Hepatit B Taşıyıcısı Bir Hastada Subkutan Sarkoidozun Hidroksiklorokin ile Tedavisi: Olgu Sunumu

Year 2025, Issue: Early Access

Tuna Sezer , Mualla Polat , Yasin Hakan Kandil , Selma Erdoğan Düzcü

https://doi.org/10.18678/dtfd.1551840

Abstract

Sarkoidoz, etiyolojisi tam olarak bilinmeyen, birçok sistemi tutan, non-kazeifiye granülomlarla karakterize bir hastalıktır. Deri sarkoidozunda spesifik lezyonların en nadir görülen formu subkutan sarkoidozdur. Subkutan sarkoidoz genellikle yaşamın dördüncü dekadında daha sık görülür ve kadınlarda erkeklerden daha yaygındır. Çoğunlukla ekstremitelerde, bilateral ve asimetrik bir şekilde yerleşen, çoklu asemptomatikten hafif ağrılıya kadar değişebilen, sert, hareketli, yuvarlak ila oval, deri renginde veya eritemli nodüller şeklinde görülür. Ayırıcı tanıda subkutan nodül ile seyreden diğer hastalıklar dışlanmalıdır. Bu çalışmada, topikal steroid tedavisine kısmen yanıt veren ve hidroksiklorokin ile başarılı bir şekilde tedavi edilen, hepatit B taşıyıcısı olan 51 yaşında bir kadın hastada görülen bir subkutan sarkoidoz olgusu sunulmaktadır. Subkutan sarkoidozda hastalar sistemik tutulum açısından da değerlendirilmelidir. Tedavi seçenekleri arasında hidroksiklorokin düşünülmelidir.

Keywords

Sarkoidoz, subkutan, hidroksiklorokin

Treatment of Subcutaneous Sarcoidosis with Hydroxychloroquine in a Hepatitis B Carrier Patient: A Case Report

Abstract

Sarcoidosis is a disorder of unknown etiology affecting many systems and characterized by non-caseating granulomas. Subcutaneous sarcoidosis is the rarest form of specific lesions in cutaneous sarcoidosis. It occurs more frequently in the fourth decade of life and is more common in females than in males. Multiple asymptomatic to slightly painful, firm, mobile, round to oval, skin-colored, or erythematous nodules frequently occur in a bilateral and asymmetric pattern on the extremities. In the differential diagnosis, other diseases presenting with subcutaneous nodules should be excluded. Here, a case of subcutaneous sarcoidosis in a 51-year-old female hepatitis B carrier patient who partially responded to topical steroid treatment and was successfully treated with hydroxychloroquine was presented. In subcutaneous sarcoidosis, patients should be evaluated for systemic involvement. Hydroxychloroquine should be considered among the treatment options.

Keywords

Sarcoidosis, subcutaneous, hydroxychloroquine

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