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Cognitive function and event related potentials in children with type I diabetes mellitus

Yıl 2007, Cilt: 12 Sayı: 1-2, 25 - 31, 20.03.2013

Öz

Abstract. Type 1 diabetes mellitus is associated with cognitive changes, but the extent of cognition decline depends on age at onset, duration of diabetes and occurrence of attacks of hypoglycemia or ketoacidosis.This study was designed to assess cognitive function in a group of children with type I diabetes mellitus. Forty diabetic children, with mean age at onset of 8.59±2.71 year, were recruited from the Pediatric Department of Assuit University Hospital, Egypt. Forty healthy children matched for age, sex, socioeconomic states were chosen as controls for comparison. Cognition was assessed using the psychometric (Stanford Binet test) and electrophysiologic (Event Related Potentials) tests. Compared to control group, patients reported significant reduction in intelligent quotient, comprehension, abstract visual reasoning, quantitative reasoning, bead memory and total short memory testing for cognitive functions. Prolonged N1, P200, N2 and P300 latencies and reduced P300-N2 amplitude of event related potentials were also reported. Significant negative correlations were identified between in most studied cognitive functions and ketoacidosis or family history of diabetes mellitus. Type I diabetes mellitus and diabetes-related factors are important risks for cognitive deficits in children group of population.

Key words: Type I diabetes mellitus,cognitive functions, event related potentials

Kaynakça

  • 1. Northam EA, Anderson PJ, Jacobs R, Hughes M, Warne GL, Werther GA. Neuropsychological profiles of children with type 1 diabetes 6 years after disease onset. Diabetes Care. 2001; 24: 1541 -1546.
  • 2. Rayn CM, Why is cognitive dysfunction associated with the development of diabetes early in life? The diathesis hypothesis. Pediatr Diabetes 2006; 7: 289-297.
  • 3. Ryan CM, Memory and metabolic control in children. Diabetes Care 1999; 22: 1239-1241.
  • 4. McCarthy AM, Lindgren S, Mengeling MA, Tsalikian E, Engvall JC. Effects of diabetes on learning in children. Pediatrics 2002; 109-e9.
  • 5. Schoenle, EJ, Schoenle D, Molinari L, Largo RH. Impaired intellectual development in children with type 1 diabetes: Association with HbA1c, age at diagnosis and sex. Diabetologia 2002; 45: 108- 114.
  • 6. Hagen J, Barclay C, Anderson B, et al. Intellective functioning and strategy use in children with insulin-dependent diabetes mellitus. Child Development 1990; 6: 1714-1727.
  • 7. Elwan O, Madkour O, Elwan F, et al, Brain aging in normal Egyptians: cognition, education, personality, genetic and immunological study, J. Neurol Sci 2003; 122: 15-22.
  • 8. Elwan O, Helmy AA, Abdel Naseer M, Elwan F, El-Banhawy E, El-Fatatry M. Brain aging in a sample of normal Egyptian cognition, education, addiction and smoking. J Neurol Sci 1997; 148: 79-86.
  • 9. Farrage AF, Khedr EM, Abdel-Aleem H and Rageh TA. Effect of Surgical Menopause on Cognitive Functions, Dementia and Geriatric Cognitive Disorders 2002; 13: 193-198.
  • 10. Zadeh RA, and Wyah DT, Diabetes Mellitus in Children. In Nelson Textbook of Pediatrics, WB Saunders, 7th edition; 2004. ch.583.p.1947.
  • 11. Fahmy SI. El-Sherbini AF. Determining simple parameters for social classification for health research. The Bulletin of the High Institute of Public Health, 1983; Vol. V111, No 5.
  • 12. Hershey T, Perantie DC, Warren Sl, Zimmerman Ec, Sadler M,White NH. Frequency and timing of severe hypoglycemia affects spatial memory in children with type 1 diabetes. Diabetes Care, 2005; Oct; 28 (10): 2372-2377.
  • 13. Nedlman RD, Growth and Development. In Nilson Textbook of Pediatrics, WB Saunders, 7th edition; 2004. ch. 7.p.23.
  • 14. Melika LK, The Stanford. Binet Intelligence scale: fourth Edition, Arabic Examiner’s Handbook. Dar El _Maref Publishing, Egypt, Cairo, 1998.
  • 15. Delany EA, and Hopkins TF, the Stanford. Binet Intelligence scale: fourth Edition: Examiner’s Handbook. Chicago. The Riverside Publishing Co., 1986.
  • 16. Hansch EC, Syndalko K, Cohen SN, Goldberg ZI, Potvin AR, Touretellotte WW. Cognition in Parkinson’s disease: An event related potential perspective. Ann Neurol 1982; 11: 599-607.
  • 17. Ferguson C, Stewart, Annette B, et al. Influence of an early onset age of type 1 diabetes on cerebral structure and cognitive function. Diabetes care 2005; 28: 1431-1437.
  • 18. Rovert J, Ehrlich R, Hope M, Behavioral problems in children with diabetes as a function of sex and age of onset of disease. J Child Psychol Psychiatry 1987; 28: 477-491.
  • 19. Ryan CM. Diabetes, aging and cognitive decline. Neurobiological Aging. 2005; 26, (suppl 1): 21-5.
  • 20. Biessels GJ, Heide LP, Kamal A, Bleys RL, Gispen WH. Ageing and diabetes: implications for brain function Eur J Pharmacol 2002;441: 1– 14
  • 21. Polich J, Starr A. Evoked potentials in aging. In Clinical Neurology of Aging, Ed., ML Albert. New York: Oxford University Press, 1984; pp 149-177.
  • 22. Polich J. P300 in the evaluation of aging and dementia. In Event-Related Brain Potential Research; EEG Supplement Eds., M. Brunia, G. Mulder, and M.N Verbaten. Amsterdam: Elsevier, 1991.
  • 23. Fukai M, Motomura N, Kobayashi S, Asaba H and Sakai T. Event-related potential (P300) in epilepsy. Acta Neurol Scand 1990; 82:197-202.
  • 24. McCall AL. The impact of diabetes on the CNS. Diabetes 1992; 41: 557-570.
  • 25. Araki A., Ito H. Glucose metabolism, advanced glycation endproducts, and cognition. Geriatrics and Gerontology International 2004; 4 Issue S1 Page S108
  • 26. RyanC. Vega A. Drash A. Cognitive deficit in adolescents who develop diabetes early in life. Pediatrics, 1985; 75:921-7.
  • 27. Ornoy A, Ratzon N, Greenbaum C, Peretz E, Soriano D, Dulitzky M. Neurobehaviour of school age children born to diabetic mothers. Arch Dis Child Fetal Neonatal Ed .2006; 79:F94–F9.
  • 28. Acardo PJ, Blondis TA, Whirman BY. Disorders of attention and activity level in a referral population. Pediatrics 1990; 85: 426-31.
  • 29. Strudwick Sk, CarneC, Gardiner J, Foster Jk, Davis Ea, Jones TW. Cognitive functioning in children with early onset type 1 diabetes and severe hypoglycemia. J Pediatric 2005; 147: 680- 685.
  • 30. Wisocki T, Harris MA, Mauras N, Tailor LA. Absence of adverse effects of severe hypoglycemia on cognitive function in School aged children with diabetes over 18 months. Diabetes care, 2003: vol 26, number 4. 2003; 26: 1100-1105.
  • 31. Matyka KA, Wigg L, Pramming S, Stores G, Dunger DB. Cognitive function and mood after profound nocturnal hypoglycemia in prepubertal children with conventional insulin treatment for diabetes Arch Dis Child 1999; 81: 138-142.
Yıl 2007, Cilt: 12 Sayı: 1-2, 25 - 31, 20.03.2013

Öz

Kaynakça

  • 1. Northam EA, Anderson PJ, Jacobs R, Hughes M, Warne GL, Werther GA. Neuropsychological profiles of children with type 1 diabetes 6 years after disease onset. Diabetes Care. 2001; 24: 1541 -1546.
  • 2. Rayn CM, Why is cognitive dysfunction associated with the development of diabetes early in life? The diathesis hypothesis. Pediatr Diabetes 2006; 7: 289-297.
  • 3. Ryan CM, Memory and metabolic control in children. Diabetes Care 1999; 22: 1239-1241.
  • 4. McCarthy AM, Lindgren S, Mengeling MA, Tsalikian E, Engvall JC. Effects of diabetes on learning in children. Pediatrics 2002; 109-e9.
  • 5. Schoenle, EJ, Schoenle D, Molinari L, Largo RH. Impaired intellectual development in children with type 1 diabetes: Association with HbA1c, age at diagnosis and sex. Diabetologia 2002; 45: 108- 114.
  • 6. Hagen J, Barclay C, Anderson B, et al. Intellective functioning and strategy use in children with insulin-dependent diabetes mellitus. Child Development 1990; 6: 1714-1727.
  • 7. Elwan O, Madkour O, Elwan F, et al, Brain aging in normal Egyptians: cognition, education, personality, genetic and immunological study, J. Neurol Sci 2003; 122: 15-22.
  • 8. Elwan O, Helmy AA, Abdel Naseer M, Elwan F, El-Banhawy E, El-Fatatry M. Brain aging in a sample of normal Egyptian cognition, education, addiction and smoking. J Neurol Sci 1997; 148: 79-86.
  • 9. Farrage AF, Khedr EM, Abdel-Aleem H and Rageh TA. Effect of Surgical Menopause on Cognitive Functions, Dementia and Geriatric Cognitive Disorders 2002; 13: 193-198.
  • 10. Zadeh RA, and Wyah DT, Diabetes Mellitus in Children. In Nelson Textbook of Pediatrics, WB Saunders, 7th edition; 2004. ch.583.p.1947.
  • 11. Fahmy SI. El-Sherbini AF. Determining simple parameters for social classification for health research. The Bulletin of the High Institute of Public Health, 1983; Vol. V111, No 5.
  • 12. Hershey T, Perantie DC, Warren Sl, Zimmerman Ec, Sadler M,White NH. Frequency and timing of severe hypoglycemia affects spatial memory in children with type 1 diabetes. Diabetes Care, 2005; Oct; 28 (10): 2372-2377.
  • 13. Nedlman RD, Growth and Development. In Nilson Textbook of Pediatrics, WB Saunders, 7th edition; 2004. ch. 7.p.23.
  • 14. Melika LK, The Stanford. Binet Intelligence scale: fourth Edition, Arabic Examiner’s Handbook. Dar El _Maref Publishing, Egypt, Cairo, 1998.
  • 15. Delany EA, and Hopkins TF, the Stanford. Binet Intelligence scale: fourth Edition: Examiner’s Handbook. Chicago. The Riverside Publishing Co., 1986.
  • 16. Hansch EC, Syndalko K, Cohen SN, Goldberg ZI, Potvin AR, Touretellotte WW. Cognition in Parkinson’s disease: An event related potential perspective. Ann Neurol 1982; 11: 599-607.
  • 17. Ferguson C, Stewart, Annette B, et al. Influence of an early onset age of type 1 diabetes on cerebral structure and cognitive function. Diabetes care 2005; 28: 1431-1437.
  • 18. Rovert J, Ehrlich R, Hope M, Behavioral problems in children with diabetes as a function of sex and age of onset of disease. J Child Psychol Psychiatry 1987; 28: 477-491.
  • 19. Ryan CM. Diabetes, aging and cognitive decline. Neurobiological Aging. 2005; 26, (suppl 1): 21-5.
  • 20. Biessels GJ, Heide LP, Kamal A, Bleys RL, Gispen WH. Ageing and diabetes: implications for brain function Eur J Pharmacol 2002;441: 1– 14
  • 21. Polich J, Starr A. Evoked potentials in aging. In Clinical Neurology of Aging, Ed., ML Albert. New York: Oxford University Press, 1984; pp 149-177.
  • 22. Polich J. P300 in the evaluation of aging and dementia. In Event-Related Brain Potential Research; EEG Supplement Eds., M. Brunia, G. Mulder, and M.N Verbaten. Amsterdam: Elsevier, 1991.
  • 23. Fukai M, Motomura N, Kobayashi S, Asaba H and Sakai T. Event-related potential (P300) in epilepsy. Acta Neurol Scand 1990; 82:197-202.
  • 24. McCall AL. The impact of diabetes on the CNS. Diabetes 1992; 41: 557-570.
  • 25. Araki A., Ito H. Glucose metabolism, advanced glycation endproducts, and cognition. Geriatrics and Gerontology International 2004; 4 Issue S1 Page S108
  • 26. RyanC. Vega A. Drash A. Cognitive deficit in adolescents who develop diabetes early in life. Pediatrics, 1985; 75:921-7.
  • 27. Ornoy A, Ratzon N, Greenbaum C, Peretz E, Soriano D, Dulitzky M. Neurobehaviour of school age children born to diabetic mothers. Arch Dis Child Fetal Neonatal Ed .2006; 79:F94–F9.
  • 28. Acardo PJ, Blondis TA, Whirman BY. Disorders of attention and activity level in a referral population. Pediatrics 1990; 85: 426-31.
  • 29. Strudwick Sk, CarneC, Gardiner J, Foster Jk, Davis Ea, Jones TW. Cognitive functioning in children with early onset type 1 diabetes and severe hypoglycemia. J Pediatric 2005; 147: 680- 685.
  • 30. Wisocki T, Harris MA, Mauras N, Tailor LA. Absence of adverse effects of severe hypoglycemia on cognitive function in School aged children with diabetes over 18 months. Diabetes care, 2003: vol 26, number 4. 2003; 26: 1100-1105.
  • 31. Matyka KA, Wigg L, Pramming S, Stores G, Dunger DB. Cognitive function and mood after profound nocturnal hypoglycemia in prepubertal children with conventional insulin treatment for diabetes Arch Dis Child 1999; 81: 138-142.
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Articles
Yazarlar

Ghaydaa A. Shehata Bu kişi benim

Azza A. Eltayeb Bu kişi benim

Yayımlanma Tarihi 20 Mart 2013
Yayımlandığı Sayı Yıl 2007 Cilt: 12 Sayı: 1-2

Kaynak Göster

APA Shehata, G. A., & Eltayeb, A. A. (2013). Cognitive function and event related potentials in children with type I diabetes mellitus. EASTERN JOURNAL OF MEDICINE, 12(1-2), 25-31.
AMA Shehata GA, Eltayeb AA. Cognitive function and event related potentials in children with type I diabetes mellitus. EASTERN JOURNAL OF MEDICINE. Mart 2013;12(1-2):25-31.
Chicago Shehata, Ghaydaa A., ve Azza A. Eltayeb. “Cognitive Function and Event Related Potentials in Children With Type I Diabetes Mellitus”. EASTERN JOURNAL OF MEDICINE 12, sy. 1-2 (Mart 2013): 25-31.
EndNote Shehata GA, Eltayeb AA (01 Mart 2013) Cognitive function and event related potentials in children with type I diabetes mellitus. EASTERN JOURNAL OF MEDICINE 12 1-2 25–31.
IEEE G. A. Shehata ve A. A. Eltayeb, “Cognitive function and event related potentials in children with type I diabetes mellitus”, EASTERN JOURNAL OF MEDICINE, c. 12, sy. 1-2, ss. 25–31, 2013.
ISNAD Shehata, Ghaydaa A. - Eltayeb, Azza A. “Cognitive Function and Event Related Potentials in Children With Type I Diabetes Mellitus”. EASTERN JOURNAL OF MEDICINE 12/1-2 (Mart 2013), 25-31.
JAMA Shehata GA, Eltayeb AA. Cognitive function and event related potentials in children with type I diabetes mellitus. EASTERN JOURNAL OF MEDICINE. 2013;12:25–31.
MLA Shehata, Ghaydaa A. ve Azza A. Eltayeb. “Cognitive Function and Event Related Potentials in Children With Type I Diabetes Mellitus”. EASTERN JOURNAL OF MEDICINE, c. 12, sy. 1-2, 2013, ss. 25-31.
Vancouver Shehata GA, Eltayeb AA. Cognitive function and event related potentials in children with type I diabetes mellitus. EASTERN JOURNAL OF MEDICINE. 2013;12(1-2):25-31.