Yıl 2021, Cilt , Sayı , Sayfalar 0 - 0 2021-04-30

COVID-19 Hastalarında Potansiyel İmmünolojik Tedaviler
Potential Immunological Treatments in COVID-19 Patients

Muhammet Mesut Nezir ENGİN [1] , Öner ÖZDEMİR [2]


Şiddetli akut solunum yolu sendromu koronavirüsü 2 (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) Aralık 2019'da Çin'in Wuhan kentinde görüldü. İnsanlarda SARS-CoV-2 enfeksiyonu koronavirüs hastalığı 2019 (coronavirus disease 2019, COVID-19) olarak adlandırıldı. Şu anda dünya çapında 69 milyondan fazla insanı enfekte etti ve 10 Aralık 2020'ye kadar 1,5 milyondan fazla ölümden sorumlu bir salgın haline geldi. Salgın hala devam ediyor. Bu salgın, 21. yüzyılda koronavirüslerin neden olduğu üçüncü salgındır ve tüm dünya için önemli bir halk sağlığı tehdidini temsil eden en önemli bulaşıcı hastalık olabilir. COVID-19'a karşı tedaviler, kanıta dayalı olarak literatürde sürekli olarak güncellenmektedir. Ne yazık ki, COVID-19 için kesin bir tedavi yoktur ve şiddetli COVID-19 vakalarında kullanılmak üzere bir dizi ilaç şu anda bir dizi randomize olmayan veya randomize çalışmada incelenmektedir. Bunlar arasında klorokin, steroidler, anti-enflamatuar ve antiviral ajanlar bulunmaktadır. COVID-19 hastalığında konvalesan plazma, intravenöz immünoglobulin, monoklonal antikorlar (tocilizumab, eculizumab, itolizumab vb.) ve anakinra tedavileri gibi immünolojik tedaviler denenmektedir. Bazı çalışmalardan elde edilen sonuçlar umut verici görünmektedir. COVID-19 vakalarında immünolojik tedavilerin kullanımı hakkında şimdiye kadar çok az sayıda rapor yayınlandı. Bu derlemede, COVID-19 hastalarında kullanılan ve çoğunlukla güncel literatürde bahsedilen temel immünolojik tedaviler ayrıntılı olarak tartışılacaktır.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seemed in Wuhan, China in December 2019. SARS-CoV-2 infection in human was named as coronavirus disease 2019 (COVID-19). It has now infected more than 69 million people worldwide, becoming an epidemic responsible for more than 1,5 million deaths until 10th of December 2020. The epidemic still continues. This epidemic is the third epidemic caused by coronaviruses in the 21st century and may be the most important infectious disease representing a major public health threat to the whole world. Treatments against COVID-19 are constantly updated in the literature, based on evidence. Unfortunately, there is no definitive cure for COVID-19, and a number of drugs for use in severe cases of COVID-19 are now being studied in a number of nonrandomized or randomized trials. These include chloroquine, steroids, anti-inflammatory, and antiviral agents. Immunological treatments such as convalescent plasma, intravenous immunoglobulin, monoclonal antibodies (tocilizumab, eculizumab, itolizumab etc.), and anakinra treatments are tried in COVID-19 disease. Results from some trials look promising. Quite a few reports have also stood published so far on the use of immunological treatments for COVID-19 cases. In this review, we will discuss the key immunological treatments, mostly mentioned in the current literature, used in COVID-19 patients in detail.
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Orcid: 0000-0002-0874-6857
Yazar: Muhammet Mesut Nezir ENGİN
Kurum: SAKARYA SAĞLIK BAKANLIĞI SAKARYA ÜNİVERSİTESİ EĞİTİM VE ARAŞTIRMA HASTANESİ
Ülke: Turkey


Orcid: 0000-0002-5338-9561
Yazar: Öner ÖZDEMİR (Sorumlu Yazar)
Kurum: SAKARYA UNIVERSITY, FACULTY OF MEDICINE
Ülke: Turkey


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Yayımlanma Tarihi : 30 Nisan 2021

Bibtex @derleme { dtfd856165, journal = {Duzce Medical Journal}, issn = {}, eissn = {1307-671X}, address = {}, publisher = {Düzce Üniversitesi}, year = {2021}, volume = {}, pages = {0 - 0}, doi = {10.18678/dtfd.856165}, title = {Potential Immunological Treatments in COVID-19 Patients}, key = {cite}, author = {Engin, Muhammet Mesut Nezir and Özdemir, Öner} }
APA Engin, M , Özdemir, Ö . (2021). Potential Immunological Treatments in COVID-19 Patients . Duzce Medical Journal , , 0-0 . DOI: 10.18678/dtfd.856165
MLA Engin, M , Özdemir, Ö . "Potential Immunological Treatments in COVID-19 Patients" . Duzce Medical Journal (2021 ): 0-0 <https://dergipark.org.tr/tr/pub/dtfd/issue/60168/856165>
Chicago Engin, M , Özdemir, Ö . "Potential Immunological Treatments in COVID-19 Patients". Duzce Medical Journal (2021 ): 0-0
RIS TY - JOUR T1 - Potential Immunological Treatments in COVID-19 Patients AU - Muhammet Mesut Nezir Engin , Öner Özdemir Y1 - 2021 PY - 2021 N1 - doi: 10.18678/dtfd.856165 DO - 10.18678/dtfd.856165 T2 - Duzce Medical Journal JF - Journal JO - JOR SP - 0 EP - 0 VL - IS - SN - -1307-671X M3 - doi: 10.18678/dtfd.856165 UR - https://doi.org/10.18678/dtfd.856165 Y2 - 2021 ER -
EndNote %0 Düzce Tıp Fakültesi Dergisi Potential Immunological Treatments in COVID-19 Patients %A Muhammet Mesut Nezir Engin , Öner Özdemir %T Potential Immunological Treatments in COVID-19 Patients %D 2021 %J Duzce Medical Journal %P -1307-671X %V %N %R doi: 10.18678/dtfd.856165 %U 10.18678/dtfd.856165
ISNAD Engin, Muhammet Mesut Nezir , Özdemir, Öner . "Potential Immunological Treatments in COVID-19 Patients". Duzce Medical Journal / (Nisan 2021): 0-0 . https://doi.org/10.18678/dtfd.856165
AMA Engin M , Özdemir Ö . Potential Immunological Treatments in COVID-19 Patients. Duzce Medical Journal. 2021; 0-0.
Vancouver Engin M , Özdemir Ö . Potential Immunological Treatments in COVID-19 Patients. Duzce Medical Journal. 2021; 0-0.
IEEE M. Engin ve Ö. Özdemir , "Potential Immunological Treatments in COVID-19 Patients", Duzce Medical Journal, ss. 0-0, Nis. 2021, doi:10.18678/dtfd.856165