The synthesizing of defatted chia- chitosan beads for drug delivery

Abstract

Chia (Salvia hispanica L.), Lamiaceae (Mint) family's long-year herbaceous, tropical and subtropical climates an angiosperm plant. The Chia seeds are a good source of fat, they contain protein, dietary fiber, minerals and polyphenolic compounds. After removing the oil, defatted chia seeds are mainly covered with a layer of muslin which consists of carbohydrates and protein. At optimal conditions, these seeds can be produced mucilages. These kind of mucilages are hydrophilic carbohydrate polymers of high molecular weights and consisted of many monosaccharide units joined by glucocidic bonds. Hydrophilic polymers are the most suitable materials for drug delivery systems. Chia seed mucilage has good water adsorption capacity, gel formation, emulsion stabilizing properties. Because of these structural and chemical properties, chia can be used in many areas such as; bakery compounds, nutritional supplement, thickener in food industry and coating materials as edible films. Also, natural mucilages like chia seed mucilage are biocompatible, cheap, easily avaible, low cost and lack of toxicity. In this study, we aimed to prepare the drug delivery material with defatted chia seed mucilage chitosan beads. The chia seed was defatted by Soxhlet extraction. To get best defatted the chia seed mucilage was incubated at different buffer (acetate, phosphate) and water at different ratios. After the defatted chia mucilage was ready, the different seed: buffer/ water ratio, pH and temperature were studied to get best form of beads for drug delivery. The water adsorption capacity and a model study for drug delivery with medicine was tested.

Keywords

• chia seed,drug delivery,natural mucilage,biopolymer

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