Investigation of the Effects of Metformin and Ifosfamide Applications on Cell Proliferation and Apoptosis in Hepatocellular Carcinoma Cells

Betül Nur Güney; Halime Topal Kızıloğlu; Kübra Solak; Derya Ulusoy; Adem Kara

EN

Investigation of the Effects of Metformin and Ifosfamide Applications on Cell Proliferation and Apoptosis in Hepatocellular Carcinoma Cells

Abstract

Cancer is a concern, for health ranking as the second leading cause of death after cardiovascular diseases. Among types of cancers hepatocellular carcinoma (HCC) is particularly noteworthy being the most common type following lung and stomach cancers. Various treatment approaches are used for managing HCC like chemotherapy. In this study the HepG2 cancer cell line was used as a model to investigate the effects of ifosfamide and metformin on cancer cells. Cell viability tests and RT PCR analysis targeting genes associated with the PI3K/AKT/mTOR pathway were conducted to evaluate these effects. These results offer valuable insights for advancing further research for their potential application in the treatment not only of HCC but also of other cancer types.

Keywords

Hepatocellular Cancer , Metformin , Ifosfamide , Cell Proliferation , PI3K/AKT/mTOR pathway

References

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Details

Primary Language

English

Subjects

Biochemistry and Cell Biology (Other)

Journal Section

Research Article

Authors

Betül Nur Güney
Türkiye

Halime Topal Kızıloğlu
Türkiye

Kübra Solak ^*
0000-0001-6643-3368
Türkiye

Derya Ulusoy
Türkiye

Adem Kara
0000-0002-5766-6116
Türkiye

Publication Date

July 23, 2024

Submission Date

January 27, 2024

Acceptance Date

April 22, 2024

Published in Issue

Year 2024 Volume: 3 Number: 1

IZ

https://izlik.org/JA73LA58JG

APA

Güney, B. N., Topal Kızıloğlu, H., Solak, K., Ulusoy, D., & Kara, A. (2024). Investigation of the Effects of Metformin and Ifosfamide Applications on Cell Proliferation and Apoptosis in Hepatocellular Carcinoma Cells. Eurasian Journal of Molecular and Biochemical Sciences, 3(1), 17-24. https://izlik.org/JA73LA58JG

Investigation of the Effects of Metformin and Ifosfamide Applications on Cell Proliferation and Apoptosis in Hepatocellular Carcinoma Cells

Abstract

Keywords

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References

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Published in Issue

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