Hypothalamic hamartoma presenting with gelastic seizures and precocious puberty: Report of a case

Yıl 2010, Cilt: 15 Sayı: 2, 67 - 70, 16.01.2013

Feroze Shaheen Aijaz Hakim Maqbool Wani Rauf Asmi

Öz

Abstract. Hypothalamic hamartoma is a rare condition and usually presents with precocious puberty. Clinical manifestation as gelastic seizures is less common and combined presentation as gelastic seizures and precocious puberty is even less frequent. Being a treatable condition, prompt diagnosis is important. offers precise diagnosis in most cases.

Key words:  Hypothalamic hamartoma, gelastic seizures, precocious puberty, MRI

Anahtar Kelimeler

Hypothalamic hamartoma, gelastic seizures, precocious puberty, MRI

Kaynakça

• Hahn FJ, Leibrock LG, Huseman CA, Makos MM. The MR appearance of hypothalamic hamartoma. Neuroradiology 1988; 30: 65-68.
• Munari C, Kahane P, Francione S et al. Role of the hypothalamic hamartoma in the genesis of gelastic fits (avideo-stereo-EEG study). Electroencephalogr Clin Neurophysiol 1995; 95: 154-160.
• Northfield DW. Russell DS Pubertas praecox due to hypothalamic hamartoma: report of two cases surviving surgical removal of the tumor. J. Neurol Neurosurg Psychiatry 1967; 30: 166-173.
• Karnaze MG, Sartor K, Winthrop JD, Gado MH, Hodges FJ. 3rd. Suprasellar lesions: evaluation with MR imaging. Radiology 1986; 161: 77-82.
• Freeman JL, Coleman LT, Wellard RM, et al. MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases. AJNR Am J Neuroradiol 2004; 25: 450-62.
• Tasch F, Candes F, Li LM. Hypothalamic hamartoma and gelastic epilepsy: a spectroscopic study. Neurology 1998; 51: 1046-1050.
• Barkovich AJ. Intracranial, orbital and neck tumors of childhood: Pediatric Neuroimaging- Philadelphia Lippincot and Wilkins 2000: 443- 580.
• Lona Soto A, Takahashi M, Yamashita Y, Sakamoto Y, Shinzato J. MRI findings of hypothalamic hamartoma; report of five cases and review of literature. Comput Med Imaging Graph 1991; 15:15-21.
• Marliani AF, Tampieri D, Melancon D, Ethier R, Berkovic SF, Andermann F. Magnetic Resonance Imaging of hypothalamic hamartoma causing gelastic epilepsy. Can Assoc. Radiol J 1991; 42: 335-339.
• de Brito VN, Latronico AC, Arnhold IJ, Lo LS. Domenice S. Treatment of gonadotrophin dependent precocious puberty due to hypothalamic hamartoma with gonadotrophin releasing harmone agonist depot. Arch Dis Child 1999; 80: 231-234.
• Gascon GG, Lumbroso CT. Epileptic laughter Epilepsia 1971; 12: 63-76.
• Biraben A, Sartori E, Tausig D, Bernard AM, Scarabin JM. Gelastic seizures: video EEG and scintigraphic analysis of a case with a frontal lobe focus;a review of literature and pathophysiological hypothesis. Epileptic Disorders 1999; 1: 221-227.
• Striano S, Meo R, Bilo L. Gelastic epilepsy: Symptomatic and cryptogenic cases. Epilepsia 1999; 40: 294-302.
• Kahane P, Munari C, Minotti L. The role of hypothalamic hamartoma in the genesis of gelastic and dacrystic seizures. In Tuxhan I, Holthausen H, Boenigk K eds. Paediatric epilepsy syndromes and their surgical treatment, London ; John Libby 1997: 447-461.
• Freeman JL, Harwey AS, Rosenfeld JV, Wrennal JA, Bailey CA. Generalised epilepsy in hypothalamic hamartoma : evolution and post operative resolution. Neurology 2003; 60: 762- 767.
• Striano S, Striano P, Cirillo S, et al. Small hypothalamic hamartomas and gelastic seizures. Epileptic disorders 2002; 4: 129-133.
• Palmini A, Paglioti-Neto E, Montes J, Farmer JP. The treatment of patients with hypothalamic hamartoma, epilepsy and behavioral abnormalities: facts and hypotheses. Epilep Disord 2003; 5: 249- 255.
• Téllez-Zenteno JF, Serrano-Almeida C, Moien- Afshari F. Gelastic seizures associated with hypothalamic hamartomas. An update in the clinical presentation, diagnosis and treatment. Neuropsychiatr Dis Treat 2008; 4: 1021-1031.
• Choi JU, Yang KH, Kim TG, et al. Endoscopic disconnection for hypothalamic hamartoma with intractable seizure. Report of four cases. J Neurosurg 2004; 100 (5 Suppl Pediatrics): 506- 511.
• Kuzniecky R, Guthrie B, Knowlton R, Faught F. M. İnvasive surgical management of hypothalamic hamartomas in gelastic epilepsy. Epilepsia 2002; 43 (Suppl 7): s34-s38.
• Fukuda M, Kamayama S, Wachi M, Tanaka R. Stereotaxy for hypothalamic hamartoma with intractable gelastic seizures: technical case report. Neurosurgery 1999; 44: 1347-1350.
• Schulze-Bonhage A, Trippel M, Wagner K, Bast T.Diemling FV. Outcome and predictors of interstitial radio surgery in treatment of gelastic epilepsy. Neurology 2008; 71: 277-282.
• Regis J, Scarvarda D, Tamura M. Gamma knife surgery for epilepsy related to hypothalamic hamartoma. Semin Pediatr Neurol 2007; 14: 73-79.
• Regis J, Bartolomei F, de Toffol B. Gamma knife surgery for epilepsy related to hypothalamic hamartomas. Neurosurgery 2000; 47: 1343-1352.