Uncovering the Global Landscape of PTZ-Induced Experimental Epilepsy Model Research: A Bibliometric Analysis

Arzuhan Çetindağ; Levent Hacısüleyman

doi:10.51754/ejmhs.1899351

Uncovering the Global Landscape of PTZ-Induced Experimental Epilepsy Model Research: A Bibliometric Analysis

Abstract

Epilepsy is a neurological disorder affecting millions of individuals worldwide and remains a major focus of experimental research. The pentylenetetrazole (PTZ)-induced seizure model is widely used in preclinical epilepsy studies; however, its global research landscape has not been systematically evaluated. In this study, a comprehensive bibliometric analysis of PTZ-related epilepsy publications was conducted to identify research trends, influential contributors, and evolving thematic areas. A total of 1,768 original articles published between January 2000 and October 2023 were retrieved from the Scopus database and analyzed using bibliometric tools, including Biblioshiny and VOSviewer, to assess publication output, citation patterns, authorship, institutional and national productivity, and conceptual structure. The results demonstrated a steady growth in PTZ-related publications over time, with China emerging as the leading contributor in terms of publication volume, while Poland showed a high degree of international collaboration. The most cited study was the work by Baraban et al. investigating PTZ-induced behavioral and neural changes in zebrafish. Epilepsy and Behavior, Epilepsy Research, and Epilepsia were identified as the most productive journals in this field. Keyword and thematic analyses revealed frequently studied topics such as oxidative stress, anticonvulsant activity, and neuroinflammation, along with emerging research interests including brain-derived neurotrophic factor and neuronal damage. This study represents the first bibliometric evaluation specifically focused on the PTZ-induced experimental epilepsy model and provides a comprehensive overview of the global research landscape. The findings may assist researchers in recognizing key contributors, identifying research gaps, and guiding future experimental studies in epilepsy.

Keywords

Supporting Institution

Not applicable.

Ethical Statement

Not applicable.

Thanks

The authors would like to thank Gülay DEMİR for her contribution to this study.

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Details

Primary Language

English

Subjects

Cell Neurochemistry

Journal Section

Research Article

Authors

Arzuhan Çetindağ
0000-0002-5420-3546
Türkiye

Levent Hacısüleyman ^*
0000-0002-4374-9025
Türkiye

Publication Date

April 30, 2026

Submission Date

February 27, 2026

Acceptance Date

April 27, 2026

Published in Issue

Year 2026 Volume: 11 Number: 1

DOI

https://doi.org/10.51754/ejmhs.1899351

IZ

https://izlik.org/JA92XT48NM

Cite

RIS / Bibtex

APA

Çetindağ, A., & Hacısüleyman, L. (2026). Uncovering the Global Landscape of PTZ-Induced Experimental Epilepsy Model Research: A Bibliometric Analysis. European Journal of Multidisciplinary Health Sciences, 11(1), 41-53. https://doi.org/10.51754/ejmhs.1899351

AMA

1.Çetindağ A, Hacısüleyman L. Uncovering the Global Landscape of PTZ-Induced Experimental Epilepsy Model Research: A Bibliometric Analysis. Eur J Multidiscip Health Sci. 2026;11(1):41-53. doi:10.51754/ejmhs.1899351

Chicago

Çetindağ, Arzuhan, and Levent Hacısüleyman. 2026. “Uncovering the Global Landscape of PTZ-Induced Experimental Epilepsy Model Research: A Bibliometric Analysis”. European Journal of Multidisciplinary Health Sciences 11 (1): 41-53. https://doi.org/10.51754/ejmhs.1899351.

EndNote

Çetindağ A, Hacısüleyman L (April 1, 2026) Uncovering the Global Landscape of PTZ-Induced Experimental Epilepsy Model Research: A Bibliometric Analysis. European Journal of Multidisciplinary Health Sciences 11 1 41–53.

IEEE

[1]A. Çetindağ and L. Hacısüleyman, “Uncovering the Global Landscape of PTZ-Induced Experimental Epilepsy Model Research: A Bibliometric Analysis”, Eur J Multidiscip Health Sci, vol. 11, no. 1, pp. 41–53, Apr. 2026, doi: 10.51754/ejmhs.1899351.

ISNAD

Çetindağ, Arzuhan - Hacısüleyman, Levent. “Uncovering the Global Landscape of PTZ-Induced Experimental Epilepsy Model Research: A Bibliometric Analysis”. European Journal of Multidisciplinary Health Sciences 11/1 (April 1, 2026): 41-53. https://doi.org/10.51754/ejmhs.1899351.

JAMA

1.Çetindağ A, Hacısüleyman L. Uncovering the Global Landscape of PTZ-Induced Experimental Epilepsy Model Research: A Bibliometric Analysis. Eur J Multidiscip Health Sci. 2026;11:41–53.

MLA

Çetindağ, Arzuhan, and Levent Hacısüleyman. “Uncovering the Global Landscape of PTZ-Induced Experimental Epilepsy Model Research: A Bibliometric Analysis”. European Journal of Multidisciplinary Health Sciences, vol. 11, no. 1, Apr. 2026, pp. 41-53, doi:10.51754/ejmhs.1899351.

Vancouver

1.Arzuhan Çetindağ, Levent Hacısüleyman. Uncovering the Global Landscape of PTZ-Induced Experimental Epilepsy Model Research: A Bibliometric Analysis. Eur J Multidiscip Health Sci. 2026 Apr. 1;11(1):41-53. doi:10.51754/ejmhs.1899351