New Index for the Discrimination of Acute Streptococcal Tonsillopharyngitis and Infectious Mononucleosis: Infection Discrimination Index

Yusuf Çağdaş Kumbul; Hasan Yasan; Mehmet Emre Sivrice; Vural Akın; Hasan Çetin

doi:10.5152/ejra.2020.333

New Index for the Discrimination of Acute Streptococcal Tonsillopharyngitis and Infectious Mononucleosis: Infection Discrimination Index

Abstract

Objective: This study aimed to discriminate group A β-hemolytic streptococcus (GABHS) and Epstein-Barr virus (EBV) that cause acute tonsillopharyngitis with a new index called the infection discrimination index (IDI). Material and Methods: Based on the throat culture and viral capsid Ag Ig M results, 110 GABHS-positive children and 52 EBV-positive children were enrolled in the GABHS and EBV groups, respectively. Fifty children who had undergone a medical examination at the pediatric clinic comprised the control group. The IDI means of the three groups (GABHS, EBV, control) were subjected to a statistical comparison. Results: The groups did not significantly differ in terms of sex and age (p: 0.453 and 0.662, respectively). The IDI means of the three groups were significantly different (p<0.001). Receiver operating characteristic (ROC) analysis was performed to calculate the sensitivity and specificity of IDI in the GABHS and EBV groups. The ROC analysis demonstrated a sensitivity of 68.2% and specificity of 92% for predicting GABHS infection. The sensitivity and specificity was 53.8% and 96%, respectively, for predicting EBV infection. Conclusion: IDI calculated from the data of complete blood count can serve as a biomarker for discriminating between GABHS and EBV infections. We believe that the findings of this study would be particularly helpful for centers where throat culture and/or antibody tests cannot be performed. It is a rapid, practical, noninvasive, and cost-effective index.

Keywords

References

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Details

Primary Language

English

Subjects

Otorhinolaryngology

Journal Section

Research Article

Authors

Yusuf Çağdaş Kumbul
0000-0002-0713-2933
Türkiye

Hasan Yasan
0000-0002-5470-6784
Türkiye

Mehmet Emre Sivrice
0000-0002-2396-6794
Türkiye

Vural Akın
0000-0002-0050-4837
Türkiye

Hasan Çetin
0000-0002-8301-5405
Türkiye

Publication Date

December 20, 2020

Submission Date

October 13, 2020

Acceptance Date

November 26, 2020

Published in Issue

Year 2020 Volume: 3 Number: 3

DOI

https://doi.org/10.5152/ejra.2020.333

IZ

https://izlik.org/JA36XL48KM

Cite

RIS / Bibtex

APA

Kumbul, Y. Ç., Yasan, H., Sivrice, M. E., Akın, V., & Çetin, H. (2020). New Index for the Discrimination of Acute Streptococcal Tonsillopharyngitis and Infectious Mononucleosis: Infection Discrimination Index. European Journal of Rhinology and Allergy, 3(3), 64-68. https://doi.org/10.5152/ejra.2020.333

AMA

1.Kumbul YÇ, Yasan H, Sivrice ME, Akın V, Çetin H. New Index for the Discrimination of Acute Streptococcal Tonsillopharyngitis and Infectious Mononucleosis: Infection Discrimination Index. Eur J Rhinol Allergy. 2020;3(3):64-68. doi:10.5152/ejra.2020.333

Chicago

Kumbul, Yusuf Çağdaş, Hasan Yasan, Mehmet Emre Sivrice, Vural Akın, and Hasan Çetin. 2020. “New Index for the Discrimination of Acute Streptococcal Tonsillopharyngitis and Infectious Mononucleosis: Infection Discrimination Index”. European Journal of Rhinology and Allergy 3 (3): 64-68. https://doi.org/10.5152/ejra.2020.333.

EndNote

Kumbul YÇ, Yasan H, Sivrice ME, Akın V, Çetin H (December 1, 2020) New Index for the Discrimination of Acute Streptococcal Tonsillopharyngitis and Infectious Mononucleosis: Infection Discrimination Index. European Journal of Rhinology and Allergy 3 3 64–68.

IEEE

[1]Y. Ç. Kumbul, H. Yasan, M. E. Sivrice, V. Akın, and H. Çetin, “New Index for the Discrimination of Acute Streptococcal Tonsillopharyngitis and Infectious Mononucleosis: Infection Discrimination Index”, Eur J Rhinol Allergy, vol. 3, no. 3, pp. 64–68, Dec. 2020, doi: 10.5152/ejra.2020.333.

ISNAD

Kumbul, Yusuf Çağdaş - Yasan, Hasan - Sivrice, Mehmet Emre - Akın, Vural - Çetin, Hasan. “New Index for the Discrimination of Acute Streptococcal Tonsillopharyngitis and Infectious Mononucleosis: Infection Discrimination Index”. European Journal of Rhinology and Allergy 3/3 (December 1, 2020): 64-68. https://doi.org/10.5152/ejra.2020.333.

JAMA

1.Kumbul YÇ, Yasan H, Sivrice ME, Akın V, Çetin H. New Index for the Discrimination of Acute Streptococcal Tonsillopharyngitis and Infectious Mononucleosis: Infection Discrimination Index. Eur J Rhinol Allergy. 2020;3:64–68.

MLA

Kumbul, Yusuf Çağdaş, et al. “New Index for the Discrimination of Acute Streptococcal Tonsillopharyngitis and Infectious Mononucleosis: Infection Discrimination Index”. European Journal of Rhinology and Allergy, vol. 3, no. 3, Dec. 2020, pp. 64-68, doi:10.5152/ejra.2020.333.

Vancouver

1.Yusuf Çağdaş Kumbul, Hasan Yasan, Mehmet Emre Sivrice, Vural Akın, Hasan Çetin. New Index for the Discrimination of Acute Streptococcal Tonsillopharyngitis and Infectious Mononucleosis: Infection Discrimination Index. Eur J Rhinol Allergy. 2020 Dec. 1;3(3):64-8. doi:10.5152/ejra.2020.333