Gene Expression Analysis of Tissue Remodeling in Chronic Rhinosinusitis: A Preliminary Investigation

Ceren Günel; Gökay Bozkurt; Yaşar Can Akar

doi:10.5152/ejra.2019.215

Gene Expression Analysis of Tissue Remodeling in Chronic Rhinosinusitis: A Preliminary Investigation

Abstract

Objective: This study aims to understand the pathophysiology of bone and tissue remodeling by demonstrating the gene expression profiles in the development of chronic rhinosinusitis (CRS). Material and Methods: The study included patients who were operated with the diagnosis of CRS. The study group consisted of eight patients who underwent endoscopic sinus surgery with the diagnosis of CRS and had a history of chronic sinusitis as well as osteitic bone changes. The control group consisted of ethmoid bulla specimens of eight patients who had no history of sinusitis or sinus surgery with the diagnosis of acute sinusitis or antrochoanal polyp. In both bone and mucosal samples, RNA isolation was performed to identify and analyze genes that were upregulated and downregulated by whole-gene expression profiling using microarray technology. Results: When the diseased and healthy bone samples were compared, a total of 1302 genes were detected in 1766, and the disease was intact. Four genes, CD36 (FC[Fold Change]=31.19), tenascin XB (FC=13.6), S100 calcium binding protein A12 (FC=9.4), and G0/G1 switch 2 (FC=9.3) up-regulated in both bone and mucosa. Conclusion: Chronic rhinosinusitis is a disease that decreases both quality of life of the patient and the high cost of treatment. Gene expression analysis in tissue samples of patients with CRS and treatment-resistant CRS disease early can be used in the diagnosis of the period. With the understanding of the mechanisms involved in disease development, new treatment protocols can be established in the early period to prevent insufficiencies in medical and surgical treatment.

Keywords

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Details

Primary Language

English

Subjects

Otorhinolaryngology

Journal Section

Research Article

Authors

Ceren Günel
0000-0002-1760-6397
Türkiye

Gökay Bozkurt
0000-0002-6963-3186
Türkiye

Yaşar Can Akar This is me
0000-0002-9033-2206
Türkiye

Publication Date

October 8, 2019

Submission Date

September 30, 2019

Acceptance Date

October 7, 2019

Published in Issue

Year 2019 Volume: 2 Number: 2

DOI

https://doi.org/10.5152/ejra.2019.215

IZ

https://izlik.org/JA67HW85HC

Cite

RIS / Bibtex

APA

Günel, C., Bozkurt, G., & Akar, Y. C. (2019). Gene Expression Analysis of Tissue Remodeling in Chronic Rhinosinusitis: A Preliminary Investigation. European Journal of Rhinology and Allergy, 2(2), 35-40. https://doi.org/10.5152/ejra.2019.215

AMA

1.Günel C, Bozkurt G, Akar YC. Gene Expression Analysis of Tissue Remodeling in Chronic Rhinosinusitis: A Preliminary Investigation. Eur J Rhinol Allergy. 2019;2(2):35-40. doi:10.5152/ejra.2019.215

Chicago

Günel, Ceren, Gökay Bozkurt, and Yaşar Can Akar. 2019. “Gene Expression Analysis of Tissue Remodeling in Chronic Rhinosinusitis: A Preliminary Investigation”. European Journal of Rhinology and Allergy 2 (2): 35-40. https://doi.org/10.5152/ejra.2019.215.

EndNote

Günel C, Bozkurt G, Akar YC (October 1, 2019) Gene Expression Analysis of Tissue Remodeling in Chronic Rhinosinusitis: A Preliminary Investigation. European Journal of Rhinology and Allergy 2 2 35–40.

IEEE

[1]C. Günel, G. Bozkurt, and Y. C. Akar, “Gene Expression Analysis of Tissue Remodeling in Chronic Rhinosinusitis: A Preliminary Investigation”, Eur J Rhinol Allergy, vol. 2, no. 2, pp. 35–40, Oct. 2019, doi: 10.5152/ejra.2019.215.

ISNAD

Günel, Ceren - Bozkurt, Gökay - Akar, Yaşar Can. “Gene Expression Analysis of Tissue Remodeling in Chronic Rhinosinusitis: A Preliminary Investigation”. European Journal of Rhinology and Allergy 2/2 (October 1, 2019): 35-40. https://doi.org/10.5152/ejra.2019.215.

JAMA

1.Günel C, Bozkurt G, Akar YC. Gene Expression Analysis of Tissue Remodeling in Chronic Rhinosinusitis: A Preliminary Investigation. Eur J Rhinol Allergy. 2019;2:35–40.

MLA

Günel, Ceren, et al. “Gene Expression Analysis of Tissue Remodeling in Chronic Rhinosinusitis: A Preliminary Investigation”. European Journal of Rhinology and Allergy, vol. 2, no. 2, Oct. 2019, pp. 35-40, doi:10.5152/ejra.2019.215.

Vancouver

1.Ceren Günel, Gökay Bozkurt, Yaşar Can Akar. Gene Expression Analysis of Tissue Remodeling in Chronic Rhinosinusitis: A Preliminary Investigation. Eur J Rhinol Allergy. 2019 Oct. 1;2(2):35-40. doi:10.5152/ejra.2019.215