Antimicrobial and Antibiofilm Activity of Methanol and Ethyl Acetate Extract of Ferula sp. Growing in Erzurum

Yıl 2022, Cilt: 1 Sayı: 1, 22 - 27, 29.04.2022

Şimal Topçu Elif Arslan Şeymanur Çobanoğlu Ayşenur Yazıcı Ümit İncekara

Öz

This study investigated the antimicrobial and antibiofilm activities of Ferula species (sp.) obtained from Erzurum province.
Antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis,
Candida albicans, and Candida tropicalis were determined by agar well diffusion assay. Ethyl acetate extract showed
antimicrobial activity against S. aureus, and methanol extract showed antimicrobial activity against E. coli and C. albicans with
a zone diameter of 21, 18, and 15 mm, respectively. The extract's minimum inhibitory concentrations (MIC) were 16, 32, and
32 μg/mL ml for S. aureus, E. coli, and C. albicans, respectively. Furthermore, it was determined for the first time that Ferula
sp. extracts were effective against biofilm formations of S. aureus and C. albicans. In the light of these results, we think that
extracts of Ferula sp. contain potential candidate molecules against biofilm-associated infections, and further characterization
studies are needed.

Anahtar Kelimeler

Antimicrobial, Antibiofilm, Extraction, Ferula sp