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Ağız içi candida enfeksiyonları ve tedavisi

Year 2014, Volume: 41 Issue: 3 - Volume: 41 Issue: 3, 191 - 198, 01.10.2014

Abstract

İnsan immün sistemindeki bozulma sonucu candida enfeksiyonları ortaya çıkabilir. Ağız içi candidal enfeksiyonlar olarak tanımlanan oral candidosis tablosu, sıklıkla konak ve konağa bağlı lokal ya da sistemik durumlara bağlı olarak gelişir. Lokal faktörler, tükrük akışının azalması, zayıf oral hijyen, protez kullanımı olarak sayılabilirken; endokrin hastalıklar, beslenme bozuklukları, HIV enfeksiyonu gibi durumlar candidal enfeksiyona yol açan sistemik faktörler arasındadır. Oral candidosis sıklıkla lokal faktörlere bağlı, daha nadiren de sistemik nedenli ortaya çıkar. Bu derlemede, candidal enfeksiyon açısından predispozan faktörler, klinik görünüm, teşhis ve tedavi yaklaşımları tartışılmıştır

References

  • Lass-Flörl C. The changing face of ep- idemiology of invasive fungal disease in Eu- rope. Mycoses 2009: 52: 197–205.
  • Ruping MJ, Vehreschild JJ, Cornely OA. Patients at high risk of invasive fungal in- fections: when and how to treat. Drugs 2008: 68: 1941–1962.
  • Williams DW, Kuriyama T, Silva S, Malic S, Lewis MA. Candida biofilms and oral candidosis: treatment and prevention. Perio- dontol 2000. 2011 Feb;55(1):250-65.
  • Gonza´lez GM, Elizondo M, Ayala J. Trends in species distribution and susceptibil- ity of bloodstream isolates of Candida collect- ed in Monterrey, Mexico, to seven antifungal agents: results of a 3-year (2004 to 2007) sur- veillance study. J Clin Microbiol 2008: 46: 2902–2905.
  • Hajjeh RA, Sofair AN, Harrison LH, Lyon GM, Arthington-Skaggs BA, Mirza SA, Phelan M, Morgan J, Lee-Yang W, Ciblak MA, Benjamin LE, Sanza LT, Huie S, Yeo SF, Brandt ME, Warnock DW. Incidence of blood- stream infections due to Candida species and in vitro susceptibilities of isolates collected from 1998 to 2000 in a population-based active surveillance program. J Clin Microbiol 2004: 42:1519–1527.
  • Sitheeque MA, Samaranayake LP. Chronic hyperplastic candidosis » candidiasis (candidal leukoplakia). Crit Rev Oral Biol Med 2003: 14: 253–267.
  • Samaranayake LP, Lamb AB, Lamey PJ, MacFarlane TW. Oral carriage of Candida species and coliforms in patients with burning mouth syndrome. J Oral Pathol Med 1989:18: 233–235.
  • Sakashita S, Takayama K, Nishioka K, Katoh T. Taste disorders in healthy carriers and non-carriers of Candida albicans and in pa- tients with candidosis of the tongue. J Derma- tol 2004: 31: 890–897.
  • Nair PN, Sjogren U, Krey G, Kahnberg KE, Sundqvist G. Intraradicular bac- teria and fungi in root-filled, asymptomatic human teeth with therapy-resistant periapical lesions: a long-term light and electron micro- scopic followup study. J Endod 1990: 16: 580– 588.
  • Grbic JT, Mitchell-Lewis DA, Fine JB, Phelan JA, BucklanRS, Zambon JJ, Lam- ster IB. The relationship of candidiasis to line- ar gingival erythema in HIV-infected homo- sexual men and parenteral drug users. J Perio- dontol 1995: 66: 30–37.
  • Leonhardt A, Renvert S, Dahle´n G. Microbial findings at failing implants. Clin Oral Implants Res 1999: 10: 339–345.
  • Odds FC. Pathogenesis of Candida infections. J Am Acad Dermatol 1994: 31:2-5.
  • Kuriyama T, Williams DW, Lewis MAO. In vitro secreted aspartyl proteinase ac- tivity of Candida albicans isolated from oral diseases and healthy oral cavities. Oral Micro- biol Immunol 2003: 18: 405–407.
  • Krishnan PA. Fungal infections of the oral mucosa. Indian J Dent Res. 2012 Sep- Oct;23(5):650-9.
  • Samaranayake LP, Keung Leung W, Jin L. Oral mucosal fungal infections. Perio- dontol 2000 2009: 49: 39–59.
  • Sitheeque MA, Samaranayake LP. Chronic hyperplastic candidosis » candidiasis (candidal leukoplakia). Crit Rev Oral Biol Med 2003: 14: 253–267.
  • Barrett AW, Kingsmill VJ, Speight PM. The frequency of fungal infection in biop- sies of oral mucosal lesions. Oral Dis 1998: 4: 26–31.
  • Figueiral MH, Azul A, Pinto E, Fonseca PA, Branco FM, Scully C. Denture- related stomatitis: identification of aetiological and predisposing factors – a large cohort. J Oral Rehabil 2007: 34: 448–455.
  • Smith AJ, Robertson D, Tang MK, Jackson MS, MacKenzie D, Bagg J. Staphylo- coccus aureus in the oral cavity: a threeyear retrospective analysis of clinical laboratory da- ta. Br Dent J 2003: 195: 701–703.
  • Farah CS, Ashman RB, Chal- lacombe SJ. Oral candidosis. Clin Dermatol 2000;18:553-62.
  • MacNeill S, Rindler E, Walker A, Brown AR, Cobb CM. Effects of tetracycline hydrochloride and chlorhexidine gluconate on Candida albicans: an in vitro study. J Clin Per- iodontol 1997: 24: 753–760.
  • Budtz-Jorgensen E. Etiology, path- ogenesis, therapy, and prophylaxis of oral yeast infections. Acta Odontol Scand. 1990: 48: 61–69.
  • Ellepola ANB, Samaranayake LP. Oral candidal infections and antimycotics. Crit Rev Oral Biol Med 2000: 11: 172–198.
  • Filoche SK, Soma K, Sissons CH. Antimicrobial effects of essential oils in com- bination with chlorhexidine digluconate. Oral Microbiol Immunol 2005: 20: 221–225.
  • Kılıç A, Saraçlı M, Özyurt M, Saygun I, Başustaoğlu C. Ağız çalkalama su- larının (gargara) in vitro antifungal aktiviteleri. Türk Hij Den Biyol Derg 2001: Cilt 58, No 3, S : 81 – 86.
  • de Oliveira LF, Jorge AO, Dos San- tos SS. In vitro minocycline activity on super- infecting microorganisms isolated from chron- ic periodontitis patients. Braz Oral Res, 2006:20, 202–206.
  • Furletti VF, Teixeira IP, Obando- Pereda G, Mardegan RC, Sartoratto A, Figuei- ra GM, Duarte RM, Rehder VL, Duarte MC, Höfling JF. Action of Coriandrum sativum L. essential oil upon oral Candida albicans bio- film formation. Evid Based Complement Al- ternat Med, 2011.
  • Lu XO, Zhang BL, Wang YB, Zhou XL, Weng J, Qu SX, Feng B, Watari F, Ding YH, Leng Y. Nano-Ag-loaded hydroxyapatite coatings on titanium surfaces by electrochemi- cal deposition. 2011;8:529-539.
  • Kim KJ, Sung WS, Moon SK, Choi JS, Kim JG, Lee DG. Antifungal effect of sil- ver nanoparticles on dermatophytes. J Micro- biol Biotechnol, 2008:18, 1482–1484.
  • Junqueira JC, Jorge AO, Barbosa JO, Rossoni RD, Vilela SF, Costa AC, Primo FL, Gonçalves JM, Tedesco AC, Suleiman JM. Photodynamic inactivation of biofilms formed by Candida spp., Trichosporon mucoides, and Kodamaea ohmeri by cationic nanoemulsion of zinc 2,9,16,23-tetrakis(phenylthio)-29H, 31H- phthalocyanine (ZnPc). Lasers Med Sci, 2012;27, 1205–1212.
  • Mima EG, Vergani CE, Machado AL, Massucato EM, Colombo AL, Bagnato VS, Pavarina AC. Comparison of Photody- namic Therapy versus conventional antifungal therapy for the treatment of denture stomatitis: a randomized clinical trial. Clin Microbiol In- fect. 2012 Oct;18(10):E380-8.
  • Scwingel AR, Barcessat AR, Nşñez SC, Ribeiro MS. Antimicrobial photodynamic therapy in the treatment of oral candidiasis in HIV-infected patients. Photomed Laser Surg. 2012 Aug;30(8):429-32.
  • Redding S, Bhatt B, Rawls HR, Siegel G, Scott K, Lopez-Ribot J. Inhibition of Candida albicans biofilm formation on denture material. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009: 107: 669–672.
  • Meurman JH. Probiotics: do they have a role in oral medicine and dentistry? Eur J Oral Sci 2005: 113: 188–196.

Oral Candidal Infections and Treatment

Year 2014, Volume: 41 Issue: 3 - Volume: 41 Issue: 3, 191 - 198, 01.10.2014

Abstract

Candidal infections in humans occur as a result of defects in the immune system. Oral candidal infection usually involves a compromised host and the compromise may be local or systemic. Local compromising factors include decreased salivation, poor oral hygiene, wearing dentures among others while systemic factors include diabetes mellitus, nutritional deficiency, HIV infection/AIDS and others. Oral candidosis is generally a localized infection and rarely appears as a systemic fungal disease. This review discusses the various predisposing factors, clinical presentations, clinical differential diagnosis, diagnosis and management of oral candidosis

References

  • Lass-Flörl C. The changing face of ep- idemiology of invasive fungal disease in Eu- rope. Mycoses 2009: 52: 197–205.
  • Ruping MJ, Vehreschild JJ, Cornely OA. Patients at high risk of invasive fungal in- fections: when and how to treat. Drugs 2008: 68: 1941–1962.
  • Williams DW, Kuriyama T, Silva S, Malic S, Lewis MA. Candida biofilms and oral candidosis: treatment and prevention. Perio- dontol 2000. 2011 Feb;55(1):250-65.
  • Gonza´lez GM, Elizondo M, Ayala J. Trends in species distribution and susceptibil- ity of bloodstream isolates of Candida collect- ed in Monterrey, Mexico, to seven antifungal agents: results of a 3-year (2004 to 2007) sur- veillance study. J Clin Microbiol 2008: 46: 2902–2905.
  • Hajjeh RA, Sofair AN, Harrison LH, Lyon GM, Arthington-Skaggs BA, Mirza SA, Phelan M, Morgan J, Lee-Yang W, Ciblak MA, Benjamin LE, Sanza LT, Huie S, Yeo SF, Brandt ME, Warnock DW. Incidence of blood- stream infections due to Candida species and in vitro susceptibilities of isolates collected from 1998 to 2000 in a population-based active surveillance program. J Clin Microbiol 2004: 42:1519–1527.
  • Sitheeque MA, Samaranayake LP. Chronic hyperplastic candidosis » candidiasis (candidal leukoplakia). Crit Rev Oral Biol Med 2003: 14: 253–267.
  • Samaranayake LP, Lamb AB, Lamey PJ, MacFarlane TW. Oral carriage of Candida species and coliforms in patients with burning mouth syndrome. J Oral Pathol Med 1989:18: 233–235.
  • Sakashita S, Takayama K, Nishioka K, Katoh T. Taste disorders in healthy carriers and non-carriers of Candida albicans and in pa- tients with candidosis of the tongue. J Derma- tol 2004: 31: 890–897.
  • Nair PN, Sjogren U, Krey G, Kahnberg KE, Sundqvist G. Intraradicular bac- teria and fungi in root-filled, asymptomatic human teeth with therapy-resistant periapical lesions: a long-term light and electron micro- scopic followup study. J Endod 1990: 16: 580– 588.
  • Grbic JT, Mitchell-Lewis DA, Fine JB, Phelan JA, BucklanRS, Zambon JJ, Lam- ster IB. The relationship of candidiasis to line- ar gingival erythema in HIV-infected homo- sexual men and parenteral drug users. J Perio- dontol 1995: 66: 30–37.
  • Leonhardt A, Renvert S, Dahle´n G. Microbial findings at failing implants. Clin Oral Implants Res 1999: 10: 339–345.
  • Odds FC. Pathogenesis of Candida infections. J Am Acad Dermatol 1994: 31:2-5.
  • Kuriyama T, Williams DW, Lewis MAO. In vitro secreted aspartyl proteinase ac- tivity of Candida albicans isolated from oral diseases and healthy oral cavities. Oral Micro- biol Immunol 2003: 18: 405–407.
  • Krishnan PA. Fungal infections of the oral mucosa. Indian J Dent Res. 2012 Sep- Oct;23(5):650-9.
  • Samaranayake LP, Keung Leung W, Jin L. Oral mucosal fungal infections. Perio- dontol 2000 2009: 49: 39–59.
  • Sitheeque MA, Samaranayake LP. Chronic hyperplastic candidosis » candidiasis (candidal leukoplakia). Crit Rev Oral Biol Med 2003: 14: 253–267.
  • Barrett AW, Kingsmill VJ, Speight PM. The frequency of fungal infection in biop- sies of oral mucosal lesions. Oral Dis 1998: 4: 26–31.
  • Figueiral MH, Azul A, Pinto E, Fonseca PA, Branco FM, Scully C. Denture- related stomatitis: identification of aetiological and predisposing factors – a large cohort. J Oral Rehabil 2007: 34: 448–455.
  • Smith AJ, Robertson D, Tang MK, Jackson MS, MacKenzie D, Bagg J. Staphylo- coccus aureus in the oral cavity: a threeyear retrospective analysis of clinical laboratory da- ta. Br Dent J 2003: 195: 701–703.
  • Farah CS, Ashman RB, Chal- lacombe SJ. Oral candidosis. Clin Dermatol 2000;18:553-62.
  • MacNeill S, Rindler E, Walker A, Brown AR, Cobb CM. Effects of tetracycline hydrochloride and chlorhexidine gluconate on Candida albicans: an in vitro study. J Clin Per- iodontol 1997: 24: 753–760.
  • Budtz-Jorgensen E. Etiology, path- ogenesis, therapy, and prophylaxis of oral yeast infections. Acta Odontol Scand. 1990: 48: 61–69.
  • Ellepola ANB, Samaranayake LP. Oral candidal infections and antimycotics. Crit Rev Oral Biol Med 2000: 11: 172–198.
  • Filoche SK, Soma K, Sissons CH. Antimicrobial effects of essential oils in com- bination with chlorhexidine digluconate. Oral Microbiol Immunol 2005: 20: 221–225.
  • Kılıç A, Saraçlı M, Özyurt M, Saygun I, Başustaoğlu C. Ağız çalkalama su- larının (gargara) in vitro antifungal aktiviteleri. Türk Hij Den Biyol Derg 2001: Cilt 58, No 3, S : 81 – 86.
  • de Oliveira LF, Jorge AO, Dos San- tos SS. In vitro minocycline activity on super- infecting microorganisms isolated from chron- ic periodontitis patients. Braz Oral Res, 2006:20, 202–206.
  • Furletti VF, Teixeira IP, Obando- Pereda G, Mardegan RC, Sartoratto A, Figuei- ra GM, Duarte RM, Rehder VL, Duarte MC, Höfling JF. Action of Coriandrum sativum L. essential oil upon oral Candida albicans bio- film formation. Evid Based Complement Al- ternat Med, 2011.
  • Lu XO, Zhang BL, Wang YB, Zhou XL, Weng J, Qu SX, Feng B, Watari F, Ding YH, Leng Y. Nano-Ag-loaded hydroxyapatite coatings on titanium surfaces by electrochemi- cal deposition. 2011;8:529-539.
  • Kim KJ, Sung WS, Moon SK, Choi JS, Kim JG, Lee DG. Antifungal effect of sil- ver nanoparticles on dermatophytes. J Micro- biol Biotechnol, 2008:18, 1482–1484.
  • Junqueira JC, Jorge AO, Barbosa JO, Rossoni RD, Vilela SF, Costa AC, Primo FL, Gonçalves JM, Tedesco AC, Suleiman JM. Photodynamic inactivation of biofilms formed by Candida spp., Trichosporon mucoides, and Kodamaea ohmeri by cationic nanoemulsion of zinc 2,9,16,23-tetrakis(phenylthio)-29H, 31H- phthalocyanine (ZnPc). Lasers Med Sci, 2012;27, 1205–1212.
  • Mima EG, Vergani CE, Machado AL, Massucato EM, Colombo AL, Bagnato VS, Pavarina AC. Comparison of Photody- namic Therapy versus conventional antifungal therapy for the treatment of denture stomatitis: a randomized clinical trial. Clin Microbiol In- fect. 2012 Oct;18(10):E380-8.
  • Scwingel AR, Barcessat AR, Nşñez SC, Ribeiro MS. Antimicrobial photodynamic therapy in the treatment of oral candidiasis in HIV-infected patients. Photomed Laser Surg. 2012 Aug;30(8):429-32.
  • Redding S, Bhatt B, Rawls HR, Siegel G, Scott K, Lopez-Ribot J. Inhibition of Candida albicans biofilm formation on denture material. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009: 107: 669–672.
  • Meurman JH. Probiotics: do they have a role in oral medicine and dentistry? Eur J Oral Sci 2005: 113: 188–196.
There are 34 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Nilsun Bağış This is me

Şivge Kurgan This is me

Canan Önder This is me

Publication Date October 1, 2014
Published in Issue Year 2014 Volume: 41 Issue: 3 - Volume: 41 Issue: 3

Cite

Vancouver Bağış N, Kurgan Ş, Önder C. Ağız içi candida enfeksiyonları ve tedavisi. EADS. 2014;41(3):191-8.