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Osteonecrosis of the Jaw in a Young Patient: Beyond Medication-Related Causes

Year 2025, Volume: 4 Issue: 1, 7 - 10, 29.01.2025

Abstract

Medication-Related Osteonecrosis of the Jaw (MRONJ) is commonly associated with pharmacological agents like bisphosphonates. However, osteonecrosis can also develop due to other etiologies, including dental trauma and infections. This case report describes osteonecrosis in a 26-year-old male patient who underwent simultaneous implant placement and surgical tooth extraction. The absence of systemic diseases or medication history highlights the role of dental trauma and impaired healing in osteonecrosis development. Management included surgical debridement and antibiotic therapy, consistent with Stage 2 osteonecrosis guidelines. The case emphasizes the importance of minimizing trauma during dental procedures to prevent osteonecrosis, even in younger patients.

Ethical Statement

The present study was conducted in accordance with the Declaration of Helsinki.

References

  • 1. Kılınç, Y. (2024). İlaca Bağlı Çene Osteonekrozu. ADO Klinik Bilimler Dergisi, 13(2), 264-277.
  • 2. Anastasilakis AD, Pepe J, Napoli N, Palermo A, Magopoulos C, Khan AA, et al. Osteonecrosis of the jaw and antiresorptive agents in benign and malignant diseases: a critical review organized by the ECTS. J Clin Endocrinol Metab. 2022;107(5):1441-60.
  • 3. Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg. 2003;61(9):1115-7.
  • 4. Advisory Task Force on Bisphosphonate-Related Osteonecrosis of the Jaws, American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2007;65:369-76.
  • 5. Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, et al. American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw—2014 update. J Oral Maxillofac Surg. 2014;72(10):1938- 56.
  • 6. Bassir SH, El Kholy K, Chen CY, Lee KH, Intini G. Outcome of early dental implant placement versus other dental implant placement protocols: a systematic review and meta-analysis. J Periodontol. 2019 May;90(5):493-506.
  • 7. Dahiya M, Dhawan P, Rani S, Saxena V. Critical analysis of the effect of antiresorptive drugs on osteonecrosis associated with dental implants: an umbrella review. Cureus. 2024 Oct 15;16(10):e71506.
  • 8. Assouline-Dayan Y, Chang C, Greenspan A, Shoenfeld Y, Gershwin ME. Pathogenesis and natural history of osteonecrosis. Semin Arthritis Rheum. 2002;32(2):94-124.
  • 9. Magremanne M, Picheca S, Reychler H. Etiologic diagnosis of jaw osteonecrosis, other than bisphosphonate and radiotherapy related osteonecrosis. Rev Stomatol Chir Maxillofac Chir Orale. 2014;115(1):45-50.
  • 10. de Molon RS, et al. OPG‐Fc but not zoledronic acid discontinuation reverses osteonecrosis of the jaws (ONJ) in mice. J Bone Miner Res. 2015;30(9):1627-40.

Genç Bir Hastada Çene Osteonekrozu: İlaç Dışı Nedenler

Year 2025, Volume: 4 Issue: 1, 7 - 10, 29.01.2025

Abstract

İlaca Bağlı Çene Osteonekrozu (MRONJ), genellikle bifosfonatlar gibi farmakolojik ajanlarla ilişkilendirilse de, dental travma ve enfeksiyonlar gibi diğer etiyolojik faktörlere bağlı olarak da gelişebilmektedir. Bu vaka raporu, eş zamanlı implant yerleştirilmesi ve cerrahi diş çekimi uygulanan 26 yaşındaki bir erkek hastada gelişen osteonekrozu ele almaktadır. Hastanın sistemik bir hastalık veya ilaç kullanım öyküsünün bulunmaması; osteonekroz gelişiminde dental travma ve bozulmuş iyileşme sürecinin etkisini ön plana çıkarmaktadır. Tedavi, Evre 2 osteonekroz kılavuzları doğrultusunda, cerrahi debridman ve antibiyotik uygulaması ile gerçekleştirilmiştir. Çıkarılan materyalin histopatolojik incelemesi, osteonekroz tanısını doğulamıştır. Bu vaka, genç hastalarda dahi osteonekrozu önlemek için dental işlemler sırasında travmayı en aza indirmenin önemine dikkat çekmektedir.

References

  • 1. Kılınç, Y. (2024). İlaca Bağlı Çene Osteonekrozu. ADO Klinik Bilimler Dergisi, 13(2), 264-277.
  • 2. Anastasilakis AD, Pepe J, Napoli N, Palermo A, Magopoulos C, Khan AA, et al. Osteonecrosis of the jaw and antiresorptive agents in benign and malignant diseases: a critical review organized by the ECTS. J Clin Endocrinol Metab. 2022;107(5):1441-60.
  • 3. Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg. 2003;61(9):1115-7.
  • 4. Advisory Task Force on Bisphosphonate-Related Osteonecrosis of the Jaws, American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2007;65:369-76.
  • 5. Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, et al. American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw—2014 update. J Oral Maxillofac Surg. 2014;72(10):1938- 56.
  • 6. Bassir SH, El Kholy K, Chen CY, Lee KH, Intini G. Outcome of early dental implant placement versus other dental implant placement protocols: a systematic review and meta-analysis. J Periodontol. 2019 May;90(5):493-506.
  • 7. Dahiya M, Dhawan P, Rani S, Saxena V. Critical analysis of the effect of antiresorptive drugs on osteonecrosis associated with dental implants: an umbrella review. Cureus. 2024 Oct 15;16(10):e71506.
  • 8. Assouline-Dayan Y, Chang C, Greenspan A, Shoenfeld Y, Gershwin ME. Pathogenesis and natural history of osteonecrosis. Semin Arthritis Rheum. 2002;32(2):94-124.
  • 9. Magremanne M, Picheca S, Reychler H. Etiologic diagnosis of jaw osteonecrosis, other than bisphosphonate and radiotherapy related osteonecrosis. Rev Stomatol Chir Maxillofac Chir Orale. 2014;115(1):45-50.
  • 10. de Molon RS, et al. OPG‐Fc but not zoledronic acid discontinuation reverses osteonecrosis of the jaws (ONJ) in mice. J Bone Miner Res. 2015;30(9):1627-40.
There are 10 citations in total.

Details

Primary Language English
Subjects Surgery (Other)
Journal Section Case Report
Authors

İpek Atak Seçen 0000-0001-9663-5454

Berkay Mülayim 0009-0000-1834-7430

Bilgesu Kurt 0000-0002-1944-3210

Emre Barış 0000-0001-5096-4279

Early Pub Date January 29, 2025
Publication Date January 29, 2025
Submission Date January 3, 2025
Acceptance Date January 13, 2025
Published in Issue Year 2025 Volume: 4 Issue: 1

Cite

Vancouver Atak Seçen İ, Mülayim B, Kurt B, Barış E. Osteonecrosis of the Jaw in a Young Patient: Beyond Medication-Related Causes. EJOMS. 2025;4(1):7-10.

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