Management of Maxillary Gingival Enlargement in a Neurofibromatosis Type 1 Patient Using a PRF-Assisted Surgical Approach: A Case Report

Year 2025, Volume: 3 Issue: 3, 74 - 77, 31.12.2025

Muhammet Caner Dere , Harika Yalçın , Tunahan Kart , İlker Özeç , Hatice Reyhan Egilmez

https://doi.org/10.62243/edr.1727484

Abstract

Aim Neurofibromatosis type 1 (NF1) is a hereditary disorder with variable clinical presentations, including oral manifestations. Gingival overgrowth in NF1 can occur independently of local irritants and may lead to both functional and esthetic problems. This report aims to present the surgical management of a localized gingival enlargement in an NF1 patient using platelet-rich fibrin (PRF) for enhanced healing.
Case Report A 17-year-old female with a diagnosis of NF1 presented with a painless gingival swelling in the right maxillary molar region. Clinical and radiographic evaluations revealed diffuse gingival enlargement involving buccal and palatal aspects. Additional findings included café-au-lait spots, axillary freckling, and unilateral condylar asymmetry. Surgical excision was performed, and a PRF membrane was placed over the surgical site to promote tissue repair. Histopathological analysis confirmed the lesion as a neurofibroma.
Discussion Oral manifestations of NF1, although uncommon, require careful recognition due to their potential functional and esthetic consequences. Surgical excision remains the mainstay of treatment, and adjunctive use of PRF may accelerate soft tissue healing and improve postoperative outcomes. This case highlights the importance of multidisciplinary evaluation and the potential value of regenerative adjuncts in NF1-associated oral lesions.
Conclusion PRF-assisted excision of NF1-related gingival neurofibroma provided satisfactory clinical outcomes and uneventful healing. Awareness of such oral findings is essential for early diagnosis and effective management in NF1 patients.

Keywords

Gingival enlargement , Neurofibromatosis type 1 , Oral neurofibroma , Platelet rich fibrin , von Recklinghausen disease

Ethical Statement

Written informed consents were obtained from patients who participated in this study.

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