Araştırma Makalesi
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Yıl 2021, Cilt 5, Sayı 2, 147 - 166, 31.12.2021

Öz

Kaynakça

  • Aebi H. 1984. Catalase Methods. Enzymol, 105, 121–126.
  • Akgül A. 1997. Baharatlar: Lezzet, koku ve renk dünyası, Gıda Sanayii, 48, 27-34.
  • Albayrak F., Odabasoglu F., Halici Z., Polat B., Dursun H., Uyanik A., Bayir Y., Koc F., Suleyman H. & Albayrak Y. 2010. The role of erythropoietin in the protection of gastric mucosa from indomethacin-induced gastric injury and its relationship with oxidant and antioxidant parameters in rats, J Pharm Pharmacol, 62, 85–90.
  • Ames B.N., Gold L.S. & Wille W.C. 1995. The causes and prevention of cancer, Proc Natl Acad Sci USA, 92, 5258–5265.
  • Aran N. 1988. Baharatın antimikrobiyal etkileri. 20. Diyabet ve Beslenme Günleri, 5. Diyabet Yıllığı: 16-18 Haziran, İstanbul, 383-387.
  • Atalay F., Halici M., Cadirci E., Aydin-Berktas O., Halici Z. & Cakir A. 2016. N-acetyl cysteine has both gastro-protective and anti-inflammatory effects in experimental rat models: Its gastro-protective effect is related to its in vivo and in vitro antioxidant properties, J Cell Biochem, 117, 308-319.
  • Baublis A. J., Clydesdale F. M. & Decker E. A. 2000. Antioxidants in Wheat-Based Breakfast Cereals, Cereals Foods World, 45, 71-74.
  • Baytop A. 1983. Farmasötik Botanik. İstanbul: İstanbul. Üniversitesi, Eczacılık Fakültesi Dilek Matbaasi Yayınları, 3158.
  • Bradley P.P., Priebat D.A., Christensen R.D. & Rothstein G. 1982. Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker J Invest Dermatol, 78, 206–20.
  • Cadirci E., Oral A., Odabasoglu F., Kilic C., Coskun K., Halici Z., Suleyman H., Keles O.N. & Unal B. 2016b. Alpha-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats, Shock, 33(5), 479–84.
  • Cadirci E., Altunkaynak B.Z., Halici Z., Odabasoglu F., Uyanik H., Gundogdu C., Suleyman H., Halici M., Albayrak M. & Unal B. 2010. Atorvastatin reduces tissue damage in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation, N-S Arch Pharmacol, 381(5), 455–466.
  • Caia Y., Luob Q., Sunc M. & Corkea H. 2004. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer Life Sci, 72, pp. 2157–2184.
  • Chen G., Kamal M., Hannon R. & Warner T.D. 1998. Regulation of cyclo-oxygenase gene expression in rat smooth muscle cells by catalase, Biochem Pharmacol, 55, 1621–1631.
  • Davis P.H. 1967. Flora of Turkey and the East Aegean Islands, Edinburgh:University Press, 2
  • De la Lastra C.A., Martin B.M., Herrerias M.J. & Motilva J.V. 2002. Extra virgin olive oil enriched diets reduce indomethacin-induced gastric oxidative damage in rats, Digest Dis Sci, 47, 2783-2790.
  • Elliott S.N. & Wallace J.L. 1997. Neutrophil-mediated gastrointestinal injury, Canadian journal of gastroenterology= Journal canadien de gastroenterologie, 12(8), 559-68.
  • El-Missiry M., El-Sayed I. & Othman A. 2001. Protection by metal complexes with SOD-mimetic activity against oxidative gastric injury induced by indometacin and ethanol in rats, An Clin Biochem, 38, 694-700.
  • Freeman B.A. & Crapo J.D. 1982. Free radicals and tissue injury, Lab Invest, 47, 412–426.
  • Giese J. 1994. Spices and seasoning blends:A taste for all seasons, Food Technol,48(4): 87-98
  • Gunther R.T. 1959. The Grek Herbal of Dioscorides. Hafner Publishing Co, New York.
  • Gurib F.A. 2006. Medicinal plants: traditions of yesterday and drugs of tomorrow, Mol Aspects Med, 27, 1-93.
  • Halici Z., Karaca M., Keles O.N., Borekci B., Odabasoglu F., Suleyman H., Cadirci E., Bayir Y. & Unal B. 2008. Protective effects of amlodipine on ischemia-reperfusion injury of rat ovary: biochemical and histopathologic evaluation, Fertil Steril, 90(6), 2408–2415.
  • Hiraishi H., Terano A., Ota S., Mutoh H., Sugimoto T., Harada T., Razandi M. & Ivey K. 1994. Protection of cultured rat gastric cells against oxidant-induced damage by exogenous glutathione, Gastroenterology, 106, 1199-1207.
  • Kandaz M., Ertekin M.C., Erdemc B., Kızıltunc A., Kocer I., Qzmen H.K., Aktan M.I. & Bese A.V. 2009. The effects of zinc sulfate on the levels of some elements and oxidative stress occurring in lenses of rats exposed to total cranium radiotherapy, Eurasian J Med, 41, 110–115.
  • Kaplan K.A., Odabasoglu F., Halici Z., Halici M., Cadirci E., Atalay F., Aydin O. & Cakir A. 2012. Alpha‐Lipoic Acid Protects against Indomethacin‐Induced Gastric Oxidative Toxicity by Modulating Antioxidant System, J Food Sci, 77(11), H224-H30.
  • Karaca M., Odabasoglu F., Kumtepe Y., Albayrak A., Cadirci E. & Keles O.N. 2009. Protective effects of erythropoietin on ischemia/reperfusion injury of rat ovary, Eur J Obstet Gynecol Reprod Biol, 144(2), 157–62.
  • Karaca T., Cemek B.F., Comba M., Ayaz B. & Karaboğa A. 2013. Effects of green tea extract and lactobacillus casei strain shirota on levels of serum minerals, cholesterol, triglycerides, glucose and lactate in rats fed on high-carbohydrate and high-lipid diets, Kafkas J Med Sci, 3(1), 1-7.
  • Karakus B., Odabasoglu F., Cakir A., Halici Z., Bayir Y., Halici M., Aslan A. & Suleyman H. 2009. The effects of methanol extract of Lobaria pulmonaria, a lichen species on indomethacin-induced gastric mucosal damage, oxidative stress, and neutrophil infiltration, Phytother Res, 23, 635–639.
  • Katiyar S.K. & Mukhtar H. 1997. Tea Antioxidants in Cancer Chemoprevention, J Cellular Bioch, Suppl. 27, 59-67.
  • Kaur C. & Kapoo H.C. 2001. Antioxidants in fruits and vegetables the millennium’s health, Int J Food Sci Technol, 703–725
  • Koc M., Imik H. & Odabasoglu F. 2008. Gastroprotective and anti-oxidative properties of ascorbic acid on indomethacin-induced gastric injuries in rats, Biol Trace Elem Res, 126 (1-3), 222–236.
  • Kosar M., Bozan B., Temelli F. & Baser K.H.C. 2007. Antioxidant activity and phenolic composition of sumac (Rhus coriaria L.) extracts, Food Chem, 103, 952–959.
  • Kumtepe Y., Odabasoglu F., Karaca M., Polat B., Halici M.B., Keles O.N., Altunkaynak Z. & Gocer F. 2010. Protective effects of telmisartan on ischemia/reperfusion injury of rat ovary: biochemical and histopathologic evaluation, Fertil Steril, 93(4), 1299-307.
  • Lachance P.A. 2002. Nutraceuticals, for real, Food Technol, 56, p. 20.
  • Luximon-Ramna L., Bahorun T. & Crozier A. 2003. Antioxidant action and phenolic and vitamin C contents of common Mauritian exotic fruits, J Sci Food Agric, 83, pp. 496– 502.
  • Mahadik S.P. & Scheffer R.E. 1996. Oxidative injury and potential use of antioxidants in schizophrenia, Prost Leukot Essent Fatty Acids, 55, 45–54.
  • Mates J.M., Perez-Gomez C. & Nudez de Castro I. 1999. Antioxidant enzymes and human diseases, Clin Biochem, 32, 595–603.
  • Mathew S. & Abraham T.E. 2006. Studies on the antioxidant activities of cinnamon (Cinnamomum verum) bark extracts, through various in vitro models, Food Chem, 94, 520-528.
  • Mitsuda H., Yasumoto K. & Iwami K. 1996. Antioxidative action of indole compounds during the autoxidation of linoleic acid, Eiyo to Shokuryo, 19, 210-214.
  • Miura T., Muraoka S. & Fujimoto Y. 2002. Lipid peroxidation induced by indomethacin with horseradish peroxidase and hydrogen peroxide: involvement of indomethacin radicals, Biochem Pharmacol, 63, 2069–2074.
  • Mizoguchi H., Ogawa Y., Kanatsu K., Tanaka A., Kato S. & Takeuchi K., 2001. Protective effect of rebamipide on indomethacin‐induced intestinal damage in rats, J Gastroen Hepatol, 16, 1112-1119.
  • Odabasoglu F. 2006. Alfa-lipoik asit, Pharma Sark, 1(4), 12–15.
  • Odabasoglu F., Karakus B., Bayir Y., Suleyman H., Yucel O., Aslan A., Cakir A. & Halici M. 2006b. Effects of methanol extract of Lobaria pulmonaria on glutathione s- transferase activity and gastric damages in rats, Drugs Future, 31(Suppl. A), 168.
  • Odabasoglu F., Halici M., Suleyman H., Aslan A., Bayir Y. & Cakir A. 2006a. The effects of olive oil and usnic acid on glutathione and lipid peroxidation levels in gastric damaged tissues induced by indomethacine in rats, Drugs Future, 31(Suppl. A), 168.
  • Odabasoglu F., Halici Z., Aygun H., Cakir A., Bayir Y., Halici M., Atalay F., Cadirci E. & Suleyman H. 2011. Alpha-lipoic acid has anti-inflammatory and anti-oxidative properties: An experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations, Brit J Nutr, 105, 31–43.
  • Ohkawa H., Ohishi H. & Yagi K. 1979. Assay for lipid peroxide in animal tissues by thiobarbutiric acid reaction, Anal Biochem, 95, 351–358. Pamuk A. 1998. Şifalı Bitkiler Ansiklopedisi. İstanbul: Pamuk Yayıncılık ve Matbaacılık, (1), 656.
  • Pruthi J.S. 1980. Spices and Condiments: Chemistry, Microbiology, Technology. Academic Press: New York, 449s.
  • Romani A., Coinu R., Carta S., Pinelli P., Galardi C., Vincieri F.F. & Franconi F. 2004. Evaluation of antioxidant effect of different extracts of Myrtus communis L, Free Radical Res, 38, 97–103.
  • Sakurai K. & Yamasaki K. 1994. Protective effect of rebamipide against hydrogen peroxide-induced hemorrhagic mucosal lesions in rat stomach, Jpn J Pharmacol, 64, 229-234.
  • Sandip K., Pakrashi B.S.C. & Pakrashi A. 2000. The role of antioxidant activity of Phyllanthus emblica fruits on prevention from indomethacin induced gastric ulcer, J Ethnopharmacol, 70, 171-176.
  • Sedlak J. & Lindsay R.H. 1968. Estimation of total, protein-bound, and nonprotein sulfhydryls groups in tissue with Ellman's reagent, Anal Biochem, 25,192–205.
  • Shan B., Cai Y.Z., Sun M. & Corke H. 2005. Antioxidant capacity of 26 spices extracts and characterization of their phenolic constituents, J Agric Food Chem, 53(20), 7749-7759.
  • Shelef L. A. 1983. Antimicrobial effects of spices, J Food Safety, 6, 29-44.
  • Sivritepe N. 2000. Asma, Üzüm ve Şaraptaki Antioksidantlar, Gıda. Dünya Yayınları, 12, 73-78.
  • Sun Y., Larry W.O. & Ying L. 1988. A simple method for clinical assay of superoxide dismutase, Clin Chem, 34, 497–500.
  • Szabo S. 1987. Mechanism of mucosal injury in the stomach and duodenum: time-sequence analysis of morphologic, functional, biochemical and histochemical studies, Scand J Gastroenterol, 127, 21–28.
  • Takeuchi K., Ueshima K., Hironaka Y., Fujioka Y., Matsumoto J. & Okabe S. 1991. Oxygen free radical and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats, Digestion, 49,175–184.
  • Tanas S., Odabasoglu F., Halici Z., Cakir A., Aygun H., Aslan A. & Suleyman, H. 2010.Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models, J Natur Med, 64 (1), 42-9
  • Tanas S., Odabasoglu F., Halici Z., Cakir A., Aygun H., Aslan A. & Suleyman H. 2010. Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models, J Natur Med, 64(1), 42-9
  • Toyokuni S., Tanaka T., Kawaguchi W., Fang N.R.R., Pzeki M., Akatsuka S., Hiai H., Aruoma O.I. & Bahorun T. 2003. Effects of the phenolic contents of Mauritian endemic plant extracts on promoter activities of antioxidant enzymes, Free Radical Res, 37, 1215–1224.
  • Weiss J.S. & Lobuglio A.F. 1982. Phagocyte-generated oxygen metabolites and cellular injury, Lab Invest, 47, 5–16.
  • Whittle B.J.R. 1981. Temporal relationship between COX inhibition, as measured by prostaglandin biosynthesis and the gastrointestinal damage induced by indomethacin in rat, Gastroenterology, 80, 94–98.,
  • Wildman R.E.C. 2001. Handbook of Nutraceuticals and Functional Foods. CRC Press: Boca Raton, FL.
  • Yaldız G. & Kılınç E. 2010. Electronic determination of spice consumption habits in Rize urban area, J Food Techn, 5, 28-34.
  • Yoshikawa T., Minamiyama Y., Ichikawa H., Takahashi S., Naito Y. & Kondo M. 1997. Role of lipid peroxidation and antioxidants in gastric mucosal injury induced by the hypoxanthine-xanthine oxidase system in rats, Free Radical Bio Med, 23, 243-250.

Gastroprotective and Antioxidant Effects of the Cinnamon, Cumin, Sumac on Indomethacin Induced Gastric Ulcer in Rats

Yıl 2021, Cilt 5, Sayı 2, 147 - 166, 31.12.2021

Öz

The gastro-protective effect of water extracts spice of cinnamon, cumin and sumac in indomethacin induced ulcer model in rats was investigated, in vivo and biochemical mechanism of spice extracts were monitored by measuring their antioxidant. For each cumin, cinnamon and sumach extracts 50, 100, 200 and 400 mg/kg, positive control famotidine (FAM) 25 mg/kg and negative control indomethacin (IND) 25 mg/kg dosage form was orally administered. After that catalase (CAT), superoxide dismutase (SOD), myeloperoxidase (MPx) enzyme activities and glutathione (GSH), lipid perxidase (LPO) amounts were measured. In IND induced ulcer group, It is determined that each four dosage form of spices and positive control FAM group significantly decreased the ulcer area (p<0.05). In addition to this, CAT, SOD, MPx enzyme activities and GSH, LPO amounts were measured in spice extract administered gastric damaged rat stomach tissues in order to explain the effects of antioxidant defense system on antiulcerogenic activity. In IND induced tissues, while LPO, MPx and CAT increased GSH and SOD decreased with respect to the (healthy) control group. It is claimed by the measured enzyme activity differences that these spices have antiulcerogenic activity. 

Kaynakça

  • Aebi H. 1984. Catalase Methods. Enzymol, 105, 121–126.
  • Akgül A. 1997. Baharatlar: Lezzet, koku ve renk dünyası, Gıda Sanayii, 48, 27-34.
  • Albayrak F., Odabasoglu F., Halici Z., Polat B., Dursun H., Uyanik A., Bayir Y., Koc F., Suleyman H. & Albayrak Y. 2010. The role of erythropoietin in the protection of gastric mucosa from indomethacin-induced gastric injury and its relationship with oxidant and antioxidant parameters in rats, J Pharm Pharmacol, 62, 85–90.
  • Ames B.N., Gold L.S. & Wille W.C. 1995. The causes and prevention of cancer, Proc Natl Acad Sci USA, 92, 5258–5265.
  • Aran N. 1988. Baharatın antimikrobiyal etkileri. 20. Diyabet ve Beslenme Günleri, 5. Diyabet Yıllığı: 16-18 Haziran, İstanbul, 383-387.
  • Atalay F., Halici M., Cadirci E., Aydin-Berktas O., Halici Z. & Cakir A. 2016. N-acetyl cysteine has both gastro-protective and anti-inflammatory effects in experimental rat models: Its gastro-protective effect is related to its in vivo and in vitro antioxidant properties, J Cell Biochem, 117, 308-319.
  • Baublis A. J., Clydesdale F. M. & Decker E. A. 2000. Antioxidants in Wheat-Based Breakfast Cereals, Cereals Foods World, 45, 71-74.
  • Baytop A. 1983. Farmasötik Botanik. İstanbul: İstanbul. Üniversitesi, Eczacılık Fakültesi Dilek Matbaasi Yayınları, 3158.
  • Bradley P.P., Priebat D.A., Christensen R.D. & Rothstein G. 1982. Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker J Invest Dermatol, 78, 206–20.
  • Cadirci E., Oral A., Odabasoglu F., Kilic C., Coskun K., Halici Z., Suleyman H., Keles O.N. & Unal B. 2016b. Alpha-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats, Shock, 33(5), 479–84.
  • Cadirci E., Altunkaynak B.Z., Halici Z., Odabasoglu F., Uyanik H., Gundogdu C., Suleyman H., Halici M., Albayrak M. & Unal B. 2010. Atorvastatin reduces tissue damage in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation, N-S Arch Pharmacol, 381(5), 455–466.
  • Caia Y., Luob Q., Sunc M. & Corkea H. 2004. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer Life Sci, 72, pp. 2157–2184.
  • Chen G., Kamal M., Hannon R. & Warner T.D. 1998. Regulation of cyclo-oxygenase gene expression in rat smooth muscle cells by catalase, Biochem Pharmacol, 55, 1621–1631.
  • Davis P.H. 1967. Flora of Turkey and the East Aegean Islands, Edinburgh:University Press, 2
  • De la Lastra C.A., Martin B.M., Herrerias M.J. & Motilva J.V. 2002. Extra virgin olive oil enriched diets reduce indomethacin-induced gastric oxidative damage in rats, Digest Dis Sci, 47, 2783-2790.
  • Elliott S.N. & Wallace J.L. 1997. Neutrophil-mediated gastrointestinal injury, Canadian journal of gastroenterology= Journal canadien de gastroenterologie, 12(8), 559-68.
  • El-Missiry M., El-Sayed I. & Othman A. 2001. Protection by metal complexes with SOD-mimetic activity against oxidative gastric injury induced by indometacin and ethanol in rats, An Clin Biochem, 38, 694-700.
  • Freeman B.A. & Crapo J.D. 1982. Free radicals and tissue injury, Lab Invest, 47, 412–426.
  • Giese J. 1994. Spices and seasoning blends:A taste for all seasons, Food Technol,48(4): 87-98
  • Gunther R.T. 1959. The Grek Herbal of Dioscorides. Hafner Publishing Co, New York.
  • Gurib F.A. 2006. Medicinal plants: traditions of yesterday and drugs of tomorrow, Mol Aspects Med, 27, 1-93.
  • Halici Z., Karaca M., Keles O.N., Borekci B., Odabasoglu F., Suleyman H., Cadirci E., Bayir Y. & Unal B. 2008. Protective effects of amlodipine on ischemia-reperfusion injury of rat ovary: biochemical and histopathologic evaluation, Fertil Steril, 90(6), 2408–2415.
  • Hiraishi H., Terano A., Ota S., Mutoh H., Sugimoto T., Harada T., Razandi M. & Ivey K. 1994. Protection of cultured rat gastric cells against oxidant-induced damage by exogenous glutathione, Gastroenterology, 106, 1199-1207.
  • Kandaz M., Ertekin M.C., Erdemc B., Kızıltunc A., Kocer I., Qzmen H.K., Aktan M.I. & Bese A.V. 2009. The effects of zinc sulfate on the levels of some elements and oxidative stress occurring in lenses of rats exposed to total cranium radiotherapy, Eurasian J Med, 41, 110–115.
  • Kaplan K.A., Odabasoglu F., Halici Z., Halici M., Cadirci E., Atalay F., Aydin O. & Cakir A. 2012. Alpha‐Lipoic Acid Protects against Indomethacin‐Induced Gastric Oxidative Toxicity by Modulating Antioxidant System, J Food Sci, 77(11), H224-H30.
  • Karaca M., Odabasoglu F., Kumtepe Y., Albayrak A., Cadirci E. & Keles O.N. 2009. Protective effects of erythropoietin on ischemia/reperfusion injury of rat ovary, Eur J Obstet Gynecol Reprod Biol, 144(2), 157–62.
  • Karaca T., Cemek B.F., Comba M., Ayaz B. & Karaboğa A. 2013. Effects of green tea extract and lactobacillus casei strain shirota on levels of serum minerals, cholesterol, triglycerides, glucose and lactate in rats fed on high-carbohydrate and high-lipid diets, Kafkas J Med Sci, 3(1), 1-7.
  • Karakus B., Odabasoglu F., Cakir A., Halici Z., Bayir Y., Halici M., Aslan A. & Suleyman H. 2009. The effects of methanol extract of Lobaria pulmonaria, a lichen species on indomethacin-induced gastric mucosal damage, oxidative stress, and neutrophil infiltration, Phytother Res, 23, 635–639.
  • Katiyar S.K. & Mukhtar H. 1997. Tea Antioxidants in Cancer Chemoprevention, J Cellular Bioch, Suppl. 27, 59-67.
  • Kaur C. & Kapoo H.C. 2001. Antioxidants in fruits and vegetables the millennium’s health, Int J Food Sci Technol, 703–725
  • Koc M., Imik H. & Odabasoglu F. 2008. Gastroprotective and anti-oxidative properties of ascorbic acid on indomethacin-induced gastric injuries in rats, Biol Trace Elem Res, 126 (1-3), 222–236.
  • Kosar M., Bozan B., Temelli F. & Baser K.H.C. 2007. Antioxidant activity and phenolic composition of sumac (Rhus coriaria L.) extracts, Food Chem, 103, 952–959.
  • Kumtepe Y., Odabasoglu F., Karaca M., Polat B., Halici M.B., Keles O.N., Altunkaynak Z. & Gocer F. 2010. Protective effects of telmisartan on ischemia/reperfusion injury of rat ovary: biochemical and histopathologic evaluation, Fertil Steril, 93(4), 1299-307.
  • Lachance P.A. 2002. Nutraceuticals, for real, Food Technol, 56, p. 20.
  • Luximon-Ramna L., Bahorun T. & Crozier A. 2003. Antioxidant action and phenolic and vitamin C contents of common Mauritian exotic fruits, J Sci Food Agric, 83, pp. 496– 502.
  • Mahadik S.P. & Scheffer R.E. 1996. Oxidative injury and potential use of antioxidants in schizophrenia, Prost Leukot Essent Fatty Acids, 55, 45–54.
  • Mates J.M., Perez-Gomez C. & Nudez de Castro I. 1999. Antioxidant enzymes and human diseases, Clin Biochem, 32, 595–603.
  • Mathew S. & Abraham T.E. 2006. Studies on the antioxidant activities of cinnamon (Cinnamomum verum) bark extracts, through various in vitro models, Food Chem, 94, 520-528.
  • Mitsuda H., Yasumoto K. & Iwami K. 1996. Antioxidative action of indole compounds during the autoxidation of linoleic acid, Eiyo to Shokuryo, 19, 210-214.
  • Miura T., Muraoka S. & Fujimoto Y. 2002. Lipid peroxidation induced by indomethacin with horseradish peroxidase and hydrogen peroxide: involvement of indomethacin radicals, Biochem Pharmacol, 63, 2069–2074.
  • Mizoguchi H., Ogawa Y., Kanatsu K., Tanaka A., Kato S. & Takeuchi K., 2001. Protective effect of rebamipide on indomethacin‐induced intestinal damage in rats, J Gastroen Hepatol, 16, 1112-1119.
  • Odabasoglu F. 2006. Alfa-lipoik asit, Pharma Sark, 1(4), 12–15.
  • Odabasoglu F., Karakus B., Bayir Y., Suleyman H., Yucel O., Aslan A., Cakir A. & Halici M. 2006b. Effects of methanol extract of Lobaria pulmonaria on glutathione s- transferase activity and gastric damages in rats, Drugs Future, 31(Suppl. A), 168.
  • Odabasoglu F., Halici M., Suleyman H., Aslan A., Bayir Y. & Cakir A. 2006a. The effects of olive oil and usnic acid on glutathione and lipid peroxidation levels in gastric damaged tissues induced by indomethacine in rats, Drugs Future, 31(Suppl. A), 168.
  • Odabasoglu F., Halici Z., Aygun H., Cakir A., Bayir Y., Halici M., Atalay F., Cadirci E. & Suleyman H. 2011. Alpha-lipoic acid has anti-inflammatory and anti-oxidative properties: An experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations, Brit J Nutr, 105, 31–43.
  • Ohkawa H., Ohishi H. & Yagi K. 1979. Assay for lipid peroxide in animal tissues by thiobarbutiric acid reaction, Anal Biochem, 95, 351–358. Pamuk A. 1998. Şifalı Bitkiler Ansiklopedisi. İstanbul: Pamuk Yayıncılık ve Matbaacılık, (1), 656.
  • Pruthi J.S. 1980. Spices and Condiments: Chemistry, Microbiology, Technology. Academic Press: New York, 449s.
  • Romani A., Coinu R., Carta S., Pinelli P., Galardi C., Vincieri F.F. & Franconi F. 2004. Evaluation of antioxidant effect of different extracts of Myrtus communis L, Free Radical Res, 38, 97–103.
  • Sakurai K. & Yamasaki K. 1994. Protective effect of rebamipide against hydrogen peroxide-induced hemorrhagic mucosal lesions in rat stomach, Jpn J Pharmacol, 64, 229-234.
  • Sandip K., Pakrashi B.S.C. & Pakrashi A. 2000. The role of antioxidant activity of Phyllanthus emblica fruits on prevention from indomethacin induced gastric ulcer, J Ethnopharmacol, 70, 171-176.
  • Sedlak J. & Lindsay R.H. 1968. Estimation of total, protein-bound, and nonprotein sulfhydryls groups in tissue with Ellman's reagent, Anal Biochem, 25,192–205.
  • Shan B., Cai Y.Z., Sun M. & Corke H. 2005. Antioxidant capacity of 26 spices extracts and characterization of their phenolic constituents, J Agric Food Chem, 53(20), 7749-7759.
  • Shelef L. A. 1983. Antimicrobial effects of spices, J Food Safety, 6, 29-44.
  • Sivritepe N. 2000. Asma, Üzüm ve Şaraptaki Antioksidantlar, Gıda. Dünya Yayınları, 12, 73-78.
  • Sun Y., Larry W.O. & Ying L. 1988. A simple method for clinical assay of superoxide dismutase, Clin Chem, 34, 497–500.
  • Szabo S. 1987. Mechanism of mucosal injury in the stomach and duodenum: time-sequence analysis of morphologic, functional, biochemical and histochemical studies, Scand J Gastroenterol, 127, 21–28.
  • Takeuchi K., Ueshima K., Hironaka Y., Fujioka Y., Matsumoto J. & Okabe S. 1991. Oxygen free radical and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats, Digestion, 49,175–184.
  • Tanas S., Odabasoglu F., Halici Z., Cakir A., Aygun H., Aslan A. & Suleyman, H. 2010.Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models, J Natur Med, 64 (1), 42-9
  • Tanas S., Odabasoglu F., Halici Z., Cakir A., Aygun H., Aslan A. & Suleyman H. 2010. Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models, J Natur Med, 64(1), 42-9
  • Toyokuni S., Tanaka T., Kawaguchi W., Fang N.R.R., Pzeki M., Akatsuka S., Hiai H., Aruoma O.I. & Bahorun T. 2003. Effects of the phenolic contents of Mauritian endemic plant extracts on promoter activities of antioxidant enzymes, Free Radical Res, 37, 1215–1224.
  • Weiss J.S. & Lobuglio A.F. 1982. Phagocyte-generated oxygen metabolites and cellular injury, Lab Invest, 47, 5–16.
  • Whittle B.J.R. 1981. Temporal relationship between COX inhibition, as measured by prostaglandin biosynthesis and the gastrointestinal damage induced by indomethacin in rat, Gastroenterology, 80, 94–98.,
  • Wildman R.E.C. 2001. Handbook of Nutraceuticals and Functional Foods. CRC Press: Boca Raton, FL.
  • Yaldız G. & Kılınç E. 2010. Electronic determination of spice consumption habits in Rize urban area, J Food Techn, 5, 28-34.
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Ayrıntılar

Birincil Dil İngilizce
Konular Gıda Bilimi ve Teknolojisi
Bölüm Article
Yazarlar

Özlem AYDIN BERKTAŞ (Sorumlu Yazar)
Giresun Univ. Healthy Science Fac. Nursing Dep.
Türkiye


Fehmi ODABASOGLU
KAFKAS ÜNİVERSİTESİ, TIP FAKÜLTESİ
Türkiye


Fadime ATALAY DUMLU
KAFKAS UNIVERSITY
Türkiye


Zerrin KUTLU
ATATURK UNIVERSITY
0000-0002-6279-9810
Türkiye


Elif ÇADIRCI
ATATURK UNIVERSITY
0000-0003-0836-7205
Türkiye


Mesut HALICI
ATATURK UNIVERSITY
0000-0002-7473-2955
Türkiye


Fazlı ÖZTÜRK
VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ
Türkiye


Ahmet ÇAKIR
KILIS 7 ARALIK UNIVERSITY
Türkiye

Yayımlanma Tarihi 31 Aralık 2021
Yayınlandığı Sayı Yıl 2021, Cilt 5, Sayı 2

Kaynak Göster

Bibtex @araştırma makalesi { ejfst958381, journal = {Eurasian Journal of Food Science and Technology}, issn = {}, eissn = {2667-4890}, address = {Nevşehir Hacı Bektaş Veli Üniversitesi Mühendislik Mimarlık Fakültesi Biyosistem Mühendisliği Bölümü, Nevşehir}, publisher = {İlknur BAĞDATLI}, year = {2021}, volume = {5}, pages = {147 - 166}, doi = {}, title = {Gastroprotective and Antioxidant Effects of the Cinnamon, Cumin, Sumac on Indomethacin Induced Gastric Ulcer in Rats}, key = {cite}, author = {Aydın Berktaş, Özlem and Odabasoglu, Fehmi and Atalay Dumlu, Fadime and Kutlu, Zerrin and Çadırcı, Elif and Halıcı, Mesut and Öztürk, Fazlı and Çakır, Ahmet} }
APA Aydın Berktaş, Ö. , Odabasoglu, F. , Atalay Dumlu, F. , Kutlu, Z. , Çadırcı, E. , Halıcı, M. , Öztürk, F. & Çakır, A. (2021). Gastroprotective and Antioxidant Effects of the Cinnamon, Cumin, Sumac on Indomethacin Induced Gastric Ulcer in Rats . Eurasian Journal of Food Science and Technology , Volume 5 Issue 2 , 147-166 . Retrieved from https://dergipark.org.tr/tr/pub/ejfst/issue/67811/958381
MLA Aydın Berktaş, Ö. , Odabasoglu, F. , Atalay Dumlu, F. , Kutlu, Z. , Çadırcı, E. , Halıcı, M. , Öztürk, F. , Çakır, A. "Gastroprotective and Antioxidant Effects of the Cinnamon, Cumin, Sumac on Indomethacin Induced Gastric Ulcer in Rats" . Eurasian Journal of Food Science and Technology 5 (2021 ): 147-166 <https://dergipark.org.tr/tr/pub/ejfst/issue/67811/958381>
Chicago Aydın Berktaş, Ö. , Odabasoglu, F. , Atalay Dumlu, F. , Kutlu, Z. , Çadırcı, E. , Halıcı, M. , Öztürk, F. , Çakır, A. "Gastroprotective and Antioxidant Effects of the Cinnamon, Cumin, Sumac on Indomethacin Induced Gastric Ulcer in Rats". Eurasian Journal of Food Science and Technology 5 (2021 ): 147-166
RIS TY - JOUR T1 - Gastroprotective and Antioxidant Effects of the Cinnamon, Cumin, Sumac on Indomethacin Induced Gastric Ulcer in Rats AU - Özlem Aydın Berktaş , Fehmi Odabasoglu , Fadime Atalay Dumlu , Zerrin Kutlu , Elif Çadırcı , Mesut Halıcı , Fazlı Öztürk , Ahmet Çakır Y1 - 2021 PY - 2021 N1 - DO - T2 - Eurasian Journal of Food Science and Technology JF - Journal JO - JOR SP - 147 EP - 166 VL - 5 IS - 2 SN - -2667-4890 M3 - UR - Y2 - 2021 ER -
EndNote %0 Eurasian Journal of Food Science and Technology Gastroprotective and Antioxidant Effects of the Cinnamon, Cumin, Sumac on Indomethacin Induced Gastric Ulcer in Rats %A Özlem Aydın Berktaş , Fehmi Odabasoglu , Fadime Atalay Dumlu , Zerrin Kutlu , Elif Çadırcı , Mesut Halıcı , Fazlı Öztürk , Ahmet Çakır %T Gastroprotective and Antioxidant Effects of the Cinnamon, Cumin, Sumac on Indomethacin Induced Gastric Ulcer in Rats %D 2021 %J Eurasian Journal of Food Science and Technology %P -2667-4890 %V 5 %N 2 %R %U
ISNAD Aydın Berktaş, Özlem , Odabasoglu, Fehmi , Atalay Dumlu, Fadime , Kutlu, Zerrin , Çadırcı, Elif , Halıcı, Mesut , Öztürk, Fazlı , Çakır, Ahmet . "Gastroprotective and Antioxidant Effects of the Cinnamon, Cumin, Sumac on Indomethacin Induced Gastric Ulcer in Rats". Eurasian Journal of Food Science and Technology 5 / 2 (Aralık 2021): 147-166 .
AMA Aydın Berktaş Ö. , Odabasoglu F. , Atalay Dumlu F. , Kutlu Z. , Çadırcı E. , Halıcı M. , Öztürk F. , Çakır A. Gastroprotective and Antioxidant Effects of the Cinnamon, Cumin, Sumac on Indomethacin Induced Gastric Ulcer in Rats. EJFST. 2021; 5(2): 147-166.
Vancouver Aydın Berktaş Ö. , Odabasoglu F. , Atalay Dumlu F. , Kutlu Z. , Çadırcı E. , Halıcı M. , Öztürk F. , Çakır A. Gastroprotective and Antioxidant Effects of the Cinnamon, Cumin, Sumac on Indomethacin Induced Gastric Ulcer in Rats. Eurasian Journal of Food Science and Technology. 2021; 5(2): 147-166.
IEEE Ö. Aydın Berktaş , F. Odabasoglu , F. Atalay Dumlu , Z. Kutlu , E. Çadırcı , M. Halıcı , F. Öztürk ve A. Çakır , "Gastroprotective and Antioxidant Effects of the Cinnamon, Cumin, Sumac on Indomethacin Induced Gastric Ulcer in Rats", Eurasian Journal of Food Science and Technology, c. 5, sayı. 2, ss. 147-166, Ara. 2021

Eurasian Journal of Food Science and Technology (EJFST)   e-ISSN: 2667-4890   Web: https://dergipark.org.tr/en/pub/ejfst   e-mail: foodsciencejournal@gmail.com