Two Novel Inflammation Indexes; Can Systemic İmmune-inflammation Index and Pan-immune-inflammation Value Be Associated with Chronic Rhinosinusitis?

Year 2024, Volume: 7 Issue: 2, 55 - 60, 20.08.2024

Sevinç Hepkarşı , Cüneyt Yılmazer

Abstract

Objective: Chronic rhinosinusitis (CRS) can be classified as CRS with nasal polyps (CRSwNP) and CRS without nasal
polyps (CRSsNP). The aim of this study was to evaluate and compare the Systemic Immune-Inflammation Index (SII)
and Pan-I mmune -Infl ammat ion Value (PIV) levels of patients diagnosed with chronic rhinosinusitis (CRS) with nasal
polyposis (CRSwNP) and CRS without nasal polyposis (CRSsNP) along with healthy controls.

Methods: The study analyzed 320 patients from 2022 to 2023. Patients were divided into three groups. 110 CRSwNP
patients, 110 CRSsNP patients, and 100 healthy individuals were included in Groups A, B, and C, respectively. SII and
PIV levels were assessed after CRSwNP or CRSsNP diagnosis. The values of complete blood count, SII, and PIV were
compared.

Results: The mean SII levels of patients in groups A, B, and C were 685.3 ± 641.3; 1034.18 ± 1083.12; and 532.18 ±
310.77, respectively. The mean SII levels were significantly higher in group B compared to groups A and C (P = .012 and
P = .000). The mean PIV levels of patients in groups A;B and C were 405.31 ± 486.15; 539.08 ± 599.63; and 311.29 ±
217.52, respectively. The mean PIV levels were significantly higher in group B compared to group C (P = 0.001). Results
of the ROC analyses for both SII and PIV were statistically significant. Patients with an SII cut-of value of 278.6 had a
sensitivity of 91% and sensitivity 91%, specificity of 90%. Patients with a PIV cut-off value of 117.51 had a sensitivity of
92% and sensitivity 92%, specificity of 90%.

Conclusions: SII and PIV, which are important inflammatory markers, especially in systemic inflammation, were sig-
nificantly elevated in CRSwNP patients compared to CRSsNP patients and healthy controls. This may support the pres-
ence of chronic mucosal inflammation in CRSwNP patients. However, SII and PIV are indirect markers of inflammation,
and further studies with larger patient groups are warranted.

Keywords

Rhinosinusitis , Chronic rhinosinusitis , Inflammation , Systemic immune inflammation index , Pan-immune-inflammation value

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