Expression of Discoidin Domain Receptor 1 and Collagen Type IV Alpha in Nasal Polyposis

Seda Turkoglu Babakurban; Yeşim Korkmaz; Erkan Yurtcu; Hakan Akkaş; Handan Özdemir; Selim S. Erbek

doi:10.5152/ejra.2021.20023

Expression of Discoidin Domain Receptor 1 and Collagen Type IV Alpha in Nasal Polyposis

Abstract

Background and Aim: There are various studies on the inflammatory pathogenesis of nasal polyposis (NP). It has been suggested that discoidin domain receptor-1 (DDR1) and collagen type 4A (COL4A) have a role in formation of inflammatory responses in the tissue microenvironment. The aim of the study was to study the expressions of DDR1 and COL4A in NP, and nasal mucosa. Materials and Methods: This randomized, prospective, controlled clinical study was conducted on 17 patients’ NP tissue and 24 subjects’ inferior nasal turbinate. DDR1 and COL4A expressions were determined by quantitative realtime PCR. Histopathologic examinations were also carried out. Protein levels of the samples were determined using ELISA. The associations between the parameters were explored. Results: DDR1 and COL4A transcripts were found at similar levels in all of the samples. There were correlations between DDR1 and COL4A mRNA levels in both the NP and control groups. There was also a negative correlation between extracellular edema and COL4A protein levels in NP. Conclusion: To our knowledge, this is the first study to report DDR1 expression in NP tissue. We did not find any significant differences between NP and inferior nasal turbinate in terms of expressions of DDR1 and COL4A. Prospective studies with large populations should be planned for understanding DDR1 role in NP.

Keywords

References

Hamilos DL. Chronic rhinosinusitis: Epidemiology and medical management. J Allergy Clin Immun. 2011;128:693-707.
Stevens WW, Lee RJ, Schleimer RP, Cohen NA. Chronic rhinosinusitis pathogenesis. J Allergy Clin Immunol. 2015;136(6):1442-1453.
Bachert C, Van Bruaene N, Toskala E, et al. Important research questions in allergy and related diseases: 3-Chronic rhinosinusitis and nasal polyposis—A GALEN study. Allergy. 2009;64:520-533.
Bachert C, Patou J, Van Cauwenberge P. The role of sinus disease in asthma. Curr Opin Allergy Clin Immunol. 2006;6:29-36.
Leitinger B. Transmembrane collagen receptors. Annu Rev Cell Dev Biol. 2011;27:265-290.
Vogel W, Gish GD, Alves F, Pawson T. The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell. 1997;1:13-23.
Gelse K, Poschl E, Aigner T. Collagens–structure, function, and biosynthesis. Adv Drug Deliv Rev. 2003;55:1531-1546.
Valiathan RR, Marco M, Leitinger B, et al. Discoidin domain receptor tyrosine kinases: New players in cancer progression. Cancer Metastasis Rev. 2012;31:295-321.

Vogel WF, Abdulhussein R, Ford CE. Sensing extracellular matrix: An update on discoidin domain receptor function. Cell Signal. 2006;18:1108-1116.
Lee JY, Lee SH, Lee HM, et al. Analysis of gene expression profiles of normal human nasal mucosa and nasal polyp tissues by SAGE. J Allergy Clin Immunol. 2006;118:134-142.
Hou G, Vogel WF, Bendeck MP. Tyrosine kinase activity of discoidin domain receptor 1 is necessary for smooth muscle cell migration and matrix metalloproteinase expression. Circ Res. 2002;90:1147 -1149.
Meng J, Zhou P, Liu Y, et al. The development of nasal polyp disease involves early nasal mucosal inflammation and remodelling. PLoS One. 2013;8:E82373.
Khoshnoodi J, Pedchenko V, Hudson BG. Mammalian collagen IV. Microsc Res Tech. 2008;71:357-370.
Yan Y, Gordon WM, Wang D-Y. Nasal epithelial repair and remodeling in physical injury, infection, and inflammatory diseases. Curr Opin Otolaryngol Head Neck Surg. 2013;21:263-270. [Database]
Matsuyama W, Wang L, Farrar WL, Yoshimura T. Activation of discoidin domain receptor 1 isoform b with collagen up-regulates chemokine production in human macrophages: Role of p38 mitogen-activated protein kinase and NF-kappa B. J Immunol. 2004;172:2332-2340.
Matsuyama W, Watanabe M, Shirahama Y, et al. Discoidin domain receptor 1 contributes to the survival of lung fibroblast in idiopathic pulmonary fibrosis. Am J Pathol. 2006;168:866-877.
Wu M, Tu T, Huang Y, et al. Suppression subtractive hybridization identified differentially expressed genes in lung adenocarcinoma: ERGIC3 as a novel lung cancer-related gene. BMC Cancer. 2013;13:44.
Pegorier S, Campbell GA, Kay AB, et al. Bone morphogenetic protein (BMP)-4 and BMP-7 regulate differentially transforming growth factor (TGF)-beta1 in normal human lung fibroblasts (NHLF). Respir Res. 2010;11:85.
Wang T, Liang ZA, Sandford AJ, et al. Selection of suitable housekeeping genes for real-time quantitative PCR in CD4(þ) lymphocytes from asthmatics with or without depression. PLoS One. 2012;7:e48367.
Slavin RG. Asthma and sinusitis. J Allergy Clin Immunol. 1992;90:534-537.
Ponikau JU, Sherris DA, Kephart GM, et al. Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: Is the histopathology similar to asthma? J Allergy Clin Immunol. 2003;112:877-882.
Nonaka M, Pawankar R, Saji F, et al. Distinct expression of RANTES and GM-CSF by lipopolysaccharide in human nasal fibroblasts but not in other airway fibroblasts. Int Arch Allergy Immunol. 1999;119:314-321.
Saitoh T, Kusunoki T, Yao T, et al. Relationship between epithelial damage or basement membrane thickness and eosinophilic infiltration in nasal polyps with chronic rhinosinusitis. Rhinology. 2009;47(3):275-279.
Roberts ME, Magowan L, Hall IP, et al. Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production. Eur Respir J. 2011;37:1482-1493.
Chua HH1, Yeh TH, Wang YP, et al. Upregulation of discoidin domain receptor 2 in nasopharyngeal carcinoma. Head Neck. 2008;30(4):427-436.
Van Bruaene N, Derycke L, Perez-Novo CA, et al. TGF-beta signaling and collagen deposition in chronic rhinosinusitis. J Allergy Clin Immunol. 2009;124:253-259.
Molet SM, Hamid QA, Hamilos DL. IL-11 and IL-17 expression in nasal polyps: Relationship to collagen deposition and suppression by intranasal fluticasone propionate. Laryngoscope. 2010;113:1803-1812.
Berger G, Kattan A, Bernheim J, et al. Polypoid mucosa with eosinophilia and glandular hyperplasia in chronic sinusitis: A histopathological and immunohistochemical study. Laryngoscope. 2002;112:738-745.
Payne SC, Early SB, Huyett P, et al. Evidence for distinct histologic profile of nasal polyps with and without eosinophilia. Laryngoscope. 2011;121:2262-2267.

Details

Primary Language

English

Subjects

Otorhinolaryngology

Journal Section

Research Article

Authors

Seda Turkoglu Babakurban This is me
0000-0001-5067-4044
Türkiye

Yeşim Korkmaz This is me
0000-0002-0950-7890
Türkiye

Erkan Yurtcu
0000-0003-4930-8164
Türkiye

Hakan Akkaş This is me
0000-0001-8265-2659
Türkiye

Handan Özdemir This is me
0000-0002-7528-3557
Türkiye

Selim S. Erbek This is me
0000-0003-4825-3499
Türkiye

Publication Date

August 30, 2021

Submission Date

November 19, 2020

Acceptance Date

February 24, 2021

Published in Issue

Year 2021 Volume: 4 Number: 2

DOI

https://doi.org/10.5152/ejra.2021.20023

IZ

https://izlik.org/JA82UM53TD

Cite

RIS / Bibtex

APA

Turkoglu Babakurban, S., Korkmaz, Y., Yurtcu, E., Akkaş, H., Özdemir, H., & Erbek, S. S. (2021). Expression of Discoidin Domain Receptor 1 and Collagen Type IV Alpha in Nasal Polyposis. European Journal of Rhinology and Allergy, 4(2), 53-57. https://doi.org/10.5152/ejra.2021.20023

AMA

1.Turkoglu Babakurban S, Korkmaz Y, Yurtcu E, Akkaş H, Özdemir H, Erbek SS. Expression of Discoidin Domain Receptor 1 and Collagen Type IV Alpha in Nasal Polyposis. Eur J Rhinol Allergy. 2021;4(2):53-57. doi:10.5152/ejra.2021.20023

Chicago

Turkoglu Babakurban, Seda, Yeşim Korkmaz, Erkan Yurtcu, Hakan Akkaş, Handan Özdemir, and Selim S. Erbek. 2021. “Expression of Discoidin Domain Receptor 1 and Collagen Type IV Alpha in Nasal Polyposis”. European Journal of Rhinology and Allergy 4 (2): 53-57. https://doi.org/10.5152/ejra.2021.20023.

EndNote

Turkoglu Babakurban S, Korkmaz Y, Yurtcu E, Akkaş H, Özdemir H, Erbek SS (August 1, 2021) Expression of Discoidin Domain Receptor 1 and Collagen Type IV Alpha in Nasal Polyposis. European Journal of Rhinology and Allergy 4 2 53–57.

IEEE

[1]S. Turkoglu Babakurban, Y. Korkmaz, E. Yurtcu, H. Akkaş, H. Özdemir, and S. S. Erbek, “Expression of Discoidin Domain Receptor 1 and Collagen Type IV Alpha in Nasal Polyposis”, Eur J Rhinol Allergy, vol. 4, no. 2, pp. 53–57, Aug. 2021, doi: 10.5152/ejra.2021.20023.

ISNAD

Turkoglu Babakurban, Seda - Korkmaz, Yeşim - Yurtcu, Erkan - Akkaş, Hakan - Özdemir, Handan - Erbek, Selim S. “Expression of Discoidin Domain Receptor 1 and Collagen Type IV Alpha in Nasal Polyposis”. European Journal of Rhinology and Allergy 4/2 (August 1, 2021): 53-57. https://doi.org/10.5152/ejra.2021.20023.

JAMA

1.Turkoglu Babakurban S, Korkmaz Y, Yurtcu E, Akkaş H, Özdemir H, Erbek SS. Expression of Discoidin Domain Receptor 1 and Collagen Type IV Alpha in Nasal Polyposis. Eur J Rhinol Allergy. 2021;4:53–57.

MLA

Turkoglu Babakurban, Seda, et al. “Expression of Discoidin Domain Receptor 1 and Collagen Type IV Alpha in Nasal Polyposis”. European Journal of Rhinology and Allergy, vol. 4, no. 2, Aug. 2021, pp. 53-57, doi:10.5152/ejra.2021.20023.

Vancouver

1.Seda Turkoglu Babakurban, Yeşim Korkmaz, Erkan Yurtcu, Hakan Akkaş, Handan Özdemir, Selim S. Erbek. Expression of Discoidin Domain Receptor 1 and Collagen Type IV Alpha in Nasal Polyposis. Eur J Rhinol Allergy. 2021 Aug. 1;4(2):53-7. doi:10.5152/ejra.2021.20023