The interaction of neutron and gamma radiation with some cancer drug effect ingredients

Yıl 2020, Cilt: 6 Sayı: 2, 35 - 43, 16.12.2020

Bünyamin Aygün , Abdulhalik Karabulut

Öz

In recent years, great advances have been made in cancer treatments with new treatment methods. Radiation therapy has an important place in cancer treatments and approximately 50% of these patients applied radiation therapy. In this investigation, fast neutron and gamma radiation, absorption characteristics were determined of pharmaceutical active ingredients such as Bevacizumab (Avastin), Camptosar (Irinotecan Hydrochloride), Capecitabine, Everolimus, Oxaliplatin, Leucovorin Calcium and Regorafenib which especially used in cancer treatments. GEANT4 Monte Carlo simulation code was used in this calculates. It was found that Everolimus, Leucovorin Calcium has the best neutron attenuation capacity among the investigated drug effect ingredients. In addition to neutron attenuation properties, the gamma-ray attenuation properties of Oxaliplatin is found to good than other drug effect ingredients. According to the results obtained in the present work, we suggest that the Everolimus and Leucovorin Calcium drug effect ingredients by neutron radiotherapy and Oxaliplatin drug effect ingredients by gamma radiothrapy can be used both chemotherapy and radiotherapy. In addition in study examined drug effect ingredients can be used for chemotherapy and radiotherapy combinaison at the same time so, cancer patients to be more effective treatment.

Anahtar Kelimeler

Drug, Geant4, Gamma, Neutron

Kaynakça

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