Case Report
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Low Grade Mucoepidermoid Carcinoma Localized in the Posterior Hard Palate: Case Report

Year 2025, Volume: 3 Issue: 1, 17 - 21, 30.04.2025
https://doi.org/10.62243/edr.1630371

Abstract

Aim Mucoepidermoid carcinoma (MEC) is the most commonly diagnosed malignant tumor of the salivary glands. While it predominantly occurs in the parotid gland, it may also affect the submandibular, submental, and minor salivary glands. This case report aims to contribute to the literature by presenting a low-grade MEC, clinically resembling benign lesions, detected asymptomatically in the hard palate.
Case Report A 30-year-old female patient with no systemic health issues visited the Department of Dentomaxillofacial Radiology at Sivas Cumhuriyet University Faculty of Dentistry for a routine examination. An asymptomatic, well-defined swelling with a slightly erythematous mucosal covering was detected at the junction of the hard and soft palate. The patient was not aware of the lesion. Histopathological analysis of the tissue sample, obtained through an incisional biopsy, confirmed features indicative of low-grade MEC.
Discussion Low-grade MEC can mimic benign salivary gland tumors, particularly pleomorphic adenoma, when presenting as an asymptomatic palatal lesion. This highlights the necessity of biopsy for accurate diagnosis. Early detection enables conservative treatment and improves prognosis. While surgical excision with clear margins is the preferred approach, long-term follow-up is essential due to the risk of recurrence.
Conclusion Asymptomatic low-grade mucoepidermoid carcinoma can be confused with pleomorphic adenoma when it occurs in the palatal region and must be considered in the differential diagnosis. Early-stage diagnosis of MEC is associated with a better prognosis and allows for more conservative treatment approaches.

References

  • Regezi J, Sciubba J, Jordan R, editors. Oral Pathology: Clinical Pathologic Correlations. 7th ed. Elsevier; 2016.
  • White SC, Pharoah MJ, editors. Oral Radiology: Principles and Interpretation. 7th ed. New York, USA: Elsevier Health Sciences; 2014.
  • Neville BW, Damm DD, Allen CM, Chi AC, editors. Oral and Maxillofacial Pathology. 4th ed. Elsevier Health Sciences; 2015.
  • Nance MA, Seethala RR, Wang Y, Chiosea SI, Myers EN, Johnson JT, et al. Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma. Cancer. 2008;113(8):2082-2089.
  • Aro K, Leivo I, Mäkitie AA. Management and outcome of patients with mucoepidermoid carcinoma of major salivary gland origin: a single institution's 30-year experience. Laryngoscope. 2008;118(2):258-262.
  • Brandwein MS, Ivanov K, Wallace DI, Hille JJ, Wang B, Fahmy A, et al. Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol. 2001;25(7):835-845.
  • Esen HH, Toy H, Erden FC. The comparison of grade systems of the mucoepidermoid carcinomas. Eur J Ther. 2010;16(3):42-44.
  • Hoda SA, Hoda RS. Diagnostic histopathology of tumors. Am J Clin Pathol. 2021;155(1):148-149.
  • Luna MA. Salivary mucoepidermoid carcinoma: revisited. Adv Anat Pathol. 2006;13(6):293-307.
  • Marx RE, Stern D, editors. Oral and Maxillofacial Pathology: A Rationale for Diagnosis and Treatment. 2nd ed. Quintessence; 2012.
  • Granholm C, Walhjalt H, Magnusson B. Oral mucoceles; extravasation cysts and retention cysts. A study of 298 cases. Swed Dent J. 2009;33(3):125-130.
  • Graham RM, Thomson EF, Cousin GC, Kumar S, Awasthi A. A case of facial lymphoma mimicking dental infection. Dent Update. 2009;36(4):244-246.
  • Pires FR, Pringle GA, de Almeida OP, Chen S-Y. Intra-oral minor salivary gland tumors: a clinicopathological study of 546 cases. Oral Oncol. 2007;43(5):463-470.
  • Ord RA, Salama AR. Is it necessary to resect bone for low-grade mucoepidermoid carcinoma of the palate? Br J Oral Maxillofac Surg. 2012;50(8):712-714.
  • Yih W-Y, Kratochvil FJ, Stewart JC. Intraoral minor salivary gland neoplasms: review of 213 cases. J Oral Maxillofac Surg. 2005;63(6):805-810.
  • Azman D, Gültekin H, Tassoker M, Esen A. Pleomorfik adenom taklit eden palatal minör tükürük bezlerinden kaynaklanan düşük dereceli mukoepidermoid karsinom: bir vaka raporu. NEU Dent J. 2021;3(1):40-44.
  • Brajdić D, Virag M, Manojlović S, Lukšić I, Franćeski D, Biočić J, et al. Mucoepidermoid carcinoma misdiagnosed as palatal odontogenic infection: an overview on the differential diagnosis of palatal lesions. Coll Antropol. 2010;34(4):1473-1479.
  • Baumgardt C, Günther L, Sari-Rieger A, Rustemeyer J. Mucoepidermoid carcinoma of the palate in a 5-year-old girl: case report and literature review. Oral Maxillofac Surg. 2014;18:465-469.
  • Peraza A, Gómez R, Beltran J, Amarista FJ. Mucoepidermoid carcinoma: an update and review of the literature. J Stomatol Oral Maxillofac Surg. 2020;121(6):713-720.
  • Ritwik P, Cordell KG, Brannon RB. Minor salivary gland mucoepidermoid carcinoma in children and adolescents: a case series and review of the literature. J Med Case Rep. 2012;6:1-8.
  • Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ. Major and minor salivary gland tumours. Crit Rev Oncol Hematol. 2020;152:102959.
  • Baddour HM, Fedewa SA, Chen AY. Five- and 10-year cause-specific survival rates in carcinoma of the minor salivary gland. JAMA Otolaryngol Head Neck Surg. 2016;142(1):67-73.
  • Myers EN, Ferris RL, editors. Salivary Gland Disorders. Springer Science & Business Media; 2007.
  • Mathew AL, Joseph BB, Sarojini DM, Premkumar P, Nair SS. Mucoepidermoid carcinoma of palate—a rare entity. Clin Pract. 2017;7(4):1009.
  • Kumar A, Nair PP, Thomas S, Raman PS, Bhambal A. Mucoepidermoid carcinoma of sublingual gland: a malignant neoplasm in an uncommon region. BMJ Case Rep. 2011;2011:bcr0220113864.
  • Eversole L, Rovin S, Sabes W. Mucoepidermoid carcinoma of minor salivary glands: report of 17 cases with follow-up. J Oral Surg. 1972;30(2):107-112.
  • Melrose RJ, Abrams AM, Howell FV. Mucoepidermoid tumors of the intraoral minor salivary glands: a clinicopathologic study of 54 cases. J Oral Pathol Med. 1973;2(6):314-325.
  • Olsen KD, Devine KD, Weiland LH. Mucoepidermoid carcinoma of the oral cavity. Otolaryngol Head Neck Surg. 1981;89(5):783-791.

Year 2025, Volume: 3 Issue: 1, 17 - 21, 30.04.2025
https://doi.org/10.62243/edr.1630371

Abstract

References

  • Regezi J, Sciubba J, Jordan R, editors. Oral Pathology: Clinical Pathologic Correlations. 7th ed. Elsevier; 2016.
  • White SC, Pharoah MJ, editors. Oral Radiology: Principles and Interpretation. 7th ed. New York, USA: Elsevier Health Sciences; 2014.
  • Neville BW, Damm DD, Allen CM, Chi AC, editors. Oral and Maxillofacial Pathology. 4th ed. Elsevier Health Sciences; 2015.
  • Nance MA, Seethala RR, Wang Y, Chiosea SI, Myers EN, Johnson JT, et al. Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma. Cancer. 2008;113(8):2082-2089.
  • Aro K, Leivo I, Mäkitie AA. Management and outcome of patients with mucoepidermoid carcinoma of major salivary gland origin: a single institution's 30-year experience. Laryngoscope. 2008;118(2):258-262.
  • Brandwein MS, Ivanov K, Wallace DI, Hille JJ, Wang B, Fahmy A, et al. Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol. 2001;25(7):835-845.
  • Esen HH, Toy H, Erden FC. The comparison of grade systems of the mucoepidermoid carcinomas. Eur J Ther. 2010;16(3):42-44.
  • Hoda SA, Hoda RS. Diagnostic histopathology of tumors. Am J Clin Pathol. 2021;155(1):148-149.
  • Luna MA. Salivary mucoepidermoid carcinoma: revisited. Adv Anat Pathol. 2006;13(6):293-307.
  • Marx RE, Stern D, editors. Oral and Maxillofacial Pathology: A Rationale for Diagnosis and Treatment. 2nd ed. Quintessence; 2012.
  • Granholm C, Walhjalt H, Magnusson B. Oral mucoceles; extravasation cysts and retention cysts. A study of 298 cases. Swed Dent J. 2009;33(3):125-130.
  • Graham RM, Thomson EF, Cousin GC, Kumar S, Awasthi A. A case of facial lymphoma mimicking dental infection. Dent Update. 2009;36(4):244-246.
  • Pires FR, Pringle GA, de Almeida OP, Chen S-Y. Intra-oral minor salivary gland tumors: a clinicopathological study of 546 cases. Oral Oncol. 2007;43(5):463-470.
  • Ord RA, Salama AR. Is it necessary to resect bone for low-grade mucoepidermoid carcinoma of the palate? Br J Oral Maxillofac Surg. 2012;50(8):712-714.
  • Yih W-Y, Kratochvil FJ, Stewart JC. Intraoral minor salivary gland neoplasms: review of 213 cases. J Oral Maxillofac Surg. 2005;63(6):805-810.
  • Azman D, Gültekin H, Tassoker M, Esen A. Pleomorfik adenom taklit eden palatal minör tükürük bezlerinden kaynaklanan düşük dereceli mukoepidermoid karsinom: bir vaka raporu. NEU Dent J. 2021;3(1):40-44.
  • Brajdić D, Virag M, Manojlović S, Lukšić I, Franćeski D, Biočić J, et al. Mucoepidermoid carcinoma misdiagnosed as palatal odontogenic infection: an overview on the differential diagnosis of palatal lesions. Coll Antropol. 2010;34(4):1473-1479.
  • Baumgardt C, Günther L, Sari-Rieger A, Rustemeyer J. Mucoepidermoid carcinoma of the palate in a 5-year-old girl: case report and literature review. Oral Maxillofac Surg. 2014;18:465-469.
  • Peraza A, Gómez R, Beltran J, Amarista FJ. Mucoepidermoid carcinoma: an update and review of the literature. J Stomatol Oral Maxillofac Surg. 2020;121(6):713-720.
  • Ritwik P, Cordell KG, Brannon RB. Minor salivary gland mucoepidermoid carcinoma in children and adolescents: a case series and review of the literature. J Med Case Rep. 2012;6:1-8.
  • Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ. Major and minor salivary gland tumours. Crit Rev Oncol Hematol. 2020;152:102959.
  • Baddour HM, Fedewa SA, Chen AY. Five- and 10-year cause-specific survival rates in carcinoma of the minor salivary gland. JAMA Otolaryngol Head Neck Surg. 2016;142(1):67-73.
  • Myers EN, Ferris RL, editors. Salivary Gland Disorders. Springer Science & Business Media; 2007.
  • Mathew AL, Joseph BB, Sarojini DM, Premkumar P, Nair SS. Mucoepidermoid carcinoma of palate—a rare entity. Clin Pract. 2017;7(4):1009.
  • Kumar A, Nair PP, Thomas S, Raman PS, Bhambal A. Mucoepidermoid carcinoma of sublingual gland: a malignant neoplasm in an uncommon region. BMJ Case Rep. 2011;2011:bcr0220113864.
  • Eversole L, Rovin S, Sabes W. Mucoepidermoid carcinoma of minor salivary glands: report of 17 cases with follow-up. J Oral Surg. 1972;30(2):107-112.
  • Melrose RJ, Abrams AM, Howell FV. Mucoepidermoid tumors of the intraoral minor salivary glands: a clinicopathologic study of 54 cases. J Oral Pathol Med. 1973;2(6):314-325.
  • Olsen KD, Devine KD, Weiland LH. Mucoepidermoid carcinoma of the oral cavity. Otolaryngol Head Neck Surg. 1981;89(5):783-791.
There are 28 citations in total.

Details

Primary Language English
Subjects Oral and Maxillofacial Radiology
Journal Section Case Report
Authors

İlknur Eninanç 0000-0002-4583-6237

Aslıhan Şahan Keskin 0000-0001-5786-9610

Submission Date January 31, 2025
Acceptance Date April 13, 2025
Publication Date April 30, 2025
Published in Issue Year 2025 Volume: 3 Issue: 1

Cite

Vancouver Eninanç İ, Şahan Keskin A. Low Grade Mucoepidermoid Carcinoma Localized in the Posterior Hard Palate: Case Report. EDR. 2025;3(1):17-21.