The Neuroprotective Effects Of Eritropoietin In The Central Nervous System

Yıl 2012, Cilt: 14 Sayı: 2, 66 - 69, 01.07.2012

Süber Dikici Şerif Demir Seyit Ankaralı Şule Bulur

Öz

Erythropoietin (Epo) acts primarily to stimulate erythroid cell production by supporting thesurvival, proliferation and differentiation of erythroid progenitor cells but It is now widelyknown that erythropoietin does not only affect the haematopoietic system. Erythropoietin has adominant role for neuroprotection, neurogenesis, and acting as a neurotrophic factor in thecentral nervous system. A wide variety of experimental studies have shown that Epo and itsreceptor are expressed in the nervous system also Epo exerts remarkable neuroprotection in cellculture and animal models of nervous system disorders. The discovery that erythropoietin exertsneuroprotective properties has opened new therapeutic avenues. In this review, we summarizethe current knowledge on the neuroprotective properties of Epo

Anahtar Kelimeler

Erythropoietin, neuroprotection, central nervous system

Eritropoetinin Santral Sinir Sistemindeki Nöroprotektif Etkileri

Öz

Eritropoietin (Epo), esas olarak eritroid progenitör hücrelerin proliferasyonu, farklılaşması vedevamlılığını destekleyerek eritroid hücre üretimini uyarır. Ancak Epo’nun sadece hematopoetiksistemde etki etmediği artık yaygın olarak bilinmektedir. Eritropoetin santral sinir sistemindenöroprotektif etkili, nörogenezde baskın bir role sahip ve nörotrofik bir faktör olarak etkigöstermektedir. Çok çeşitli deneysel çalışmalar Epo ve reseptörünün sinir sisteminde varlığınıortaya koymuştur. Ayrıca Epo, hücre kültürü ve sinir sistemi bozukluklarının oluşturulduğuhayvan modellerinde belirgin nöroprotektif etki göstermektedir. Eritropoetinin nöroprotektifetkisinin keşfi yeni tedavi yollarının açığa çıkmasını sağlamıştır. Biz bu derlemede, Epo’nunmevcut nöroprotektif özellikleri hakkındaki bilgileri özetlemekteyiz

Anahtar Kelimeler

Eritropoetin, nöroprotektif etki, santral sinir sistemi

Kaynakça

• Farrell F, Lee A. The erythropoietin receptor and its expression in tumor cells and other tissues. Oncologist. 2004; 9 Suppl 5:18-30.
• Fisher JW. Erythropoietin: physiology and pharmacology update. Exp Biol Med (Maywood). 2003 Jan; 228(1):1-1.
• Jelkmann W. Molecular biology of erythropoietin. Intern Med. 2004 Aug; 43(8):649-59.
• Lacombe C, Mayeux P. The molecular biology of erythropoietin. Nephrol Dial Transplant. 1999; 14 Suppl 2:22- 8.
• Genc S, Koroglu TF, Genc K. Erythropoietin and the nervous system.. Brain Res. 2004 Mar 12; 1000(1-2):19-31.
• Chong ZZ, Kang JQ, Maiese K. Hematopoietic factor erythropoietin fosters neuroprotection through novel signal transduction cascades. J Cereb Blood Flow Metab. 2002 May; 22(5):503-14.
• Lappin T. The cellular biology of erythropoietin receptors. Oncologist. 2003; 8 Suppl 1:15-8.
• Noguchi CT, Asavaritikrai P, Teng R, Jia Y. Role of erythropoietin in the brain. Crit Rev Oncol Hematol. 2007 Nov; 64(2):159-71. Epub2007 May 4.
• Brines M, Cerami A. Emerging biological roles for erythropoietin in the nervous system.. Nat Rev Neurosci. 2005 Jun; 6(6):484-94.
• Nagai A, Nakagawa E, Choi HB, Hatori K, Kobayashi S, Kim SU. Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia and oligodendrocytes grown in culture. J Neuropathol Exp Neurol. 2001 Apr; 60(4):386-92.
• Yoshimura A, Misawa H.Curr. Physiology and function of the erythropoietin receptor. Opin Hematol. 1998 May; 5(3):171- 6.
• Arcasoy MO. The non-haematopoietic biological effects of erythropoietin. Br J Haematol. 2008 Apr; 141(1):14-31.
• Cariou A, André S, Claessens YE. Extra-hematopoietic effects of erythropoietin. Cardiovasc Hematol Disord Drug Targets. 2008 Sep; 8(3):173-8.
• Genc S, Köroğlu TF, Genc K. Erythropoietin as a novel neuroprotectant. Restor Neurol Neurosci. 2004; 22(2):105-19.
• Kumral A, Gonenc S, Acikgoz O, Sonmez A, Genc K, Yilmaz O, Gokmen N, Duman N, Ozkan H. Erythropoietin increases glutathione peroxidase enzyme activity and decreases lipid peroxidation levels in hypoxic-ischemic brain injury in neonatal rats. Biol Neonate. 2005; 87(1):15-8. Epub 2004 Aug 27.
• Ghezzi P, Brines M. Erythropoietin as an antiapoptotic, tissue- protective cytokine. Cell Death Differ. 2004 Jul; 11 Suppl 1:S37-44.
• Ribatti D, Vacca A, Roccaro AM, Crivellato E, Presta M. Erythropoietin as an angiogenic factor. Eur J Clin Invest. 2003 Oct; 33(10):891-6.
• Kertesz N, Wu J, Chen TH, Sucov HM, Wu H. The role of erythropoietin in regulating angiogenesis. Dev Biol. 2004 Dec 1; 276(1):101-10.
• Wang L, Zhang Z, Wang Y, Zhang R, Chopp M. Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke. 2004 Jul; 35(7):1732-7. Epub 2004 Jun 3.
• Campana WM, Myers RR. Exogenous erythropoietin protects against dorsal root ganglion apoptosis and pain following peripheral nerve injury. Eur J Neurosci. 2003 Sep; 18(6):1497- 506.
• Ehrenreich H, Degner D, Meller J, Brines M, Béhé M, Hasselblatt M, Woldt H, Falkai P, Knerlich F, Jacob S, von Ahsen N, Maier W, Brück W, Rüther E, Cerami A, Becker W, Sirén AL. Erythropoietin: a candidate compound for neuroprotection in schizophrenia. Mol Psychiatry. 2004 Jan; 9(1):42-54.
• Lu GW, Yu S, Li RH, Cui XY, Gao CY. Hypoxic preconditioning: a novel intrinsic cytoprotective strategy. Mol Neurobiol. 2005; 31(1-3):255-71.
• Sugawa M, Sakurai Y, Ishikawa-Ieda Y, Suzuki H, Asou H. Effects of erythropoietin on glial cell development; oligodendrocyte maturation and astrocyte proliferation. Neurosci Res. 2002 Dec; 44(4):391-403.