Effects of Different Remineralization Gels on Post-Orthodontic White Spot Lesions: A 4-Week Follow-Up Clinical Trial

Dilanur Demiroğlu Akay; Betül Şen Yavuz; Müesser Ahu Yılmaz; Nural Bekiroğlu; Betül Kargül

doi:10.52037/eads.2025.0023

Effects of Different Remineralization Gels on Post-Orthodontic White Spot Lesions: A 4-Week Follow-Up Clinical Trial

Abstract

Purpose: This in vivo study assessed and compared the remineralizing effects of gels containing Calcium Glycerophosphate (CaGP) and Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) on white spot lesions (WSLs) after orthodontic treatment. Materials and Methods: A total of 67 teeth from five patients (aged 19–21) with post-orthodontic WSLs were included. Patients were allocated into two groups: Group 1 received a CaGP-containing gel, and Group 2 received a CPP-ACP-containing gel. Both groups used reservoir trays to apply the gels for 5 minutes twice daily over four weeks. Evaluation methods included the Quantitative Light-Induced Fluorescence (QLF), Laser Fluorescence (LF) measurements and the Modified Gorelick Index, assessed at preintervention and postintervention. Results: QLF analysis showed a reduction in lesion depth (ΔF), area (A), and lesion volume (ΔQ) in both groups. A significant improvement in ΔF was found only in the CaGP group (p=0.003), while significant reductions in lesion area and ΔQ were observed only in the CPP-ACP group (p=0.030, p=0.023). LF values decreased significantly in both groups (p<0.001), with a greater reduction in the CPP-ACP group. Both groups also showed significant clinical improvement in Modified Gorelick scores. Both gels showed positive effects in the remineralization of WSLs. Conclusions: These findings suggest that both CaGP and CPP-ACP gels, when applied with reservoir trays, may be effective adjuncts for the remineralization of post-orthodontic WSLs.

Keywords

Ethical Statement

The study protocol was approved by the Clinical Research Ethics Committee of Marmara University Faculty of Medicine (Approval date: 07.04.2023, Protocol No: 09.2023.612).

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Details

Primary Language

English

Subjects

Paedodontics, Orthodontics and Dentofacial Orthopaedics

Journal Section

Research Article

Authors

Dilanur Demiroğlu Akay ^*
0000-0003-0157-5060
Türkiye

Betül Şen Yavuz
0000-0002-7561-8396
Türkiye

Müesser Ahu Yılmaz
0000-0002-0605-1250
Türkiye

Nural Bekiroğlu
0000-0001-6471-6612
Türkiye

Betül Kargül
0000-0002-3294-8846
Türkiye

Early Pub Date

December 29, 2025

Publication Date

December 29, 2025

Submission Date

July 21, 2025

Acceptance Date

October 10, 2025

Published in Issue

Year 2025 Volume: 52 Number: 3

DOI

https://doi.org/10.52037/eads.2025.0023

IZ

https://izlik.org/JA53WF73KA

Cite

RIS / Bibtex

APA

Demiroğlu Akay, D., Şen Yavuz, B., Yılmaz, M. A., Bekiroğlu, N., & Kargül, B. (2025). Effects of Different Remineralization Gels on Post-Orthodontic White Spot Lesions: A 4-Week Follow-Up Clinical Trial. European Annals of Dental Sciences, 52(3), 148-155. https://doi.org/10.52037/eads.2025.0023

AMA

1.Demiroğlu Akay D, Şen Yavuz B, Yılmaz MA, Bekiroğlu N, Kargül B. Effects of Different Remineralization Gels on Post-Orthodontic White Spot Lesions: A 4-Week Follow-Up Clinical Trial. EADS. 2025;52(3):148-155. doi:10.52037/eads.2025.0023

Chicago

Demiroğlu Akay, Dilanur, Betül Şen Yavuz, Müesser Ahu Yılmaz, Nural Bekiroğlu, and Betül Kargül. 2025. “Effects of Different Remineralization Gels on Post-Orthodontic White Spot Lesions: A 4-Week Follow-Up Clinical Trial”. European Annals of Dental Sciences 52 (3): 148-55. https://doi.org/10.52037/eads.2025.0023.

EndNote

Demiroğlu Akay D, Şen Yavuz B, Yılmaz MA, Bekiroğlu N, Kargül B (December 1, 2025) Effects of Different Remineralization Gels on Post-Orthodontic White Spot Lesions: A 4-Week Follow-Up Clinical Trial. European Annals of Dental Sciences 52 3 148–155.

IEEE

[1]D. Demiroğlu Akay, B. Şen Yavuz, M. A. Yılmaz, N. Bekiroğlu, and B. Kargül, “Effects of Different Remineralization Gels on Post-Orthodontic White Spot Lesions: A 4-Week Follow-Up Clinical Trial”, EADS, vol. 52, no. 3, pp. 148–155, Dec. 2025, doi: 10.52037/eads.2025.0023.

ISNAD

Demiroğlu Akay, Dilanur - Şen Yavuz, Betül - Yılmaz, Müesser Ahu - Bekiroğlu, Nural - Kargül, Betül. “Effects of Different Remineralization Gels on Post-Orthodontic White Spot Lesions: A 4-Week Follow-Up Clinical Trial”. European Annals of Dental Sciences 52/3 (December 1, 2025): 148-155. https://doi.org/10.52037/eads.2025.0023.

JAMA

1.Demiroğlu Akay D, Şen Yavuz B, Yılmaz MA, Bekiroğlu N, Kargül B. Effects of Different Remineralization Gels on Post-Orthodontic White Spot Lesions: A 4-Week Follow-Up Clinical Trial. EADS. 2025;52:148–155.

MLA

Demiroğlu Akay, Dilanur, et al. “Effects of Different Remineralization Gels on Post-Orthodontic White Spot Lesions: A 4-Week Follow-Up Clinical Trial”. European Annals of Dental Sciences, vol. 52, no. 3, Dec. 2025, pp. 148-55, doi:10.52037/eads.2025.0023.

Vancouver

1.Dilanur Demiroğlu Akay, Betül Şen Yavuz, Müesser Ahu Yılmaz, Nural Bekiroğlu, Betül Kargül. Effects of Different Remineralization Gels on Post-Orthodontic White Spot Lesions: A 4-Week Follow-Up Clinical Trial. EADS. 2025 Dec. 1;52(3):148-55. doi:10.52037/eads.2025.0023