Cu katkılı biyocam ve Cu nanoparçacıklı Sr katkılı biyocamdan 3D kompozit yapı iskelesi üretimi

Yıl 2018, Cilt: 1 Sayı: 1, 16 - 21, 15.08.2018

Ayşe Özyuğuran-arifoğlu , Melek Erol Taygun Sadriye Küçükbayrak

Öz

Bu çalışmada, çözücü döküm ve tanecik uzaklaştırma yöntemi kullanılarak, çok
işlevli yapı iskelelerinin geliştirilmesi için ilgili iyonlarla BG / polimer 3D
kompozit yapı iskelelerinin üretilmesi amaçlanmıştır. Gözenekli yapıya sahip
yapı iskeleleri başarıyla sentezlenmiş ve yapı iskelelerinin mikroyapısında iyi
bir gözenek bağlantısının bulunduğu gözlemlenmiştir. Kompozit yapı
iskelelerinin in vitro biyoaktivitesi; Taramalı Elektron Mikroskopisi (SEM),
X-ışını kırınımı ve Fourier-Dönüşümlü Kızılötesi Spektroskopi ölçümleri ile
teyit edilmiştir. Bunun dışında, terapatik iyonların salımının; SBF'de kalma
sürelerinin bir fonksiyonu olarak, Sr iyon salımı 1.27-4.81 ppm aralığında iken, Cu
iyon salımları sırasıyla, Cu katkılı BG için 0.67-1.42 ppm, Sr katkılı BG-%1 Cu için 1.53-4.54
ppm,  Sr katkılı BG-%2 Cu için
3.08-7.59 ppm olarak saptanmıştır. Bu sonuç yapı iskelelerinin,
kemik dokusu rejenerasyonunun belirleyicisi olan SBF ortamına, stronsiyum ve
bakır dozlarını kontrollü olarak verebileceğini göstermiştir.

Anahtar Kelimeler

Kompozit yapı iskelesi, biyoaktif cam, terapatik iyonlar

3D composite scaffold production using Cu doped bioglass and Sr doped bioglass with Cu nanoparticles

Öz

In this study, it was aimed to produce BG/polymer 3D composite
scaffolds with relevant ions in order to develop multifunctional scaffolds by using salt
template-particulate leaching technique.
The porous scaffolds were successfully synthesized and it was observed that there was a good pore
interconnectivity maintained in the scaffold microstructure. In vitro bioactivity of the composite scaffolds was
confirmed by Scanning Electron Microscopy, X-ray diffraction and
Fourier-Transform Infrared Spectroscopy measurements. Furthermore, the release
of therapeutic ions were determined as a function of immersion time in SBF, while
the Sr ion release is in the range of 1.27-4.81 ppm, the Cu ion releases are
0.67-1.42 ppm for Cu doped BG, 1.53-4.54 ppm for Sr doped BG- 1% Cu, and
3.08-7.59 ppm for Sr doped BG- 2% Cu, respectively. This result indicated that
the scaffolds can deliver controlled doses of strontium and copper toward the
SBF medium that is the determinant for bone tissue regeneration.

Anahtar Kelimeler

Composite scaffold, bioactive glass, theraupatic ions

Kaynakça

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