Two Novel Inflammation Indexes; Can Systemic İmmune-inflammation Index and Pan-immune-inflammation Value Be Associated with Chronic Rhinosinusitis?

Sevinç Hepkarşı; Cüneyt Yılmazer

doi:10.5152/ejra.2024.24132

Two Novel Inflammation Indexes; Can Systemic İmmune-inflammation Index and Pan-immune-inflammation Value Be Associated with Chronic Rhinosinusitis?

Abstract

Objective: Chronic rhinosinusitis (CRS) can be classified as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). The aim of this study was to evaluate and compare the Systemic Immune-Inflammation Index (SII) and Pan-I mmune -Infl ammat ion Value (PIV) levels of patients diagnosed with chronic rhinosinusitis (CRS) with nasal polyposis (CRSwNP) and CRS without nasal polyposis (CRSsNP) along with healthy controls. Methods: The study analyzed 320 patients from 2022 to 2023. Patients were divided into three groups. 110 CRSwNP patients, 110 CRSsNP patients, and 100 healthy individuals were included in Groups A, B, and C, respectively. SII and PIV levels were assessed after CRSwNP or CRSsNP diagnosis. The values of complete blood count, SII, and PIV were compared. Results: The mean SII levels of patients in groups A, B, and C were 685.3 ± 641.3; 1034.18 ± 1083.12; and 532.18 ± 310.77, respectively. The mean SII levels were significantly higher in group B compared to groups A and C (P = .012 and P = .000). The mean PIV levels of patients in groups A;B and C were 405.31 ± 486.15; 539.08 ± 599.63; and 311.29 ± 217.52, respectively. The mean PIV levels were significantly higher in group B compared to group C (P = 0.001). Results of the ROC analyses for both SII and PIV were statistically significant. Patients with an SII cut-of value of 278.6 had a sensitivity of 91% and sensitivity 91%, specificity of 90%. Patients with a PIV cut-off value of 117.51 had a sensitivity of 92% and sensitivity 92%, specificity of 90%. Conclusions: SII and PIV, which are important inflammatory markers, especially in systemic inflammation, were sig- nificantly elevated in CRSwNP patients compared to CRSsNP patients and healthy controls. This may support the pres- ence of chronic mucosal inflammation in CRSwNP patients. However, SII and PIV are indirect markers of inflammation, and further studies with larger patient groups are warranted.

Keywords

References

Orlandi RR, Kingdom TT, Hwang PH, et al. International consensus Statement on Allergy and Rhinology: rhinosinusitis. Int Forum Allergy Rhinol. 2016;6(1 suppl 1):S22-209.
Bhattacharyya N. Contemporary incremental healthcare costs for chronic rhinosinusitis in the United States. Laryngoscope. 2021;131(10):2169-2172.
Hastan D, Fokkens WJ, Bachert C, et al. Chronic rhinosinusitis in Europe—an underestimated disease. A GA2LEN study. Allergy. 2011;66(9):1216-1223.
Shi JB, Fu QL, Zhang H, et al. Epidemiology of chronic rhinosinusitis: results from a cross-sectional survey in seven Chinese cities. Allergy. 2015;70(5):533-539.
Fokkens WJ, Lund VJ, Hopkins C, et al. Executive summary of EPOS 2020 including integrated care pathways. Rhinology. 2020;58(2):82-111.
Turhal G, Eraslan S, Kaya İ, Midilli R, Karci B, Göde S. Procalcitonin levels in chronic rhinosinusitis. Turk Arch Otorhinolaryngol. 2019;57(3):113-116.
Brescia G, Pedruzzi B, Barion U, et al. Are neutrophil-, eosinophil-, and basophil-to-lymphocyte ratios useful markers for pinpointing patients at higher risk of recurrent sinonasal polyps? Am J Otolaryngol. 2016;37(4):339-345.
Kara A, Guven M, Yilmaz MS, Demir D, Elden H. Are neutrophil, platelet and eosinophil-to-lymphocyte ratio and red blood cell distribution width can be used for nasal polyposis? Eur Arch Otorhinolaryngol. 2018;275(2):409-413.

Singh SP, Jain S, Keshari S, Kumar P, Prakash A, Singh K. Comparison of inflammatory markers for prediction of recurrence of nasal polyp after functional endoscopy sinus surgery. Indian J Otolaryngol Head Neck Surg. 2023;75(4):3596-3601.
Bayer K, Hamidovic S, Brkic FF, Besser G, Mueller CA, Liu DT. Peripheral eosinophil count and eosinophil-to-lymphocyte ratio are associated with revision sinus surgery. Eur Arch Otorhinolaryngol. 2023;280(1):183-190.
Hu B, Yang XR, Xu Y, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014;20(23):6212-6222.
Fucà G, Guarini V, Antoniotti C, et al. The Pan-Immune-Inflammation Value is a new prognostic biomarker in metastatic colorectal cancer: results from a pooled-analysis of the Valentino and TRIBE first-line trials. Br J Cancer. 2020;123(3):403-409.
Lee LE, Ahn SS, Pyo JY, Song JJ, Park YB, Lee SW. Pan-immune-inflammation value at diagnosis independently predicts all-cause mortality in patients with antineutrophil cytoplasmic antibody-associated vasculitis. Clin Exp Rheumatol. 2021;39(2 suppl 129):88-93.
Yang YL, Wu CH, Hsu PF, et al. Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease. Eur J Clin Investig. 2020;50(5):e13230.
Alanin MC, Hopkins C. Effect of functional endoscopic sinus surgery on outcomes in chronic rhinosinusitis. Curr Allergy Asthma Rep. 2020;20(7):27.
Bachert C, Akdis CA. Phenotypes and emerging endotypes of chronic rhinosinusitis. J Allergy Clin Immunol Pract. 2016;4(4):621-628.
Kato A. Immunopathology of chronic rhinosinusitis. Allergol Int. 2015;64(2):121-130.
Wang X, Zhang N, Bo M, et al. Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: a multicenter study in Europe, Asia, and Oceania. J Allergy Clin Immunol. 2016;138(5):1344-1353.
Benjamin MR, Stevens WW, Li N, et al. Clinical characteristics of patients with chronic rhinosinusitis without nasal polyps in an academic setting. J Allergy Clin Immunol Pract. 2019;7(3):1010-1016.
Pawankar R. Nasal polyposis: an update: editorial review. Curr Opin Allergy Clin Immunol. 2003;3(1):1-6.
Boztepe OF, Gün T, Demir M, Gür ÖE, Ozel D, Doğru H. A novel predictive marker for the recurrence of nasal polyposis following endoscopic sinus surgery. Eur Arch Otorhinolaryngol. 2016;273(6):1439-1444.
Yenigün A. Assessment of patients with nasal polyposis by the neutrophil-to-lymphocyte ratio and eosinophil-to-lymphocyte ratio. Kulak Burun Bogaz Ihtis Derg. 2015;25(4):193-199.
Zhong JH, Huang DH, Chen ZY. Prognostic role of systemic immune-inflammation index in solid tumors: a systematic review and meta-analysis. Oncotarget. 2017;8(43):75381-75388.
Zhang Y, Lin S, Yang X, Wang R, Luo L. Prognostic value of pretreatment systemic immune-inflammation index in patients with gastrointestinal cancers. J Cell Physiol. 2019;234(5):5555-5563.
Sivrice ME, Okur E, Yasan H, Tüz M, Kumbul YÇ, Akın V. Can the systemic immune inflammation index preoperatively predict nasal polyp subtypes? Eur Arch Otorhinolaryngol. 2020;277(11):3045-3050.
Yang Y, Zhu J, Zhang M, et al. Systemic inflammation response index predicts the postoperative recurrence of chronic rhinosinusitis with nasal polyps: a retrospective study in the Chinese population. Eur Arch Otorhinolaryngol. 2024;281(1):207-217.
Murat B, Murat S, Ozgeyik M, Bilgin M. Comparison of pan-immune-inflammation value with other inflammation markers of long-term survival after ST-segment elevation myocardial infarction. Eur J Clin Investig. 2023;53(1):e13872.

Details

Primary Language

English

Subjects

Otorhinolaryngology

Journal Section

Research Article

Authors

Sevinç Hepkarşı
0000-0001-6608-4508
Türkiye

Cüneyt Yılmazer
0000-0001-8397-0712
Türkiye

Publication Date

August 20, 2024

Submission Date

April 3, 2024

Acceptance Date

July 25, 2024

Published in Issue

Year 2024 Volume: 7 Number: 2

DOI

https://doi.org/10.5152/ejra.2024.24132

IZ

https://izlik.org/JA76RA87LY

Cite

RIS / Bibtex

APA

Hepkarşı, S., & Yılmazer, C. (2024). Two Novel Inflammation Indexes; Can Systemic İmmune-inflammation Index and Pan-immune-inflammation Value Be Associated with Chronic Rhinosinusitis? European Journal of Rhinology and Allergy, 7(2), 55-60. https://doi.org/10.5152/ejra.2024.24132

AMA

1.Hepkarşı S, Yılmazer C. Two Novel Inflammation Indexes; Can Systemic İmmune-inflammation Index and Pan-immune-inflammation Value Be Associated with Chronic Rhinosinusitis? Eur J Rhinol Allergy. 2024;7(2):55-60. doi:10.5152/ejra.2024.24132

Chicago

Hepkarşı, Sevinç, and Cüneyt Yılmazer. 2024. “Two Novel Inflammation Indexes; Can Systemic İmmune-Inflammation Index and Pan-Immune-Inflammation Value Be Associated With Chronic Rhinosinusitis?”. European Journal of Rhinology and Allergy 7 (2): 55-60. https://doi.org/10.5152/ejra.2024.24132.

EndNote

Hepkarşı S, Yılmazer C (August 1, 2024) Two Novel Inflammation Indexes; Can Systemic İmmune-inflammation Index and Pan-immune-inflammation Value Be Associated with Chronic Rhinosinusitis? European Journal of Rhinology and Allergy 7 2 55–60.

IEEE

[1]S. Hepkarşı and C. Yılmazer, “Two Novel Inflammation Indexes; Can Systemic İmmune-inflammation Index and Pan-immune-inflammation Value Be Associated with Chronic Rhinosinusitis?”, Eur J Rhinol Allergy, vol. 7, no. 2, pp. 55–60, Aug. 2024, doi: 10.5152/ejra.2024.24132.

ISNAD

Hepkarşı, Sevinç - Yılmazer, Cüneyt. “Two Novel Inflammation Indexes; Can Systemic İmmune-Inflammation Index and Pan-Immune-Inflammation Value Be Associated With Chronic Rhinosinusitis?”. European Journal of Rhinology and Allergy 7/2 (August 1, 2024): 55-60. https://doi.org/10.5152/ejra.2024.24132.

JAMA

1.Hepkarşı S, Yılmazer C. Two Novel Inflammation Indexes; Can Systemic İmmune-inflammation Index and Pan-immune-inflammation Value Be Associated with Chronic Rhinosinusitis? Eur J Rhinol Allergy. 2024;7:55–60.

MLA

Hepkarşı, Sevinç, and Cüneyt Yılmazer. “Two Novel Inflammation Indexes; Can Systemic İmmune-Inflammation Index and Pan-Immune-Inflammation Value Be Associated With Chronic Rhinosinusitis?”. European Journal of Rhinology and Allergy, vol. 7, no. 2, Aug. 2024, pp. 55-60, doi:10.5152/ejra.2024.24132.

Vancouver

1.Sevinç Hepkarşı, Cüneyt Yılmazer. Two Novel Inflammation Indexes; Can Systemic İmmune-inflammation Index and Pan-immune-inflammation Value Be Associated with Chronic Rhinosinusitis? Eur J Rhinol Allergy. 2024 Aug. 1;7(2):55-60. doi:10.5152/ejra.2024.24132