The interaction of neutron and gamma radiation with some cancer drug effect ingredients

Year 2020, Volume: 6 Issue: 2, 35 - 43, 16.12.2020

Bünyamin Aygün , Abdulhalik Karabulut

Abstract

In recent years, great advances have been made in cancer treatments with new treatment methods. Radiation therapy has an important place in cancer treatments and approximately 50% of these patients applied radiation therapy. In this investigation, fast neutron and gamma radiation, absorption characteristics were determined of pharmaceutical active ingredients such as Bevacizumab (Avastin), Camptosar (Irinotecan Hydrochloride), Capecitabine, Everolimus, Oxaliplatin, Leucovorin Calcium and Regorafenib which especially used in cancer treatments. GEANT4 Monte Carlo simulation code was used in this calculates. It was found that Everolimus, Leucovorin Calcium has the best neutron attenuation capacity among the investigated drug effect ingredients. In addition to neutron attenuation properties, the gamma-ray attenuation properties of Oxaliplatin is found to good than other drug effect ingredients. According to the results obtained in the present work, we suggest that the Everolimus and Leucovorin Calcium drug effect ingredients by neutron radiotherapy and Oxaliplatin drug effect ingredients by gamma radiothrapy can be used both chemotherapy and radiotherapy. In addition in study examined drug effect ingredients can be used for chemotherapy and radiotherapy combinaison at the same time so, cancer patients to be more effective treatment.

Keywords

Drug, Geant4, Gamma, Neutron

References

• AYGÜN, B., ALAYLAR, B., TURHAN, K., ŞAKAR, E., KARADAYI, M., SAYYED, M.I., PELİT, E., GÜLLÜCE, M., KARABULUT, A., TURGUT, Z., ALIM, B. (2020). Investigation of neutron and gamma radiation protectivecharacteristics of synthesized quinoline derivatives. International journal of radiatıon biology,
• AYGÜN, B. (2019). High alloyed new stainless steel shielding material for gamma and fast neutron radiation. Nuclear Engineering and Technology, 52:3,647-653 BOSLAUGH, SE. (2016). American Society of Health-System Pharmacists. In: The SAGE Encyclopedia of Pharmacology and Society, 73:19
• BURRİS, HA., HURTİG, J. (2010). Radiation Recall with Anticancer Agents. The Oncologist, 15:11,1227–1237
• CARLO, M, N-particle MC, Shower EG, Safety R, Computational I, Ridge O. 2004. Shielding of Gamma Radiation. Technology.
• CHADWICK, G., GREENAWAY, K. (2015). An audit of the care received by people with Oesophago-Gastric Cancer in England and Wales Annual Report. Clinical Research Fellow Mira Varagunam Reader in Health Services Research.
• EATON, DJ., SCHNEIDER, F. (2014). Radiation protection. In: Targeted Intraoperative Radiotherapy in Oncology.
• EKİNCİ, N., KAVAZ E., AYGÜN, B., PERİŞANOĞLU, U. (2019). Gamma ray shielding capabilities of rhenium-based superalloys. Radiation Effects and Defects in Solids, 174:1-5, 435-451
• GAİKWAD, DK., PAWAR, PP., SELVAM, TP. (2016). Measurement of attenuation cross-sections of some fatty acids in the energy range 122-1330 keV. Pramana - Journal of Physics, 87:12, 1-7
• HASSKARL, J. (2018). Everolimus. In: Recent Results in Cancer Research.
• KAVAZ, E., YORGUN, NY. (2018). Gamma ray buildup factors of lithium borate glasses doped with minerals. Journal of Alloys and Compounds, 752, 61-67
• KORKUT, T., KORKUT, H., AYGÜN, B., BAYRAM, Ö., KARABULUT, A. (2018). Investigation of high-temperature-resistant rhenium–boron neutron shields by experimental studies and Monte Carlo simulations. Nuclear Science and Techniques, 29:102, 2-5
• KURUDİREK, M. (2016). Water and tissue equivalence properties of biological materials for photons, electrons, protons and alpha particles in the energy region 10 keV–1 GeV: a comparative study. International Journal of Radiation Biology, 92:9, 508-520
• Lİ, Y., DONG, J., XIAO, H., ZHANG, S., WANG, B., CUİ, M., FAN, S. (2020). Gut commensal derived-valeric acid protects against radiation injuries. Gut Microbes, 11:4, 789-806
• MORE, C V., LOKHANDE, RM., PAWAR, PP. (2016). Effective atomic number and electron density of Amino acids within the energy range of 0.122-1.330 MeV. Radiation Physics and Chemistry, 125, 14-20
• OSORİO, E., BRAVO, K., CARDONA, W., YEPES, A, OSORİO EH, COA JC. (2019). Antiaging activity, molecular docking, and prediction of percutaneous absorption parameters of quinoline–hydrazone hybrids. Medicinal Chemistry Research 28, 1956-1973
• PARK, B., YEE, C., LEE, KM. (2014). The effect of radiation on the immune response to cancers. International Journal of Molecular Sciences, 15:1, 927-43
• PATYAR, RR., PATYAR, S. (2018). Role of drugs in the prevention and amelioration of radiation induced toxic effects. European Journal of Pharmacology, 819, 207-2016
• PRASANNA, PGS., STONE, HB., WONG RS, CAPALA J., BERNHARD, EJ., VİKRAM, B., COLEMAN CN. (2012). Normal tissue protection for improving radiotherapy: Where are the Gaps? Translational Cancer Research, 1, 35-48
• SAYYED, MI., ISSA, SAM., AUDA, SH. (2017). Assessment of radio-protective properties of some anti-inflammatory drugs. Progress in Nuclear Energy, 100, 297-308
• SAYYED, MI., LAKSHMİNARAYANA, G. (2018). Structural, thermal, optical features and shielding parameters investigations of optical glasses for gamma radiation shielding and defense applications. Journal of Non-Crystalline Solids, 487, 53-59
• SCHOBER, H. (2014). An introduction to the theory of nuclear neutron scattering in condensed matter. Journal of Neutron Research, 17:4, 109-357
• SHEN, Y., Lİ, C., LİU, W., MAO, W., QİAN, H., WANG, H., XU, Q. (2018). Clinical analysis of hypersensitivity reactions to oxaliplatin among colorectal cancer patients. Oncology Research, 26:5, 801-807
• SİNGH, VP., BADİGER, NM. (2014). Gamma ray and neutron shielding properties of some alloy materials. Annals of Nuclear Energy, 64, 301-310
• SİNGHA, I., SAXENA, S., GAUTAM, S., SAHA, A., DAS, SK. (2020). Grape extract protect against ionizing radiation-induced dna damage. Indian Journal of Biochemistry and Biophysics, 57:2, 2-7
• WALKO, CMP., LİNDLEY, PC. (2005). Capecitabine: A review. Clinical Therapeutics, 27:1, 23-44
• WEİSS, JF., LANDAUER, MR. (2003). Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicology, 189:2, 1-20