Atypical Nasal Manifestation of Primary Immune Deficiency in A Child

Meltem Bozacı Kılıçoğlu; Levent Aydemir; Erkan Öztürk; Hakan Kara; Şenol Çomoğlu

doi:10.5152/ejra.2019.59

Atypical Nasal Manifestation of Primary Immune Deficiency in A Child

Abstract

Hyperimmunoglobulin E syndrome (HIES) is described as a primary immune deficiency that consists of recurrent skin and lung infections, eczema, and excessively elevated serum IgE. Most cases of HIES are sporadic, although it can be inherited as autosomal dominant and autosomal recessive traits. Here, we discuss that HIES was presented with a diffuse granulomatous lesion that was restricted in the nasal vestibule region in the first admission, followed by the nasal cavity and nasal septum anterior portion, lower lateral cartilages, and columella skin. A 13-year-old male patient who had atopic dermatitis and celiac disease presented with nasal swelling in the middle of the nose for 1.5 months. After an incisional biopsy, pathological examination was compatible with “granulation tissue with inflammatory infiltration, which contained a very rich abscess and eosinophils.” Genetic examination demonstrated DOCK 8 mutation. Systemic findings were added to the clinical progression at the later stages of illness. Primer immune deficiency should be suspected in vegetative granulomatous lesions that are common in infected areas such as the nasal vestibule and the anterior region of the nasal cavity in the pediatric group. This is especially important when “inflammatory granulation tissue” is reported in recurrent biopsies.

Keywords

References

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Details

Primary Language

English

Subjects

Otorhinolaryngology

Journal Section

Case Report

Authors

Meltem Bozacı Kılıçoğlu
0000-0001-9952-0329
Türkiye

Levent Aydemir
0000-0002-5836-4304
Türkiye

Erkan Öztürk
0000-0002-6671-2911
Türkiye

Hakan Kara
0000-0003-3299-9181
Türkiye

Şenol Çomoğlu
0000-0003-4632-9218
Türkiye

Publication Date

May 29, 2019

Submission Date

December 5, 2018

Acceptance Date

January 28, 2019

Published in Issue

Year 2019 Volume: 2 Number: 1

DOI

https://doi.org/10.5152/ejra.2019.59

IZ

https://izlik.org/JA83RJ48LC

Cite

RIS / Bibtex

APA

Bozacı Kılıçoğlu, M., Aydemir, L., Öztürk, E., Kara, H., & Çomoğlu, Ş. (2019). Atypical Nasal Manifestation of Primary Immune Deficiency in A Child. European Journal of Rhinology and Allergy, 2(1), 21-23. https://doi.org/10.5152/ejra.2019.59

AMA

1.Bozacı Kılıçoğlu M, Aydemir L, Öztürk E, Kara H, Çomoğlu Ş. Atypical Nasal Manifestation of Primary Immune Deficiency in A Child. Eur J Rhinol Allergy. 2019;2(1):21-23. doi:10.5152/ejra.2019.59

Chicago

Bozacı Kılıçoğlu, Meltem, Levent Aydemir, Erkan Öztürk, Hakan Kara, and Şenol Çomoğlu. 2019. “Atypical Nasal Manifestation of Primary Immune Deficiency in A Child”. European Journal of Rhinology and Allergy 2 (1): 21-23. https://doi.org/10.5152/ejra.2019.59.

EndNote

Bozacı Kılıçoğlu M, Aydemir L, Öztürk E, Kara H, Çomoğlu Ş (May 1, 2019) Atypical Nasal Manifestation of Primary Immune Deficiency in A Child. European Journal of Rhinology and Allergy 2 1 21–23.

IEEE

[1]M. Bozacı Kılıçoğlu, L. Aydemir, E. Öztürk, H. Kara, and Ş. Çomoğlu, “Atypical Nasal Manifestation of Primary Immune Deficiency in A Child”, Eur J Rhinol Allergy, vol. 2, no. 1, pp. 21–23, May 2019, doi: 10.5152/ejra.2019.59.

ISNAD

Bozacı Kılıçoğlu, Meltem - Aydemir, Levent - Öztürk, Erkan - Kara, Hakan - Çomoğlu, Şenol. “Atypical Nasal Manifestation of Primary Immune Deficiency in A Child”. European Journal of Rhinology and Allergy 2/1 (May 1, 2019): 21-23. https://doi.org/10.5152/ejra.2019.59.

JAMA

1.Bozacı Kılıçoğlu M, Aydemir L, Öztürk E, Kara H, Çomoğlu Ş. Atypical Nasal Manifestation of Primary Immune Deficiency in A Child. Eur J Rhinol Allergy. 2019;2:21–23.

MLA

Bozacı Kılıçoğlu, Meltem, et al. “Atypical Nasal Manifestation of Primary Immune Deficiency in A Child”. European Journal of Rhinology and Allergy, vol. 2, no. 1, May 2019, pp. 21-23, doi:10.5152/ejra.2019.59.

Vancouver

1.Meltem Bozacı Kılıçoğlu, Levent Aydemir, Erkan Öztürk, Hakan Kara, Şenol Çomoğlu. Atypical Nasal Manifestation of Primary Immune Deficiency in A Child. Eur J Rhinol Allergy. 2019 May 1;2(1):21-3. doi:10.5152/ejra.2019.59