ejosat Avrupa Bilim ve Teknoloji Dergisi 2148-2683 Osman SAĞDIÇ Engineering Mühendislik İmin Fonksiyonu İçeren Bazı Benzimidazol Türevlerinin Mikrodalga Destekli Sentezi Microwave-Assisted Synthesis of Some Benzimidazole Derivatives Containing Imine Function Akyüz Gülay RECEP TAYYİP ERDOĞAN ÜNİVERSİTESİ Yılmaz Fatih RECEP TAYYİP ERDOĞAN ÜNİVERSİTESİ Menteşe Emre RECEP TAYYİP ERDOĞAN ÜNİVERSİTESİ 06 19 2015 2 4 123 127 03 25 2015 06 09 2015 Copyright © 2013, Avrupa Bilim ve Teknoloji Dergisi 2013 Avrupa Bilim ve Teknoloji Dergisi

Benzimidazol modern ilaç keşfinde önemli bir farmakofordur. Birçok benzimidazole türevi yeni ilaç adayı bileşikler elde etmek amacıyla organik kimyacılar tarafından sentezlenmektedir. Bu çalışmada, imin fonksiyonu içeren yedi yeni benzimidazol türevi bileşik mikrodalga ışıma ve geleneksel yöntemle sentezlenmiştir. Elde edilen sonuçlara göre mikrodalga ısıtmanın geleneksel ısıtmaya göre verim, üründeki saflık ve zaman yönünde avantajları olduğu görülmüştür.

Benzimidazole is an important pharmacophore in modern drug discovery. Many benzimidazole derivatives have been synthesized by organic chemist to obtain new drug candidates. In this work, seven new benzimidazole derivatives containing imine function have been synthesized by using microwave irradiation and conventional heating procedure. The results showed that microwave heating has many advantages on classical heating procedure on yields, purity of product and reduced times.

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