The Analysis of Glutathione Level and Superoxide Dismutase Activity in Normal and Preeclampsia Pregnant

Year 2019, Volume: 5 Issue: 1, 23 - 29, 27.06.2019

Naim Uzun

Abstract

Preeclampsia is a disease characterized by
hypertension and significant proteinuria that occurs after the twentieth week
of pregnancy. The presence of mechanisms that detoxify free oxygen radicals
associated with increased oxygen consumption in preeclampsia is very important.
In mitochondrial and microsomal systems, molecular oxygen is reduced by taking
an electron and superoxide radical is formed which is an unstable structure.
Superoxide Dismutase is a metalloenzyme which converts superoxide radical to Hydrogen
Peroxide. Glutathione Peroxidase degrades hydrogen peroxide by converting it
into water and molecular oxygen using glutathione. Twenty-seven preeclampsia
patients and 32 healthy pregnant control groups were selected at 20-28 weeks of
gestation. There was a significant difference (p <0.05) between Superoxide
dismutase and glutathione levels in patients with preeclampsia and control group. We aimed to
investigate the effect of two important components of the antioxidant system,
superoxide dismutase and glutathione, on preeclampsia causing fetal and
maternal mortality.

Keywords

Preeclampsia, Superoxide Dismutase, Glutathione

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