The Bıologıcal Importance of Curcumın

Yıl 2020, Cilt: 6 Sayı: 1, 21 - 34, 24.06.2020

Merve Arlı Hülya Çelik

Öz

Turmeric (Curcuma longa); In India, China and South East Asia, spices are widely used as aromatic stimulants, food preservatives and coloring materials. Among the people as "castor saffron, turmeric, turmeric, saffron root"; Turmeric as the commonly used name is a yellow-orange colored polyphenolic natural substance derived from C. longa rhizomes. In traditional medicine for inflammation and tumors, biliary disorders, anorexia, cough, topical wounds, diabetic wounds, hepatic disorders, rheumatism and sinusitis. It was used as a medicine. In recent years, extensive studies have been conducted to determine the biological activities and pharmacological effects of turmeric and its extracts. Curcumin, which is the main yellow bioactive component of turmeric, is known to have a wide bioactivity such as anti-inflammatory, antioxidant, anticarcinogenic, antidiabetic, antibacterial, antifungal, antiprotozoal, antiviral, antifibrotic, immunomodulator and antiulcer. Safety assessment studies show that curcumin is well tolerated without toxic effects when used in very high doses. Therefore, curcumin is a substance of high biological importance with the development potential of modern medicine for the treatment of various diseases. For this reason, more scientific studies on curcumin should be done and all the dark sides about this important compound should be illuminated.

Anahtar Kelimeler

Biological activity, Curcumin, Turmeric

Kaynakça

• AKBİK, D. GHADİRİ, M.CHRZANOWSKİ, W. ROHANİZADEH, R. (2014). Curcumin as a Wound Healing Agent. Life Sciences, 116(1), 1-7.
• AKRAM, M. SHAHAB-UDDİN, A. A. USMANGHANİ, K. HANNAN, A. MOHİUDDİN, E. ASİF, M. (2010). Curcuma longa and curcumin: a review article. Rom J Biol Plant Biol, 55, 65–70.
• ANAND, P. THOMAS, S. KUNNUMAKKARA, A., SUNDARAM, C., HARİKUMAR, K. B., SUNG, B., THARAKAN, S. T. MİSRA, K. PRİYADARSİNİ, I. K., RAJASEKHARAN, K. N. AGGARWAL , B. B. (2008). Biological activities of curcumin and its analogues(congeners) made by man and mother nature. Biochem Pharm, 7(6), 1590–611.
• ARTİCO , M. Dİ SANTO, R., COSTİ , R., NOVELLİNO , E., GRECO, G., MASSA, S., TRAMONTONO, E., MARONGİU, M.E., DE MONTİS, A., LA COLLA, P. (1998). Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-I intergrase. Journal of Medicinal Chemistry, 41, 3948-3960.
• BOURNE, K. Z. BOURNE, N. REİSİNG, S. F. STANBERRY, L. R. (1999). Plant products as topical microbicide candidates: assessment of in vitro and in vivo activity against herpes simplex virus type 2. Antivir. Res., 42, 219-226.
• BOZ, İ. (2013). Kurkumin Takviyesinin Sıçanlarda Ekzantrik Egzersizle Oluşan Kas Hasarı Üzerine Etkisi. Yüksek Lisans Tezi, T.C. Selçuk Üniversitesi Sağlık Bilimleri Enstitüsü, Konya.
• BRİGHT, J. J. (2007). Curcumin and autoimmune disease. Adv Exp Med Biol, 595, 425–451.
• BURKE JR. T. R., FESEN, M. R. MAZUMDER, A. WANG, J. CAROTHERS, A. M. GRUNBERGER, D. DRİSCOLL, J. KOHN, K., POMMİER, Y. (1995). Hydroxylated aromatic inhibitors of HIV-1 integrase. J. Med. Chem., 38 , 4171-4178.
• DAVİS, J. M. MURPHY, E. A. CARMİCHAEL, M. D. ZİELİNSKİ, M. R. GROSCHWİTZ, C. M. BROWN, A. S., GANGEMİ, J. D. GHAFFAR, A. MAYER, E. P. (2007). Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. Am J Physiol Regul Integr Comp Physiol., 292(6), R2168-73.
• Delikanlı Akbay, G. Pekcan, A. G. (2016). Zerdeçal: Beslenme ve Sağlık Yönünden Değerlendirilmesi. Beslenme ve Diyet Dergisi, 44(1), 68-72.
• UZER, N. (2007). Sıçanlarda Deri Fleplerinin Yaşayabilirliğinde Curcumin Kullanımının Etkilerinin Araştırılması. Uzmanlık Tezi, T.C Sağlık Bakanlığı Şişli Etfal Eğitim ve Araştırma Hastanesi Plastik, Rekonstruktif ve Estetik Cerrahi Kliniği , İstanbul.
• ESATBEYOĞLU, T. HUEBBE, P. ERNST, I. M. CHİN, D., WAGNER, A. E. RİMBACH, G. (2012). Curcumin-from molecule to biological function. Angew Chem Int Ed Engl., 51(22), 5308-32.
• HEWLİNGS, S. J. KALMAN, D. S. (2017). Curcumin: A Review of Its’ Effects on Human Health. Foods, 6(10), 92.
• HUANG, H. C. JAN, T. R. YEH, S. F. (1992). Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation. European Journal of Pharmacology, 221(2-3), 381-384.
• JAGETİA, G. C. AGGARWAL, B. B. (2007). “Spicing up” of the immune system by curcumin. J Clin Immunol, 27, 19-35.
• JAYAPRAKASHA, G. K. RAO, L. J. SAKARİAH, K. K. (2005). Chemistry and biological activities of C. longa. Trends Food Sci. Technol., 16, 533–548.
• JİANG, M. C. YANG-YEN, H. F. LİN, J. K. YEN, J. J. (1996). Differential regulation of p53, c-myc, Bcl-2 and Bax protein expression during apoptosis induced by widely divergent stimuli in human hepatoblastoma cells. Oncogene, 13, 609-616.
• JOE, B. VİJAYKUMAR, M. LOKESH, B. R. (2004). Biological Properties of Curcumin-Cellular and Molecular Mechanisms of Action. Critical Reviews in Food Science and Nutrition, 44(2), 97-111.
• KHANNA, S. PARK, H. A., SEN, C. K., GOLAKOTİ, T., SENGUPTA, K., VENKATESWARLU, S., & ROY, S. (2009). Neuroprotective and antiinflammatory properties of a novel demethylated curcuminoid. Antioxid Redox Signal, 11(3), 449-68.
• KOWLURU, R. A. KANWAR, M. (2007). Effects of curcumin on retinal oxidative stress and inflammation in diabetes. Nutrition & Metabolism (London), 4(2007), 8.
• KURİEN, B. T., SİNGH, A. MATSUMOTO, H. SCOFİELD, R. H. (2007). Improving the solubility and pharmacological efficacy of curcumin by heat treatment. Assay Drug Dev. Technol., 5, 567–576.
• LESTARİ, M. L. INDRAYANTO, G. (2014). Chapter Three- Curcumin. Profiles of Drug Substances, Excipients and Related Methodology, 39, 113-204.
• Lİ, C. J. ZHANG, L. J. DEZUBE, B. J. CRUMPACKER, C. S. PARDEE, A. B. (1993). Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication. Proc Natl Acad Sci USA, 90(5), 1839–1842.
• LİU, J. Y. LİN, S. J. LİN, J. K. (1993). Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells. Carcinogenesis, 14(5), 857-861.
• MAZUMDER, A. NEAMATİ, N., SUNDER, S. SCHULZ, J., PERTZ, H. EİCH, E. POMMİER, Y. (1997). Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action. J. Med. Chem., 40, 3057–3063.
• MOZİOĞLU, E. YILMAZ, H. ÇIKRIKÇI, S. (2008). Biological Activity of Curcuminoids Isolated from Curcuma longa. Records Of Natural Products, 2(1), 19-24.
• NAGARAJAN, S. KUBRA, I. R. RAO, L. J. (2010). Separation of Curcuminoids Enriched Fraction from Spent Turmeric Oleoresin and Its Antioxidant Potential. J. Food Science, 75, 158-162.
• NAİR, K. P. (2013). The Agronomy and Economy of Turmeric and Ginger. Elsevier, Oxford.
• PAN, R. QİU, S., LU, D. DONG, J. (2008). Curcumin improves learning and memory ability and its neuroprotective mechanism in mice. Chin Med, 121(9), 832-839.
• PANDYA, U. SAİNİ, M. K., JİN, G. F. AWASTHİ, S. GODLEY, B. F. AWASTHİ, Y. C. (2000). Dietary curcumin prevents ocular toxicity of naphthalene in rats. Toxicology Letters, 115(3), 195-204.
• PARASURAMAN, S. ZHEN, K. M. BANİK, U. CHRİSTAPHER, P. V. (2017). Ameliorative Effect of Curcumin on Olanzapine-induced Obesity in Sprague-Dawley Rats. Pharmacognosy Research, 9(3), 247-252.
• REDDY, A. C., LOKESH, B. R. (1994). Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron. Molecular and Cellular Biochemistry, 137(1), 1-8.
• SHARMA , R. A. GESCHER, A. J. STEWARD, W. P. (2005). Curcumin: the story so far. Eur J Cancer, 41, 1955-68.
• SHARMA, O. P. (1976). Antioxidant activity of curcumin and related compounds. Biochemical Pharmacology, 25(15), 1811-1812
• SREEJAYAN, RAO, M. N.A. (1997). Nitric oxide scavenging by curcuminoids. Journal of Pharmacy and Pharmacology, 49(1), 105-107.
• UNNİKRİSHNAN, M. K., & RAO, M. N. (1995). Curcumin inhibits nitrogen dioxide induced oxidation of hemoglobin. Molecular and Cellular Biochemistry, 146(1), 35-37.
• WİCKENBERG, J. INGEMANSSON, S. L. HLEBOWİCZ, J. (2010). Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects. Nutrition Journal, 9:43.
• WİGGERS, H. ZAİONCZ, S. CHELESKİ, J. MAİNARDES, R. KHALİL, N. (2017). Curcumin, a multitarget phytochemical. Studies in Natural Products Chemistry, 53, 243-276.
• YİNG, X., BAO-SHAN, K., HAİ-YAN, Y., YAN-HUA, L., XİNG, M., YONG-HE, Z. XUE-JUN, L. (2005). Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats. Pharmacology, Biochemistry and Behavior, 82(1), 200-206.
• YOUSSEF, D. NİCHOLS, C. E. CAMERON, T. S. BALZARİNİ, J., CLERCQ, E. D. JHA, A. (2007). Design, synthesis, and cytostatic activity of novel cyclic curcumin analogues. Bioorganic & Medicinal Chemistry Letters, 17(20), 5624-5629.
• ZHANG, D. W. FU, M. GAO, S. H. LİU, J. L. (2013). Curcumin and diabetes: a systematic review. Evid Based Complement Alternat Med , 2013: 636053.