seçecegi olmamakla birlikte genelde kullanilan tedaviler genis etki spektrumlu antibiyotikler, analjezik-antienflamatuvar tedavi, testis elevasyonu ve testislere buz tatbik edilmesidir. Ancak tüm bu tedavilerin testis atrofisini engelleyememesi nedeniyle bu tedavilere ek olarak kullanilacak interferon tedavisinin testis atrofisini engelleyebilecegi belirtilmektedir (1). Bu yazida, 14 yasindaki erkek olguda kabakulak enfeksiyonundan yaklasik 1 hafta sonra gelisen orsiepididimit olgusunda testis atrofisi ve infertilite riskini en aza indirmek amaciyla 7 günlük interferon alfa (Roferon, Roche) tedavisi ile basarili bir sekilde tedavi edilen ve herhangi bir yan etki gelistirmeyen bir olgu sunuldu

Anahtar Kelimeler

Kabakulak, orsiepididimit, tedavi, interferon

Kaynakça

• Ku JH, Kim YH, Jeon YS, Lee NK. The preventive effect of systemic treatment with interferon-alpha2B for infertility from mumps orchitis. BJU Int. 84: 839-42. 1999
• Overman JR. Viremia in human mumps virus infections. Arch Intern Med; 102:354. 1958
• Weller TH, Craig JR. Isolation of mumps virus at autopsy. Am J Pathol 25:1105. 1949
• Freeman BA: Mumps virus, in Textbook of Microbiology, 21st ed. Philadelphia, WB Saunders, pp 1001–1003. 1979
• Bjorvatn B. Mumps virus isolated from testicles by fine-needle aspiration biopsy in cases of mumps orchitis. Scand J Infect Dis 5:3. 1973
• Gall EA. The histopathology of acute mumps orchitis. Am J Pathol 23:637. 1947
• Bjorvatn B: Mumps virus recovered from testicles by fine-needle aspiration biopsy in cases of mumps orchitis. Scand J Infect Dis. 5: 3–7. 1973
• Erpenbach K: Systemic treatment with interferon alpha 2B: an effective method to prevent sterility after bilateral mumps orchitis. J Urol. 146: 54–56. 1991
• Nixon N, and Lewis DB: Mumps orchitis: surgical treatment. J Urol. 56: 554–560. 1946
• Yeniyol CO, Sorguc S, Minareci S, Ayder AR: Role of Interferon-alpha-2B in prevention of testicular atrophy with unilateral mumps orchitis. Urology 55; 6: 931-3, 2000