Phenolic compounds that modulate Multi Drug Resistance through inhibiting of P-glycoprotein encoded by gene ABCB1

Abstract

One of the most important challenges in the fight against cancer is acquired drug resistance. P-glycoprotein (P-gp), encoded by the ABCB1 gene in many organs, is one of the important factors involved in the development of drug resistance. P-gp is mainly involved in efflux of toxic substances such as xenobiotics from the cell. In addition to these, it also plays a role the efflux of drugs used in the treatment of cancer, the rate of success in cancer treatment reduces. Phenolic compounds are chemicals that are naturally synthesized in plants and have many biological activities, especially antioxidant and anticancer. In previous studies, it was determined that in addition to their anticancer activities, phenolics modulate the acquired drug resistance by inhibiting the expression and function of P-gp. In this review, phenolic compounds that play a role in breaking multi-drug resistance by inhibiting the activation and expression of P-gp are discussed.

Keywords

• cancer resistance
• multi drug resistance
• p-glycoprotein
• phenolic compounds
• ABCB1

References

1. Sikic, B. I., Fisher, G. A., Lum, B. L., Halsey, J., Beketic-Oreskovic, L., & Chen, G. (1997). Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein. Cancer chemotherapy and pharmacology, 40(1), S13-S19.