Mandibular Distraksiyon Osteogenezinde Adjuvan Tedaviler: Hormonal ve Farmakolojik Ajanlar

Year 2024, Volume: 3 Issue: 1, 32 - 42, 15.01.2024

Şeyma Kale , Berkan Altay , Elif Çoban

Abstract

Distraksiyon osteogenezi traksiyon uygulanarak birbirinden uzaklaştırılan kemik segmentlerinin arasında oluşan kallusun yeni
kemik formasyonuna dönüştüğü bir tekniktir ve maksillofasiyal bölgedeki çeşitli defektlerin tedavisinde kullanılır. Distraksiyon
tekniğinin yumuşak dokular üzerinde önemli avantajlara sahiptir. Ancak tedavi süresinin uzun olması önemli bir dezavantajdır.
Son yıllarda distraksiyon sürecini kısaltabilecek pek çok materyal ve metot üzerinde çalışmalar yapılmış, çeşitli hormonal
proteinler, farmakolojik ajanların distraksiyon osteogenezinde başarılı olabileceği gösterilmiştir. Bu derlemede mandibular
distraksiyon osteogenezinde araştırılan hormonal proteinlerin ve farmakolojik ajanların kapsamlı bir incelemesini sunduk.

Keywords

distraksiyon, adjuvan tedavi, mandibular distraksiyon osteogenezi

References

• 1. Mikhail, L. S., Cherkashin, A. M. & Cope, J. B. Distraction osteogenesis: History and biologic basis of new bone formation In: Lynch SE, Genco RJ, Mark RE, editors. Tissue Eng. Appl. Maxillofac. Surg. periodontics List. Ill Quintessence 130–148 (1998).
• 2. Winters, R. & Tatum, S. A. Craniofacial distraction osteogenesis. Facial Plast. Surg. Clin. North Am. 22, 653– 664 (2014).
• 3. Erverdi, N. & Motro, M. Alveolar Distraction Osteogenesis. Alveolar Distraction Osteogenesis (2015). doi:10.1007/978- 3-319-07707-9.
• 4. Ilizarov, G. The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. Clin Orthop Relat Res 263–285 (1989).
• 5. Codivilla, A. On the means of lengthening, in the lower limbs, the muscles and tissues which are shortened through deformity. JBJS 2, 353–369 (1905).
• 6. Aykan, A., Ugurlutan, R., Zor, F. & Ozturk, S. Mandibular distraction osteogenesis with newly designed electromechanical distractor. J. Craniofac. Surg. 25, 1519–1523 (2014).
• 7. Peacock, Z. S. et al. Automated continuous distraction osteogenesis may allow faster distraction rates: a preliminary study. J. Oral Maxillofac. Surg. 71, 1073–1084 (2013).
• 8. Hatefi, S. et al. Review of physical stimulation techniques for assisting distraction osteogenesis in maxillofacial reconstruction applications. Med. Eng. Phys. 91, 28–38 (2021).
• 9. Hong, P. A clinical narrative review of mandibular distraction osteogenesis in neonates with Pierre Robin sequence. Int. J. Pediatr. Otorhinolaryngol. 75, 985–991 (2011).
• 10. Hong, P., Boyd, D., Beyea, S. D. & Bezuhly, M. Enhancement of bone consolidation in mandibular distraction osteogenesis: A contemporary review of experimental studies involving adjuvant therapies. J. Plast. Reconstr. Aesthetic Surg. 66, 883–895 (2013).
• 11. Kocyigit, I. D. et al. A comparison of the low-level laser versus low intensity pulsed ultrasound on new bone formed through distraction osteogenesis. Photomed. Laser Surg. 30, 438–443 (2012).
• 12. Pampu, A. A., Dolanmaz, D., Tüz, H. H., Avunduk, M. C. & Kisşnisşci, R. Ş. Histomorphometric evaluation of the effects of zoledronic acid on mandibular distraction osteogenesis in rabbits. J. oral Maxillofac. Surg. 66, 905– 910 (2008).
• 13. Dundar, S. et al. Evaluation of effects of topical melatonin application on osseointegration of dental implant: an experimental study. J. Oral Implantol. 42, 386–389 (2016).
• 14. Acikan, I. et al. Systemic melatonin application increases bone formation in mandibular distraction osteogenesis. Braz. Oral Res. 32, e85 (2018).
• 15. Cutando, A. et al. Melatonin stimulates osteointegration of dental implants. J. Pineal Res. 45, 174–179 (2008).
• 16. Tresguerres, I. F. et al. Effects of local melatonin application on implant osseointegration. Clin. Implant Dent. Relat. Res. 14, 395–399 (2012).
• 17. Amar, A. P. & Weiss, M. H. Pituitary anatomy and physiology. Neurosurg. Clin. 14, 11–23 (2003).
• 18. Lee, H.-J., Macbeth, A. H., Pagani, J. H. & Young 3rd, W. S. Oxytocin: the great facilitator of life. Prog. Neurobiol. 88, 127–151 (2009).
• 19. Elabd, C. et al. Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis. Stem Cells 26, 2399–2407 (2008).
• 20. Elabd, S. K., Sabry, I., Hassan, W. B., Nour, H. & Zaky, K. Possible neuroendocrine role for oxytocin in bone remodeling. Endocr. Regul. 41, 131 (2007).
• 21. Elabd, S. & Sabry, I. Two birds with one stone: possible dual-role of oxytocin in the treatment of diabetes and osteoporosis. Front. Endocrinol. (Lausanne). 6, 121 (2015).
• 22. Tamma, R. et al. Oxytocin is an anabolic bone hormone. Proc. Natl. Acad. Sci. 106, 7149–7154 (2009).
• 23. Altay, B. et al. Effect of Systemic Oxytocin Administration on New Bone Formation and Distraction Rate in Rabbit Mandible. J. Oral Maxillofac. Surg. (2020) doi:10.1016/j. joms.2020.03.005.
• 24. Cho, B. C. et al. The bone regenerative effect of growth hormone on consolidation in mandibular distraction osteogenesis of a dog model. J. Craniofac. Surg. 14, 417– 425 (2003).
• 25. Cho, B. C. et al. The bone regenerative effect of chitosan microsphere-encapsulated growth hormone on bony consolidation in mandibular distraction osteogenesis in a dog model. J. Craniofac. Surg. 15, 299–311 (2004).
• 26. Chen, H., Frankenburg, E. P., Goldstein, S. A. & McCauley, L. K. Combination of local and systemic parathyroid hormone enhances bone regeneration. Clin. Orthop. Relat. Res. 416, 291–302 (2003).
• 27. Dempster, D. W., Cosman, F., Parisien, M. A. Y., Shen, V. & Lindsay, R. Anabolic actions of parathyroid hormone on bone. Endocr. Rev. 14, 690–709 (1993).
• 28. Uzawa, T., Hori, M., Ejiri, S. & Ozawa, H. Comparison of the effects of intermittent and continuous administration of human parathyroid hormone (1–34) on rat bone. Bone 16, 477–484 (1995).
• 29. Tang, Z. L. et al. An Examination of Differences in the New Bone Formation Promoted by Different Doses of Recombinant Human Parathyroid Hormone during Mandibular Distraction Osteogenesis. Plast. Reconstr. Surg. 137, 347e-354e (2016).
• 30. Ye, B. et al. Effects of Intermittent Low-Dose Parathyroid Hormone Treatment on Rapid Mandibular Distraction Osteogenesis in Rabbits. J. Oral Maxillofac. Surg. 75, 1722–1731 (2017).
• 31. Jiang, X. et al. Effect of intermittent administration of adiponectin on bone regeneration following mandibular osteodistraction in rabbits. J. Orthop. Res. 29, 1081–1085 (2011).
• 32. Wan, L. et al. EPO promotes bone repair through enhanced cartilaginous callus formation and angiogenesis. PLoS One 9, e102010 (2014).
• 33. Mihmanli, A., Dolanmaz, D., Avunduk, M. C. & Erdemli, E. Effects of Recombinant Human Erythropoietin on Mandibular Distraction Osteogenesis. J. Oral Maxillofac. Surg. 67, 2337–2343 (2009).
• 34. Soydan S, F, V. & Araz, K. Bifosfonata Bağlı Olarak Çene Kemiklerinde Gelişen Osteonekrozun Patogenezi ve Tedavisi. Hacettepe Diş Hek. Fak. Der. 33, 61–68 (2009).
• 35. Gómez, F. R., Martínez, G. M. L. & Olmos, M. J. M. Osteochemonecrosis of the jaws due to bisphosphonate treatments. Update. Med. Oral Patol. Oral Cir. Bucal 13, E318 (2008).
• 36. Naidu, A. et al. The effects of bisphosphonates on osteoblasts in vitro. Oral Surgery, Oral Med. Oral Pathol. Oral Radiol. Endodontology 106, 5–13 (2008).
• 37. Senel, F. C., Tekin, U. S., Durmus, A. & Bagis, B. Severe osteomyelitis of the mandible associated with the use of non–nitrogen-containing bisphosphonate (disodium clodronate): report of a case. J. oral Maxillofac. Surg. 65, 562–565 (2007).
• 38. Tenenbaum, H. C., Shelemay, A., Girard, B., Zohar, R. & Fritz, P. C. Bisphosphonates and periodontics: potential applications for regulation of bone mass in the periodontium and other therapeutic/diagnostic uses. J. Periodontol. 73, 813–822 (2002).
• 39. Tekin, U., Tüz, H. H., Önder, E., Özkaynak, Ö. & Korkusuz, P. Effects of Alendronate on Rate of Distraction in Rabbit Mandibles. J. Oral Maxillofac. Surg. 66, 2042–2049 (2008).
• 40. Kucuk, D., Ay, S., Kara, M. I., Avunduk, M. C. & Gümus, C. Comparison of local and systemic alendronate on distraction osteogenesis. Int. J. Oral Maxillofac. Surg. 40, 1395–1400 (2011).
• 41. Alp, Y. E. et al. Effects of Local Low-Dose Alendronate Injections Into the Distraction Gap on New Bone Formation and Distraction Rate on Distraction Osteogenesis. J. Craniofac. Surg. 28, 2174–2178 (2017).
• 42. Dundar, S. et al. Comparison of the Effects of Local and Systemic Zoledronic Acid Application on Mandibular Distraction Osteogenesis. J. Craniofac. Surg. 28, e621– e625 (2017).
• 43. Baiomy, A. A. et al. Experimental comparison of the effects of locally administered zoledronic acid and alendronate on the rate of mandibular distraction osteogenesis in dogs. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 118, 35–42 (2014).
• 44. Pampu, A. A., Dolanmaz, D., Tüz, H. H. & Karabacakoglu, A. Experimental Evaluation of the Effects of Zoledronic Acid on Regenerate Bone Formation and Osteoporosis in Mandibular Distraction Osteogenesis. J. Oral Maxillofac. Surg. 64, 1232–1236 (2006).
• 45. Liu, Z., Liu, Q., Guo, H., Liang, J. & Zhang, Y. Overview of Physical and Pharmacological Therapy in Enhancing Bone Regeneration Formation During Distraction Osteogenesis. Front. Cell Dev. Biol. 10, (2022).
• 46. Kahraman, O. E., Erdogan, O., Namli, H. & Sencar, L. Effects of local simvastatin on periosteal distractiono steogenesis in rabbits. Br. J. Oral Maxillofac. Surg. 53, e18–e22 (2015).
• 47. Petit, C. et al. Contribution of statins towards periodontal treatment: A review. Mediators Inflamm. 2019, (2019). 48. Kiliç, E. et al. Effects of Simvastatin on Mandibular Distraction Osteogenesis. J. Oral Maxillofac. Surg. 66, 2233–2238 (2008).
• 49. Farberg, A. S., Sarhaddi, D., Donneys, A., Deshpande, S. S. & Buchman, S. R. Deferoxamine enhances bone regeneration in mandibular distraction osteogenesis. Plast. Reconstr. Surg. 133, 666–671 (2014).
• 50. Donneys, A., Farberg, A. S., Tchanque-Fossuo, C. N., Deshpande, S. S. & Buchman, S. R. Deferoxamine enhances the vascular response of bone regeneration in mandibular distraction osteogenesis. Plast. Reconstr. Surg. 129, 850–856 (2012).
• 51. Donneys, A. et al. Deferoxamine expedites consolidation during mandibular distraction osteogenesis. Bone 55, 384–390 (2013).
• 52. Wei, H. et al. Effect of icariin on bone formation during distraction osteogenesis in the rabbit mandible. Int. J. Oral Maxillofac. Surg. 40, 413–418 (2011).
• 53. Dayisoylu, E. H. et al. Effects of osteoformin in the rapid distraction osteogenesis of rabbit mandibles. JPMA 66, (2016).
• 54. Pampu, A. A. et al. The effects of osteoformin on mineralisation and quality of newly formed bone during mandibular distraction osteogenesis in rabbits. Oral Surgery, Oral Med. Oral Pathol. Oral Radiol. Endodontology 108, 833–837 (2009).
• 55. Bereket, C. et al. Propolis accelerates the consolidation phase in distraction osteogenesis. J. Craniofac. Surg. 25, 1912–1916 (2014).
• 56. Cho, B. C., Park, J. W., Baik, B. S., Kwon, I. C. & Kim, I. S. The role of hyaluronic acid, chitosan, and calcium sulfate and their combined effect on early bony consolidation in distraction osteogenesis of a canine model. J. Craniofac. Surg. 13, 783–793 (2002).
• 57. Cho, B. C. et al. The effect of chitosan bead encapsulating calcium sulfate as an injectable bone substitute on consolidation in the mandibular distraction osteogenesis of a dog model. J. Oral Maxillofac. Surg. 63, 1753–1764 (2005).
• 58. Al Ruhaimi, K. A. Effect of calcium sulphate on the rate of osteogenesis in distracted bone. Int. J. Oral Maxillofac. Surg. 30, 228–233 (2001).
• 59. Polat, H. B., Yeler, H., Gumus, C., Bulut, H. E. & Kucuk, D. Effect of oil-based calcium hydroxide (Osteoinductal) on distraction osteogenesis in rabbit mandible. Oral Surgery, Oral Med. Oral Pathol. Oral Radiol. Endodontology 107, e30–e36 (2009).
• 60. Taylor, B. A., Bezuhly, M., Brace, M., Carter, M. & Hong, P. Effect of strontium citrate on bone consolidation during mandibular distraction osteogenesis. Laryngoscope 127, E212–E218 (2017). 61. Alansi, S. Y., Khalil, M. M., Noureldin, M. G. & Abdel Fattah, H. S. EVALUATION OF THE EFFECT OF STRONTIUM CITRATE ON BONE CONSOLIDATION DURING MANDIBULAR DISTRACTION OSTEOGENESIS IN RABBITS (EXPERIMENTAL STUDY). Alexandria Dent. J. 46, 59–64 (2021).
• 62. Lee, K., Sugiyama, H., Imoto, S. & Tanne, K. Effects of bisphosphonate on the remodeling of rat sagittal suture after rapid expansion. Angle Orthod. 71, 265–273 (2001).
• 63. Teng, M. S. & Futran, N. D. Osteoradionecrosis of the mandible. Curr. Opin. Otolaryngol. Head Neck Surg. 13, 217–221 (2005).
• 64. Toker, H., Ozdemir, H., Eren, K., Ozer, H. & Sahın, G. Nacetylcysteine, a thiol antioxidant, decreases alveolar bone loss in experimental periodontitis in rats. J. Periodontol. 80, 672–678 (2009).
• 65. Akçay, H., Kuru, K., Tatar, B. & Simsek, F. Vitamin E Promotes Bone Formation in a Distraction Osteogenesis Model. J. Craniofac. Surg. 30, 2315–2318 (2019).
• 66. Goldwaser, B. R., Papadaki, M. E., Kaban, L. B. & Troulis, M. J. Automated continuous mandibular distraction osteogenesis: review of the literature. J. Oral Maxillofac. Surg. 70, 407–416 (2012).
• 67. Azuma, Y. et al. Low‐intensity pulsed ultrasound accelerates rat femoral fracture healing by acting on the various cellular reactions in the fracture callus. J. bone Miner. Res. 16, 671–680 (2001).
• 68. Marcucci, G., Della Pepa, G. & Brandi, M. L. Drug safety evaluation of parathyroid hormone for hypocalcemia in patients with hypoparathyroidism. Expert Opin. Drug Saf. 16, 617–625 (2017).
• 69. Sigalos, J. T. & Pastuszak, A. W. The safety and efficacy of growth hormone secretagogues. Sex. Med. Rev. 6, 45–53 (2018).