Osteonecrosis of the Jaw in a Young Patient: Beyond Medication-Related Causes
Year 2025,
Volume: 4 Issue: 1, 7 - 10, 29.01.2025
İpek Atak Seçen
,
Berkay Mülayim
,
Bilgesu Kurt
,
Emre Barış
Abstract
Medication-Related Osteonecrosis of the Jaw (MRONJ) is commonly associated with pharmacological agents like bisphosphonates. However, osteonecrosis can also develop due to other etiologies, including dental trauma and infections. This case report describes osteonecrosis in a 26-year-old male patient who underwent simultaneous implant placement and surgical tooth extraction. The absence of systemic diseases or medication history highlights the role of dental trauma and impaired healing in osteonecrosis development. Management included surgical debridement and antibiotic therapy, consistent with Stage 2 osteonecrosis guidelines. The case emphasizes the importance of minimizing trauma during dental procedures to prevent osteonecrosis, even in younger patients.
Ethical Statement
The present study was conducted in accordance with the Declaration of Helsinki.
References
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Res. 2015;30(9):1627-40.
Genç Bir Hastada Çene Osteonekrozu: İlaç Dışı Nedenler
Year 2025,
Volume: 4 Issue: 1, 7 - 10, 29.01.2025
İpek Atak Seçen
,
Berkay Mülayim
,
Bilgesu Kurt
,
Emre Barış
Abstract
İlaca Bağlı Çene Osteonekrozu (MRONJ), genellikle bifosfonatlar gibi farmakolojik ajanlarla ilişkilendirilse de, dental travma ve enfeksiyonlar gibi diğer etiyolojik faktörlere bağlı olarak da gelişebilmektedir. Bu vaka raporu, eş zamanlı implant yerleştirilmesi ve cerrahi diş çekimi uygulanan 26 yaşındaki bir erkek hastada gelişen osteonekrozu ele almaktadır. Hastanın sistemik bir hastalık veya ilaç kullanım öyküsünün bulunmaması; osteonekroz gelişiminde dental travma ve bozulmuş iyileşme sürecinin etkisini ön plana çıkarmaktadır. Tedavi, Evre 2 osteonekroz kılavuzları doğrultusunda, cerrahi debridman ve antibiyotik uygulaması ile gerçekleştirilmiştir. Çıkarılan materyalin histopatolojik incelemesi, osteonekroz tanısını doğulamıştır. Bu vaka, genç hastalarda dahi osteonekrozu önlemek için dental işlemler sırasında travmayı en aza indirmenin önemine dikkat çekmektedir.
References
- 1. Kılınç, Y. (2024). İlaca Bağlı Çene Osteonekrozu. ADO Klinik
Bilimler Dergisi, 13(2), 264-277.
- 2. Anastasilakis AD, Pepe J, Napoli N, Palermo A, Magopoulos C,
Khan AA, et al. Osteonecrosis of the jaw and antiresorptive agents
in benign and malignant diseases: a critical review organized by
the ECTS. J Clin Endocrinol Metab. 2022;107(5):1441-60.
- 3. Marx RE. Pamidronate (Aredia) and zoledronate (Zometa)
induced avascular necrosis of the jaws: a growing epidemic. J
Oral Maxillofac Surg. 2003;61(9):1115-7.
- 4. Advisory Task Force on Bisphosphonate-Related Osteonecrosis
of the Jaws, American Association of Oral and Maxillofacial
Surgeons. American Association of Oral and Maxillofacial
Surgeons position paper on bisphosphonate-related
osteonecrosis of the jaws. J Oral Maxillofac Surg. 2007;65:369-76.
- 5. Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T,
Mehrotra B, et al. American Association of Oral and Maxillofacial
Surgeons position paper on medication-related osteonecrosis of
the jaw—2014 update. J Oral Maxillofac Surg. 2014;72(10):1938-
56.
- 6. Bassir SH, El Kholy K, Chen CY, Lee KH, Intini G. Outcome of early
dental implant placement versus other dental implant placement
protocols: a systematic review and meta-analysis. J Periodontol.
2019 May;90(5):493-506.
- 7. Dahiya M, Dhawan P, Rani S, Saxena V. Critical analysis of the
effect of antiresorptive drugs on osteonecrosis associated
with dental implants: an umbrella review. Cureus. 2024 Oct
15;16(10):e71506.
- 8. Assouline-Dayan Y, Chang C, Greenspan A, Shoenfeld Y, Gershwin
ME. Pathogenesis and natural history of osteonecrosis. Semin
Arthritis Rheum. 2002;32(2):94-124.
- 9. Magremanne M, Picheca S, Reychler H. Etiologic diagnosis of
jaw osteonecrosis, other than bisphosphonate and radiotherapy
related osteonecrosis. Rev Stomatol Chir Maxillofac Chir Orale.
2014;115(1):45-50.
- 10. de Molon RS, et al. OPG‐Fc but not zoledronic acid discontinuation
reverses osteonecrosis of the jaws (ONJ) in mice. J Bone Miner
Res. 2015;30(9):1627-40.