The Efficacy of Obstructive Sleep Apnea Surgery on Mean Platelet Volume, Neutrophil /Lymphocyte, and Platelet/Lymphocyte Ratios

Year 2024, Volume: 7 Issue: 2, 42 - 49, 20.08.2024

Esma Altan , Volkan Yücel Güleser Saylam , Ömer Bayır

Abstract

Objective: Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder characterized by repeated upper
airway collapse. As types of surgical modalities have been defined according to the level of airway obstruction, uvu-
lopalatal flap and anterior palatoplasty are 2 of the main surgical options for patients with collapse in the soft palate
and oropharynx region. The aim of our study is to show the effect of surgery on neutrophil–lymphocyte ratio, plate-
let–lymphocyte ratio, and mean platelet volume values in OSAS patients.

Methods: The medical records of 125 patients with OSAS diagnosis in between January 2012 and December
2014 were evaluated retrospectively. Age, gender, body mass index, polysomnography results, Epworth Sleepiness
scale (ESS), complete blood count values, and surgical results of the patients were evaluated.

Results: A statistically significant decrease was observed in the mean apnea–hypopnea index, oxygen desaturation
index, and ESS scores in the postoperative period (P < .001). Considering all patients, a statistically significant decrease
was observed in th mean platelet volume (MPV) values in the postoperative period (P < .001) and no statistically sig-
nificant change was observed in the mean neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR)
values (P = .808 and P = .117). In patients whose anterior palatoplasty (78 patients) results were considered successful,
a statistically significant decrease was observed in MPV and PLR values (P < .001 and P = .038), while no significant
change was observed in NLR values (P = .185). In those with successful uvulopalatal flap (47 patients) results, a statisti-
cally significant decrease was observed in MPV values (P < .001), while no significant change was observed in NLR and
PLR values (P = .809 and P = .154).

Conclusion: While it was observed that MPV values were associated with OSAS, no clear relationship was found
between NLR and PLR values.

Keywords

Obstructive sleep apnea , surgery , mean platelet volume , neutrophil/lymphocyte ratio , platelet/lymphocyte ratio

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