Non-communicable diseases in the Brahmaputra Valley: genetic and behavioural risk factors among adult Hindu Bengalis

Immon Ghosh; Gulrukh Begum

Non-communicable diseases in the Brahmaputra Valley: genetic and behavioural risk factors among adult Hindu Bengalis

Abstract

Non-Communicable Diseases present substantial public health challenges worldwide. This study investigates the heritability of hypertension and diabetes among 473 adult Hindu Bengalis (226 sibling dyads and 7 sibling triplets). Using intraclass correlation coefficients (ICC) sibling correlations estimates are found. Shared household environments and modifiable behavioural factors such as tobacco, alcohol, physical activity, and sedentary behaviour were also assessed. Significant sibling similarities were found for hypertension (SBP: ICC = 0.495, h² = 0.99; DBP: ICC = 0.360, h² = 0.72) and diabetes (ICC = 0.308, h² = 0.62). Socioeconomic status (SES) significantly influenced hypertension (p < .01). Interactions between tobacco, alcohol, and physical activity significantly affected hypertension (p < .05), while SES combined with tobacco and activity impacted diabetes (p < .05). The findings highlight strong genetic predispositions alongside socioeconomic and behavioural determinants. Targeted interventions addressing both genetic predisposition and modifiable social factors are essential to effectively manage non-communicable disease risks.

Keywords

Supporting Institution

Gauhati University

Ethical Statement

Informed consent was obtained from each of the participants included in the study. The ethical approval for this study was granted by Institutional Ethics Committee (IEC) of Gauhati University on 15/10/2024. The Protocol/Reference number of the decision is GUIEC-10/2024.

Thanks

University Grants Comission

References

Bhavadharini B, Mohan V, Dehghan M, Rangarajan S, Swaminathan S, Rosengren A, Wielgosz A, Avezum A, Lopez-Jaramillo P, Lanas F, Dans AL, Yeates K, Poirier P, Chifamba J, Alhabib KF, Mohammadifard N, Zatońska K, Khatib R, Vural Keskinler M, Yusuf S. (2020) White rice intake and incident diabetes: a study of 132,373 participants in 21 countries. Diabetes Care 43(11):2643–2650. https://doi.org/10.2337/dc19-2335
Blok S, Haggenburg S, Collard D, Van der Linden EL, Galenkamp H, Moll van Charante EP, Agyemang C, Van den Born BJH. (2022) The association between socioeconomic status and prevalence, awareness, treatment and control of hypertension in different ethnic groups: the HELIUS study. J Hypertens 40(5):897–905. https://doi.org/10.1097/HJH.0000000000003092
Caldwell JC. (1993) Health transition: the cultural, social and behavioural determinants of health in the Third World. Soc Sci Med 36(2):125–135. https://doi.org/10.1016/0277-9536(93)90204-H
Chomiuk T, Niezgoda N, Mamcarz A, Śliż D. (2024) Physical activity in metabolic syndrome. Front Physiol 15:1365761. https://doi.org/10.3389/fphys.2024.1365761
Dahal S, Sah RB, Niraula SR, Karkee R, Chakravartty A. (2021) Prevalence and determinants of non-communicable disease risk factors among adult population of Kathmandu. PLoS One 16(9):e0257037. https://doi.org/10.1371/journal.pone.0257037
Faan FG, Faan ML. (2022) A population health approach to health disparities for nurses: Care of vulnerable populations. Springer Publishing Company.
Fraiman YS, Wojcik MH. (2021) The influence of social determinants of health on the genetic diagnostic odyssey. Pediatr Res 89(2):295–300. https://doi.org/10.1038/s41390-020-01151-5
Hampl SE, Hassink SG, Skinner AC, Armstrong SC, Barlow SE, Bolling CF, Avila Edwards KC, Eneli I, Hamre R, Joseph MM, Lunsford D, Mendonca E, Michalsky MP, Mirza N, Ochoa ER Jr, Sharifi M, Staiano AE, Weedn AE, Flinn SK, Okechukwu K. (2023) Clinical practice guideline for the evaluation and treatment of children and adolescents with obesity. Pediatrics 151(2):e2022060640. https://doi.org/10.1542/peds.2022-060640

Hanson M, Godfrey KM, Lillycrop KA, Burdge GC, Gluckman PD. (2011) Developmental plasticity and developmental origins of non-communicable disease. Prog Biophys Mol Biol 106(1):272–280. https://doi.org/10.1016/j.pbiomolbio.2010.12.008
Health NRC (US) Committee on Diet and Health. (1989) Hypertension. National Academies Press.
Hernandez LM, Blazer DG. (2006) Genes, behavior, and the social environment: moving beyond the nature/nurture debate. National Academies Press.
Hogben L. (1933) Nature and nurture. W W Norton & Co.
Hunt SC, Hasstedt SJ, Kuida H, Stults BM, Hopkins PN, Williams RR. (1989) Genetic heritability and environmental components of blood pressure. Am J Epidemiol 129(3):625–638. https://doi.org/10.1093/oxfordjournals.aje.a115175
Kardia SLR, Modell SM, Peyser PA. (2003) Family-centered approaches to preventing coronary heart disease. Am J Prev Med 24(2):143–151. https://doi.org/10.1016/S0749-3797(02)00587-1
Krieger N. (1994) Epidemiology and the web of causation. Soc Sci Med 39(7):887–903. https://doi.org/10.1016/0277-9536(94)90202-X
Kumar A, Ram F. (2013) Influence of family structure on child health in India. J Biosoc Sci 45(5):577–599. https://doi.org/10.1017/S0021932012000764
Kupper N, Willemsen G, Riese H, Posthuma D, Boomsma DI, de Geus EJC. (2005) Heritability of ambulatory blood pressure. Hypertension 45(1):80–85. https://doi.org/10.1161/01.HYP.0000149952.84391.54
Mamtani M, Jaisinghani MT, Jaiswal SG, Pipal KV, Patel AA, Kulkarni H. (2021) Genetic association of anthropometric traits with type 2 diabetes. PLoS One 16(9):e0257390. https://doi.org/10.1371/journal.pone.0257390
Pirrone I, Dieleman M, Reis R, Pell C. (2021) Syndemic contexts and non-communicable diseases. Glob Health Action 14(1):1927332. https://doi.org/10.1080/16549716.2021.1927332
Rahman M, Nakamura K, Hasan SMM, Seino K, Mostofa G. (2020) Socioeconomic status and glycemic control. Sci Rep 10(1):6690. https://doi.org/10.1038/s41598-020-63253-8
Sauce B, Matzel LD. (2018) The paradox of intelligence. Psychol Bull 144(1):26–47. https://doi.org/10.1037/bul0000131
Schousboe K, Visscher PM, Henriksen JE, Hopper JL, Sorensen TIA, Kyvik KO. (2003) Genetic and environmental influences on glucose tolerance. Diabetologia 46(9):1276–1283. https://doi.org/10.1007/s00125-003-1165-x
van Rijn MJE, Schut AFC, Aulchenko YS, Deinum J, Sayed-Tabatabaei FA, Yazdanpanah M, Isaacs A, Axenovich TI, Zorkoltseva IV, Zillikens MC, Pols HAP, Witteman JCM, Oostra BA, van Duijn CM. (2007) Heritability of blood pressure traits. J Hypertens 25(3):565–570. https://doi.org/10.1097/HJH.0b013e32801449fb
Wang B, Liao C, Zhou B, Cao W, Lv J, Yu C, Gao W, Li L. (2015) Genetic contribution to blood pressure and heart rate. Twin Res Hum Genet 18(2):158–170. https://doi.org/10.1017/thg.2015.8
Wang Y, Wu R. (2022) Effect of fasting on metabolism and psychological health. Dis Markers 2022:5653739. https://doi.org/10.1155/2022/5653739
Yang Y, Xu H, Liu X, Li J, Liew Z, Liu X, Huang C, Zhu J, Zhang J, Chen L, Hao Y, Qin G, Yu Y. (2022) Smoking, physical activity and mortality in hypertensive patients. Front Public Health 10:1005260. https://doi.org/10.3389/fpubh.2022.1005260

Details

Primary Language

English

Subjects

Biological Anthropology

Journal Section

Research Article

Authors

Immon Ghosh ^*
0009-0001-1611-4999
India

Gulrukh Begum This is me
0000-0002-5616-7825
India

Publication Date

December 31, 2025

Submission Date

June 21, 2025

Acceptance Date

August 20, 2025

Published in Issue

Year 2025 Volume: 15 Number: 2

IZ

https://izlik.org/JA63MB85TS

Cite

RIS / Bibtex

APA

Ghosh, I., & Begum, G. (2025). Non-communicable diseases in the Brahmaputra Valley: genetic and behavioural risk factors among adult Hindu Bengalis. Eurasian Journal of Anthropology, 15(2), 29-41. https://izlik.org/JA63MB85TS

AMA

1.Ghosh I, Begum G. Non-communicable diseases in the Brahmaputra Valley: genetic and behavioural risk factors among adult Hindu Bengalis. Euras J Anthropol. 2025;15(2):29-41. https://izlik.org/JA63MB85TS

Chicago

Ghosh, Immon, and Gulrukh Begum. 2025. “Non-Communicable Diseases in the Brahmaputra Valley: Genetic and Behavioural Risk Factors Among Adult Hindu Bengalis”. Eurasian Journal of Anthropology 15 (2): 29-41. https://izlik.org/JA63MB85TS.

EndNote

Ghosh I, Begum G (December 1, 2025) Non-communicable diseases in the Brahmaputra Valley: genetic and behavioural risk factors among adult Hindu Bengalis. Eurasian Journal of Anthropology 15 2 29–41.

IEEE

[1]I. Ghosh and G. Begum, “Non-communicable diseases in the Brahmaputra Valley: genetic and behavioural risk factors among adult Hindu Bengalis”, Euras J Anthropol, vol. 15, no. 2, pp. 29–41, Dec. 2025, [Online]. Available: https://izlik.org/JA63MB85TS

ISNAD

Ghosh, Immon - Begum, Gulrukh. “Non-Communicable Diseases in the Brahmaputra Valley: Genetic and Behavioural Risk Factors Among Adult Hindu Bengalis”. Eurasian Journal of Anthropology 15/2 (December 1, 2025): 29-41. https://izlik.org/JA63MB85TS.

JAMA

1.Ghosh I, Begum G. Non-communicable diseases in the Brahmaputra Valley: genetic and behavioural risk factors among adult Hindu Bengalis. Euras J Anthropol. 2025;15:29–41.

MLA

Ghosh, Immon, and Gulrukh Begum. “Non-Communicable Diseases in the Brahmaputra Valley: Genetic and Behavioural Risk Factors Among Adult Hindu Bengalis”. Eurasian Journal of Anthropology, vol. 15, no. 2, Dec. 2025, pp. 29-41, https://izlik.org/JA63MB85TS.

Vancouver

1.Immon Ghosh, Gulrukh Begum. Non-communicable diseases in the Brahmaputra Valley: genetic and behavioural risk factors among adult Hindu Bengalis. Euras J Anthropol [Internet]. 2025 Dec. 1;15(2):29-41. Available from: https://izlik.org/JA63MB85TS