Bronchocentric Granulomatosis

Yıl 2014, Cilt: 16 Sayı: 3, 42 - 44, 01.12.2014

Sevinç Sarınç Ulaşlı Mehtap Beker Acay Ersin Günay Emre Kaçar Ebru Ünlü

Öz

Bronchocentric granulomatosis is a destructive, granulomatous lesion of the bronchi andbronchioles. Bronchocentric granulomatosis is often divided clinically into two groups: patientswith or without asthma. In all cases, a careful search for an underlying cause should beconsidered. Radiographic presentation of bronchocentric granulomatosis is varied and includessolitary nodules, multiple nodules, atelectasis and areas of consolidation. The upper lobes aremore commonly involved than the lower lobes. Many patients with unexplained or idiopathicbronchocentric granulomatosis improve without medical therapy. A course of systemicglucocorticoids has resulted in improvement in a few case reports; a small number of patientshave recurrent or persistent disease requiring longer-term glucocorticoid treatment

Anahtar Kelimeler

Bronchi and bronchioles, bronchocentric granulomatosis, destruction

BRONKOSENTRİK GRANÜLOMATOZİS

Öz

Bronkosentrik granülomatozis (BG) bronş ve bronşiyollerin hava yolu hasarına vermiş olduklarıözgün olmayan yanıtı temsil eden destrüktif granülomatöz lezyonlardır. İlk olarak 1973 yılındaLiebow tarafından tanımlanmıştır. Vakaların yaklaşık yarısı astım ve alerjik bronkopulmoneraspergillozis ile ilişkilidir. İdiopatik durumlar dışında mikobakteryel ve fungal enfeksiyonlar,romatolojik hastalıklar, Wegener, kronik granülomatöz hastalık, glomerülonefrit, sklerit, diabetesinsipitus, red cell aplazi, pulmoner ekinokok, bronkojenik karsinom ve influenza A virüsü ileilişkili durumlar da rapor edilmiştir. Spesifik bir klinik tablodan ziyade, histopatolojik olaraktanı konulan bir hastalıktır. Bu derlemede BG’in klinik, radyolojik ve patolojik bulguları gözdengeçirilecek eşlik eden hastalıklar hakkında genel bilgi verilmiştir

Anahtar Kelimeler

Bronkosentrik granülomatozis, bronş ve bronşiol, destrüksiyon

Kaynakça

• Liebow AA. The J. Burns Amberson lecture--pulmonary angiitis and granulomatosis. Am Rev Respir Dis. 108:1-18, 1973.
• Clee MD, Lamb D, Clark RA. Bronchocentric granulomatosis: a review and thoughts on pathogenesis. Br J Dis Chest. 77:227-234, 1983.
• Myers JL. Bronchocentric granulomatosis. Disease or diagnosis? Chest. 96:3, 1989.
• Cordier, JF. Eosinophilic pneumonias. In: Interstitial Lung Disease, 4th ed, King TE Jr, Schwarz MI (Eds), B.C. Decker, Hamilton, ON, Canada. p.679, 2003.
• Katzenstein AL, Liebow AA, Friedman PJ. Bronchocentric granulomatosis, mucoid impaction, and hypersensitivity reactions to fungi. Am Rev Respir Dis. 111:497-537, 1975.
• Koss MN, Robinson RG, Hochholzer L. Bronchocentric granulomatosis. Hum Pathol. 12:632-638, 1981.
• Sulavik SB. Bronchocentric granulomatosis and allergic bronchopulmonary aspergillosis. Clin Chest Med. 9:609-621, 1988.
• Bonafede RP, Benatar SR. Bronchocentric granulomatosis and rheumatoid arthritis. Br J Dis Chest. 81:197-201, 1987.
• Den Hertog RW, Wagenaar SS, Wastermann CJ. Bronchocentric echinococcosis. Am Rev Respir Dis. 126:344-347, 1982.
• Rohatgi PK, Turrisi BC. Bronchocentric granulomatosis and ankylosing spondylitis. Thorax. 39:317-318, 1984.
• Rossi GP, Pavan E, Chiesura-Corona M, Rea F, Poletti A, Pessina AC. Bronchocentric granulomatosis and central diabetes insipidus successfully treated with corticosteroids. Eur Respir J. 7:1893-1898, 1994.
• Wiedemann HP, Bensinger RE, Hudson LD. Bronchocentric granulomatosis with eye involvement. Am Rev Respir Dis. 126:347-350, 1982.
• Warren J, Pitchenik AE, Saldana MJ. Bronchocentric granulomatosis with glomerulonephritis. Chest. 87:832-834, 1985.
• Yousem SA. Bronchocentric injury in Wegener's granulomatosis: a report of five cases. Hum Pathol. 22:535- 540, 1991.
• Myers JL, Katzenstein AL. Granulomatous infection mimicking bronchocentric granulomatosis. Am J Surg Pathol. 10:317-322, 1986.
• Fannin SW, Hagley MT, Seibert JD, Koenig TJ. Bronchocentric granulomatosis, acute renal failure, and high titer antineutrophil cytoplasmic antibodies: possible variants of Wegener's granulomatosis. J Rheumatol. 20:507-509, 1993.
• Houser SL, Mark EJ. Bronchocentric granulomatosis with mucus impaction due to bronchogenic carcinoma. An association with clinical relevance. Arch Pathol Lab Med. 124:1168-1171, 2000.
• Moltyaner Y, Geerts WH, Chamberlain DW, Heyworth PG, Noack D, Rae J, Doyle JJ, Downey GP. Underlying chronic granulomatous disease in a patient with bronchocentric granulomatosis. Thorax. 58:1096-1098, 2003.
• Van der Klooster JM, Nurmohamed LA, van Kaam NA. Bronchocentric granulomatosis associated with influenza-A virus infection. Respiration. 71:412-416, 2004.
• Yano S, Shishido S, Kobayashi K, Nakano H, Kawasaki Y. Bronchocentric granulomatosis due to Aspergillus terreus in an immunocompetent and non-asthmatic woman. Respir Med. 93:672-674, 1999.
• Saldana M: Bronchocentric granulomatosis: clinicopathologic observations in 17 patients. Lab Invest. 40:281-282, 1979.
• Ward S, Heyneman LE, Flint JD, Leung AN, Kazerooni EA, Müller NL. Bronchocentric granulomatosis: computed tomographic findings in five patients. Clin Radiol. 55:296- 300, 2000.
• Robinson R, Wehunt W, Tsou E, Koss MN, Hochholzer L.: Bronchocentric manifestations. Am Rev Respir Dis. 125:751-756, 1982.
• Frazier AA, Rosado-de-Christenson ML, Galvin JR, Fleming MV. Pulmonary angiitis and granulomatosis: radiologic- pathologic correlation. RadioGraphics. 18:687-710, 1998.
• Soysal O, Gokırmak M, Kuzucu A, Mızrak B, Hasanoğlu C. Spontan Pnömotoraks ile Prezente Olan Bir Bronkosentrik Granülomatozis Olgusu. Tüberküloz ve Toraks Dergisi. 48:171-174, 2000.
• Bosken CH, Myers JL, Greenberger PA, Katzenstein AL. Pathologic features of allergic bronchopulmonary aspergillosis. Am J Surg Pathol. 12:216, 1988.